pfk13-Independent Treatment Failure in Four Imported Cases of Plasmodium falciparum Malaria Treated with Artemether-Lumefantrine in the United Kingdom.


:We present case histories of four patients treated with artemether-lumefantrine for falciparum malaria in UK hospitals in 2015 to 2016. Each subsequently presented with recurrent symptoms and Plasmodium falciparum parasitemia within 6 weeks of treatment with no intervening travel to countries where malaria is endemic. Parasite isolates, all of African origin, harbored variants at some candidate resistance loci. No evidence of pfk13-mediated artemisinin resistance was found. Vigilance for signs of unsatisfactory antimalarial efficacy among imported cases of malaria is recommended.


Sutherland CJ,Lansdell P,Sanders M,Muwanguzi J,van Schalkwyk DA,Kaur H,Nolder D,Tucker J,Bennett HM,Otto TD,Berriman M,Patel TA,Lynn R,Gkrania-Klotsas E,Chiodini PL




Has Abstract


2017-02-23 00:00:00












  • Effect of N, N'-dicyclohexylcarbodiimide and nigericin on Staphylococcus aureus susceptibility to gentamicin.

    abstract::The abilities of the H+-ATPase inhibitor N, N'-dicyclohexylcarbodiimide and the antibiotic ionophore nigericin to enhance the bactericidal effect of subinhibitory concentrations of gentamicin in two strains of Staphylococcus aureus were studied. Each compound significantly increased both gentamicin uptake and killing....

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Mandel LJ,Eisenberg ES,Simkin NJ,Miller MH

    更新日期:1983-09-01 00:00:00

  • Role of the K101E substitution in HIV-1 reverse transcriptase in resistance to rilpivirine and other nonnucleoside reverse transcriptase inhibitors.

    abstract::Resistance to the recently approved nonnucleoside reverse transcriptase inhibitor (NNRTI) rilpivirine (RPV) commonly involves substitutions at positions E138K and K101E in HIV-1 reverse transcriptase (RT), together with an M184I substitution that is associated with resistance to coutilized emtricitabine (FTC). Previou...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Xu HT,Colby-Germinario SP,Huang W,Oliveira M,Han Y,Quan Y,Petropoulos CJ,Wainberg MA

    更新日期:2013-11-01 00:00:00

  • Effect of Resistance Mechanisms on the Inoculum Effect of Carbapenem in Klebsiella pneumoniae Isolates with Borderline Carbapenem Resistance.

    abstract::We aimed to examine the effects of resistance mechanisms on several resistance phenotypes among carbapenem-resistant Klebsiella pneumoniae isolates with borderline carbapenem MICs. We compared carbapenemase-negative K. pneumoniae with carbapenemase-producing K. pneumoniae (CPKP) isolates with similar MICs. CPKP isolat...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Adler A,Ben-Dalak M,Chmelnitsky I,Carmeli Y

    更新日期:2015-08-01 00:00:00

  • Rifampin reduces concentrations of trimethoprim and sulfamethoxazole in serum in human immunodeficiency virus-infected patients.

    abstract::To determine whether rifampin reduces concentrations of trimethoprim (TMP) and sulfamethoxazole (SMX) in serum of human immunodeficiency virus (HIV)-infected persons, levels of these agents were determined by high-performance liquid chromatography before and after more than 12 days of standard antituberculosis treatme...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 临床试验,杂志文章


    authors: Ribera E,Pou L,Fernandez-Sola A,Campos F,Lopez RM,Ocaña I,Ruiz I,Pahissa A

    更新日期:2001-11-01 00:00:00

  • Homologous Recombination within Large Chromosomal Regions Facilitates Acquisition of β-Lactam and Vancomycin Resistance in Enterococcus faecium.

    abstract::The transfer of DNA between Enterococcus faecium strains has been characterized both by the movement of well-defined genetic elements and by the large-scale transfer of genomic DNA fragments. In this work, we report on the whole-genome analysis of transconjugants resulting from mating events between the vancomycin-res...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: García-Solache M,Lebreton F,McLaughlin RE,Whiteaker JD,Gilmore MS,Rice LB

    更新日期:2016-09-23 00:00:00

  • IMP dehydrogenase from the protozoan parasite Toxoplasma gondii.

    abstract::The opportunistic apicomplexan parasite Toxoplasma gondii damages fetuses in utero and threatens immunocompromised individuals. The toxicity associated with standard antitoxoplasmal therapies, which target the folate pathway, underscores the importance of examining alternative pharmacological strategies. Parasitic pro...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Sullivan WJ Jr,Dixon SE,Li C,Striepen B,Queener SF

    更新日期:2005-06-01 00:00:00

  • Population pharmacokinetic analysis of piperacillin in burn patients.

    abstract::Piperacillin in combination with tazobactam, a β-lactamase inhibitor, is a commonly used intravenous antibiotic for the empirical treatment of infection in intensive care patients, including burn patients. The purpose of this study was to develop a population pharmacokinetic (PK) model for piperacillin in burn patient...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Jeon S,Han S,Lee J,Hong T,Paek J,Woo H,Yim DS

    更新日期:2014-07-01 00:00:00

  • Heterogeneity and Diversity of mcr-8 Genetic Context in Chicken-Associated Klebsiella pneumoniae.

    abstract::Increasing mobile colistin resistance, mediated by the mcr gene family, in Enterobacteriaceae has become a global concern. Among the 10 reported mcr genes, mcr-8 was first identified in Klebsiella pneumoniae, which could cause severe infections with high mortality. Information about the prevalence and genetic context ...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Wu B,Wang Y,Ling Z,Yu Z,Shen Z,Zhang S,Wang X

    更新日期:2020-12-16 00:00:00

  • Src Family Kinase Inhibitors Block Translation of Alphavirus Subgenomic mRNAs.

    abstract::Alphaviruses are arthropod-transmitted RNA viruses that can cause arthralgia, myalgia, and encephalitis in humans. Since the role of cellular kinases in alphavirus replication is unknown, we profiled kinetic changes in host kinase abundance and phosphorylation following chikungunya virus (CHIKV) infection of fibroblas...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Broeckel R,Sarkar S,May NA,Totonchy J,Kreklywich CN,Smith P,Graves L,DeFilippis VR,Heise MT,Morrison TE,Moorman N,Streblow DN

    更新日期:2019-03-27 00:00:00

  • Praziquantel in a clay nanoformulation shows more bioavailability and higher efficacy against murine Schistosoma mansoni infection.

    abstract::Consideration of existing compounds always simplifies and shortens the long and difficult process of discovering new drugs specifically for diseases of developing countries, an approach that may add to the significant potential cost savings. This study focused on improving the biological characteristics of the already...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: El-Feky GS,Mohamed WS,Nasr HE,El-Lakkany NM,Seif El-Din SH,Botros SS

    更新日期:2015-01-01 00:00:00

  • Human cytomegalovirus inhibition by cardiac glycosides: evidence for involvement of the HERG gene.

    abstract::Infection with human cytomegalovirus (HCMV) continues to be a major threat for pregnant women and the immunocompromised population. Although several anti-HCMV therapies are available, the development of new anti-HCMV agents is highly desired. There is growing interest in identifying compounds that might inhibit HCMV b...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Kapoor A,Cai H,Forman M,He R,Shamay M,Arav-Boger R

    更新日期:2012-09-01 00:00:00

  • Chlorhexidine resistance in methicillin-resistant Staphylococcus aureus or just an elevated MIC? An in vitro and in vivo assessment.

    abstract::Chlorhexidine (Hibiscrub; ICI) is generally accepted to be effective as an antiseptic hand wash for methicillin-susceptible Staphylococcus aureus (MSSA), but there is dispute whether the chlorhexidine MIC for methicillin-resistant S. aureus (MRSA) strains is higher than that for MSSA strains and, indeed, whether it is...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Cookson BD,Bolton MC,Platt JH

    更新日期:1991-10-01 00:00:00

  • Transepithelial transport of the fluoroquinolone ciprofloxacin by human airway epithelial Calu-3 cells.

    abstract::Although fluoroquinolone antibiotics such as ciprofloxacin are able to gain access to lung tissue and both pleural and bronchial secretions, the characteristics of transport and cellular uptake of ciprofloxacin in human epithelial lung tissue remain obscure. We have chosen human airway epithelial (Calu-3) cells, recon...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Cavet ME,West M,Simmons NL

    更新日期:1997-12-01 00:00:00

  • Clinical resistance to erythromycin and clindamycin in cutaneous propionibacteria isolated from acne patients is associated with mutations in 23S rRNA.

    abstract::The genetic basis of erythromycin resistance in cutaneous propionibacteria was determined by comparing the nucleotide sequences of the peptidyl transferase region in the 23S rRNAs from 9 susceptible and 26 resistant clinical isolates as well as 4 laboratory-selected erythromycin-resistant mutants of a susceptible stra...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Ross JI,Eady EA,Cove JH,Jones CE,Ratyal AH,Miller YW,Vyakrnam S,Cunliffe WJ

    更新日期:1997-05-01 00:00:00

  • Inhibition of herpesvirus replication and herpesvirus-induced deoxyribonucleic acid polymerase by phosphonoformate.

    abstract::Phosphonoformate was found to be an inhibitor of the deoxyribonucleic acid polymerase induced by the herpesvirus of turkeys. The apparent inhibition constants were 1 to 3 muM. Phosphonoformate was also able to block the replication in cell culture of Marek's disease herpesvirus, the herpesvirus of turkeys, and herpes ...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Reno JM,Lee LF,Boezi JA

    更新日期:1978-02-01 00:00:00

  • Activity of HMR 3647 compared to those of five agents against Haemophilus influenzae and moraxella catarrhalis by MIC determination and time-kill assay.

    abstract::The microdilution MICs of HMR 3647, erythromycin A, azithromycin, clarithromycin, roxithromycin, and pristinamycin against 50/90% of 249 Haemophilus influenzae and 50 Moraxella catarrhalis isolates were 2/4, 0.06/0.125; 8/16, 0.25/0.25; 2/4, 0.06/0.125; 16/16, 0.25/0.25; 32/>32, 1/2; and 2/4, 0.5/0.5 microg/ml. Azithr...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Pankuch GA,Hoellman DB,Lin G,Bajaksouzian S,Jacobs MR,Appelbaum PC

    更新日期:1998-11-01 00:00:00

  • Drug-induced regulation of the MDR1 promoter in Candida albicans.

    abstract::Resistance of Candida albicans to azole antifungal drugs is mediated by two types of efflux pumps, encoded by the MDR1 gene and the CDR gene family. MDR1 mRNA levels in a susceptible clinical isolate are induced by benomyl (BEN) but not by other drugs previously shown to induce MDR1. To monitor MDR1 expression under s...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Harry JB,Oliver BG,Song JL,Silver PM,Little JT,Choiniere J,White TC

    更新日期:2005-07-01 00:00:00

  • Effect of ampicillin and chloramphenicol against Streptococcus pneumoniae and Neisseria meningitidis.

    abstract::Antagonism, determined by isobolograms constructed from data from combinations of ampicillin and chloramphenicol at or below the minimal inhibitory or bactericidal concentrations, was observed against 13 clinical isolates of meningococcus and against one isolate of pneumococcus. Synergy occurred against six strains of...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Feldman WE,Zweighaft T

    更新日期:1979-02-01 00:00:00

  • Prophylaxis with enteral antibiotics in ventilated patients: selective decontamination or selective cross-infection?

    abstract::Selective decontamination of the digestive tract (SDD) has been evaluated as a method to prevent colonization and infection in ventilated patients in 40 trials. On the basis of an assumption that cross-infection would be reduced as a consequence of SDD and that this would distort the results of SDD studies that used c...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章,meta分析


    authors: Hurley JC

    更新日期:1995-04-01 00:00:00

  • Procedure for expediting determinations of antibiotic susceptibility of gram-negative, urinary tract pathogens.

    abstract::Standardized direct disk diffusion antibiotic susceptibility testing on monomicrobial urine specimens is compared with the Food and Drug Administration method. The direct procedure yields acceptable data and may conserve 24 h in reporting results. ...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Wegner DL,Neblett TR

    更新日期:1976-12-01 00:00:00

  • Prospective Cohort Study of Single-Day Doxycycline Therapy for Mediterranean Spotted Fever.

    abstract::The objective of this study is to evaluate the results of single-day doxycycline therapy for Mediterranean spotted fever (MSF). This is a prospective cohort study of cases with confirmed MSF treated with the single-day doxycycline regimen in a teaching hospital from 1990 to 2015. Patients received two oral doses of 20...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Espejo E,Andrés M,Garcia MC,Fajardo A,Pérez J,Bella F

    更新日期:2018-10-24 00:00:00

  • Analysis of the oxyR-ahpC region in isoniazid-resistant and -susceptible Mycobacterium tuberculosis complex organisms recovered from diseased humans and animals in diverse localities.

    abstract::Automated DNA sequencing was used to analyze the oxyR-ahpC region in 229 Mycobacterium tuberculosis complex isolates recently recovered from diseased humans and animals. The entire 1,221-bp region was studied in 118 isolates, and 111 other isolates were sequenced for oxyR, ahpC, or the 105-bp oxyR-ahpC intergenic regi...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Sreevatsan S,Pan X,Zhang Y,Deretic V,Musser JM

    更新日期:1997-03-01 00:00:00

  • Optimized elution of daptomycin from polymethylmethacrylate beads.

    abstract::We demonstrate that xylitol can be added to polymethylmethacrylate (PMMA) bone cement to enhance the elution of daptomycin in terms of both the peak and sustained release of antibiotic. We also demonstrate that a PMMA-xylitol formulation optimized for daptomycin can be used to enhance the elution of both vancomycin an...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Weiss BD,Weiss EC,Haggard WO,Evans RP,McLaren SG,Smeltzer MS

    更新日期:2009-01-01 00:00:00

  • Comparison of cyclacillin and amoxicillin for therapy for acute maxillary sinusitis.

    abstract::Cyclacillin, a new aminosalicylic semisynthetic penicillin, was compared with amoxicillin for the therapy of acute bacterial maxillary sinusitis in 80 patients (ages, 12 to 70 years) in a prospective, double-blind, randomized clinical trial. Direct sinus aspirations for quantitative culture were done for all patients ...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Scheld WM,Sydnor A Jr,Farr B,Gratz JC,Gwaltney JM Jr

    更新日期:1986-09-01 00:00:00

  • Outer membrane permeability barrier in Escherichia coli mutants that are defective in the late acyltransferases of lipid A biosynthesis.

    abstract::The tight packing of six fatty acids in the lipid A constituent of lipopolysaccharide (LPS) has been proposed to contribute to the unusually low permeability of the outer membrane of gram-negative enteric bacteria to hydrophobic antibiotics. Here it is shown that the Escherichia coli msbB mutant, which elaborates defe...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Vaara M,Nurminen M

    更新日期:1999-06-01 00:00:00

  • Posaconazole pharmacodynamic target determination against wild-type and Cyp51 mutant isolates of Aspergillus fumigatus in an in vivo model of invasive pulmonary aspergillosis.

    abstract::Invasive pulmonary aspergillosis (IPA) is a devastating disease of immunocompromised patients. Pharmacodynamic (PD) examination of antifungal drug therapy in IPA is one strategy that may improve outcomes. The current study explored the PD target of posaconazole in an immunocompromised murine model of IPA against 10 A....

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Lepak AJ,Marchillo K,Vanhecker J,Andes DR

    更新日期:2013-01-01 00:00:00

  • Inhibition of aminoglycoside 6'-N-acetyltransferase type Ib-mediated amikacin resistance in Klebsiella pneumoniae by zinc and copper pyrithione.

    abstract::The in vitro activity of the aminoglycoside 6'-N-acetyltransferase type Ib [AAC(6')-Ib] was inhibited by CuCl2 with a 50% inhibitory concentration (IC50) of 2.8 μM. The growth of an amikacin-resistant Klebsiella pneumoniae strain isolated from a neonate with meningitis was inhibited when amikacin was supplemented by t...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Chiem K,Fuentes BA,Lin DL,Tran T,Jackson A,Ramirez MS,Tolmasky ME

    更新日期:2015-09-01 00:00:00

  • Pharmacokinetics of cefepime in patients with thermal burn injury.

    abstract::The pharmacokinetics of cefepime following administration of a single 2-g dose were evaluated for 12 adult patients with thermal burn injury and suspected or documented infection. Serial blood and urine samples for cefepime concentration determination were obtained for 24 h following drug administration. Serum and uri...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 临床试验,杂志文章


    authors: Bonapace CR,White RL,Friedrich LV,Norcross ED,Bosso JA

    更新日期:1999-12-01 00:00:00

  • Comparative antimicrobial activities of the penem WY-49605 (SUN5555) against recent clinical isolates from five U.S. medical centers.

    abstract::The in vitro activity of WY-49605 (SUN5555) (WY) was compared with those of cefaclor, cefixime, and amoxicillin-clavulanic acid against 2,958 consecutive clinical isolates from five medical centers and 402 respiratory pathogens from 18 other facilities. Most members of the family Enterobacteriaceae were inhibited by W...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章,多中心研究


    authors: Sewell D,Barry A,Allen S,Fuchs P,McLaughlin J,Pfaller M

    更新日期:1995-07-01 00:00:00

  • The Combination of Fosfomycin plus Meropenem Is Synergistic for Pseudomonas aeruginosa PAO1 in a Hollow-Fiber Infection Model.

    abstract::Treating high-density bacterial infections is a challenging clinical problem. We have a paucity of new agents that can address this problem. Pseudomonas aeruginosa is a particularly difficult pathogen to treat effectively because of the plethora of resistance mechanisms it carries. Fosfomycin is an agent discovered ci...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Drusano GL,Neely MN,Yamada WM,Duncanson B,Brown D,Maynard M,Vicchiarelli M,Louie A

    更新日期:2018-11-26 00:00:00