pfk13-Independent Treatment Failure in Four Imported Cases of Plasmodium falciparum Malaria Treated with Artemether-Lumefantrine in the United Kingdom.

abstract：:The abilities of the H+-ATPase inhibitor N, N'-dicyclohexylcarbodiimide and the antibiotic ionophore nigericin to enhance the bactericidal effect of subinhibitory concentrations of gentamicin in two strains of Staphylococcus aureus were studied. Each compound significantly increased both gentamicin uptake and killing....

journal_title：Antimicrobial agents and chemotherapy

authors： Mandel LJ,Eisenberg ES,Simkin NJ,Miller MH

更新日期：1983-09-01 00:00:00

abstract：:Resistance to the recently approved nonnucleoside reverse transcriptase inhibitor (NNRTI) rilpivirine (RPV) commonly involves substitutions at positions E138K and K101E in HIV-1 reverse transcriptase (RT), together with an M184I substitution that is associated with resistance to coutilized emtricitabine (FTC). Previou...

journal_title：Antimicrobial agents and chemotherapy

authors： Xu HT,Colby-Germinario SP,Huang W,Oliveira M,Han Y,Quan Y,Petropoulos CJ,Wainberg MA

更新日期：2013-11-01 00:00:00

abstract：:We aimed to examine the effects of resistance mechanisms on several resistance phenotypes among carbapenem-resistant Klebsiella pneumoniae isolates with borderline carbapenem MICs. We compared carbapenemase-negative K. pneumoniae with carbapenemase-producing K. pneumoniae (CPKP) isolates with similar MICs. CPKP isolat...

journal_title：Antimicrobial agents and chemotherapy

authors： Adler A,Ben-Dalak M,Chmelnitsky I,Carmeli Y

更新日期：2015-08-01 00:00:00

abstract：:To determine whether rifampin reduces concentrations of trimethoprim (TMP) and sulfamethoxazole (SMX) in serum of human immunodeficiency virus (HIV)-infected persons, levels of these agents were determined by high-performance liquid chromatography before and after more than 12 days of standard antituberculosis treatme...

journal_title：Antimicrobial agents and chemotherapy

authors： Ribera E,Pou L,Fernandez-Sola A,Campos F,Lopez RM,Ocaña I,Ruiz I,Pahissa A

更新日期：2001-11-01 00:00:00

abstract：:The transfer of DNA between Enterococcus faecium strains has been characterized both by the movement of well-defined genetic elements and by the large-scale transfer of genomic DNA fragments. In this work, we report on the whole-genome analysis of transconjugants resulting from mating events between the vancomycin-res...

journal_title：Antimicrobial agents and chemotherapy

authors： García-Solache M,Lebreton F,McLaughlin RE,Whiteaker JD,Gilmore MS,Rice LB

更新日期：2016-09-23 00:00:00

abstract：:The opportunistic apicomplexan parasite Toxoplasma gondii damages fetuses in utero and threatens immunocompromised individuals. The toxicity associated with standard antitoxoplasmal therapies, which target the folate pathway, underscores the importance of examining alternative pharmacological strategies. Parasitic pro...

journal_title：Antimicrobial agents and chemotherapy

authors： Sullivan WJ Jr,Dixon SE,Li C,Striepen B,Queener SF

更新日期：2005-06-01 00:00:00

abstract：:Piperacillin in combination with tazobactam, a β-lactamase inhibitor, is a commonly used intravenous antibiotic for the empirical treatment of infection in intensive care patients, including burn patients. The purpose of this study was to develop a population pharmacokinetic (PK) model for piperacillin in burn patient...

journal_title：Antimicrobial agents and chemotherapy

authors： Jeon S,Han S,Lee J,Hong T,Paek J,Woo H,Yim DS

更新日期：2014-07-01 00:00:00

abstract：:Increasing mobile colistin resistance, mediated by the mcr gene family, in Enterobacteriaceae has become a global concern. Among the 10 reported mcr genes, mcr-8 was first identified in Klebsiella pneumoniae, which could cause severe infections with high mortality. Information about the prevalence and genetic context ...

journal_title：Antimicrobial agents and chemotherapy

authors： Wu B,Wang Y,Ling Z,Yu Z,Shen Z,Zhang S,Wang X

更新日期：2020-12-16 00:00:00

abstract：:Alphaviruses are arthropod-transmitted RNA viruses that can cause arthralgia, myalgia, and encephalitis in humans. Since the role of cellular kinases in alphavirus replication is unknown, we profiled kinetic changes in host kinase abundance and phosphorylation following chikungunya virus (CHIKV) infection of fibroblas...

journal_title：Antimicrobial agents and chemotherapy

authors： Broeckel R,Sarkar S,May NA,Totonchy J,Kreklywich CN,Smith P,Graves L,DeFilippis VR,Heise MT,Morrison TE,Moorman N,Streblow DN

更新日期：2019-03-27 00:00:00

abstract：:Consideration of existing compounds always simplifies and shortens the long and difficult process of discovering new drugs specifically for diseases of developing countries, an approach that may add to the significant potential cost savings. This study focused on improving the biological characteristics of the already...

journal_title：Antimicrobial agents and chemotherapy

authors： El-Feky GS,Mohamed WS,Nasr HE,El-Lakkany NM,Seif El-Din SH,Botros SS

更新日期：2015-01-01 00:00:00

abstract：:Infection with human cytomegalovirus (HCMV) continues to be a major threat for pregnant women and the immunocompromised population. Although several anti-HCMV therapies are available, the development of new anti-HCMV agents is highly desired. There is growing interest in identifying compounds that might inhibit HCMV b...

journal_title：Antimicrobial agents and chemotherapy

authors： Kapoor A,Cai H,Forman M,He R,Shamay M,Arav-Boger R

更新日期：2012-09-01 00:00:00

abstract：:Chlorhexidine (Hibiscrub; ICI) is generally accepted to be effective as an antiseptic hand wash for methicillin-susceptible Staphylococcus aureus (MSSA), but there is dispute whether the chlorhexidine MIC for methicillin-resistant S. aureus (MRSA) strains is higher than that for MSSA strains and, indeed, whether it is...

journal_title：Antimicrobial agents and chemotherapy

authors： Cookson BD,Bolton MC,Platt JH

更新日期：1991-10-01 00:00:00

abstract：:Although fluoroquinolone antibiotics such as ciprofloxacin are able to gain access to lung tissue and both pleural and bronchial secretions, the characteristics of transport and cellular uptake of ciprofloxacin in human epithelial lung tissue remain obscure. We have chosen human airway epithelial (Calu-3) cells, recon...

journal_title：Antimicrobial agents and chemotherapy

authors： Cavet ME,West M,Simmons NL

更新日期：1997-12-01 00:00:00

abstract：:The genetic basis of erythromycin resistance in cutaneous propionibacteria was determined by comparing the nucleotide sequences of the peptidyl transferase region in the 23S rRNAs from 9 susceptible and 26 resistant clinical isolates as well as 4 laboratory-selected erythromycin-resistant mutants of a susceptible stra...

journal_title：Antimicrobial agents and chemotherapy

authors： Ross JI,Eady EA,Cove JH,Jones CE,Ratyal AH,Miller YW,Vyakrnam S,Cunliffe WJ

更新日期：1997-05-01 00:00:00

abstract：:Phosphonoformate was found to be an inhibitor of the deoxyribonucleic acid polymerase induced by the herpesvirus of turkeys. The apparent inhibition constants were 1 to 3 muM. Phosphonoformate was also able to block the replication in cell culture of Marek's disease herpesvirus, the herpesvirus of turkeys, and herpes ...

journal_title：Antimicrobial agents and chemotherapy

authors： Reno JM,Lee LF,Boezi JA

更新日期：1978-02-01 00:00:00

abstract：:The microdilution MICs of HMR 3647, erythromycin A, azithromycin, clarithromycin, roxithromycin, and pristinamycin against 50/90% of 249 Haemophilus influenzae and 50 Moraxella catarrhalis isolates were 2/4, 0.06/0.125; 8/16, 0.25/0.25; 2/4, 0.06/0.125; 16/16, 0.25/0.25; 32/>32, 1/2; and 2/4, 0.5/0.5 microg/ml. Azithr...

journal_title：Antimicrobial agents and chemotherapy

authors： Pankuch GA,Hoellman DB,Lin G,Bajaksouzian S,Jacobs MR,Appelbaum PC

更新日期：1998-11-01 00:00:00

abstract：:Resistance of Candida albicans to azole antifungal drugs is mediated by two types of efflux pumps, encoded by the MDR1 gene and the CDR gene family. MDR1 mRNA levels in a susceptible clinical isolate are induced by benomyl (BEN) but not by other drugs previously shown to induce MDR1. To monitor MDR1 expression under s...

journal_title：Antimicrobial agents and chemotherapy

authors： Harry JB,Oliver BG,Song JL,Silver PM,Little JT,Choiniere J,White TC

更新日期：2005-07-01 00:00:00

abstract：:Antagonism, determined by isobolograms constructed from data from combinations of ampicillin and chloramphenicol at or below the minimal inhibitory or bactericidal concentrations, was observed against 13 clinical isolates of meningococcus and against one isolate of pneumococcus. Synergy occurred against six strains of...

journal_title：Antimicrobial agents and chemotherapy

authors： Feldman WE,Zweighaft T

更新日期：1979-02-01 00:00:00

abstract：:Selective decontamination of the digestive tract (SDD) has been evaluated as a method to prevent colonization and infection in ventilated patients in 40 trials. On the basis of an assumption that cross-infection would be reduced as a consequence of SDD and that this would distort the results of SDD studies that used c...

journal_title：Antimicrobial agents and chemotherapy

authors： Hurley JC

更新日期：1995-04-01 00:00:00

abstract：:Standardized direct disk diffusion antibiotic susceptibility testing on monomicrobial urine specimens is compared with the Food and Drug Administration method. The direct procedure yields acceptable data and may conserve 24 h in reporting results. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Wegner DL,Neblett TR

更新日期：1976-12-01 00:00:00

abstract：:The objective of this study is to evaluate the results of single-day doxycycline therapy for Mediterranean spotted fever (MSF). This is a prospective cohort study of cases with confirmed MSF treated with the single-day doxycycline regimen in a teaching hospital from 1990 to 2015. Patients received two oral doses of 20...

journal_title：Antimicrobial agents and chemotherapy

authors： Espejo E,Andrés M,Garcia MC,Fajardo A,Pérez J,Bella F

更新日期：2018-10-24 00:00:00

abstract：:Automated DNA sequencing was used to analyze the oxyR-ahpC region in 229 Mycobacterium tuberculosis complex isolates recently recovered from diseased humans and animals. The entire 1,221-bp region was studied in 118 isolates, and 111 other isolates were sequenced for oxyR, ahpC, or the 105-bp oxyR-ahpC intergenic regi...

journal_title：Antimicrobial agents and chemotherapy

authors： Sreevatsan S,Pan X,Zhang Y,Deretic V,Musser JM

更新日期：1997-03-01 00:00:00

abstract：:We demonstrate that xylitol can be added to polymethylmethacrylate (PMMA) bone cement to enhance the elution of daptomycin in terms of both the peak and sustained release of antibiotic. We also demonstrate that a PMMA-xylitol formulation optimized for daptomycin can be used to enhance the elution of both vancomycin an...

journal_title：Antimicrobial agents and chemotherapy

authors： Weiss BD,Weiss EC,Haggard WO,Evans RP,McLaren SG,Smeltzer MS

更新日期：2009-01-01 00:00:00

abstract：:Cyclacillin, a new aminosalicylic semisynthetic penicillin, was compared with amoxicillin for the therapy of acute bacterial maxillary sinusitis in 80 patients (ages, 12 to 70 years) in a prospective, double-blind, randomized clinical trial. Direct sinus aspirations for quantitative culture were done for all patients ...

journal_title：Antimicrobial agents and chemotherapy

authors： Scheld WM,Sydnor A Jr,Farr B,Gratz JC,Gwaltney JM Jr

更新日期：1986-09-01 00:00:00

abstract：:The tight packing of six fatty acids in the lipid A constituent of lipopolysaccharide (LPS) has been proposed to contribute to the unusually low permeability of the outer membrane of gram-negative enteric bacteria to hydrophobic antibiotics. Here it is shown that the Escherichia coli msbB mutant, which elaborates defe...

journal_title：Antimicrobial agents and chemotherapy

authors： Vaara M,Nurminen M

更新日期：1999-06-01 00:00:00

abstract：:Invasive pulmonary aspergillosis (IPA) is a devastating disease of immunocompromised patients. Pharmacodynamic (PD) examination of antifungal drug therapy in IPA is one strategy that may improve outcomes. The current study explored the PD target of posaconazole in an immunocompromised murine model of IPA against 10 A....

journal_title：Antimicrobial agents and chemotherapy

authors： Lepak AJ,Marchillo K,Vanhecker J,Andes DR

更新日期：2013-01-01 00:00:00

abstract：:The in vitro activity of the aminoglycoside 6'-N-acetyltransferase type Ib [AAC(6')-Ib] was inhibited by CuCl2 with a 50% inhibitory concentration (IC50) of 2.8 μM. The growth of an amikacin-resistant Klebsiella pneumoniae strain isolated from a neonate with meningitis was inhibited when amikacin was supplemented by t...

journal_title：Antimicrobial agents and chemotherapy

authors： Chiem K,Fuentes BA,Lin DL,Tran T,Jackson A,Ramirez MS,Tolmasky ME

更新日期：2015-09-01 00:00:00

abstract：:The pharmacokinetics of cefepime following administration of a single 2-g dose were evaluated for 12 adult patients with thermal burn injury and suspected or documented infection. Serial blood and urine samples for cefepime concentration determination were obtained for 24 h following drug administration. Serum and uri...

journal_title：Antimicrobial agents and chemotherapy

authors： Bonapace CR,White RL,Friedrich LV,Norcross ED,Bosso JA

更新日期：1999-12-01 00:00:00

abstract：:The in vitro activity of WY-49605 (SUN5555) (WY) was compared with those of cefaclor, cefixime, and amoxicillin-clavulanic acid against 2,958 consecutive clinical isolates from five medical centers and 402 respiratory pathogens from 18 other facilities. Most members of the family Enterobacteriaceae were inhibited by W...

journal_title：Antimicrobial agents and chemotherapy

authors： Sewell D,Barry A,Allen S,Fuchs P,McLaughlin J,Pfaller M

更新日期：1995-07-01 00:00:00

abstract：:Treating high-density bacterial infections is a challenging clinical problem. We have a paucity of new agents that can address this problem. Pseudomonas aeruginosa is a particularly difficult pathogen to treat effectively because of the plethora of resistance mechanisms it carries. Fosfomycin is an agent discovered ci...

journal_title：Antimicrobial agents and chemotherapy

authors： Drusano GL,Neely MN,Yamada WM,Duncanson B,Brown D,Maynard M,Vicchiarelli M,Louie A

更新日期：2018-11-26 00:00:00