National Surveillance of Antimicrobial Susceptibility of Bacteremic Gram-Negative Bacteria with Emphasis on Community-Acquired Resistant Isolates: Report from the 2019 Surveillance of Multicenter Antimicrobial Resistance in Taiwan (SMART).

abstract：:Changes in plasmid DNA supercoiling were measured following treatment of Escherichia coli cells, carrying topoisomerase mutations, with the quinolone ciprofloxacin. In quinolone-susceptible cells (top+ gyr+) as well as in topA mutants and in gyrB mutants, plasmid DNA was relaxed after the addition of ciprofloxacin. In...

journal_title：Antimicrobial agents and chemotherapy

authors： Aleixandre V,Herrera G,Urios A,Blanco M

更新日期：1991-01-01 00:00:00

abstract：:We determined whether gyrA mutations were present in fluoroquinolone-resistant laboratory mutants derived from the Bacteroides fragilis reference strain ATCC 25285 and in clinical isolates of B. fragilis. The two first-step mutants selected on ciprofloxacin (CIP) were devoid of gyrA mutations, whereas two of the three...

journal_title：Antimicrobial agents and chemotherapy

authors： Bachoual R,Dubreuil L,Soussy CJ,Tankovic J

更新日期：2000-07-01 00:00:00

abstract：:An experimental local infection system has been developed in which exudates are induced with croton oil in granuloma pouches of rats. This system provided a suitable model for the evaluation of the therapeutic effect of two antibiotics, cefazolin and cephalothin. Exudate levels of cefazolin were found to be higher tha...

journal_title：Antimicrobial agents and chemotherapy

authors： Nishida M,Murakawa T

更新日期：1977-06-01 00:00:00

abstract：:An in vitro pharmacodynamic model was used to simulate the in vivo pharmacokinetics of clarithromycin and 14-hydroxyclarithromycin in order to generate time-kill curves for three clinical isolates of Haemophilus influenzae (isolates 2019, 91-183, and 1746). Representative concentrations in serum or lung tissue and the...

journal_title：Antimicrobial agents and chemotherapy

authors： Walker KJ,Larsson AJ,Zabinski RA,Rotschafer JC

更新日期：1994-09-01 00:00:00

abstract：:By cloning studies and complementation experiments, the sulfonamide resistance gene of a serogroup B and serotype 15 (B:15) strain of Neisseria meningitidis was localized to a 1.2-kb chromosomal SspI fragment expressing a drug-resistant dihydropteroate synthase. The fragment hybridized to DNA from both resistant and s...

journal_title：Antimicrobial agents and chemotherapy

authors： Kristiansen BE,Rådström P,Jenkins A,Ask E,Facinelli B,Sköld O

更新日期：1990-11-01 00:00:00

abstract：:We investigated the contribution of multidrug resistance-associated protein 2 (MRP2) to the secretory transport of grepafloxacin and compared its functional role with that of P-glycoprotein (P-gp) by using Sprague-Dawley rats (SDRs) and Eisai hyperbilirubinemic rats (EHBRs), in which MRP2 is hereditarily defective. In...

journal_title：Antimicrobial agents and chemotherapy

authors： Naruhashi K,Tamai I,Inoue N,Muraoka H,Sai Y,Suzuki N,Tsuji A

更新日期：2002-02-01 00:00:00

abstract：:Seventeen oral streptococci and 18 enterococci were tested for the presence of DNA sequences homologous to the conjugative transposon Tn916 encoding tetracycline resistance. All the strains were resistant to tetracyclines, including minocycline, and most of them were resistant to other antibiotics. Tn916-like structur...

journal_title：Antimicrobial agents and chemotherapy

authors： Bentorcha F,Clermont D,de Cespédès G,Horaud T

更新日期：1992-01-01 00:00:00

abstract：:The production of Klebsiella pneumoniae carbapenemases (KPCs) by Enterobacteriaceae has become a significant problem in recent years. To identify factors that could predict isolation of KPC-producing K. pneumoniae (KPCKP) in clinical samples from hospitalized patients, we conducted a retrospective, matched (1:2) case-...

journal_title：Antimicrobial agents and chemotherapy

authors： Tumbarello M,Trecarichi EM,Tumietto F,Del Bono V,De Rosa FG,Bassetti M,Losito AR,Tedeschi S,Saffioti C,Corcione S,Giannella M,Raffaelli F,Pagani N,Bartoletti M,Spanu T,Marchese A,Cauda R,Viscoli C,Viale P

更新日期：2014-06-01 00:00:00

abstract：:We isolated mutant YM644, which showed elevated resistance to norfloxacin, ethidium bromide, acriflavine, and rhodamine 6G, from Pseudomonas aeruginosa YM64, a strain that lacks four major multidrug efflux pumps. The genes responsible for the resistance were mexHI-opmD. Elevated ethidium extrusion was observed with ce...

journal_title：Antimicrobial agents and chemotherapy

authors： Sekiya H,Mima T,Morita Y,Kuroda T,Mizushima T,Tsuchiya T

更新日期：2003-09-01 00:00:00

abstract：:The EmbCAB proteins have been considered a target for ethambutol (EMB). Mutations in embCAB are known to confer most EMB resistance. However, the knowledge about the effects of embCAB mutations on the EMB resistance level and about the role of mutation-mutation interactions is limited in China. Here, we sequenced embC...

journal_title：Antimicrobial agents and chemotherapy

authors： Sun Q,Xiao TY,Liu HC,Zhao XQ,Liu ZG,Li YN,Zeng H,Zhao LL,Wan KL

更新日期：2017-12-21 00:00:00

abstract：:Platelet microbicidal proteins (PMPs), small cationic peptides released at sites of endovascular damage, kill common bloodstream pathogens in vitro. Our group previously showed that in vitro resistance of clinical staphylococcal and viridans group streptococcal bacteremic strains to PMPs correlated with the diagnosis ...

journal_title：Antimicrobial agents and chemotherapy

authors： Bayer AS,Cheng D,Yeaman MR,Corey GR,McClelland RS,Harrel LJ,Fowler VG Jr

更新日期：1998-12-01 00:00:00

abstract：:Streptonigrin, a quinone antitumor antibiotic, has been reported to be effective in human trials. A sensitive and precise microbiological assay for the determination of distribution and concentrations of streptonigrin in the body fluids and tissues of treated mice has been developed in an attempt to supplement success...

journal_title：Antimicrobial agents and chemotherapy

authors： Pittillo RF,Woolley C

更新日期：1974-01-01 00:00:00

abstract：:Attachment of giardias to intestinal cells has been difficult to study because of a lack of a convenient in vitro model. We developed an assay for attachment of radiolabeled trophozoites to IEC-6 cells that can be done in microtiter trays. Attachment was confirmed by scanning and transmission electron microscopy. Trop...

journal_title：Antimicrobial agents and chemotherapy

authors： McCabe RE,Yu GS,Conteas C,Morrill PR,McMorrow B

更新日期：1991-01-01 00:00:00

abstract：:Three percent 5-ethyl-2'-deoxyuridine (EdU) in an aqueous cream base was compared with 5% acyclovir (ACV) in polyethylene glycol ointment and 3% EdU in 95% dimethyl sulfoxide (DMSO) for efficacy in the topical treatment of an experimental dorsal cutaneous herpes simplex virus type 1 infection in guinea pigs. Topical A...

journal_title：Antimicrobial agents and chemotherapy

authors： Spruance SL,Freeman DJ,Sheth NV

更新日期：1985-07-01 00:00:00

abstract：:The emergence of pneumococci resistant to penicillin and other agents prompted us to evaluate intravenous vancomycin for the therapy of pneumococcal meningitis, which has an overall mortality of 30%. Eleven consecutive adult patients with cerebrospinal fluid (CSF)-culture-proven pneumococcal meningitis and positive in...

journal_title：Antimicrobial agents and chemotherapy

authors： Viladrich PF,Gudiol F,Liñares J,Pallarés R,Sabaté I,Rufí G,Ariza J

更新日期：1991-12-01 00:00:00

abstract：:In enterobacteria, the ampG gene encodes a transmembrane protein (permease) that transports 1,6-GlcNAc-anhydro-MurNAc and the 1,6-GlcNAc-anhydro-MurNAc peptide from the periplasm to the cytoplasm, which serve as signal molecules for the induction of ampC β-lactamase. The role of AmpG as a transporter is also essential...

journal_title：Antimicrobial agents and chemotherapy

authors： Zhang Y,Bao Q,Gagnon LA,Huletsky A,Oliver A,Jin S,Langaee T

更新日期：2010-11-01 00:00:00

abstract：:A portion of the Mycobacterium tuberculosis gene encoding the beta subunit of RNA polymerase (rpoB) was amplified by PCR using degenerate oligonucleotides and used as a hybridization probe to isolate plasmid clones carrying the entire rpoB gene of M. tuberculosis H37Rv, a virulent, rifampin-susceptible strain. Sequenc...

journal_title：Antimicrobial agents and chemotherapy

authors： Miller LP,Crawford JT,Shinnick TM

更新日期：1994-04-01 00:00:00

abstract：:Low-level vancomycin-resistant Staphylococcus aureus (vancomycin-intermediate S. aureus [VISA] and heterogenous VISA [hVISA]) is increasingly reported and leads to glycopeptide treatment failure. Various phenotypic features have been reported for these isolates, but the genetic changes leading to hVISA and VISA have y...

journal_title：Antimicrobial agents and chemotherapy

authors： Howden BP,Johnson PD,Ward PB,Stinear TP,Davies JK

更新日期：2006-09-01 00:00:00

abstract：:Invasive aspergillosis is an increasingly frequent opportunistic infection in immunocompromised patients. Only two agents, amphotericin B and itraconazole, are licensed for therapy. Itraconazole acts through inhibition of a P-450 enzyme undertaking sterol 14alpha demethylation. In vitro resistance in Aspergillus fumig...

journal_title：Antimicrobial agents and chemotherapy

authors： Denning DW,Venkateswarlu K,Oakley KL,Anderson MJ,Manning NJ,Stevens DA,Warnock DW,Kelly SL

更新日期：1997-06-01 00:00:00

abstract：:A rapid method for the detection of methicillin resistance in staphylococci was developed. The method was based on the polymerase chain reaction (PCR) and primers that targeted the internal region of the coding frame of the mec gene. The amplification reaction was carried out with crude cell lysates as a source of tar...

journal_title：Antimicrobial agents and chemotherapy

authors： Predari SC,Ligozzi M,Fontana R

更新日期：1991-12-01 00:00:00

abstract：:Bacteriophage therapy is a promising alternative treatment to antibiotics, as it has been documented to be efficacious against multidrug-resistant bacteria with minimal side effects. Several groups have demonstrated the efficacy of phage suspension in vivo to treat lung infections using intranasal delivery; however, p...

journal_title：Antimicrobial agents and chemotherapy

authors： Chang RYK,Chen K,Wang J,Wallin M,Britton W,Morales S,Kutter E,Li J,Chan HK

更新日期：2018-01-25 00:00:00

abstract：:Human macrophage inflammatory protein 3alpha (MIP-3alpha), also known as CCL20, is a 70-amino-acid chemokine which exclusively binds to chemokine receptor 6. In addition, the protein also has direct antimicrobial, antifungal, and antiviral activities. The solution structure of MIP-3alpha was solved by the use of two-d...

journal_title：Antimicrobial agents and chemotherapy

authors： Chan DI,Hunter HN,Tack BF,Vogel HJ

更新日期：2008-03-01 00:00:00

abstract：:The objective of the study was to measure antiretroviral exposures in four physiological compartments during pregnancy, delivery, and postpartum. This prospective, open-label, longitudinal study collected paired blood plasma (BP) and genital tract (GT) aspirates antepartum, at delivery, and up to 12 weeks postpartum. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Yeh RF,Rezk NL,Kashuba AD,Dumond JB,Tappouni HL,Tien HC,Chen YC,Vourvahis M,Horton AL,Fiscus SA,Patterson KB

更新日期：2009-06-01 00:00:00

abstract：:Subinhibitory concentrations of antibiotics have been shown to enhance biofilm formation in multiple bacterial species. While antibiotic exposure has been associated with modulated expression of many biofilm-related genes, the mechanisms of drug-induced biofilm formation remain a focus of ongoing research efforts and ...

journal_title：Antimicrobial agents and chemotherapy

authors： Yu W,Hallinen KM,Wood KB

更新日期：2017-12-21 00:00:00

abstract：:Clindamycin was given intravenously to 15 patients undergoing colorectal surgery in an initial dose of 600 mg, given at induction of anesthesia followed by 6 doses of 600 mg at 8-h intervals. Series of serum samples and fecal specimens were taken for analysis of clindamycin concentrations. Tissue samples from the gut ...

journal_title：Antimicrobial agents and chemotherapy

authors： Kager L,Liljeqvist L,Malmborg AS,Nord CE

更新日期：1981-12-01 00:00:00

abstract：:Detailed analysis of the endogenous sterol content of purified Pneumocystis carinii preparations by gas-liquid chromatography coupled to mass spectrometry suggested that this parasite can both synthesize de novo steroid skeletons (to produce delta7 sterols) and take them from the infected host (leading to delta5 stero...

journal_title：Antimicrobial agents and chemotherapy

authors： Urbina JA,Visbal G,Contreras LM,McLaughlin G,Docampo R

更新日期：1997-07-01 00:00:00

abstract：:The purpose of this work was to evaluate the in vitro possibilities of ampicillin-ceftriaxone combinations for 10 Enterococcus faecalis strains with high-level resistance to aminoglycosides (HLRAg) and to assess the efficacy of ampicillin plus ceftriaxone, both administered with humanlike pharmacokinetics, for the tre...

journal_title：Antimicrobial agents and chemotherapy

authors： Gavaldà J,Torres C,Tenorio C,López P,Zaragoza M,Capdevila JA,Almirante B,Ruiz F,Borrell N,Gomis X,Pigrau C,Baquero F,Pahissa A

更新日期：1999-03-01 00:00:00

abstract：:Rifampin monotherapy was compared to the combination of linezolid or vancomycin with rifampin in an experimental rat model of methicillin-resistant Staphylococcus aureus (MRSA) chronic foreign body osteomyelitis. MRSA was inoculated into the proximal tibia, and a titanium wire was implanted. Four weeks after infection...

journal_title：Antimicrobial agents and chemotherapy

authors： Vergidis P,Rouse MS,Euba G,Karau MJ,Schmidt SM,Mandrekar JN,Steckelberg JM,Patel R

更新日期：2011-03-01 00:00:00

abstract：:Robust determination of the concentration-time profile of anti-infective agents in certain specialized compartments is often limited by the inability to obtain more than a single sample from such a site in any one subject. Vitreous humor and cerebrospinal fluid are obvious examples for which the determination of conce...

journal_title：Antimicrobial agents and chemotherapy

authors： Drusano GL,Liu W,Perkins R,Madu A,Madu C,Mayers M,Miller MH

更新日期：1995-08-01 00:00:00

abstract：:We recently reported that in lung tissue, thioridazine accumulates at high concentrations relative to serum levels, displaying modest synergy with isoniazid and reducing the emergence of isoniazid-resistant mutants in mouse lungs. In this study, we sought to investigate the sterilizing activity of human-equivalent dos...

journal_title：Antimicrobial agents and chemotherapy

authors： Dutta NK,Pinn ML,Karakousis PC

更新日期：2014-09-01 00:00:00