Safety and pharmacokinetics of the antiorthopoxvirus compound ST-246 following repeat oral dosing in healthy adult subjects.

abstract：:A single Klebsiella pneumoniae strain isolated in a Bulgarian hospital was found to produce CTX-M-71, a new CTX-M variant characterized by one amino acid substitution from glycine to cysteine at position 238 in comparison to CTX-M-15. This exchange decreased the hydrolytic activity of the beta-lactamase for cefotaxime...

journal_title：Antimicrobial agents and chemotherapy

authors： Schneider I,Queenan AM,Markovska R,Markova B,Keuleyan E,Bauernfeind A

更新日期：2009-10-01 00:00:00

abstract：:We and others recently identified copper resistance as important for virulence of Mycobacterium tuberculosis. Here, we introduce a high-throughput screening assay for agents that induce a copper hypersensitivity phenotype in M. tuberculosis and demonstrate that such copper-boosting compounds are effective against repl...

journal_title：Antimicrobial agents and chemotherapy

authors： Speer A,Shrestha TB,Bossmann SH,Basaraba RJ,Harber GJ,Michalek SM,Niederweis M,Kutsch O,Wolschendorf F

更新日期：2013-02-01 00:00:00

abstract：:Aspergillus fumigatus is a leading cause of death in immunocompromised patients and a frequent colonizer of the respiratory tracts of asthma and cystic fibrosis (CF) patients. Biofilms enable bacteria and yeasts to persist in infections and can contribute to antimicrobial resistance. We investigated the ability of A. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Seidler MJ,Salvenmoser S,Müller FM

更新日期：2008-11-01 00:00:00

abstract：:The objective of this study was to evaluate the effects of antimicrobial drug use, gastric acid-suppressive agent use, and infection control practices on the incidence of Clostridium difficile-associated diarrhea (CDAD) in a 426-bed general teaching hospital in Northern Ireland. The study was retrospective and ecologi...

journal_title：Antimicrobial agents and chemotherapy

authors： Aldeyab MA,Harbarth S,Vernaz N,Kearney MP,Scott MG,Funston C,Savage K,Kelly D,Aldiab MA,McElnay JC

更新日期：2009-05-01 00:00:00

abstract：:The present study investigated the effect of a model urease-binding polysaccharide in combination with a histamine H(2) receptor antagonist on Helicobacter pylori colonization in vivo. Euthymic hairless mice were treated daily with dextran sulfate via drinking water and/or famotidine via intragastric gavage starting a...

journal_title：Antimicrobial agents and chemotherapy

authors： Icatlo FC Jr,Kimura N,Goshima H,Kodama Y

更新日期：2000-09-01 00:00:00

abstract：:18F-labeled fleroxacin was used to measure the pharmacokinetics of fleroxacin in healthy and infected animals by positron emission tomography (PET) and tissue radioactivity measurements. In all experiments, a pharmacological dose of unlabeled drug (10 mg/kg) was coinjected with the tracer. The pharmacokinetics of [18F...

journal_title：Antimicrobial agents and chemotherapy

authors： Fischman AJ,Livni E,Babich J,Alpert NM,Liu YY,Thom E,Cleeland R,Prosser BL,Callahan RJ,Correia JA

更新日期：1992-10-01 00:00:00

abstract：:The dose dependence of mezlocillin pharmacokinetics was examined in relation to renal function after intravenous doses of 1 and 5 g in 16 subjects with various degrees of renal impairment. Dose and time-average model-independent physiological parameters were calculated from plasma concentration and urinary excretion d...

journal_title：Antimicrobial agents and chemotherapy

authors： Mangione A,Boudinot FD,Schultz RM,Jusko WJ

更新日期：1982-03-01 00:00:00

abstract：:The polymorphic fungus Candida albicans is one of the most versatile opportunistic pathogens in humans. Many organs of the human body are potential targets for infection by this pathogen, but infection is commonly localized in the gastrointestinal tract, an environment providing anaerobic growth conditions. We describ...

journal_title：Antimicrobial agents and chemotherapy

authors： Dumitru R,Hornby JM,Nickerson KW

更新日期：2004-07-01 00:00:00

abstract：:While it is well-known that adjunctive corticosteroid use improves the outcome of moderate-to-severe Pneumocystis jirovecii pneumonia (PcP) in patients with human immunodeficiency virus (HIV), there are limited data on its efficacy in non-HIV-infected patients with PcP. Patients undergoing fiber-optic bronchoscopy wit...

journal_title：Antimicrobial agents and chemotherapy

authors： Moon SM,Kim T,Sung H,Kim MN,Kim SH,Choi SH,Jeong JY,Woo JH,Kim YS,Lee SO

更新日期：2011-10-01 00:00:00

abstract：:Indwelling device infections are associated with considerable morbidity and extremely high cost. Pseudomonas aeruginosa is the most frequent gram-negative etiologic agent associated with infections of indwelling catheters and foreign body implants. It is generally agreed that eradication of infection in the presence o...

journal_title：Antimicrobial agents and chemotherapy

authors： Brouqui P,Rousseau MC,Stein A,Drancourt M,Raoult D

更新日期：1995-11-01 00:00:00

abstract：:There has been a resurgence of interest in aerosolization of antibiotics for treatment of patients with severe pneumonia caused by multidrug-resistant pathogens. A combination formulation of amikacin-fosfomycin is currently undergoing clinical testing although the exposure-response relationships of these drugs have no...

journal_title：Antimicrobial agents and chemotherapy

authors： Sime FB,Johnson A,Whalley S,Santoyo-Castelazo A,Montgomery AB,Walters KA,Lipman J,Hope WW,Roberts JA

更新日期：2016-12-27 00:00:00

abstract：:A prospective study was performed with 23 Helicobacter pylori-infected children (mean age, 9.5 +/- 4.4 years) with clinical symptoms of gastritis and positive results of culture and histologic examination of gastric biopsy specimens to evaluate the influence of antibiotic resistance on eradication. Positive children w...

journal_title：Antimicrobial agents and chemotherapy

authors： Raymond J,Kalach N,Bergeret M,Benhamou PH,Barbet JP,Gendrel D,Dupont C

更新日期：1998-06-01 00:00:00

abstract：:Clostridium difficile is a leading cause of health care-associated diarrhea with significant morbidity and mortality, and new options for the treatment of C. difficile-associated diarrhea (CDAD) are needed. Cadazolid is a new oxazolidinone-type antibiotic that is currently in clinical development for treatment of CDAD...

journal_title：Antimicrobial agents and chemotherapy

authors： Locher HH,Seiler P,Chen X,Schroeder S,Pfaff P,Enderlin M,Klenk A,Fournier E,Hubschwerlen C,Ritz D,Kelly CP,Keck W

更新日期：2014-01-01 00:00:00

abstract：:The mechanism of action of the fungicidal peptide auristatin PHE was investigated in Cryptococcus neoformans. Since auristatin PHE causes budding arrest in C. neoformans (T. Woyke, G. R. Pettit, G. Winkelmann, and R. K. Pettit, Antimicrob. Agents Chemother. 45:3580-3584, 2001), microtubule integrity and nuclear locali...

journal_title：Antimicrobial agents and chemotherapy

authors： Woyke T,Roberson RW,Pettit GR,Winkelmann G,Pettit RK

更新日期：2002-12-01 00:00:00

abstract：:Many potent antiviral drugs have been developed against HIV-1, and their combined action is usually successful in achieving durable virus suppression in infected individuals. This success is based on two effects: additive or even synergistic virus inhibition and an increase in the genetic threshold for development of ...

journal_title：Antimicrobial agents and chemotherapy

authors： Zhao N,Wang G,Das AT,Berkhout B

更新日期：2017-11-22 00:00:00

abstract：:In this study, concentrations of amikacin in blood and bronchial secretions of 10 patients with mechanical ventilation for acute respiratory failure due to pneumonia were measured. One-half of the patients received amikacin twice daily, and the others received once-daily administration. Concentrations in bronchial sec...

journal_title：Antimicrobial agents and chemotherapy

authors： Santré C,Georges H,Jacquier JM,Leroy O,Beuscart C,Buguin D,Beaucaire G

更新日期：1995-01-01 00:00:00

abstract：:Antifolate drugs have an important role in the treatment of malaria. Polymorphisms in the genes encoding the dihydrofolate reductase and dihydropteroate synthetase enzymes cause resistance to the antifol and sulfa drugs, respectively. Rwanda has the highest levels of antimalarial drug resistance in Africa. We correlat...

journal_title：Antimicrobial agents and chemotherapy

authors： Karema C,Imwong M,Fanello CI,Stepniewska K,Uwimana A,Nakeesathit S,Dondorp A,Day NP,White NJ

更新日期：2010-01-01 00:00:00

abstract：:Mycobacterium abscessus is an extensively drug-resistant opportunistic pathogen that can cause chronic otomastoiditis. There are no evidence-based treatment regimens for this severe infection. We treated four children with M. abscessus otomastoiditis with a structured regimen of topical imipenem and tigecycline, intra...

journal_title：Antimicrobial agents and chemotherapy

authors： van Wijk F,Waterval J,van Aerde K,Henriet SSV,Meijer FJA,Borra LC,Aarnoutse RE,van Ingen J

更新日期：2019-12-20 00:00:00

abstract：:Single amino acid substitutions in the Ω loop of KPC β-lactamases are known to lead to resistance to the ceftazidime-avibactam combination. Here, we investigate this mechanism of resistance in CTX-M enzymes, which are the most widely spread extended-spectrum β-lactamases worldwide. Nine single amino acid polymorphisms...

journal_title：Antimicrobial agents and chemotherapy

authors： Compain F,Dorchène D,Arthur M

更新日期：2018-08-27 00:00:00

abstract：:Vancomycin resistance in Enterococcus faecium 180, a clinical isolate from England, was studied. Resistance to vancomycin was transferable by conjugation to other enterococci. Expression of resistance was inducible and coincided with the appearance of a new membrane protein. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Nicas TI,Wu CY,Hobbs JN Jr,Preston DA,Allen NE

更新日期：1989-07-01 00:00:00

abstract：:In a retrospective review of 24 patients with histoplasmosis, blastomycosis, or coccidioidomycosis treated with voriconazole (most for salvage therapy), the outcome was favorable (improved or stable) for 22 (95.8%) within 2 months of starting voriconazole and for 20 (83.3%) at the last follow-up. Prospective studies a...

journal_title：Antimicrobial agents and chemotherapy

authors： Freifeld A,Proia L,Andes D,Baddour LM,Blair J,Spellberg B,Arnold S,Lentnek A,Wheat LJ

更新日期：2009-04-01 00:00:00

abstract：:The activities of trimethoprim (TMP) and sulfamethoxazole (SMZ), alone and in combination (SMZ-TMP), and of the following antibiotics were tested against 115 clinical isolates of nontyphoid Salmonella species: tobramycin, gentamicin, ampicillin, amoxicillin, neomycin, kanamycin, chloramphenicol, and tetracycline. The ...

journal_title：Antimicrobial agents and chemotherapy

authors： Marks MI,Kazemi M,MacKay E

更新日期：1973-11-01 00:00:00

abstract：:An in situ method for sensitive detection of differences in the action of chlorhexidine against subpopulations of cells in Candida albicans biofilms is described. Detection relies on monitoring the kinetics of propidium iodide (PI) penetration into the cytoplasm of individual cells during dosing with chlorhexidine. Ac...

journal_title：Antimicrobial agents and chemotherapy

authors： Suci PA,Tyler BJ

更新日期：2002-11-01 00:00:00

abstract：:MurG and MraY, essential enzymes involved in the synthesis of bacterial peptidoglycan, are difficult to assay because the substrates are lipidic and hard to prepare in large quantities. Based on the use of Escherichia coli membranes lacking PBP1b, we report a high-throughput method to measure the activity of MurG and,...

journal_title：Antimicrobial agents and chemotherapy

authors： Ravishankar S,Kumar VP,Chandrakala B,Jha RK,Solapure SM,de Sousa SM

更新日期：2005-04-01 00:00:00

abstract：:The National Committee for Clinical Laboratory Standards has proposed a reference broth macrodilution method for in vitro antifungal susceptibility testing of yeasts (the M27-P method). This method is cumbersome and time-consuming and includes MIC endpoint determination by visual and subjective inspection of growth in...

journal_title：Antimicrobial agents and chemotherapy

authors： Rodríguez-Tudela JL,Berenguer J,Martínez-Suárez JV,Sanchez R

更新日期：1996-09-01 00:00:00

abstract：:Since currently available therapies against HIV/AIDS still show important drawbacks, the development of novel anti-HIV treatments is a key issue. We recently characterized methylated oligoribonucleotides (mONs) that extensively inhibit HIV-1 replication in primary T cells at nanomolar concentrations. The mONs were sho...

journal_title：Antimicrobial agents and chemotherapy

authors： Avilov SV,Boudier C,Gottikh M,Darlix JL,Mély Y

更新日期：2012-02-01 00:00:00

abstract：:A comparison of the daclatasvir (DCV [BMS-790052]) resistance barrier on authentic or hybrid replicons containing NS5A from hepatitis C virus (HCV) genotypes 1 to 6 (GT-1 to -6) was completed using a replicon elimination assay. The data indicated that genotype 1b (GT-1b) has the highest relative resistance barrier and...

journal_title：Antimicrobial agents and chemotherapy

authors： Wang C,Jia L,O'Boyle DR 2nd,Sun JH,Rigat K,Valera L,Nower P,Huang X,Kienzle B,Roberts S,Gao M,Fridell RA

更新日期：2014-09-01 00:00:00

abstract：:A new rifampin resistance gene, arr-2, has been found in Pseudomonas aeruginosa. The ARR-2 protein shows 54% amino acid identity to the rifampin ADP-ribosylating transferase encoded by the arr gene from Mycobacterium smegmatis. This arr-2 gene is located on a gene cassette within a class I integron. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Tribuddharat C,Fennewald M

更新日期：1999-04-01 00:00:00

abstract：:The increasing resistance of human pathogens to conventional antibiotics presents a growing threat to the chemotherapeutic management of infectious diseases. The lanthionine antibiotics, still unused as therapeutic agents, have recently attracted significant scientific interest as models for targeting and management o...

journal_title：Antimicrobial agents and chemotherapy

authors： Parisot J,Carey S,Breukink E,Chan WC,Narbad A,Bonev B

更新日期：2008-02-01 00:00:00

abstract：:Therapeutic drug monitoring (TDM) of second-line antituberculosis drugs would allow for optimal individualized dosage adjustments and improve drug safety and therapeutic outcomes. To evaluate the pharmacokinetic (PK) characteristics of clinically relevant, multidrug treatment regimens and to improve the feasibility of...

journal_title：Antimicrobial agents and chemotherapy

authors： Park SI,Oh J,Jang K,Yoon J,Moon SJ,Park JS,Lee JH,Song J,Jang IJ,Yu KS,Chung JY

更新日期：2015-08-01 00:00:00