Hepatotoxicity of erythromycin estolate during pregnancy.

abstract：:Community-acquired multidrug resistant Enterobacteriaceae (MDR-Ent) infections continue to increase in the United States. In prior studies, we identified neighboring regions in Chicago, Illinois, where children have 5 to 6 times greater odds of MDR-Ent infections. To prevent community spread of MDR-Ent, we need to ide...

journal_title：Antimicrobial agents and chemotherapy

authors： Logan LK,Zhang L,Green SJ,Dorevitch S,Arango-Argoty GA,Reme K,Garner E,Aldstadt J,Johnson-Walker YJ,Hayden MK,Weinstein RA,Pruden A

更新日期：2020-03-24 00:00:00

abstract：:Cats were experimentally inoculated parenterally with the ME49 strain of Toxoplasma gondii to characterize the efficacies of two different dosages of orally administered clindamycin hydrochloride in the treatment of ocular toxoplasmosis. Concentrations of clindamycin hydrochloride at levels previously suggested to be ...

journal_title：Antimicrobial agents and chemotherapy

authors： Davidson MG,Lappin MR,Rottman JR,Tompkins MB,English RV,Bruce AT,Jayawickrama J

更新日期：1996-06-01 00:00:00

abstract：:We examined the cerebrospinal fluid penetration of daptomycin after the addition of dexamethasone and its bactericidal efficacy with and without ceftriaxone in an experimental rabbit model of pneumococcal meningitis. The combination of daptomycin with ceftriaxone was the most efficacious regimen for pneumococcal menin...

journal_title：Antimicrobial agents and chemotherapy

authors： Egermann U,Stanga Z,Ramin A,Acosta F,Stucki A,Gerber P,Cottagnoud M,Cottagnoud P

更新日期：2009-07-01 00:00:00

abstract：:A prospective study was performed with 23 Helicobacter pylori-infected children (mean age, 9.5 +/- 4.4 years) with clinical symptoms of gastritis and positive results of culture and histologic examination of gastric biopsy specimens to evaluate the influence of antibiotic resistance on eradication. Positive children w...

journal_title：Antimicrobial agents and chemotherapy

authors： Raymond J,Kalach N,Bergeret M,Benhamou PH,Barbet JP,Gendrel D,Dupont C

更新日期：1998-06-01 00:00:00

abstract：:The genetic basis for fluoroquinolone resistance was examined in 30 high-level fluoroquinolone-resistant Escherichia coli clinical isolates from Beijing, China. Each strain also demonstrated resistance to a variety of other antibiotics. PCR sequence analysis of the quinolone resistance-determining region of the topois...

journal_title：Antimicrobial agents and chemotherapy

authors： Wang H,Dzink-Fox JL,Chen M,Levy SB

更新日期：2001-05-01 00:00:00

abstract：:The M184V substitution in human immunodeficiency virus type 1 reverse transcriptase (RT) is rapidly selected in tissue culture following serial passage of wild-type virus in the presence of increasing concentrations of lamivudine (3TC). M184V is also associated with several alterations of RT enzymatic function in vitr...

journal_title：Antimicrobial agents and chemotherapy

authors： Petrella M,Oliveira M,Moisi D,Detorio M,Brenner BG,Wainberg MA

更新日期：2004-11-01 00:00:00

abstract：:The mortality rate associated with Vibrio vulnificus sepsis remains high. An in vitro time-kill assay revealed synergism between tigecycline and ciprofloxacin. The survival rate was significantly higher in mice treated with tigecycline plus ciprofloxacin than in mice treated with cefotaxime plus minocycline. Thus, com...

journal_title：Antimicrobial agents and chemotherapy

authors： Kim SE,Kim HK,Choi SM,Yu Y,Kim UJ,Darboe KS,Kang SJ,Park KH,Kang G,Kim YR,Rhee JH,Jung SI,Jang HC

更新日期：2019-09-23 00:00:00

abstract：:We have recently reported an influenza virus neuraminidase inhibitor, RWJ-270201 (BCX-1812), a novel cyclopentane derivative discovered through structure-based drug design. In this paper, we compare the potency of three compounds, RWJ-270201, oseltamivir, and zanamivir, against neuraminidase enzymes from various subty...

journal_title：Antimicrobial agents and chemotherapy

authors： Bantia S,Parker CD,Ananth SL,Horn LL,Andries K,Chand P,Kotian PL,Dehghani A,El-Kattan Y,Lin T,Hutchison TL,Montgomery JA,Kellog DL,Babu YS

更新日期：2001-04-01 00:00:00

abstract：:The in vitro activities of amphotericin B, itraconazole, fluconazole, voriconazole, posaconazole, and ravuconazole against 39 isolates of Trichosporon spp. were determined by the NCCLS M27-A microdilution method. The azoles tested appeared to be more potent than amphotericin B. Low minimal fungicidal concentration/MIC...

journal_title：Antimicrobial agents and chemotherapy

authors： Paphitou NI,Ostrosky-Zeichner L,Paetznick VL,Rodriguez JR,Chen E,Rex JH

更新日期：2002-04-01 00:00:00

abstract：:Mycobacteroides abscessus (Mab) is an opportunistic environmental pathogen that can cause chronic pulmonary disease in the setting of structural lung conditions such as bronchiectasis, COPD and cystic fibrosis. These infections are often incurable and associated with rapid lung function decline. Mab is naturally resis...

journal_title：Antimicrobial agents and chemotherapy

authors： Story-Roller E,Galanis C,Lamichhane G

更新日期：2020-12-23 00:00:00

abstract：:A multicenter collection of bacteremic isolates of Escherichia coli (n = 423), Klebsiella pneumoniae (n = 372), Pseudomonas aeruginosa (n = 300), and Acinetobacter baumannii complex (n = 199) was analyzed for susceptibility. Xpert Carba-R assay and sequencing for mcr genes were performed for carbapenem- or colistin-re...

journal_title：Antimicrobial agents and chemotherapy

authors： Liu PY,Lee YL,Lu MC,Shao PL,Lu PL,Chen YH,Cheng SH,Ko WC,Lin CY,Wu TS,Yen MY,Wang LS,Liu CP,Lee WS,Chen YS,Wang FD,Tseng SH,Lin CN,Tang HJ,Chen YH,Sheng WH,Lee CM,Liao MH,Hsueh PR

更新日期：2020-09-21 00:00:00

abstract：:Tilorone is a 50-year-old synthetic small-molecule compound with antiviral activity that is proposed to induce interferon after oral administration. This drug is used as a broad-spectrum antiviral in several countries of the Russian Federation. We have recently described activity in vitro and in vivo against the Ebola...

journal_title：Antimicrobial agents and chemotherapy

authors： Ekins S,Madrid PB

更新日期：2020-04-21 00:00:00

abstract：:We analyzed the relationship between itraconazole (ITZ) and hydroxy-itraconazole (OH-ITZ) levels in 1223 human samples. Overall, there was a statistically significant correlation between ITZ and OH-ITZ levels (correlation coefficient 0.7838), and OH-ITZ levels were generally higher than that of ITZ (median OH-ITZ:ITZ ...

journal_title：Antimicrobial agents and chemotherapy

authors： Wiederhold NP,Schwartz IS,Patterson TF,Thompson GR 3rd

更新日期：2021-01-19 00:00:00

abstract：:Isoniazid (INH) remains the most safe and cost-effective drug for the treatment and prophylaxis of tuberculosis. The use of INH has increased over the past years, largely as a result of the coepidemic of human immunodeficiency virus infection. It is frequently given chronically to critically ill patients who are copre...

journal_title：Antimicrobial agents and chemotherapy

authors： Desta Z,Soukhova NV,Flockhart DA

更新日期：2001-02-01 00:00:00

abstract：:Ten beta-lactamase-producing Enterococcus faecalis isolates were examined for the presence of the staphylococcal beta-lactamase repressor and antirepressor genes. Four isolates, previously shown to be unrelated to each other by pulsed-field gel electrophoresis analysis, were positive for both genes by PCR, although be...

journal_title：Antimicrobial agents and chemotherapy

authors： Tomayko JF,Zscheck KK,Singh KV,Murray BE

更新日期：1996-05-01 00:00:00

abstract：:Two methods for testing the susceptibility of Mycobacterium tuberculosis to rifapentine have been developed: the agar proportion method and the radiometric BACTEC technique. A critical concentration of 0.5 microg of rifapentine per ml is proposed for both methods since it provides a reliable means of distinguishing be...

journal_title：Antimicrobial agents and chemotherapy

authors： Heifets L,Sanchez T,Vanderkolk J,Pham V

更新日期：1999-01-01 00:00:00

abstract：:The sterol 14-demethylase P450 (CYP51) of a fluconazole-resistant isolate of Candida albicans, DUMC136, showed reduced susceptibility to this azole but with little change in its catalytic activity. Twelve nucleotide substitutions, resulting in four amino acid changes, were identified in the DUMC136 CYP51 gene in compa...

journal_title：Antimicrobial agents and chemotherapy

authors： Asai K,Tsuchimori N,Okonogi K,Perfect JR,Gotoh O,Yoshida Y

更新日期：1999-05-01 00:00:00

abstract：:The inhibition of the lymphadenopathy-associated virus strain of human immunodeficiency virus (HIV) by alternating regimens of two dideoxynucleosides, 3'-azido-3'-deoxythymidine (AZT) (zidovudine) and 2',3'-dideoxycytidine (ddC), was determined in CEM cells. Cultures infected with virus for 2 h were treated with clini...

journal_title：Antimicrobial agents and chemotherapy

authors： Spector SA,Ripley D,Hsia K

更新日期：1989-06-01 00:00:00

abstract：:Carbapenem-resistant Enterobacteriaceae (CRE) can be mechanistically classified into carbapenemase-producing Enterobacteriaceae (CPE) and non-carbapenemase-producing carbapenem nonsusceptible Enterobacteriaceae (NCPCRE). We sought to investigate the effect of antecedent carbapenem exposure as a risk factor for NCPCRE ...

journal_title：Antimicrobial agents and chemotherapy

authors： Marimuthu K,Ng OT,Cherng BPZ,Fong RKC,Pada SK,De PP,Ooi ST,Smitasin N,Thoon KC,Krishnan PU,Ang MLT,Chan DSG,Kwa ALH,Deepak RN,Chan YK,Chan YFZ,Huan X,Zaw Linn K,Tee NWS,Tan TY,Koh TH,Lin RTP,Hsu LY,Sengupta

更新日期：2019-09-23 00:00:00

abstract：:We found earlier that deferoxamine (DFO), a drug used for treatment of iron overload, is active against a rat model of Pneumocystis carinii pneumonia (PCP). We had assumed a mode of action by deprivation of nutritional iron; however, data here show that DFO penetrates P. carinii, causing irreversible damage, thus indi...

journal_title：Antimicrobial agents and chemotherapy

authors： Clarkson AB Jr,Turkel-Parrella D,Williams JH,Chen LC,Gordon T,Merali S

更新日期：2001-12-01 00:00:00

abstract：:We evaluated the in vitro activities of anidulafungin, micafungin, and caspofungin against Candida krusei by determining MIC and minimum fungicidal concentration (MFC) measurements and by the time-kill method. The geometric mean (GM)-MIC/GM-MFC values were 0.1/0.34, 0.25/0.44, and 1/2.29, respectively. The mean times ...

journal_title：Antimicrobial agents and chemotherapy

authors： Cantón E,Pemán J,Valentín A,Espinel-Ingroff A,Gobernado M

更新日期：2009-07-01 00:00:00

abstract：:Moxifloxacin (MXF) is a fluoroquinolone antibiotic that is effective against respiratory infections. However, the mechanisms of MXF lung diffusion are unknown. Active transport in other tissues has been suggested for several members of the fluoroquinolone family. In this study, transport of MXF was systematically inve...

journal_title：Antimicrobial agents and chemotherapy

authors： Brillault J,De Castro WV,Harnois T,Kitzis A,Olivier JC,Couet W

更新日期：2009-04-01 00:00:00

abstract：:We studied the DNA sequence variation of van genes of 34 isolates of Enterococcus spp. The isolates containing the vanB gene exhibited between 0 and 41 base pair changes per 801 bp studied when the vanB sequences were compared to that of the reference strain Enterococcus faecalis V583. The isolates carrying the vanC-2...

journal_title：Antimicrobial agents and chemotherapy

authors： Patel R,Uhl JR,Kohner P,Hopkins MK,Steckelberg JM,Kline B,Cockerill FR 3rd

更新日期：1998-01-01 00:00:00

abstract：:Current procedures for obtaining and measuring plasma concentrations of HIV protease inhibitors (PIs) are technically challenging. Dried blood spot (DBS) assays offer a way to overcome many of the obstacles. We sought to develop a DBS assay for quantitation of the PI atazanavir (ATV) and to compare this method with a ...

journal_title：Antimicrobial agents and chemotherapy

authors： Van Schooneveld T,Swindells S,Nelson SR,Robbins BL,Moore R,Fletcher CV

更新日期：2010-10-01 00:00:00

abstract：:We report the capacity of copper oxide-containing filters to reduce infectious titers of a panel of viruses spiked into culture media. Enveloped, nonenveloped, RNA, and DNA viruses were affected, suggesting the possibility of using copper oxide-containing devices to deactivate a wide spectrum of infectious viruses fou...

journal_title：Antimicrobial agents and chemotherapy

authors： Borkow G,Sidwell RW,Smee DF,Barnard DL,Morrey JD,Lara-Villegas HH,Shemer-Avni Y,Gabbay J

更新日期：2007-07-01 00:00:00

abstract：:The pathogenic yeast Candida albicans displays at its cell surface beta-1,2 oligomannosides (beta-1,2-Mans). In contrast to the ubiquitous alpha-Mans, beta-1,2-Mans bind to galectin-3, a major endogenous lectin expressed on epithelial cells. The specific role of beta-1,2-Mans in colonization of the gut by C. albicans ...

journal_title：Antimicrobial agents and chemotherapy

authors： Dromer F,Chevalier R,Sendid B,Improvisi L,Jouault T,Robert R,Mallet JM,Poulain D

更新日期：2002-12-01 00:00:00

abstract：:We evaluated the in vitro activity of piperacillin alone or in combination with the beta-lactamase inhibitor tazobactam against clinical isolates of Legionella species. At an inoculum of approximately 10(4) CFU, tazobactam, piperacillin, and the 8:1 combination had equivalent activities against Legionella spp. At an a...

journal_title：Antimicrobial agents and chemotherapy

authors： Collins LA,Wennersten CB,Ferraro MJ,Moellering RC Jr,Eliopoulos GM

更新日期：1994-01-01 00:00:00

abstract：:Rosmarinic acid (RA) reduced the mortality of mice infected with Japanese encephalitis virus (JEV). Significant decreases in viral loads (P < 0.001) and proinflammatory cytokine levels (P < 0.001) were observed in JEV-infected animals treated with RA compared to levels in infected mice without treatment, at 8 to 9 day...

journal_title：Antimicrobial agents and chemotherapy

authors： Swarup V,Ghosh J,Ghosh S,Saxena A,Basu A

更新日期：2007-09-01 00:00:00

abstract：:beta-Lactamases produced by urine isolates from patients in long-term care facilities (LTCFs), outpatient, clinics, and one hospital in a U.S. community were characterized. A total of 1.3% of all Escherichia coli and Klebsiella pneumoniae isolates collected from patients in 30 LTCFs and various outpatient clinics prod...

journal_title：Antimicrobial agents and chemotherapy

authors： Hanson ND,Moland ES,Hong SG,Propst K,Novak DJ,Cavalieri SJ

更新日期：2008-10-01 00:00:00

abstract：:ST-246, a novel compound that inhibits egress of orthopoxvirus from infected cells, is being evaluated as a treatment for pathogenic orthopoxvirus infections in humans. This phase I, double-blind, randomized, placebo-controlled, escalating multiple-dose study was conducted to determine the safety, tolerability, and ph...

journal_title：Antimicrobial agents and chemotherapy

authors： Jordan R,Chinsangaram J,Bolken TC,Tyavanagimatt SR,Tien D,Jones KF,Frimm A,Corrado ML,Pickens M,Landis P,Clarke J,Marbury TC,Hruby DE

更新日期：2010-06-01 00:00:00