Characterization of Tn6238 with a new allele of aac(6')-Ib-cr.


:Here, we report that the genetic structure of Tn1331 remained conserved in Argentina from 1989 to 2013 (72 of 73 isolates), with the exception being the plasmid-borne Tn1331-like transposon Tn6238 containing a new aac(6')-Ib-cr allele recovered from a colistin-resistant Klebsiella pneumoniae clinical isolate. A bioinformatic analysis of aac(6')-Ib-like gene cassettes suggests that this new aac(6')-Ib-cr allele emerged through mutation or homologous recombination in the Tn1331 genetic platform. Tn6238 is a novel platform for the dissemination of aminoglycoside and fluoroquinolone resistance determinants.


Quiroga MP,Orman B,Errecalde L,Kaufman S,Centrón D




Has Abstract


2015-05-01 00:00:00














  • Activities of telithromycin against 13,874 Streptococcus pneumoniae isolates collected between 1999 and 2003.

    abstract::Telithromycin MICs for 13,874 Streptococcus pneumoniae isolates collected in the first 3 years of the global PROTEKT study (1999 to 2003) were studied. There was no change in the distribution of telithromycin MICs over this period, even in countries where telithromycin is in use. The telithromycin MICs for 10 isolates...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Farrell DJ,Felmingham D

    更新日期:2004-05-01 00:00:00

  • Maternal administration of solithromycin, a new, potent, broad-spectrum fluoroketolide antibiotic, achieves fetal and intra-amniotic antimicrobial protection in a pregnant sheep model.

    abstract::Solithromycin (CEM-101) is a new antibiotic that is highly potent against Ureaplasma and Mycoplasma spp. and active against many other antibiotic-resistant organisms. We have explored the maternal-amniotic-fetal pharmacokinetics of CEM-101 in a pregnant sheep model to assess its potential for treating intrauterine and...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Keelan JA,Kemp MW,Payne MS,Johnson D,Stock SJ,Saito M,Fernandes P,Newnham JP

    更新日期:2014-01-01 00:00:00

  • Nucleotide sequence of the aacC2 gene, a gentamicin resistance determinant involved in a hospital epidemic of multiply resistant members of the family Enterobacteriaceae.

    abstract::A gentamicin resistance determinant of a conjugative plasmid from Enterobacter cloacae was cloned on a 3.2-kilobase fragment in the PstI site of pBR322. Substrate profiles for eight aminoglycosides at three concentrations showed that the resistance was due to aminoglycoside-(3)-N-acetyltransferase isoenzyme II. Insert...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Vliegenthart JS,Ketelaar-van Gaalen PA,van de Klundert JA

    更新日期:1989-08-01 00:00:00

  • Novel Ser79Leu and Ser81Ile substitutions in the quinolone resistance-determining regions of ParC topoisomerase IV and GyrA DNA gyrase subunits from recent fluoroquinolone-resistant Streptococcus pneumoniae clinical isolates.

    abstract::Resistance of Streptococcus pneumoniae to fluoroquinolones is caused predominantly by amino acid substitutions at positions Ser79 of ParC and Ser81 of GyrA to either Phe or Tyr encoded in the quinolone resistance-determining regions of the parC topoisomerase IV and gyrA DNA gyrase genes. Analysis of highly resistant c...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Korzheva N,Davies TA,Goldschmidt R

    更新日期:2005-06-01 00:00:00

  • Comparison of drug resistance scores for tipranavir in protease inhibitor-naive patients infected with HIV-1 B and non-B subtypes.

    abstract::Genotypes of samples from protease inhibitor-naïve patients in Frankfurt's HIV Cohort were analyzed with five tipranavir resistance prediction algorithms. Mean scores were higher in non-B than in B subtypes. The proportion of non-B subtypes increased with increasing scores, except in weighted algorithms. Virtual and i...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Stürmer M,Stephan C,Gute P,Knecht G,Bickel M,Brodt HR,Doerr HW,Gürtler L,Lecocq P,van Houtte M

    更新日期:2011-11-01 00:00:00

  • Mode of action of lividomycin on protein synthesis in Escherichia coli.

    abstract::Lividomycin specifically inhibited bacterial protein synthesis and had codon misreading activity. Lividomycin, moreover, stimulated the binding of aminoacyl-transfer ribonucleic acid to ribosomes, but did not show any significant effects on the formation of aminoacyl-transfer ribonucleic acid and the puromycin reactio...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Yamaguchi M,Eda J,Kobayashi F,Mitsuhashi S

    更新日期:1973-09-01 00:00:00

  • Clarithromycin in treatment of early Lyme disease: a pilot study.

    abstract::Forty-one patients with erythema migrans were enrolled in an open-labelled pilot study of oral clarithromycin, 500 mg twice daily for 21 days, for the treatment of early Lyme disease. Immediately posttherapy, pretreatment signs and symptoms resolved among 91% of the 33 evaluable patients. At 6 months, all 28 of the ev...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Dattwyler RJ,Grunwaldt E,Luft BJ

    更新日期:1996-02-01 00:00:00

  • Synthesis and antibacterial activities of optically active ofloxacin.

    abstract::Two optically active (100% enantiomeric excess) isomers of ofloxacin [(+/-)-ofloxacin; DL-8280; (+/-)-9-fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-7 H-pyrido[1,2,3-de] [1,4] benzoxazine-6-carboxylic acid] were prepared by use of their optically resolved synthetic intermediates. One of the isomers, (...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Hayakawa I,Atarashi S,Yokohama S,Imamura M,Sakano K,Furukawa M

    更新日期:1986-01-01 00:00:00

  • Comparative intracellular (THP-1 macrophage) and extracellular activities of beta-lactams, azithromycin, gentamicin, and fluoroquinolones against Listeria monocytogenes at clinically relevant concentrations.

    abstract::The activities of ampicillin, meropenem, azithromycin, gentamicin, ciprofloxacin, and moxifloxacin against intracellular hemolysin-positive Listeria monocytogenes were measured in human THP-1 macrophages and were compared with the extracellular activities observed in broth. All extracellular concentrations were adjust...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Carryn S,Van Bambeke F,Mingeot-Leclercq MP,Tulkens PM

    更新日期:2002-07-01 00:00:00

  • Cefepime versus imipenem-cilastatin for treatment of nosocomial pneumonia in intensive care unit patients: a multicenter, evaluator-blind, prospective, randomized study.

    abstract::In a randomized, evaluator-blind, multicenter trial, we compared cefepime (2 g three times a day) with imipenem-cilastatin (500 mg four times a day) for the treatment of nosocomial pneumonia in 281 intensive care unit patients from 13 centers in six European countries. Of 209 patients eligible for per-protocol analysi...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验


    authors: Zanetti G,Bally F,Greub G,Garbino J,Kinge T,Lew D,Romand JA,Bille J,Aymon D,Stratchounski L,Krawczyk L,Rubinstein E,Schaller MD,Chiolero R,Glauser MP,Cometta A,Cefepime Study Group,.

    更新日期:2003-11-01 00:00:00

  • Hydrophilicity of quinolones is not an exclusive factor for decreased activity in efflux-mediated resistant mutants of Staphylococcus aureus.

    abstract::The elevated expression of the norA gene is responsible for efflux-mediated resistance to quinolones in Staphylococcus aureus (E.Y.W. Ng, M. Trucksis, and D.C. Hooper, Antimicrob. Agents Chemother. 38:1345-1355, 1994). For S. aureus transformed with a plasmid containing the cloned norA gene, SA113(pTUS20) (H. Yoshida,...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Takenouchi T,Tabata F,Iwata Y,Hanzawa H,Sugawara M,Ohya S

    更新日期:1996-08-01 00:00:00

  • Plasmid-determined resistance to boron and chromium compounds in Pseudomonas aeruginosa.

    abstract::Plasmids determining resistance to arsenic, mercury, silver, and tellurium compounds in Escherichia coli and Pseudomonas aeruginosa were tested for resistance to 40 other metal compounds. Resistance to trivalent boron and hexavalent chromium compounds was a property of certain P. aeruginosa plasmids. ...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Summers AO,Jacoby GA

    更新日期:1978-04-01 00:00:00

  • Interference with effects of amphotericin B on Candida albicans cells by 2-chloroethyl-1-nitrosoureas.

    abstract::Two nitrosoureas, 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU) and 1,3-bis-(2-chloroethyl)-1-nitrosourea (BCNU), with strong carbamoylating and weak alkylating activities, interfered with the induction of potassium leakage and lethal action of amphotericin B (AmB) on Candida albicans. 2-Cyclohexyl isocyanate, t...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Brajtburg J,Elberg S,Kobayashi GS,Medoff G

    更新日期:1988-03-01 00:00:00

  • Antibiofilm Activity and Synergistic Inhibition of Staphylococcus aureus Biofilms by Bactericidal Protein P128 in Combination with Antibiotics.

    abstract::P128 is an antistaphylococcal protein, comprising a cell wall-degrading enzymatic region and a Staphylococcus-specific binding region, which possesses specific and potent bactericidal activity against sensitive and drug-resistant strains of Staphylococcus aureus To explore P128's ability to kill S. aureus in a range o...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Nair S,Desai S,Poonacha N,Vipra A,Sharma U

    更新日期:2016-11-21 00:00:00

  • Inhibition of herpesvirus replication and herpesvirus-induced deoxyribonucleic acid polymerase by phosphonoformate.

    abstract::Phosphonoformate was found to be an inhibitor of the deoxyribonucleic acid polymerase induced by the herpesvirus of turkeys. The apparent inhibition constants were 1 to 3 muM. Phosphonoformate was also able to block the replication in cell culture of Marek's disease herpesvirus, the herpesvirus of turkeys, and herpes ...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Reno JM,Lee LF,Boezi JA

    更新日期:1978-02-01 00:00:00

  • Foscarnet treatment of cytomegalovirus retinitis in patients with the acquired immunodeficiency syndrome.

    abstract::Ten patients with acquired immunodeficiency syndrome with newly diagnosed cytomegalovirus (CMV) retinitis were treated with an induction regimen of intravenous foscarnet, 60 mg/kg of body weight, administered as a 2-h infusion and repeated every 8 h for 14 days. At the end of induction, 9 of 10 patients had stabilized...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Jacobson MA,O'Donnell JJ,Mills J

    更新日期:1989-05-01 00:00:00

  • A cell-based strategy to assess intrinsic inhibition efficiencies of HIV-1 reverse transcriptase inhibitors.

    abstract::During HIV-1 reverse transcription, there are increasing opportunities for nucleos(t)ide (NRTI) or nonnucleoside (NNRTI) reverse transcriptase (RT) inhibitors to stop elongation of the nascent viral DNA (vDNA). In addition, RT inhibitors appear to influence the kinetics of vDNA synthesis differently. While cell-free k...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Abram ME,Tsiang M,White KL,Callebaut C,Miller MD

    更新日期:2015-02-01 00:00:00

  • Efficacy of NZ2114, a novel plectasin-derived cationic antimicrobial peptide antibiotic, in experimental endocarditis due to methicillin-resistant Staphylococcus aureus.

    abstract::Cationic antimicrobial peptides (CAPs) play important roles in host immune defenses. Plectasin is a defensin-like CAP isolated from the saprophytic fungus Pseudoplectania nigrella. NZ2114 is a novel variant of plectasin with potent activity against Gram-positive bacteria. In this study, we investigated (i) the in vivo...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Xiong YQ,Hady WA,Deslandes A,Rey A,Fraisse L,Kristensen HH,Yeaman MR,Bayer AS

    更新日期:2011-11-01 00:00:00

  • Development and Validation of a Phenotypic High-Content Imaging Assay for Assessing the Antiviral Activity of Small-Molecule Inhibitors Targeting Zika Virus.

    abstract::Zika virus (ZIKV) has been linked to the development of microcephaly in newborns, as well as Guillain-Barré syndrome. There are currently no drugs available to treat ZIKV infection, and accordingly, there is an unmet medical need for the discovery of new therapies. High-throughput drug screening efforts focusing on in...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Bernatchez JA,Yang Z,Coste M,Li J,Beck S,Liu Y,Clark AE,Zhu Z,Luna LA,Sohl CD,Purse BW,Li R,Siqueira-Neto JL

    更新日期:2018-09-24 00:00:00

  • First characterization of fluoroquinolone resistance in Streptococcus suis.

    abstract::We have identified and sequenced the genes encoding the quinolone-resistance determining region (QRDR) of ParC and GyrA in fluoroquinolone-susceptible and -resistant Streptococcus suis clinical isolates. Resistance is the consequence of single point mutations in the QRDRs of ParC and GyrA and is not due to clonal spre...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Escudero JA,San Millan A,Catalan A,de la Campa AG,Rivero E,Lopez G,Dominguez L,Moreno MA,Gonzalez-Zorn B

    更新日期:2007-02-01 00:00:00

  • Colonization and infection with Enterococcus faecalis in intensive care units: the role of antimicrobial agents.

    abstract::We studied the influences of antimicrobial agents on the colonization of the respiratory tract and infection with Enterococcus faecalis in intensive care unit (ICU) patients receiving mechanical respiration for at least 3 days. In a matched-cohort analysis, patients receiving topical antimicrobial prophylaxis (TAP) of...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Bonten MJ,Gaillard CA,van Tiel FH,van der Geest S,Stobberingh EE

    更新日期:1995-12-01 00:00:00

  • In vitro induction of human immunodeficiency virus type 1 variants resistant to 2'-beta-Fluoro-2',3'-dideoxyadenosine.

    abstract::2'-beta-Fluoro-2',3'-dideoxyadenosine (F-ddA) is an acid-stable purine dideoxynucleoside analog active against a wide spectrum of human immunodeficiency virus type 1 (HIV-1) and HIV-2 strains in vitro. F-ddA is presently undergoing a phase I clinical trial at the National Cancer Institute. We induced HIV-1 variants re...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Tanaka M,Srinivas RV,Ueno T,Kavlick MF,Hui FK,Fridland A,Driscoll JS,Mitsuya H

    更新日期:1997-06-01 00:00:00

  • High-Dose Ceftriaxone for Bacterial Meningitis and Optimization of Administration Scheme Based on Nomogram.

    abstract::High dosages of ceftriaxone are used to treat central nervous system (CNS) infections. Dosage adaptation according to the glomerular filtration rate is currently not recommended. Ceftriaxone pharmacokinetics (PK) was investigated by a population approach in patients enrolled in a French multicenter prospective cohort ...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 临床试验,杂志文章,多中心研究


    authors: Grégoire M,Dailly E,Le Turnier P,Garot D,Guimard T,Bernard L,Tattevin P,Vandamme YM,Hoff J,Lemaitre F,Verdier MC,Deslandes G,Bellouard R,Sébille V,Chiffoleau A,Boutoille D,Navas D,Asseray N

    更新日期:2019-08-23 00:00:00

  • In vitro killing effect of moxifloxacin on clinical isolates of Stenotrophomonas maltophilia resistant to trimethoprim-sulfamethoxazole.

    abstract::The time-kill effect of moxifloxacin on 20 genetically distinct isolates of Stenotrophomonas maltophilia resistant to trimethoprim-sulfamethoxazole was studied. The majority (80%) were killed by a concentration equivalent to four times the MIC; the MIC induced a transient decrease in bacterial counts at 4 h, followed ...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Giamarellos-Bourboulis EJ,Karnesis L,Galani I,Giamarellou H

    更新日期:2002-12-01 00:00:00

  • Chimeric Cyanovirin-MPER recombinantly engineered proteins cause cell-free virolysis of HIV-1.

    abstract::Human immunodeficiency virus (HIV) is the primary etiologic agent responsible for the AIDS pandemic. In this work, we used a chimeric recombinant protein strategy to test the possibility of irreversibly destroying the HIV-1 virion using an agent that simultaneously binds the Env protein and viral membrane. We construc...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Contarino M,Bastian AR,Kalyana Sundaram RV,McFadden K,Duffy C,Gangupomu V,Baker M,Abrams C,Chaiken I

    更新日期:2013-10-01 00:00:00

  • Impact of antifungal prophylaxis on colonization and azole susceptibility of Candida species.

    abstract::Two large studies compared posaconazole and fluconazole or itraconazole for prophylaxis in subjects undergoing allogeneic hematopoietic stem cell transplantation or subjects with acute myelogenous leukemia. To assess the impact of prophylaxis on colonization and the development of resistance in Saccharomyces yeasts, i...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章,随机对照试验


    authors: Mann PA,McNicholas PM,Chau AS,Patel R,Mendrick C,Ullmann AJ,Cornely OA,Patino H,Black TA

    更新日期:2009-12-01 00:00:00

  • Use of fluoroquinolones in patients with chronic hepatitis C virus-induced liver failure.

    abstract::Fluroquinolone antibiotics have been reported to have antiviral properties against RNA viruses, including hepatitis C virus (HCV). In the present study, five patients with advanced liver disease secondary to chronic HCV received 500 mg daily of oral ciprofloxacin for 30 days. Serum HCV-RNA levels and liver enzyme abno...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Kojima H,Kaita KD,Hawkins K,Uhanova J,Minuk GY

    更新日期:2002-10-01 00:00:00

  • Caspofungin Weight-Based Dosing Supported by a Population Pharmacokinetic Model in Critically Ill Patients.

    abstract::The objective of this study was to develop a population pharmacokinetic model and to determine a dosing regimen for caspofungin in critically ill patients. Nine blood samples were drawn per dosing occasion. Fifteen patients with (suspected) invasive candidiasis had one dosing occasion and five had two dosing occasions...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Märtson AG,van der Elst KCM,Veringa A,Zijlstra JG,Beishuizen A,van der Werf TS,Kosterink JGW,Neely M,Alffenaar JW

    更新日期:2020-08-20 00:00:00

  • Cross-resistance profile determination of two second-generation HIV-1 integrase inhibitors using a panel of recombinant viruses derived from raltegravir-treated clinical isolates.

    abstract::The integrase inhibitor raltegravir (RAL) is currently used for the treatment of both treatment-naïve and treatment-experienced HIV-1-infected patients. Elvitegravir (EVG) is in late phases of clinical development. Since significant cross-resistance between RAL and EVG is observed, there is a need for second-generatio...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Van Wesenbeeck L,Rondelez E,Feyaerts M,Verheyen A,Van der Borght K,Smits V,Cleybergh C,De Wolf H,Van Baelen K,Stuyver LJ

    更新日期:2011-01-01 00:00:00

  • Impact of Morphological Sectors on Antifungal Susceptibility Testing and Virulence Studies.

    abstract::Morphological heterogeneity of Aspergillus terreus cultures was observed during continued cultivation of amphotericin B (AMB)-resistant isolates on drug-free medium. Outgrowth leads to the emergence of multiple sectors that might result from increased growth rates at drug-free conditions. We evaluated the differences ...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Jukic E,Blatzer M,Binder U,Mayr L,Lass-Flörl C,Lackner M

    更新日期:2017-11-22 00:00:00