Abstract:
:Seventy-two A. fumigatus clinical isolates from China were investigated for azole resistance based on mutations of cyp51A. We identified four azole-resistant strains, among which we found three strains highly resistant to itraconazole, two of which exhibit the TR34/L98H/S297T/F495I mutation, while one carries only the TR34/L98H mutation. To our knowledge, the latter has not been found previously in China. The fourth multiazole-resistant isolate (with only moderate itraconazole resistance) carries a new G432A mutation.
journal_name
Antimicrob Agents Chemotherjournal_title
Antimicrobial agents and chemotherapyauthors
Liu M,Zeng R,Zhang L,Li D,Lv G,Shen Y,Zheng H,Zhang Q,Zhao J,Zheng N,Liu Wdoi
10.1128/AAC.00003-15subject
Has Abstractpub_date
2015-07-01 00:00:00pages
4321-5issue
7eissn
0066-4804issn
1098-6596pii
AAC.00003-15journal_volume
59pub_type
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journal_title:Antimicrobial agents and chemotherapy
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journal_title:Antimicrobial agents and chemotherapy
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