Characterization of Tn6238 with a new allele of aac(6')-Ib-cr.

Abstract:

:Here, we report that the genetic structure of Tn1331 remained conserved in Argentina from 1989 to 2013 (72 of 73 isolates), with the exception being the plasmid-borne Tn1331-like transposon Tn6238 containing a new aac(6')-Ib-cr allele recovered from a colistin-resistant Klebsiella pneumoniae clinical isolate. A bioinformatic analysis of aac(6')-Ib-like gene cassettes suggests that this new aac(6')-Ib-cr allele emerged through mutation or homologous recombination in the Tn1331 genetic platform. Tn6238 is a novel platform for the dissemination of aminoglycoside and fluoroquinolone resistance determinants.

authors

Quiroga MP,Orman B,Errecalde L,Kaufman S,Centrón D

doi

10.1128/AAC.03213-14

subject

Has Abstract

pub_date

2015-05-01 00:00:00

pages

2893-7

issue

5

eissn

0066-4804

issn

1098-6596

pii

AAC.03213-14

journal_volume

59

pub_type

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