In vitro activity of temocillin (BRL 17421), a novel beta-lactam antibiotic.

abstract：:Candida auris is an emerging pathogen that can cause virulent central-line-associated bloodstream infections. Catheter salvage through the eradication of biofilms is a desirable therapeutic option. We compared taurolidine and minocycline-EDTA-ethanol (MEE) catheter lock solutions in vitro for the eradication of biofil...

journal_title：Antimicrobial agents and chemotherapy

authors： Reitzel RA,Rosenblatt J,Gerges BZ,Vargas-Cruz N,Raad II

更新日期：2020-03-24 00:00:00

abstract：:[14C]aztreonam was administered intramuscularly (50 mg/kg) to male and female rats. Groups of 10 rats (five male and five female) were sacrificed at 0.25, 2, 6, and 24 h after dosing. Blood and various tissues were removed from six rats (three male and three female) in each group for determination of total radioactivi...

journal_title：Antimicrobial agents and chemotherapy

authors： Singhvi SM,Ita CE,Shaw JM,Migdalof BH

更新日期：1984-08-01 00:00:00

abstract：:A prospective, randomized, and double-blind study comparing teicoplanin with vancomycin in the initial management of febrile neutropenic patients was conducted. Teicoplanin was administered at 6 mg per kg of body weight every 24 h (q24h) intravenously (i.v.) after initial loading at 6 mg/kg q12h for three doses. Vanco...

journal_title：Antimicrobial agents and chemotherapy

authors： Kureishi A,Jewesson PJ,Rubinger M,Cole CD,Reece DE,Phillips GL,Smith JA,Chow AW

更新日期：1991-11-01 00:00:00

abstract：:A radioimmunoassay system has been developed for the measurement of two major metabolites of 9,3"-diacetylmidecamycin, Mb-6 and Mb-12. A radioimmunoassay for Mb-6 was performed by using anti-Mb-6 serum and a [125I]tyramined Mb-6 derivative as a radiolabeled antigen. The labeled antigen was prepared by the chloramine T...

journal_title：Antimicrobial agents and chemotherapy

authors： Shimada N,Ueda T,Yokoshima T,Umemura K,Shomura T

更新日期：1982-12-01 00:00:00

abstract：:The global spread of carbapenem-resistant Klebsiella pneumoniae (CR-Kp) has been largely associated with sequence type 258 (ST258) and its related variants (clonal group 258 [CG258]). Here we describe the molecular epidemiology of CR-Kp from five tertiary care hospitals in Medellín, the second largest city in Colombia...

journal_title：Antimicrobial agents and chemotherapy

authors： Ocampo AM,Chen L,Cienfuegos AV,Roncancio G,Chavda KD,Kreiswirth BN,Jiménez JN

更新日期：2015-10-26 00:00:00

abstract：:The population pharmacokinetics of tafenoquine were studied in Australian soldiers taking tafenoquine for malarial prophylaxis. The subjects (476 males and 14 females) received a loading dose of 200 mg tafenoquine base daily for 3 days, followed by a weekly dose of 200 mg tafenoquine for 6 months. Blood samples were c...

journal_title：Antimicrobial agents and chemotherapy

authors： Charles BG,Miller AK,Nasveld PE,Reid MG,Harris IE,Edstein MD

更新日期：2007-08-01 00:00:00

abstract：:The effects of 6-amino-2-n-pentylthiobenzothiazole (APB), a new antifungal agent, on ergosterol biosynthesis in Candida albicans and Saccharomyces cerevisiae were studied, using [14C]acetate incorporation. In C. albicans, the inhibition of growth was accompanied by a marked inhibition of acetate incorporation in 4-des...

journal_title：Antimicrobial agents and chemotherapy

authors： Kuchta T,Léka C,Farkas P,Bujdáková H,Belajová E,Russell NJ

更新日期：1995-07-01 00:00:00

abstract：:Butylated hydroxytoluene (BHT) is a potent inactivator of the enveloped bacterial virus ø6 at concentrations as low as 3 x 10(-5) M. The viral envelope is not removed by BHT treatment, in contrast to the effects of exposure to the detergent Triton X-100. BHT-treated viruses are morphologically indistinguishable from c...

journal_title：Antimicrobial agents and chemotherapy

authors： Wanda P,Cupp J,Snipes W,Deith A,Rucinsky T,Polish L,Sands J

更新日期：1976-07-01 00:00:00

abstract：:Botulinum neurotoxin A is a category A bioterrorism agent. Current antitoxin therapies are scarce and produce adverse reactions. XOMA 3AB consists of 3 IgG1 monoclonal antibodies (MAbs), each with a distinct human or humanized variable region, which bind to distinct epitopes on botulinum neurotoxin serotype A. This fi...

journal_title：Antimicrobial agents and chemotherapy

authors： Nayak SU,Griffiss JM,McKenzie R,Fuchs EJ,Jurao RA,An AT,Ahene A,Tomic M,Hendrix CW,Zenilman JM

更新日期：2014-09-01 00:00:00

abstract：:Pokeweed antiviral protein at a concentration of 3 microM inhibited both the synthesis and release of infectious herpes simplex virus type 1 in cell culture by 90 and 99%, respectively. Addition of pokeweed antiviral protein to Vero cell monolayers before virus infection was 10 to 15% more effective in reducing virus ...

journal_title：Antimicrobial agents and chemotherapy

authors： Teltow GJ,Irvin JD,Aron GM

更新日期：1983-03-01 00:00:00

abstract：:Rifapentine is highly protein bound in blood, but the free, unbound drug is the microbiologically active fraction. In this exploratory study, we characterized the free plasma fraction of rifapentine in 41 patients with tuberculosis. We found a lower total rifapentine concentration but significantly higher free rifapen...

journal_title：Antimicrobial agents and chemotherapy

authors： Egelund EF,Weiner M,Singh RP,Prihoda TJ,Gelfond JA,Derendorf H,Mac Kenzie WR,Peloquin CA

更新日期：2014-08-01 00:00:00

abstract：:The pharmacokinetics of cefepime following administration of a single 2-g dose were evaluated for 12 adult patients with thermal burn injury and suspected or documented infection. Serial blood and urine samples for cefepime concentration determination were obtained for 24 h following drug administration. Serum and uri...

journal_title：Antimicrobial agents and chemotherapy

authors： Bonapace CR,White RL,Friedrich LV,Norcross ED,Bosso JA

更新日期：1999-12-01 00:00:00

abstract：:A novel beta-lactamase gene, blaOXA-61, from Campylobacter jejuni GC015 was cloned and its nucleotide sequence determined. blaOXA-61 encodes a protein of 257 amino acids in which the active-site STFK tetrad and conserved class D beta-lactamase motifs YGN and KTG were identified. A conserved sequence upstream of blaOXA...

journal_title：Antimicrobial agents and chemotherapy

authors： Alfredson DA,Korolik V

更新日期：2005-06-01 00:00:00

abstract：:Curcumin, a principal component of turmeric, acts as an immunomodulator regulating the host defenses in response to a diseased condition. The role of curcumin in controlling certain infectious diseases is highly controversial. It is known to alleviate symptoms of Helicobacter pylori infection and exacerbate that of Le...

journal_title：Antimicrobial agents and chemotherapy

authors： Marathe SA,Sen M,Dasgupta I,Chakravortty D

更新日期：2012-11-01 00:00:00

abstract：:The susceptibility of 4,929 unselected clinical isolates of bacteria to cefoxitin and cephalothin was determined by the single-disk method, using a computer-associated electronic zone analyzer to obtain, record, and process measurements of sizes of zones of inhibition. Both cefoxitin and cephalothin were effective aga...

journal_title：Antimicrobial agents and chemotherapy

authors： Moellering RC Jr,Dray M,Kunz LJ

更新日期：1974-09-01 00:00:00

abstract：:The susceptibilities of 430 Campylobacter jejuni strains and 79 C. coli strains to six antimicrobial agents were tested and analyzed. The two sets of strains originated from retail market chicken and turkey samples and from humans, respectively, in Berlin, Germany. Two groups of isolates, one dating from 1991 and the ...

journal_title：Antimicrobial agents and chemotherapy

authors： Luber P,Wagner J,Hahn H,Bartelt E

更新日期：2003-12-01 00:00:00

abstract：:The interaction of miltefosine with amphotericin B, sodium stibogluconate, paromomycin, and sitamaquine was assessed in vitro and additionally for the first three combinations in vivo. In vitro interactions were indifferent for miltefosine combined with amphotericin B (mean sums of fractional inhibitory concentrations...

journal_title：Antimicrobial agents and chemotherapy

authors： Seifert K,Croft SL

更新日期：2006-01-01 00:00:00

abstract：:A fluorometric assay, based on the natural fluorescence of the quinolone nucleus, was used to determine the uptake of ofloxacin by human polymorphonuclear leukocytes. The ratio of cellular concentration to extracellular concentration (C/E) at 20 min and 37 degrees C was 7.2, using an extracellular concentration of 5 m...

journal_title：Antimicrobial agents and chemotherapy

authors： Pascual A,Garcia I,Perea EJ

更新日期：1989-05-01 00:00:00

abstract：:PER-2 was the first detected and the second most prevalent extended-spectrum beta-lactamase in clinical pathogens isolated in Argentina and was also reported only in other South American countries. Citrobacter freundii 33587 was isolated in 1999 in Buenos Aires and was resistant to all tested beta-lactams except cepha...

journal_title：Antimicrobial agents and chemotherapy

authors： Power P,Di Conza J,Rodríguez MM,Ghiglione B,Ayala JA,Casellas JM,Radice M,Gutkind G

更新日期：2007-07-01 00:00:00

abstract：:One hundred thirty nonimmune subjects living in Yaoundé, Cameroon, completed an 18-month prospective study on the efficacy and safety of weekly chloroquine and daily proguanil (chloroguanide) (Ch-P) in malaria prevention. A total of 9 of 78 Ch-P-treated subjects and 26 of 52 subjects who received no prophylaxis contra...

journal_title：Antimicrobial agents and chemotherapy

authors： Gozal D,Hengy C,Fadat G

更新日期：1991-02-01 00:00:00

abstract：:Bacterial protein synthesis is the target for numerous natural and synthetic antibacterial agents. We have developed a poly(U) mRNA-directed aminoacylation/translation protein synthesis system composed of phenyl-tRNA synthetases, ribosomes, and ribosomal factors from Escherichia coli. This system, utilizing purified c...

journal_title：Antimicrobial agents and chemotherapy

authors： Ribble W,Hill WE,Ochsner UA,Jarvis TC,Guiles JW,Janjic N,Bullard JM

更新日期：2010-11-01 00:00:00

abstract：:Herpes simplex ocular infection is a major cause of corneal blindness. Local antiviral treatments exist but are associated with corneal toxicity, and resistance has become an issue. We evaluated the biodistribution and efficacy of a humanized anti-herpes simplex virus (anti-HSV) IgG FAb fragment (AC-8; 53 kDa) followi...

journal_title：Antimicrobial agents and chemotherapy

authors： Berdugo M,Larsen IV,Abadie C,Deloche C,Kowalczuk L,Touchard E,Dubielzig R,Brandt CR,Behar-Cohen F,Combette JM

更新日期：2012-03-01 00:00:00

abstract：:The activity of cefotaxime, either alone or combined with an aminoglycoside, was determined against 50 isolates of Pseudomonas aeruginosa, of which 50, 33, and 10 were resistant to gentamicin, tobramycin, and amikacin, respectively. Cefotaxime inhibited 34 isolates at a concentration of 16 microgram/ml and all isolate...

journal_title：Antimicrobial agents and chemotherapy

authors： Murray PR

更新日期：1980-03-01 00:00:00

abstract：:Ampicillin, trimethoprim-sulfamethoxazole, mecillinam, nitrofurantoin, and ciprofloxacin mean resistance rates for 2,000 urinary tract isolates collected from outpatients across Canada in 1998 were 41.1, 19.2, 14.7, 5.0, and 1.8%, respectively. For Escherichia coli isolates alone (n = 1,681) comparable rates were 41. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Zhanel GG,Karlowsky JA,Harding GK,Carrie A,Mazzulli T,Low DE,Hoban DJ

更新日期：2000-04-01 00:00:00

abstract：:Thirty-two strains of Trichophyton rubrum and 16 strains of Trichophyton mentagrophytes isolated from patients with tinea unguium in various parts of Germany were subjected to a microdilution test with six systemic or topical antimycotic agents. Apart from griseofulvin, there were no species-specific differences betwe...

journal_title：Antimicrobial agents and chemotherapy

authors： Korting HC,Ollert M,Abeck D

更新日期：1995-05-01 00:00:00

abstract：:Yersinia enterocolitica has emerged as an enteropathogen associated with several types of human infections that often require antimicrobial therapy, but little is known about the antimicrobial susceptibilities of pathogenic strains isolated from humans in Canada. To determine the present patterns of antimicrobial susc...

journal_title：Antimicrobial agents and chemotherapy

authors： Preston MA,Brown S,Borczyk AA,Riley G,Krishnan C

更新日期：1994-09-01 00:00:00

abstract：:The influence of five antibiotics (netilmicin, ceftriaxone, cefepime, fleroxacin, and ciprofloxacin) on capsular polysaccharide distribution and on opsonophagocytosis by human polymorphonuclear leukocytes of unencapsulated and encapsulated Escherichia coli strains was studied. Unencapsulated E. coli strains were readi...

journal_title：Antimicrobial agents and chemotherapy

authors： Raponi G,Keller N,Overbeek BP,Rozenberg-Arska M,van Kessel KP,Verhoef J

更新日期：1990-02-01 00:00:00

abstract：:We have developed a new recombinant retroviral system in which a library of infectious molecular clones of human immunodeficiency virus type 1 (HIV-1) is constructed with reverse transcriptase (RT) genes derived from viral RNA sequences in plasma. HIV-1 RT is amplified from plasma HIV-1 RNA by nested RT-PCR and cloned...

journal_title：Antimicrobial agents and chemotherapy

authors： Shi C,Mellors JW

更新日期：1997-12-01 00:00:00

abstract：:To study the antimalarial action of chloroquine, normal mouse erythrocytes were used as surrogates for erythrocytoid bodies. These bodies form in the endosomes of intraerythrocytic malaria parasites as they feed on their host and consist of erythrocyte cytoplasm enclosed in a vestige of the erythrocyte membrane. In su...

journal_title：Antimicrobial agents and chemotherapy

authors： Fitch CD,Russell NV

更新日期：2006-07-01 00:00:00

abstract：:The role of mutations in the genes for GyrA and ParC in quinolone resistance in Mycoplasma hominis was studied. Selection with sparfloxacin gave mutations at GyrA83 (Ser-->Leu; Escherichia coli numbering) or GyrA87 (Glu-->Lys), and mutants had increased levels of resistance to sparfloxacin (8- to 16-fold) but not to o...

journal_title：Antimicrobial agents and chemotherapy

authors： Kenny GE,Young PA,Cartwright FD,Sjöström KE,Huang WM

更新日期：1999-10-01 00:00:00