Radioimmunoassay for metabolites of 9,3"-diacetylmidecamycin, a macrolide antibiotic.

abstract：:The susceptibility of Saccharomyces cerevisiae JG436 multidrug transporter deletion mutant, Deltapdr5, to several antifungal agents was compared to that of JG436-derived JGCDR1 and JGCaMDR1 transformants, harboring the CDR1 and CaMDR1 genes, encoding the main drug-extruding membrane proteins of Candida albicans. The J...

journal_title：Antimicrobial agents and chemotherapy

authors： Milewski S,Mignini F,Prasad R,Borowski E

更新日期：2001-01-01 00:00:00

abstract：:The in vitro activities of two new carboxyquinolones, A-56619 (difloxacin) and A-56620, were compared with those of ciprofloxacin, norfloxacin, and ofloxacin against genital tract pathogens. All the quinolones were highly active against Neisseria gonorrhoeae. A-56619 had the lowest MICs against Chlamydia trachomatis (...

journal_title：Antimicrobial agents and chemotherapy

authors： Liebowitz LD,Saunders J,Fehler G,Ballard RC,Koornhof HJ

更新日期：1986-12-01 00:00:00

abstract：:DNA gyrase is a bacterial enzyme which catalyzes the ATP-dependent negative supercoiling of DNA. It is the accepted target of quinolones. The enzyme from Citrobacter freundii IID976 was purified by affinity chromatography on novobiocin-Sepharose and heparin-Sepharose. It had two subunits, designated A and B, which clo...

journal_title：Antimicrobial agents and chemotherapy

authors： Aoyama H,Sato K,Fujii T,Fujimaki K,Inoue M,Mitsuhashi S

更新日期：1988-01-01 00:00:00

abstract：:Fifty-seven cultures of Haemophilus influenzae were tested for production of beta-lactamase by use of a modified, 1-min test. Only the 24 cultures that were ampicillin resistant, whether type b or not, yielded positive results for the enzyme; all ampicillin-susceptible isolates were uniformly negative. The beta-lactam...

journal_title：Antimicrobial agents and chemotherapy

authors： Escamilla J

更新日期：1976-01-01 00:00:00

abstract：:Methylene blue (MB) represents a promising antimalarial drug candidate for combination therapies against drug-resistant parasite strains. To support and facilitate the application of MB in future field trials, we studied its antiparasitic effects in vitro. MB is active against all blood stages of both chloroquine (CQ)...

journal_title：Antimicrobial agents and chemotherapy

authors： Akoachere M,Buchholz K,Fischer E,Burhenne J,Haefeli WE,Schirmer RH,Becker K

更新日期：2005-11-01 00:00:00

abstract：:The activities of 25 8-aminoquinolines were compared in tests assessing the ability of the compounds to inhibit the growth of Pneumocystis carinii in culture. Six compounds were effective at or below 0.03 microM: CDRI 80/53, NSC19894, NSC305805, NSC305812, WR182234, and primaquine. Four others were effective at betwee...

journal_title：Antimicrobial agents and chemotherapy

authors： Queener SF,Bartlett MS,Nasr M,Smith JW

更新日期：1993-10-01 00:00:00

abstract：:The long-term cumulative cytotoxicity of antiretrovirals (ARVs) is among the major causes of treatment failure in patients infected with human immunodeficiency virus (HIV) and patients with AIDS. This calls for the development of novel ARVs with less or no cytotoxicity. In the present study, we compared the cytotoxic ...

journal_title：Antimicrobial agents and chemotherapy

authors： Lopes de Campos WR,Coopusamy D,Morris L,Mayosi BM,Khati M

更新日期：2009-07-01 00:00:00

abstract：:Topical administration of live commensal bacteria to the vaginal tract holds significant potential as a cost-effective strategy for the treatment of sexually transmitted infections and the delivery of mucosal vaccines. Probiotic-releasing intravaginal rings (IVRs) embody significant theoretical advantages over traditi...

journal_title：Antimicrobial agents and chemotherapy

authors： Gunawardana M,Mullen M,Yoo J,Webster P,Moss JA,Baum MM

更新日期：2014-01-01 00:00:00

abstract：:Colistin is used to treat infections caused by multidrug-resistant gram-negative bacteria (MDR-GNB). It is administered intravenously in the form of colistin methanesulfonate (CMS), which is hydrolyzed in vivo to the active drug. However, pharmacokinetic data are limited. The aim of the present study was to characteri...

journal_title：Antimicrobial agents and chemotherapy

authors： Plachouras D,Karvanen M,Friberg LE,Papadomichelakis E,Antoniadou A,Tsangaris I,Karaiskos I,Poulakou G,Kontopidou F,Armaganidis A,Cars O,Giamarellou H

更新日期：2009-08-01 00:00:00

abstract：:Given that tedizolid exhibits substantial lung penetration, we hypothesize that it could achieve good efficacy against Streptococcus pneumoniae lung infections. We evaluated the pharmacodynamics of tedizolid for treatment of S. pneumoniae lung infections and compared the efficacies of tedizolid human-simulated epithel...

journal_title：Antimicrobial agents and chemotherapy

authors： Abdelraouf K,Nicolau DP

更新日期：2016-12-27 00:00:00

abstract：:Resistance of Streptococcus pneumoniae to fluoroquinolones is caused predominantly by amino acid substitutions at positions Ser79 of ParC and Ser81 of GyrA to either Phe or Tyr encoded in the quinolone resistance-determining regions of the parC topoisomerase IV and gyrA DNA gyrase genes. Analysis of highly resistant c...

journal_title：Antimicrobial agents and chemotherapy

authors： Korzheva N,Davies TA,Goldschmidt R

更新日期：2005-06-01 00:00:00

abstract：:Seventy-one strains of 15 species of rapidly growing mycobacteria were studied for their susceptibilities to fatty acids with 2 to 20 carbons by the agar dilution method at pH 7.0. Most mycobacteria other than potential pathogens (Mycobacterium fortuitum and Mycobacterium chelonei) were resistant to saturated fatty ac...

journal_title：Antimicrobial agents and chemotherapy

authors： Saito H,Tomioka H,Yoneyama T

更新日期：1984-08-01 00:00:00

abstract：:We previously demonstrated the efficacy of ceftriaxone (CRO), at 50 mg/kg of body weight every 12 h, against a highly penicillin-resistant (MIC, 4 micrograms/ml) Streptococcus pneumoniae strain with low-level resistance to CRO (MIC, 0.5 microgram/ml) in a leukopenic-mouse pneumonia model (P. Moine, E. Vallée, E. Azoul...

journal_title：Antimicrobial agents and chemotherapy

authors： Sauve C,Azoulay-Dupuis E,Moine P,Darras-Joly C,Rieux V,Carbon C,Bédos JP

更新日期：1996-12-01 00:00:00

abstract：:Women in the second half of pregnancy, who were infected with genital mycoplasmas and who gave written informed consent, were randomly assigned to receive capsules of identical appearance containing erythromycin estolate, clindamycin hydrochloride, or a placebo for 6 weeks. Levels of serum glutamic oxalacetic transami...

journal_title：Antimicrobial agents and chemotherapy

authors： McCormack WM,George H,Donner A,Kodgis LF,Alpert S,Lowe EW,Kass EH

更新日期：1977-11-01 00:00:00

abstract：:AG205 was identified from high-throughput screening as a potent inhibitor of FabK, the enoyl-ACP reductase in Streptococcus pneumoniae. Specific inhibition of lipid biosynthesis in a macromolecular biosynthesis assay and identification of an Ala141Ser substitution in FabK from spontaneous AG205-resistant mutants indic...

journal_title：Antimicrobial agents and chemotherapy

authors： Takahata S,Iida M,Osaki Y,Saito J,Kitagawa H,Ozawa T,Yoshida T,Hoshiko S

更新日期：2006-08-01 00:00:00

abstract：:The pyrazinamide (PZA) analog 5-chloropyrazinamide (5-Cl PZA) is active against mycobacterial species, including PZA-resistant strains of Mycobacterium tuberculosis. In M. smegmatis, overexpression of the type 1 fatty acid synthase (FAS I) confers resistance to 5-Cl PZA, a potent FAS I inhibitor. Since M. tuberculosis...

journal_title：Antimicrobial agents and chemotherapy

authors： Baughn AD,Deng J,Vilchèze C,Riestra A,Welch JT,Jacobs WR Jr,Zimhony O

更新日期：2010-12-01 00:00:00

abstract：:Penetration of linezolid into bone and joint tissues was studied by high-performance liquid chromatography in 13 patients suffering from implant-associated infections with methicillin-resistant staphylococci. Mean concentrations of linezolid in infected tissues were greater than 10 mg/liter in a sampling time range of...

journal_title：Antimicrobial agents and chemotherapy

authors： Kutscha-Lissberg F,Hebler U,Muhr G,Köller M

更新日期：2003-12-01 00:00:00

abstract：:BILN 2061 is a novel, specific hepatitis C virus (HCV) NS3 serine protease inhibitor discovered by Boehringer Ingelheim that has shown potent activity against HCV replicons in tissue culture and is currently under clinical investigation for the treatment of HCV infection. The poor fidelity of the HCV RNA-dependent RNA...

journal_title：Antimicrobial agents and chemotherapy

authors： Lu L,Pilot-Matias TJ,Stewart KD,Randolph JT,Pithawalla R,He W,Huang PP,Klein LL,Mo H,Molla A

更新日期：2004-06-01 00:00:00

abstract：:Extended-infusion ceftolozane-tazobactam treatment at 1.5 g every 8 h was used to treat multidrug-resistant Pseudomonas aeruginosa in a critically ill patient on continuous venovenous hemofiltration. Serum drug concentrations were measured at 1, 4, 5, 6, and 8 h after the start of infusion. Prefilter levels of ceftolo...

journal_title：Antimicrobial agents and chemotherapy

authors： Oliver WD,Heil EL,Gonzales JP,Mehrotra S,Robinett K,Saleeb P,Nicolau DP

更新日期：2015-12-28 00:00:00

abstract：:Dihydrofolate reductase-thymidylate synthase (DHFR-TS) is a well-validated antifolate drug target in certain pathogenic apicomplexans, but not in the genus Babesia, including Babesia gibsoni. Therefore, we isolated, cloned, and expressed the wild-type B. gibsoni dhfr-ts gene in Escherichia coli and evaluated the inhib...

journal_title：Antimicrobial agents and chemotherapy

authors： Aboge GO,Jia H,Terkawi MA,Goo YK,Nishikawa Y,Sunaga F,Namikawa K,Tsuji N,Igarashi I,Suzuki H,Fujisaki K,Xuan X

更新日期：2008-11-01 00:00:00

abstract：:Genome studies suggest that DNA gyrase is the sole type II topoisomerase and likely the unique target of quinolones in Mycobacterium tuberculosis. Despite the emerging importance of quinolones in the treatment of mycobacterial disease, the slow growth and high pathogenicity of M. tuberculosis have precluded direct pur...

journal_title：Antimicrobial agents and chemotherapy

authors： Aubry A,Pan XS,Fisher LM,Jarlier V,Cambau E

更新日期：2004-04-01 00:00:00

abstract：:As an obligate aerobe, Mycobacterium tuberculosis uses its electron transport chain (ETC) to produce energy via oxidative phosphorylation. This pathway has recently garnered a lot of attention and is a target for several new antimycobacterials. We tested the respiratory adaptation of M. tuberculosis to phenoxyalkylben...

journal_title：Antimicrobial agents and chemotherapy

authors： Berube BJ,Parish T

更新日期：2017-12-21 00:00:00

abstract：:Of five parenteral cephalosporins tested against 43 lactobacilli, cephaloridine, cefazolin, and cefamandole were the most active inhibitory and bactericidal agents. Timed-kill analysis revealed a slow bactericidal effect, with significant declines in mean minimal bactericidal concentration values at 48 h versus 24 h. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Bayer AS,Chow AW,Concepcion NF,Guze LB

更新日期：1979-07-01 00:00:00

abstract：:Surotomycin (formerly called CB-183,315) is a novel, orally administered cyclic lipopeptide antibacterial in development for the treatment of Clostridium difficile infection (CDI) that has potent activity against vancomycin-resistant enterococci (VRE) but limited activity against Gram-negative bacilli, including Bacte...

journal_title：Antimicrobial agents and chemotherapy

authors： Deshpande A,Hurless K,Cadnum JL,Chesnel L,Gao L,Chan L,Kundrapu S,Polinkovsky A,Donskey CJ

更新日期：2016-05-23 00:00:00

abstract：:We found that cells of Vibrio parahaemolyticus possess an energy-dependent efflux system for norfloxacin. We cloned a gene for a putative norfloxacin efflux protein from the chromosomal DNA of V. parahaemolyticus by using an Escherichia coli mutant lacking the major multidrug efflux system AcrAB as the host and sequen...

journal_title：Antimicrobial agents and chemotherapy

authors： Morita Y,Kodama K,Shiota S,Mine T,Kataoka A,Mizushima T,Tsuchiya T

更新日期：1998-07-01 00:00:00

abstract：:18F-labeled fleroxacin was used to measure the pharmacokinetics of fleroxacin in healthy and infected animals by positron emission tomography (PET) and tissue radioactivity measurements. In all experiments, a pharmacological dose of unlabeled drug (10 mg/kg) was coinjected with the tracer. The pharmacokinetics of [18F...

journal_title：Antimicrobial agents and chemotherapy

authors： Fischman AJ,Livni E,Babich J,Alpert NM,Liu YY,Thom E,Cleeland R,Prosser BL,Callahan RJ,Correia JA

更新日期：1992-10-01 00:00:00

abstract：:We investigated the impact of the piperacillin-tazobactam MIC in the outcome of 39 bloodstream infections due to extended-spectrum-β-lactamase-producing Escherichia coli. All 11 patients with urinary tract infections survived, irrespective of the MIC. For other sources, 30-day mortality was lower for isolates with a M...

journal_title：Antimicrobial agents and chemotherapy

authors： Retamar P,López-Cerero L,Muniain MA,Pascual Á,Rodríguez-Baño J,ESBL-REIPI\/GEIH Group.

更新日期：2013-07-01 00:00:00

abstract：:Sparfloxacin, a new fluorinated quinolone, exhibits higher in vitro activity against pneumococci than do ciprofloxacin and ofloxacin. Since up to 30% of cases of pneumococcal pneumonia are associated with bacteremia, and since an increasing percentage of pneumococci are resistant against penicillin, we studied the ser...

journal_title：Antimicrobial agents and chemotherapy

authors： Trautmann M,Ruhnke M,Borner K,Wagner J,Koeppe P

更新日期：1996-03-01 00:00:00

abstract：:The treatment of choice for Stenotrophomonas maltophilia is trimethoprim-sulfamethoxazole (SXT). Fluoroquinolones (FQs) have in vitro activity against S. maltophilia; however, there is limited published information on their effectiveness. The purpose of this study is to compare the effectiveness of FQs and SXT for the...

journal_title：Antimicrobial agents and chemotherapy

authors： Wang YL,Scipione MR,Dubrovskaya Y,Papadopoulos J

更新日期：2014-01-01 00:00:00

abstract：:We undertook a prospective, randomized open comparison of the broad-spectrum cephalosporins cefepime and ceftazidime in treatment of hospitalized subjects with skin or wound infections and complicated nosocomial urinary tract infections. Cefepime treatment (dosage, 2.0 g intravenously twice daily for 4 to 28 days) was...

journal_title：Antimicrobial agents and chemotherapy

authors： Gentry LO,Rodriguez-Gomez G

更新日期：1991-11-01 00:00:00