Effect of auristatin PHE on microtubule integrity and nuclear localization in Cryptococcus neoformans.

abstract：:A survey carried out in 2005 among members of a healthy population of children living in Bolivia and Peru revealed that fecal carriage of Escherichia coli strains resistant to expanded-spectrum cephalosporins was remarkably increased compared to that observed in the same settings in 2002 (1.7% in 2005 versus 0.1% in 2...

journal_title：Antimicrobial agents and chemotherapy

authors： Pallecchi L,Bartoloni A,Fiorelli C,Mantella A,Di Maggio T,Gamboa H,Gotuzzo E,Kronvall G,Paradisi F,Rossolini GM

更新日期：2007-08-01 00:00:00

abstract：:The activities of teicoplanin and vancomycin against 362 coagulase-negative staphylococci were determined by an agar dilution method. At the 4- and 32-micrograms/ml breakpoint levels of the National Committee for Clinical Laboratory Standards, 23.2% of the strains were intermediate and 1.7% were resistant to teicoplan...

journal_title：Antimicrobial agents and chemotherapy

authors： Goldstein FW,Coutrot A,Sieffer A,Acar JF

更新日期：1990-05-01 00:00:00

abstract：:Due to the widespread resistance of bacteria to the available drugs, the discovery of new classes of antibiotics is urgently needed, and naturally occurring antimicrobial peptides (AMPs) are considered promising candidates for future therapeutic use. Amphibian skin is one of the richest sources of such AMPs. In the pr...

journal_title：Antimicrobial agents and chemotherapy

authors： Mangoni ML,Maisetta G,Di Luca M,Gaddi LM,Esin S,Florio W,Brancatisano FL,Barra D,Campa M,Batoni G

更新日期：2008-01-01 00:00:00

abstract：:A comparative evaluation of daptomycin and eight other antimicrobial agents was performed by the agar dilution technique with 56 strains of vancomycin-resistant gram-positive bacteria, including Leuconostoc, Lactobacillus, and Pediococcus spp. Erythromycin, deptomycin, clindamycin, and gentamicin exhibited the greates...

journal_title：Antimicrobial agents and chemotherapy

authors： de la Maza L,Ruoff KL,Ferraro MJ

更新日期：1989-08-01 00:00:00

abstract：:The 54-kDa outer membrane protein (designated OprJ) of a norfloxacin-resistant nfxB mutant of Pseudomonas aeruginosa PAO1 was purified by ion-exchange high-performance liquid chromatography. Mobility of OprJ in sodium dodecyl sulfate-polyacrylamide gel electrophoresis was not affected by reduction and heating. A murin...

journal_title：Antimicrobial agents and chemotherapy

authors： Hosaka M,Gotoh N,Nishino T

更新日期：1995-08-01 00:00:00

abstract：:We determined the in vitro susceptibilities of 54 isolates of Haemophilus ducreyi from Thailand (29 isolates) and San Francisco (25 isolates) to penicillin G, tetracycline, amoxicillin-clavulanic acid, ceftriaxone, cefixime, erythromycin, azithromycin, ciprofloxacin, ofloxacin, and trimethoprim-sulfamethoxazole. Isola...

journal_title：Antimicrobial agents and chemotherapy

authors： Knapp JS,Back AF,Babst AF,Taylor D,Rice RJ

更新日期：1993-07-01 00:00:00

abstract：:Since the discovery and use of penicillin, the increase of antibiotic resistance among bacterial pathogens has become a major health concern. The most prevalent resistance mechanism in Gram-negative bacteria is due to β-lactamase expression. Class D β-lactamases are of particular importance due to their presence in mu...

journal_title：Antimicrobial agents and chemotherapy

authors： June CM,Vallier BC,Bonomo RA,Leonard DA,Powers RA

更新日期：2014-01-01 00:00:00

abstract：:A wide variety of prokaryotic and eukaryotic cells exhibit a multidrug resistance (MDR) phenotype, indicating that resistance to potentially toxic compounds is mediated by their active efflux from the cell. We have sought to determine whether resistance to azoles in some strains of Candida species may be due in part t...

journal_title：Antimicrobial agents and chemotherapy

authors： Clark FS,Parkinson T,Hitchcock CA,Gow NA

更新日期：1996-02-01 00:00:00

abstract：:The inhibition of the lymphadenopathy-associated virus strain of human immunodeficiency virus (HIV) by alternating regimens of two dideoxynucleosides, 3'-azido-3'-deoxythymidine (AZT) (zidovudine) and 2',3'-dideoxycytidine (ddC), was determined in CEM cells. Cultures infected with virus for 2 h were treated with clini...

journal_title：Antimicrobial agents and chemotherapy

authors： Spector SA,Ripley D,Hsia K

更新日期：1989-06-01 00:00:00

abstract：:PPI-0903M is a novel N-phosphono-type cephalosporin active against oxacillin-resistant staphylococci and many other gram-positive organisms. This study evaluated the in vitro activity and spectrum of PPI-0903M against 1,478 recent clinical isolates collected from 80 medical centers (22 countries). PPI-0903M demonstrat...

journal_title：Antimicrobial agents and chemotherapy

authors： Sader HS,Fritsche TR,Kaniga K,Ge Y,Jones RN

更新日期：2005-08-01 00:00:00

abstract：:Clostridium difficile is a major nosocomial pathogen responsible for pseudomembranous colitis and many cases of antibiotic-associated diarrhea. Because of potential relapse of disease with current antimicrobial therapy protocols, there is a need for additional and/or alternative antimicrobial agents for the treatment ...

journal_title：Antimicrobial agents and chemotherapy

authors： Mahony DE,Lim-Morrison S,Bryden L,Faulkner G,Hoffman PS,Agocs L,Briand GG,Burford N,Maguire H

更新日期：1999-03-01 00:00:00

abstract：:In determining the quality control limits for the Clinical Laboratory Standards Institute-recommended quality control organisms with tigecycline, a number of inconsistencies in the results were encountered that appeared to be related to the age of the Mueller-Hinton broth II. This study was performed to examine the ef...

journal_title：Antimicrobial agents and chemotherapy

authors： Petersen PJ,Bradford PA

更新日期：2005-09-01 00:00:00

abstract：:MurG and MraY, essential enzymes involved in the synthesis of bacterial peptidoglycan, are difficult to assay because the substrates are lipidic and hard to prepare in large quantities. Based on the use of Escherichia coli membranes lacking PBP1b, we report a high-throughput method to measure the activity of MurG and,...

journal_title：Antimicrobial agents and chemotherapy

authors： Ravishankar S,Kumar VP,Chandrakala B,Jha RK,Solapure SM,de Sousa SM

更新日期：2005-04-01 00:00:00

abstract：:ME1100 (arbekacin inhalation solution) is an inhaled aminoglycoside that is being developed to treat patients with hospital-acquired and ventilator-associated bacterial pneumonia (HABP and VABP, respectively). Pharmacokinetic-pharmacodynamic (PK-PD) target attainment analyses were undertaken to evaluate ME1100 regimen...

journal_title：Antimicrobial agents and chemotherapy

authors： Bhavnani SM,Hammel JP,Lakota EA,Safir MC,VanScoy BD,Nagira Y,Rubino CM,Sato N,Koresawa T,Kondo K,Ambrose PG

更新日期：2020-09-21 00:00:00

abstract：:Two ceftazidime-resistant variants of Pseudomonas aeruginosa (PA-48, PA-60), obtained from cardiac vegetations of rabbits with endocarditis receiving ceftazidime therapy, were studied for mechanisms of resistance. Both resistant variants were stably derepressed for the type Id beta-lactamase, which was ceftazidime ind...

journal_title：Antimicrobial agents and chemotherapy

authors： Bayer AS,Peters J,Parr TR Jr,Chan L,Hancock RE

更新日期：1987-02-01 00:00:00

abstract：:Passive antibody administration is a potentially useful approach for the therapy of human Cryptococcus neoformans infections. To evaluate the efficacy of the human immunoglobulin G1 (IgG1) constant region against C. neoformans and to construct murine antibody derivatives with reduced immunogenicities and longer half-l...

journal_title：Antimicrobial agents and chemotherapy

authors： Zebedee SL,Koduri RK,Mukherjee J,Mukherjee S,Lee S,Sauer DF,Scharff MD,Casadevall A

更新日期：1994-07-01 00:00:00

abstract：:In vitro susceptibility tests were performed on 84 strains of Clostridium difficile to 11 antimicrobial agents. All isolates were from the stools of patients with antibiotic-associated diarrhea or colitis in which there was a cytopathic toxin that was neutralized by Clostridium sordellii antitoxin. Over 95% of the str...

journal_title：Antimicrobial agents and chemotherapy

authors： Dzink J,Bartlett JG

更新日期：1980-04-01 00:00:00

abstract：:The diversity of OXA-48-like carbapenemases is continually expanding. In this study, we describe the dissemination and characteristics of a novel carbapenem-hydrolyzing class D β-lactamase (CHDL) named OXA-436. In total, six OXA-436-producing Enterobacteriaceae isolates, including Enterobacter asburiae (n = 3), Citrob...

journal_title：Antimicrobial agents and chemotherapy

authors： Samuelsen Ø,Hansen F,Aasnæs B,Hasman H,Lund BA,Leiros HS,Lilje B,Janice J,Jakobsen L,Littauer P,Søes LM,Holzknecht BJ,Andersen LP,Stegger M,Andersen PS,Hammerum AM

更新日期：2017-12-21 00:00:00

abstract：:Aminoglycoside 2″-phosphotransferases are the major aminoglycoside-modifying enzymes in clinical isolates of enterococci and staphylococci. We describe a novel aminoglycoside 2″-phosphotransferase from the Gram-negative pathogen Campylobacter jejuni, which shares 78% amino acid sequence identity with the APH(2″)-Ia do...

journal_title：Antimicrobial agents and chemotherapy

authors： Toth M,Frase H,Antunes NT,Vakulenko SB

更新日期：2013-01-01 00:00:00

abstract：:Seventy-two A. fumigatus clinical isolates from China were investigated for azole resistance based on mutations of cyp51A. We identified four azole-resistant strains, among which we found three strains highly resistant to itraconazole, two of which exhibit the TR34/L98H/S297T/F495I mutation, while one carries only the...

journal_title：Antimicrobial agents and chemotherapy

authors： Liu M,Zeng R,Zhang L,Li D,Lv G,Shen Y,Zheng H,Zhang Q,Zhao J,Zheng N,Liu W

更新日期：2015-07-01 00:00:00

abstract：:The activities of the purine acyclic nucleoside 9-(1,3-dihydroxy-2-propoxymethyl)guanine (DHPG) against two human and five animal strains of cytomegalovirus were compared with those of acyclovir. DHPG was significantly more active than acyclovir against all but one (mouse cytomegalovirus) of the strains tested, with 5...

journal_title：Antimicrobial agents and chemotherapy

authors： Freitas VR,Smee DF,Chernow M,Boehme R,Matthews TR

更新日期：1985-08-01 00:00:00

abstract：:RU44790 belongs to a new class of synthetic monocyclic beta-lactam antibiotics which feature a bioisosteric tetrazole moiety instead of the more classical acidic functions at the N-1 position of the beta-lactam ring. Its antibacterial activity was evaluated against some 900 strains and was compared with those of other...

journal_title：Antimicrobial agents and chemotherapy

authors： Chantot JF,Klich M,Teutsch G,Bryskier A,Collette P,Markus A,Seibert G

更新日期：1992-08-01 00:00:00

abstract：:A series of 3,5-dioxopyrazolidines was identified as novel inhibitors of UDP-N-acetylenolpyruvylglucosamine reductase (MurB). Compounds 1 to 3, which are 1,2-bis(4-chlorophenyl)-3,5-dioxopyrazolidine-4-carboxamides, inhibited Escherichia coli MurB, Staphyloccocus aureus MurB, and E. coli MurA with 50% inhibitory conce...

journal_title：Antimicrobial agents and chemotherapy

authors： Yang Y,Severin A,Chopra R,Krishnamurthy G,Singh G,Hu W,Keeney D,Svenson K,Petersen PJ,Labthavikul P,Shlaes DM,Rasmussen BA,Failli AA,Shumsky JS,Kutterer KM,Gilbert A,Mansour TS

更新日期：2006-02-01 00:00:00

abstract：:Mice treated with antibiotics early or late after active infection had resolved were examined for chlamydial DNA in endocervical swabs. The early eradication of infection limited oviduct pathology, despite the continued detection of chlamydial DNA by nested PCR. Late antibiotic treatment had no effect on the ability t...

journal_title：Antimicrobial agents and chemotherapy

authors： Reeves DM,Nagarajan U,O'Connell C,Andrews CW Jr,Darville T

更新日期：2007-07-01 00:00:00

abstract：:Ofloxacin, a potent quinolone antibacterial agent, has a tricyclic ring structure with a methyl group attached to the asymmetric carbon at the C-3 position on the oxazine ring. The S isomer (DR-3355) of ofloxacin has antibacterial activity up to 2 orders of magnitude greater than that of the R isomer (DR-3354). This d...

journal_title：Antimicrobial agents and chemotherapy

authors： Morrissey I,Hoshino K,Sato K,Yoshida A,Hayakawa I,Bures MG,Shen LL

更新日期：1996-08-01 00:00:00

abstract：:Streptococcus pneumoniae is one of the leading pathogens that cause a variety of mucosal and invasive infections. With the increased emergence of multidrug-resistant S. pneumoniae, new antimicrobials with mechanisms of action different from conventional antibiotics are urgently needed. In this study, we identified a p...

journal_title：Antimicrobial agents and chemotherapy

authors： Yang H,Gong Y,Zhang H,Etobayeva I,Miernikiewicz P,Luo D,Li X,Zhang X,Dąbrowska K,Nelson DC,He J,Wei H

更新日期：2019-03-27 00:00:00

abstract：:Nocardia species are gram-positive environmental saprophytes, but some cause the infectious disease nocardiosis. The complete genomic sequence of Nocardia farcinica IFM 10152 has been determined, and analyses indicated the presence of two different RNA polymerase beta subunit genes, rpoB and rpoB2, in the genome (J. I...

journal_title：Antimicrobial agents and chemotherapy

authors： Ishikawa J,Chiba K,Kurita H,Satoh H

更新日期：2006-04-01 00:00:00

abstract：:Of the 176 randomly selected, commensal, gram-negative bacteria isolated from healthy children with low exposure to antibiotics, 138 (78%) carried one or more of the seven macrolide resistance genes tested in this study. These isolates included 79 (91%) isolates from the oral cavity and 59 (66%) isolates from urine sa...

journal_title：Antimicrobial agents and chemotherapy

authors： Ojo KK,Ulep C,Van Kirk N,Luis H,Bernardo M,Leitao J,Roberts MC

更新日期：2004-09-01 00:00:00

abstract：:To determine whether rifampin reduces concentrations of trimethoprim (TMP) and sulfamethoxazole (SMX) in serum of human immunodeficiency virus (HIV)-infected persons, levels of these agents were determined by high-performance liquid chromatography before and after more than 12 days of standard antituberculosis treatme...

journal_title：Antimicrobial agents and chemotherapy

authors： Ribera E,Pou L,Fernandez-Sola A,Campos F,Lopez RM,Ocaña I,Ruiz I,Pahissa A

更新日期：2001-11-01 00:00:00

abstract：:The increasing incidence and severity of infection by Clostridium difficile have stimulated attempts to develop new antimicrobial therapies. We report here the relative abilities of two antibiotics (metronidazole and vancomycin) in current use for treating C. difficile infection and of a third antimicrobial, surotomyc...

journal_title：Antimicrobial agents and chemotherapy

authors： Bouillaut L,McBride S,Sorg JA,Schmidt DJ,Suarez JM,Tzipori S,Mascio C,Chesnel L,Sonenshein AL

更新日期：2015-07-01 00:00:00