Genotypic identification of methicillin-resistant coagulase-negative staphylococci by polymerase chain reaction.

abstract：:Oral doses of norfloxacin (80 mg/kg of body weight per day) and ciprofloxacin (25 and 80 mg/kg/day) and intramuscular doses of teicoplanin (5 mg/kg/day), all administered once a day for 10 days, were evaluated as a means of preventing encrusted cystitis caused by Corynebacterium group D2. Zinc disks dipped into a 24-h...

journal_title：Antimicrobial agents and chemotherapy

authors： Soriano F,Rodriguez-Tudela JL,Castilla C,Avilés P

更新日期：1991-12-01 00:00:00

abstract：:The in vitro activity of GR-20263, a new aminothiazolyl cephalosporin, was compared with the activities of other beta-lactam antibiotics by using 800 clinical bacterial isolates. GR-20263 was highly active (inhibition of 90% of the isolates between 0.03 and 1 microgram/ml) against the common Enterobacteriaceae and 5 t...

journal_title：Antimicrobial agents and chemotherapy

authors： Verbist L,Verhaegen J

更新日期：1980-05-01 00:00:00

abstract：:Retrospective analysis of 189 nonredundant strains of Pseudomonas aeruginosa sequentially recovered from the sputum samples of 46 cystic fibrosis (CF) patients over a 10-year period (1998 to 2007) revealed that 53 out of 189 (28%) samples were hypersusceptible to the beta-lactam antibiotic ticarcillin (MIC < or = 4 mi...

journal_title：Antimicrobial agents and chemotherapy

authors： Vettoretti L,Plésiat P,Muller C,El Garch F,Phan G,Attrée I,Ducruix A,Llanes C

更新日期：2009-05-01 00:00:00

abstract：:Infections with enterohemorrhagic Escherichia coli (EHEC) cause disease ranging from mild diarrhea to hemolytic-uremic syndrome (HUS) and are the most common cause of renal failure in children in high-income countries. The severity of the disease derives from the release of Shiga toxins (Stx). The use of antibiotics t...

journal_title：Antimicrobial agents and chemotherapy

authors： Mühlen S,Ramming I,Pils MC,Koeppel M,Glaser J,Leong J,Flieger A,Stecher B,Dersch P

更新日期：2020-03-24 00:00:00

abstract：:Pseudomonas putida is well known for its metabolic capabilities, but recently, it has been shown to exhibit resistance to a wide range of antibiotics. In P. putida DOT-T1E, the TtgABC efflux pump, which has a broad substrate specificity, extrudes antibiotics such as ampicillin, carbenicillin, tetracycline, nalidixic a...

journal_title：Antimicrobial agents and chemotherapy

authors： Terán W,Felipe A,Segura A,Rojas A,Ramos JL,Gallegos MT

更新日期：2003-10-01 00:00:00

abstract：:Defensins are small cationic bactericidal peptides present abundantly in the granules of polymorphonuclear neutrophils (PMNs). Human PMNs contain four defensins termed HNP-1 to HNP-4. We used a new assay system in agar plates, the radial diffusion assay, to evaluate the effects of human defensins against gram-positive...

journal_title：Antimicrobial agents and chemotherapy

authors： Takemura H,Kaku M,Kohno S,Hirakata Y,Tanaka H,Yoshida R,Tomono K,Koga H,Wada A,Hirayama T,Kamihira S

更新日期：1996-10-01 00:00:00

abstract：:The potential for resistance development in Streptococcus pneumoniae secondary to exposure to gatifloxacin, gemifloxacin, levofloxacin, and moxifloxacin at various levels was examined at high inoculum (10(8.5) to 10(9) log10 CFU/ml) over 96 h in an in vitro pharmacodynamic (PD) model using two fluoroquinolone-suscepti...

journal_title：Antimicrobial agents and chemotherapy

authors： LaPlante KL,Rybak MJ,Tsuji B,Lodise TP,Kaatz GW

更新日期：2007-04-01 00:00:00

abstract：:Ledipasvir (LDV; GS-5885), a component of Harvoni (a fixed-dose combination of LDV with sofosbuvir [SOF]), is approved to treat chronic hepatitis C virus (HCV) infection. Here, we report key preclinical antiviral properties of LDV, including in vitro potency, in vitro resistance profile, and activity in combination wi...

journal_title：Antimicrobial agents and chemotherapy

authors： Cheng G,Tian Y,Doehle B,Peng B,Corsa A,Lee YJ,Gong R,Yu M,Han B,Xu S,Dvory-Sobol H,Perron M,Xu Y,Mo H,Pagratis N,Link JO,Delaney W

更新日期：2016-01-11 00:00:00

abstract：:Pharmacological studies of netilmicin were conducted in 30 cancer patients. After intravenous administration of 50 mg of netilmicin or gentamicin per m(2) over a 1-h period in 10 patients, the mean peak serum concentrations occurred at the end of the infusion and were 7.6 and 7.3 mug/ml, respectively. At 6 h, the mean...

journal_title：Antimicrobial agents and chemotherapy

authors： Yap BS,Stewart D,Bodey GP

更新日期：1977-12-01 00:00:00

abstract：:Macrolactin A (MA) and 7-O-succinyl macrolactin A (SMA), polyene macrolides containing a 24-membered lactone ring, show antibiotic effects superior to those of teicoplanin against vancomycin-resistant enterococci and methicillin-resistant Staphylococcus aureus. MA and SMA are currently being evaluated as antitumor age...

journal_title：Antimicrobial agents and chemotherapy

authors： Bae SH,Kwon MJ,Park JB,Kim D,Kim DH,Kang JS,Kim CG,Oh E,Bae SK

更新日期：2014-09-01 00:00:00

abstract：:The in vitro susceptibilities of 11 strains of Chlamydia pneumoniae to azithromycin, clarithromycin, erythromycin, L-oflaxacin, and doxycycline were determined. Clarithromycin was the most active agent tested, with an MIC for 90% of strains and minimal chlamydiacidal concentration for 90% of strains of 0.03 microns/ml...

journal_title：Antimicrobial agents and chemotherapy

authors： Hammerschlag MR,Qumei KK,Roblin PM

更新日期：1992-07-01 00:00:00

abstract：:A novel and highly accurate diagnostic assay platform was established for rapid identification of FKS mutations associated with echinocandin resistance in Candida glabrata The assay platform uses allele-specific molecular beacon and DNA melt analysis following asymmetric PCR. A dual assay for FKS1 and FKS2 was develop...

journal_title：Antimicrobial agents and chemotherapy

authors： Zhao Y,Nagasaki Y,Kordalewska M,Press EG,Shields RK,Nguyen MH,Clancy CJ,Perlin DS

更新日期：2016-10-21 00:00:00

abstract：:Intranasal inoculation of newborn mice with Herpesvirus hominis type 2 provides an experimental infection that closely resembles disseminated herpesvirus infection of human newborn infants. After inoculation of mice, the virus multiplies in the respiratory tract and is disseminated through the blood to the liver and s...

journal_title：Antimicrobial agents and chemotherapy

authors： Kern ER,Overall JC Jr,Glasgow LA

更新日期：1975-05-01 00:00:00

abstract：:Polymorphisms and the overexpression of transporter genes, especially of the ATP-binding cassette superfamily, have been involved in antimalarial drug resistance. The objective of this study was to use 77 Senegalese Plasmodium falciparum isolates to evaluate the association between the number of Asn residues in the po...

journal_title：Antimicrobial agents and chemotherapy

authors： Gendrot M,Diawara S,Madamet M,Kounta MB,Briolant S,Wade KA,Fall M,Benoit N,Nakoulima A,Amalvict R,Diémé Y,Fall B,Wade B,Diatta B,Pradines B

更新日期：2017-02-23 00:00:00

abstract：:Streptonigrin, a quinone antitumor antibiotic, has been reported to be effective in human trials. A sensitive and precise microbiological assay for the determination of distribution and concentrations of streptonigrin in the body fluids and tissues of treated mice has been developed in an attempt to supplement success...

journal_title：Antimicrobial agents and chemotherapy

authors： Pittillo RF,Woolley C

更新日期：1974-01-01 00:00:00

abstract：:Ninety-two strains of Yersinia pestis recovered over a 21-year period were evaluated for susceptibility to traditional and newer antimicrobial agents. In vitro resistance was noted only against rifampin and imipenem (approximately 20% of strains). The most active compounds (MIC at which 90% of the isolates tested are ...

journal_title：Antimicrobial agents and chemotherapy

authors： Wong JD,Barash JR,Sandfort RF,Janda JM

更新日期：2000-07-01 00:00:00

abstract：:Between 1986 and 1988, the incidence of ampicillin-resistant enterococci increased sevenfold at a university-affiliated hospital. Forty-three patients acquired nosocomial infections with ampicillin-resistant enterococci, most of which were also resistant to mezlocillin, piperacillin, and imipenem. An analysis of plasm...

journal_title：Antimicrobial agents and chemotherapy

authors： Boyce JM,Opal SM,Potter-Bynoe G,LaForge RG,Zervos MJ,Furtado G,Victor G,Medeiros AA

更新日期：1992-05-01 00:00:00

abstract：:Azithromycin concentrations in the tonsils of 56 pediatric patients, treated with 10 or 20 mg of the drug per kg of body weight for 3 days, were compared. Azithromycin levels in plasma and tonsil samples were determined up to 8.5 days after the last dose. The 20-mg/kg regimen resulted in an improved tonsillar distribu...

journal_title：Antimicrobial agents and chemotherapy

authors： Blandizzi C,Malizia T,Batoni G,Ghelardi E,Baschiera F,Bruschini P,Senesi S,Campa M,Del Tacca M

更新日期：2002-05-01 00:00:00

abstract：:We determined the complete nucleotide sequence of a self-transmissible IncL/M plasmid, pKOI-34, from a Klebsiella oxytoca isolate. pKOI-34 possessed the core structure of an IncL/M plasmid found in Erwinia amylovora, pEL60, with two mobile elements inserted, a transposon carrying the arsenic resistance operon and a Tn...

journal_title：Antimicrobial agents and chemotherapy

authors： Shimada N,Kayama S,Shigemoto N,Hisatsune J,Kuwahara R,Nishio H,Yamasaki K,Wada Y,Sueda T,Ohge H,Sugai M

更新日期：2016-04-22 00:00:00

abstract：:Pokeweed antiviral protein at a concentration of 3 microM inhibited both the synthesis and release of infectious herpes simplex virus type 1 in cell culture by 90 and 99%, respectively. Addition of pokeweed antiviral protein to Vero cell monolayers before virus infection was 10 to 15% more effective in reducing virus ...

journal_title：Antimicrobial agents and chemotherapy

authors： Teltow GJ,Irvin JD,Aron GM

更新日期：1983-03-01 00:00:00

abstract：:Aspergillus flavus is the second most significant pathogenic cause of invasive aspergillosis; however, its emergence risks and mechanisms of voriconazole (VRC) resistance have not yet been elucidated in detail. Here, we demonstrate that repeated exposure of A. flavus to subinhibitory concentrations of VRC in vitro cau...

journal_title：Antimicrobial agents and chemotherapy

authors： Ukai Y,Kuroiwa M,Kurihara N,Naruse H,Homma T,Maki H,Naito A

更新日期：2018-10-24 00:00:00

abstract：:Current antimalarials are under continuous threat due to the relentless development of drug resistance by malaria parasites. We previously reported promising in vitro parasite-killing activity with the histone methyltransferase inhibitor BIX-01294 and its analogue TM2-115. Here, we further characterize these diaminoqu...

journal_title：Antimicrobial agents and chemotherapy

authors： Malmquist NA,Sundriyal S,Caron J,Chen P,Witkowski B,Menard D,Suwanarusk R,Renia L,Nosten F,Jiménez-Díaz MB,Angulo-Barturen I,Santos Martínez M,Ferrer S,Sanz LM,Gamo FJ,Wittlin S,Duffy S,Avery VM,Ruecker A,Delves MJ

更新日期：2015-02-01 00:00:00

abstract：:Thirty-four infants and children ranging in age from 2.5 to 180 months (mean, 40 months) were treated with parenteral moxalactam (150 mg/kg per day) for suspected or proved bacterial infections outside the central nervous system. Six patients infected with Haemophilus influenzae b, nine infected with Staphylococcus au...

journal_title：Antimicrobial agents and chemotherapy

authors： Keyserling H,Feldman WE,Moffitt S,Manning N,Hollins M

更新日期：1982-06-01 00:00:00

abstract：:Etest susceptibilities to amoxicillin, chloramphenicol, and trimethoprim-sulfamethoxazole of 240 invasive isolates of Haemophilus influenzae cultured from children in rural Kenya were 66%, 66%, and 38%, respectively. Resistance increased markedly over 9 years and was concentrated among serotype b isolates. In Africa, ...

journal_title：Antimicrobial agents and chemotherapy

authors： Scott JA,Mwarumba S,Ngetsa C,Njenga S,Lowe BS,Slack MP,Berkley JA,Mwangi I,Maitland K,English M,Marsh K

更新日期：2005-07-01 00:00:00

abstract：:The interaction of miltefosine with amphotericin B, sodium stibogluconate, paromomycin, and sitamaquine was assessed in vitro and additionally for the first three combinations in vivo. In vitro interactions were indifferent for miltefosine combined with amphotericin B (mean sums of fractional inhibitory concentrations...

journal_title：Antimicrobial agents and chemotherapy

authors： Seifert K,Croft SL

更新日期：2006-01-01 00:00:00

abstract：:Two patients (patients A and B) infected with Salmonella typhimurium failed ciprofloxacin therapy, and the posttherapy isolates had reduced susceptibilities to quinolones; 6 of 11 isolates from patient B were also cross-resistant to chemically unrelated agents. No transferable resistance, chloramphenicol-acetylating e...

journal_title：Antimicrobial agents and chemotherapy

authors： Piddock LJ,Griggs DJ,Hall MC,Jin YF

更新日期：1993-04-01 00:00:00

abstract：:Febrifugine is the active principal isolated 50 years ago from the Chinese herb chang shan (Dichroa febrifuga Lour), which has been used as an antimalarial in Chinese traditional medicine for more than 2,000 years. However, intensive study of the properties of febrifugine has been hindered for decades due to its side ...

journal_title：Antimicrobial agents and chemotherapy

authors： Jiang S,Zeng Q,Gettayacamin M,Tungtaeng A,Wannaying S,Lim A,Hansukjariya P,Okunji CO,Zhu S,Fang D

更新日期：2005-03-01 00:00:00

abstract：:Arylimidamides (AIAs) have been shown to have considerable biological activity against intracellular pathogens, includingTrypanosoma cruzi, which causes Chagas disease. In the present study, the activities of 12 novel bis-AIAs and 2 mono-AIAs against different strains ofT. cruziin vitroandin vivowere analyzed. The mos...

journal_title：Antimicrobial agents and chemotherapy

authors： Guedes-da-Silva FH,Batista DG,Meuser MB,Demarque KC,Fulco TO,Araújo JS,Da Silva PB,Da Silva CF,Patrick DA,Bakunova SM,Bakunov SA,Tidwell RR,Oliveira GM,Britto C,Moreira OC,Soeiro MN

更新日期：2016-03-25 00:00:00

abstract：:Antibiotic therapy is the most commonly used strategy to control pathogenic infections; however, it has contributed to the generation of antibiotic-resistant bacteria. To circumvent this emerging problem, we are searching for compounds that target bacterial virulence factors rather than their viability. Pseudomonas ae...

journal_title：Antimicrobial agents and chemotherapy

authors： Yamazaki A,Li J,Zeng Q,Khokhani D,Hutchins WC,Yost AC,Biddle E,Toone EJ,Chen X,Yang CH

更新日期：2012-01-01 00:00:00

abstract：:In a randomized crossover trial, six volunteers received 200- and 400-mg doses of loracarbef (LY 163892), a new oral cephalosporin. Mean +/- standard error of the mean concentrations in serum obtained after 1.5 and 3 h were 13.2 +/- 2.8 and 4.3 +/- 0.7 mg/liter, respectively, after the 400-mg dose and 6.9 +/- 1.0 and ...

journal_title：Antimicrobial agents and chemotherapy

authors： Van der Auwera P

更新日期：1992-03-01 00:00:00