Distribution of [14C]aztreonam in rat tissue.

abstract：:The nonnucleoside reverse transcriptase inhibitor UC781 is under development as a potential microbicide to prevent sexual transmission of human immunodeficiency virus type 1 (HIV-1). Two gel formulations of UC781 (0.1% and 1.0%) were evaluated in a range of preclinical safety assessments, including systemic absorption...

journal_title：Antimicrobial agents and chemotherapy

authors： Patton DL,Sweeney YT,Balkus JE,Rohan LC,Moncla BJ,Parniak MA,Hillier SL

更新日期：2007-05-01 00:00:00

abstract：:Cryptic species of Aspergillus fumigatus, including the Aspergillus viridinutans species complex, are increasingly reported to be causes of invasive aspergillosis. Their identification is clinically relevant, as these species frequently have intrinsic resistance to common antifungals. We evaluated the susceptibilities...

journal_title：Antimicrobial agents and chemotherapy

authors： Lyskova P,Hubka V,Svobodova L,Barrs V,Dhand NK,Yaguchi T,Matsuzawa T,Horie Y,Kolarik M,Dobias R,Hamal P

更新日期：2018-03-27 00:00:00

abstract：:This study was directed at characterizing the genetic elements carrying the methylase gene erm(B), encoding ribosome modification-mediated resistance to macrolide, lincosamide, and streptogramin B (MLS) antibiotics, in Streptococcus pyogenes. In this species, erm(B) is responsible for MLS resistance in constitutively ...

journal_title：Antimicrobial agents and chemotherapy

authors： Brenciani A,Bacciaglia A,Vecchi M,Vitali LA,Varaldo PE,Giovanetti E

更新日期：2007-04-01 00:00:00

abstract：:A beta-lactam-sensitive strain (C152) of Shigella dysenteriae showed two major outer membrane proteins (OMPs) with M(r)s of 43,000 and 38,000, while the clinical isolate M2 lacked the 43,000-Mr OMP, which acted as a channel for beta-lactam antibiotics. Permeability of beta-lactams across the outer membrane (OM) of M2 ...

journal_title：Antimicrobial agents and chemotherapy

authors： Kar AK,Ghosh AS,Chauhan K,Ahamed J,Basu J,Chakrabarti P,Kundu M

更新日期：1997-10-01 00:00:00

abstract：:Platelet microbicidal proteins (PMPs), small cationic peptides released at sites of endovascular damage, kill common bloodstream pathogens in vitro. Our group previously showed that in vitro resistance of clinical staphylococcal and viridans group streptococcal bacteremic strains to PMPs correlated with the diagnosis ...

journal_title：Antimicrobial agents and chemotherapy

authors： Bayer AS,Cheng D,Yeaman MR,Corey GR,McClelland RS,Harrel LJ,Fowler VG Jr

更新日期：1998-12-01 00:00:00

abstract：:The in vitro activity of tebipenem (TBM), a new oral carbapenem antibiotic, against Streptococcus pneumoniae clinical isolates (n = 202) was compared with those of 15 reference agents. The isolates were classified into five genotypic classes after PCR identification of abnormal pbp1a, pbp2x, and pbp2b genes: (i) penic...

journal_title：Antimicrobial agents and chemotherapy

authors： Kobayashi R,Konomi M,Hasegawa K,Morozumi M,Sunakawa K,Ubukata K

更新日期：2005-03-01 00:00:00

abstract：:A total of 20 serious infections were treated with piperacillin. These infections included bacteremias (5), pneumonias (5), urinary tract infections (5), soft tissue infections (3), septic arthritis (1), and osteomyelitis (1). The most common bacterial pathogen was Pseudomonas aeruginosa, accounting for eight infectio...

journal_title：Antimicrobial agents and chemotherapy

authors： Simon GL,Snydman DR,Tally FP,Gorbach SL

更新日期：1980-07-01 00:00:00

abstract：:Ribavirin 5'-triphosphate (RTP), derived from the broad-spectrum antiviral compound ribavirin (Virazole), can selectively inhibit influenza virus ribonucleic acid polymerase in a cell-free assay. Ribavirin and its 5'-monophosphate have no effect on the polymerase. The inhibition is competitive with respect to adenosin...

journal_title：Antimicrobial agents and chemotherapy

authors： Eriksson B,Helgstrand E,Johansson NG,Larsson A,Misiorny A,Norén JO,Philipson L,Stenberg K,Stening G,Stridh S,Oberg B

更新日期：1977-06-01 00:00:00

abstract：:The pharmacokinetics of gentamicin C(1), C(2), and C(1a) were studied in six beagles after administration of gentamicin at 4 mg/kg of body weight as a single intravenous bolus dose. Plasma concentrations of the gentamicin components were analyzed with a novel high-performance liquid chromatography method capable of id...

journal_title：Antimicrobial agents and chemotherapy

authors： Isoherranen N,Lavy E,Soback S

更新日期：2000-06-01 00:00:00

abstract：:Spontaneous binding of infected erythrocytes to uninfected erythrocytes to form rosettes is a property of some strains of Plasmodium falciparum that is linked to severe complications of malaria. Curdlan sulfate (CRDS) is a sulfated glycoconjugate compound that is chemically similar to known rosette-inhibiting drugs su...

journal_title：Antimicrobial agents and chemotherapy

authors： Kyriacou HM,Steen KE,Raza A,Arman M,Warimwe G,Bull PC,Havlik I,Rowe JA

更新日期：2007-04-01 00:00:00

abstract：:Resistance to β-lactam antibiotics is a frequent problem in Pseudomonas aeruginosa lung infection of cystic fibrosis (CF) patients. This resistance is mainly due to the hyperproduction of chromosomally encoded β-lactamase and biofilm formation. The purpose of this study was to investigate the role of β-lactamase in th...

journal_title：Antimicrobial agents and chemotherapy

authors： Hengzhuang W,Ciofu O,Yang L,Wu H,Song Z,Oliver A,Høiby N

更新日期：2013-01-01 00:00:00

abstract：:The stage-dependent susceptibility of Plasmodium falciparum to a short exposure to docetaxel (Taxotere) was evaluated by subjecting ring-infected, trophozoite-infected, and schizont-infected erythrocytes to a 5-h exposure to various concentrations of the drug. The schizont stage was shown to be the most sensitive stag...

journal_title：Antimicrobial agents and chemotherapy

authors： Sinou V,Grellier P,Schrevel J

更新日期：1996-02-01 00:00:00

abstract：:Lethal mutagenesis is an antiviral approach that consists in extinguishing a virus by an excess of mutations acquired during replication in the presence of a mutagenic agent, often a nucleotide analogue. One of its advantages is its broad spectrum nature that renders the strategy potentially effective against emergent...

journal_title：Antimicrobial agents and chemotherapy

authors： Gallego I,Soria ME,Gregori J,de Ávila AI,García-Crespo C,Moreno E,Gadea I,Esteban J,Fernández-Roblas R,Esteban JI,Gómez J,Quer J,Domingo E,Perales C

更新日期：2019-09-30 00:00:00

abstract：:C-8-methoxy fluoroquinolones were more lethal than C-8-bromine, C-8-ethoxy, and C-8-H derivatives for Staphylococcus aureus, especially when topoisomerase IV was resistant. The methoxy group also increased lethality against wild-type cells when protein synthesis was inhibited. These properties encourage refinement of ...

journal_title：Antimicrobial agents and chemotherapy

authors： Zhao X,Wang JY,Xu C,Dong Y,Zhou J,Domagala J,Drlica K

更新日期：1998-04-01 00:00:00

abstract：:Although the use of probiotics based on Bacillus strains to fight off intestinal pathogens and antibiotic-associated diarrhea is widespread, the mechanisms involved in producing their beneficial effects remain unclear. Here, we studied the ability of compounds secreted by the probiotic Bacillus clausii strain O/C to c...

journal_title：Antimicrobial agents and chemotherapy

authors： Ripert G,Racedo SM,Elie AM,Jacquot C,Bressollier P,Urdaci MC

更新日期：2016-05-23 00:00:00

abstract：:We analyzed the relationship between rifampin MICs and rpoB mutations of 40 clinical isolates of Mycobacterium tuberculosis. A point mutation in either codon 516, 526, or 531 was found in 13 strains requiring MICs of > or = 64 micrograms/ml, while 21 strains requiring MICs of < or = 1 microgram/ml showed no alteration...

journal_title：Antimicrobial agents and chemotherapy

authors： Ohno H,Koga H,Kohno S,Tashiro T,Hara K

更新日期：1996-04-01 00:00:00

abstract：:The biochemical properties of tetrahydrofuranyl (THF) carbapenems, carbapenems with THF substituents, were evaluated with respect to enzyme stability, binding to penicillin-binding proteins (PBPs), and penetration into gram-negative organisms. THF carbapenems showed increased stability to hog renal dehydropeptidases (...

journal_title：Antimicrobial agents and chemotherapy

authors： Yang Y,Testa RT,Bhachech N,Rasmussen BA,Bush K

更新日期：1999-12-01 00:00:00

abstract：:The pathogenic yeast Candida albicans displays at its cell surface beta-1,2 oligomannosides (beta-1,2-Mans). In contrast to the ubiquitous alpha-Mans, beta-1,2-Mans bind to galectin-3, a major endogenous lectin expressed on epithelial cells. The specific role of beta-1,2-Mans in colonization of the gut by C. albicans ...

journal_title：Antimicrobial agents and chemotherapy

authors： Dromer F,Chevalier R,Sendid B,Improvisi L,Jouault T,Robert R,Mallet JM,Poulain D

更新日期：2002-12-01 00:00:00

abstract：:Ceftizoxime was evaluated in the treatment of 18 patients (6 adults and 12 children) with bacterial meningitis. In seven patients Haemophilus influenzae was the causative agent, in three Neisseria meningitidis, in five Streptococcus pneumoniae, and in one each alpha-streptococcus and Escherichia coli; one case was cul...

journal_title：Antimicrobial agents and chemotherapy

authors： Overturf GD,Cable DC,Forthal DN,Shikuma C

更新日期：1984-02-01 00:00:00

abstract：:Positive carbon-containing electrodes conveying 5 or more microA of constant direct current per cm2 showed bactericidal activity on intact back skin of 13 human subjects. This effect increased with the duration of stimulation up to a total surface bacterial kill at 20 h. When total current and current density were var...

journal_title：Antimicrobial agents and chemotherapy

authors： Bolton L,Foleno B,Means B,Petrucelli S

更新日期：1980-07-01 00:00:00

abstract：:The effects of caspofungin combined with amphotericin B were investigated with Candida glabrata. Although in vitro experiments showed an indifferent interaction, the combination regimen was the only therapeutic approach yielding organ sterilization in a murine candidemia model. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Barchiesi F,Spreghini E,Fothergill AW,Arzeni D,Greganti G,Giannini D,Rinaldi MG,Scalise G

更新日期：2005-06-01 00:00:00

abstract：:Ertapenem at 1 g once daily has been suggested to be underdosed in intensive care unit (ICU) patients to attain optimal concentrations in target tissues. Therefore, our study aimed to assess the kinetics of ertapenem in plasma and skeletal muscle in ICU patients using microdialysis. Average muscle free-ertapenem conce...

journal_title：Antimicrobial agents and chemotherapy

authors： Boyadjiev I,Boulamery A,Simon N,Martin C,Bruguerolle B,Leone M

更新日期：2011-07-01 00:00:00

abstract：:To investigate the occurrence of multinucleoside analog resistance during therapy failure, we surveyed the drug susceptibilities and genotypes of nearly 900 human immunodeficiency virus type 1 (HIV-1) samples. For 302 of these, the 50% inhibitory concentrations of at least four of the approved nucleoside analogs had f...

journal_title：Antimicrobial agents and chemotherapy

authors： Larder BA,Bloor S,Kemp SD,Hertogs K,Desmet RL,Miller V,Sturmer M,Staszewski S,Ren J,Stammers DK,Stuart DI,Pauwels R

更新日期：1999-08-01 00:00:00

abstract：:Penetration of cefprozil into the middle ear fluid was investigated in patients with chronic otitis media. A total of 89 patients ranging from 7 months to 11 years old participated in the study. The middle ear fluid was removed by ventilation tubes inserted through the tympanic membrane at times ranging from 0.38 to 5...

journal_title：Antimicrobial agents and chemotherapy

authors： Shyu WC,Haddad J,Reilly J,Khan WN,Campbell DA,Tsai Y,Barbhaiya RH

更新日期：1994-09-01 00:00:00

abstract：:To investigate whether grapefruit juice inhibits the metabolism of clarithromycin, 12 healthy subjects were given water or grapefruit juice before and after a clarithromycin dose of 500 mg in a randomized crossover study. Administration of grapefruit juice increased the time to peak concentration of both clarithromyci...

journal_title：Antimicrobial agents and chemotherapy

authors： Cheng KL,Nafziger AN,Peloquin CA,Amsden GW

更新日期：1998-04-01 00:00:00

abstract：:Development of anthrax countermeasures that may be used concomitantly in a postexposure setting requires an understanding of the interaction between these products. Anthrax immune globulin intravenous (AIGIV) is a candidate immunotherapeutic that contains neutralizing antibodies against protective antigen (PA), a comp...

journal_title：Antimicrobial agents and chemotherapy

authors： Malkevich NV,Basu S,Rudge TL Jr,Clement KH,Chakrabarti AC,Aimes RT,Nabors GS,Skiadopoulos MH,Ionin B

更新日期：2013-11-01 00:00:00

abstract：:The effects of trimethoprim, sulfadiazine, sulfamethoxazole, and sulfathiazole on the hemagglutination and adhesion by three Escherichia coli strains were studied. The strains were isolated from the urine of patients with acute pyelonephritis and carried P antigen-recognizing fimbriae (P fimbriae). At antimicrobial co...

journal_title：Antimicrobial agents and chemotherapy

authors： Väisänen V,Lounatmaa K,Korhonen TK

更新日期：1982-07-01 00:00:00

abstract：:The MICs of ofloxacin, sparfloxacin, clarithromycin, azithromycin, and fusidic acid for clinical isolates of Mycobacterium kansasii were determined by the radiometric (BACTEC) method. All drugs except azithromycin elicited MICs for 90% of the strains tested that were lower than previously reported achievable maximum c...

journal_title：Antimicrobial agents and chemotherapy

authors： Witzig RS,Franzblau SG

更新日期：1993-09-01 00:00:00

abstract：:The activity of azlocillin and mezlocillin, new semisynthetic ureido penicillins, was investigated and compared with that of other known beta-lactam antibiotics. At a concentration of 25 mug/ml, azlocillin inhibited 74% of Enterobacter, 97% of Proteus mirabilis, 64% of Citrobacter, 91% of Pseudomonas aeruginosa, and 8...

journal_title：Antimicrobial agents and chemotherapy

authors： Fu KP,Neu HC

更新日期：1978-06-01 00:00:00

abstract：:Foscarnet (phosphonoformic acid) is a pyrophosphate analog that inhibits the replication of human immunodeficiency virus type 1 (HIV-1) in vitro and in patients with AIDS. HIV-1 resistance to foscarnet has not been reported despite long-term foscarnet therapy of AIDS patients with cytomegalovirus disease. We therefore...

journal_title：Antimicrobial agents and chemotherapy

authors： Mellors JW,Bazmi HZ,Schinazi RF,Roy BM,Hsiou Y,Arnold E,Weir J,Mayers DL

更新日期：1995-05-01 00:00:00