Herpesvirus hominis infection in newborn mice: comparison of the therapeutic efficacy of 1-beta-D-arabinofuranosylcytosine and 9-beta-D-arabinofuranosyladenine.

abstract：:Replication complexes of hepatitis C virus synthesized two major species of viral RNA in vitro, double stranded and single stranded. NS5B nonnucleoside inhibitors inhibited dose dependently the synthesis of single-stranded RNA but not double-stranded RNA. Moreover, replication complexes carrying a mutation resistant t...

journal_title：Antimicrobial agents and chemotherapy

authors： Yang W,Sun Y,Phadke A,Deshpande M,Huang M

更新日期：2007-01-01 00:00:00

abstract：:Parallel administration of the proton pump inhibitor (PPI) esomeprazole has been shown to decrease oral bioavailability of posaconazole in healthy volunteers. We prospectively analyzed serum samples (n = 59) obtained from hematology patients (n = 27) under posaconazole prophylaxis. Patients treated concomitantly with ...

journal_title：Antimicrobial agents and chemotherapy

authors： Neubauer WC,Engelhardt M,König A,Hieke S,Jung M,Bertz H,Kümmerer K

更新日期：2010-09-01 00:00:00

abstract：:Artemisinins are peroxidic antimalarial drugs known to be very potent but highly chemically unstable; they degrade in the presence of ferrous iron, Fe(II)-heme, or biological reductants. Less documented is how this translates into chemical stability and antimalarial activity across a range of conditions applying to in...

journal_title：Antimicrobial agents and chemotherapy

authors： Parapini S,Olliaro P,Navaratnam V,Taramelli D,Basilico N

更新日期：2015-07-01 00:00:00

abstract：:Epidemiological data on carbapenemase-producing Gram-negative bacteria on the African continent are limited. Here, we report the identification of VIM-2-producing Pseudomonas aeruginosa isolates in Tanzania. Eight out of 90 clinical isolates of P. aeruginosa from a tertiary care hospital in Dar es Salaam were shown to...

journal_title：Antimicrobial agents and chemotherapy

authors： Moyo S,Haldorsen B,Aboud S,Blomberg B,Maselle SY,Sundsfjord A,Langeland N,Samuelsen Ø

更新日期：2015-01-01 00:00:00

abstract：:Clinical isolates of Klebsiella pneumoniae resistant to carbapenems are being isolated with increasing frequency. Loss of the expression of the major nonspecific porins OmpK35/36 is a frequent feature in these isolates. In this study, we looked for porins that could compensate for the loss of the major porins in carba...

journal_title：Antimicrobial agents and chemotherapy

authors： García-Sureda L,Doménech-Sánchez A,Barbier M,Juan C,Gascó J,Albertí S

更新日期：2011-10-01 00:00:00

abstract：:Most methicillin-resistant Staphylococcus aureus (MRSA) isolates identified among blood isolates collected in Denmark between 1957 and 1970 belonged to either phage group III or the closely related 83A complex and had a PSTM antibiotype (resistance to penicillin [P], streptomycin [S], tetracycline [T], and methicillin...

journal_title：Antimicrobial agents and chemotherapy

authors： Gomes AR,Westh H,de Lencastre H

更新日期：2006-10-01 00:00:00

abstract：:9-R-[2-(Phosphonomethoxy)propyl]-adenine (tenofovir) is an acyclic nucleoside phosphonate with antiviral activity against human immunodeficiency virus type 1 (HIV-1) and hepatitis B virus (HBV). Tenofovir is not orally bioavailable but becomes orally active against HIV-1 infection as the disoproxil ester (tenofovir di...

journal_title：Antimicrobial agents and chemotherapy

authors： Painter GR,Almond MR,Trost LC,Lampert BM,Neyts J,De Clercq E,Korba BE,Aldern KA,Beadle JR,Hostetler KY

更新日期：2007-10-01 00:00:00

abstract：:Tiacumicins B and C are members of a novel group of 18-membered macrolide antibiotics with in vitro activity against Clostridium difficile. The MICs against 15 strains of C. difficile were 0.12 to 0.25 microgram/ml for tiacumicin B, 0.25 to 1 microgram/ml for tiacumicin C, and 0.5 to 1 microgram/ml for vancomycin. The...

journal_title：Antimicrobial agents and chemotherapy

authors： Swanson RN,Hardy DJ,Shipkowitz NL,Hanson CW,Ramer NC,Fernandes PB,Clement JJ

更新日期：1991-06-01 00:00:00

abstract：:Lamivudine [beta-L-(-)-2',3'-dideoxy-3'-thiacytidine] is a potent inhibitor of hepadnavirus replication and is used both to treat chronic hepatitis B virus (HBV) infections and to prevent reinfection of transplanted livers. Unfortunately, lamivudine-resistant HBV variants do arise during prolonged therapy, indicating ...

journal_title：Antimicrobial agents and chemotherapy

authors： Walters KA,Tipples GA,Allen MI,Condreay LD,Addison WR,Tyrrell L

更新日期：2003-06-01 00:00:00

abstract：:Toxoplasma gondii is a cosmopolitan protozoan parasite which affects approximately 30% of the population worldwide. The drugs currently used against toxoplasmosis are few in number and show several limitations, such as drug intolerance, poor bioavailability, or drug resistance mechanism developed by the parasite. Thus...

journal_title：Antimicrobial agents and chemotherapy

authors： Spalenka J,Escotte-Binet S,Bakiri A,Hubert J,Renault JH,Velard F,Duchateau S,Aubert D,Huguenin A,Villena I

更新日期：2018-01-25 00:00:00

abstract：:Drug repositioning is the only feasible option to immediately address the COVID-19 global challenge. We screened a panel of 48 FDA-approved drugs against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) which were preselected by an assay of SARS-CoV. We identified 24 potential antiviral drug candidates aga...

journal_title：Antimicrobial agents and chemotherapy

authors： Jeon S,Ko M,Lee J,Choi I,Byun SY,Park S,Shum D,Kim S

更新日期：2020-06-23 00:00:00

abstract：:The in vitro activity of ceftriaxone was compared with those of other recently introduced beta-lactam antimicrobial agents (cefoperazone, cefotaxime, and moxalactam) and with those of cefoxitin, clindamycin, and metronidazole against 227 strains of anaerobic bacteria. The data obtained in this investigation suggest th...

journal_title：Antimicrobial agents and chemotherapy

authors： Rolfe RD,Finegold SM

更新日期：1982-08-01 00:00:00

abstract：:Pseudomonas aeruginosa exploits intrinsic and acquired resistance mechanisms to resist almost every antibiotic used in chemotherapy. Antimicrobial resistance in P. aeruginosa isolates recovered from cystic fibrosis (CF) patients is further enhanced by the occurrence of hypermutator strains, a hallmark of chronic infec...

journal_title：Antimicrobial agents and chemotherapy

authors： Colque CA,Albarracín Orio AG,Feliziani S,Marvig RL,Tobares AR,Johansen HK,Molin S,Smania AM

更新日期：2020-04-21 00:00:00

abstract：:Lamivudine is a major drug approved for treatment of chronic hepatitis B virus (HBV) infection. Emergence of drug-resistant mutants with amino acid substitutions in the YMDD motif is a well-documented problem during long-term lamivudine therapy. Here we report a novel lamivudine-resistant strain of HBV with an intact ...

journal_title：Antimicrobial agents and chemotherapy

authors： Yatsuji H,Noguchi C,Hiraga N,Mori N,Tsuge M,Imamura M,Takahashi S,Iwao E,Fujimoto Y,Ochi H,Abe H,Maekawa T,Tateno C,Yoshizato K,Suzuki F,Kumada H,Chayama K

更新日期：2006-11-01 00:00:00

abstract：:Purified recombinant protein encoded by the BXLF-I open reading frame of the Epstein-Barr virus genome has thymidine kinase activity. The substrate behaviors of various nucleosides toward this enzyme were tested. Halogenated deoxyuridines, zidovudine, and bromovinyldeoxyuridine are efficient substrates, while acyclovi...

journal_title：Antimicrobial agents and chemotherapy

authors： Tung PP,Summers WC

更新日期：1994-09-01 00:00:00

abstract：:The aim of this study was to investigate the influence of hypovolemia on the distribution of imipenem in muscle extracellular fluid determined by microdialysis in awake rats. Microdialysis probes were inserted into the jugular vein and hind leg muscle. Imipenem recoveries in muscle and blood were determined in each ra...

journal_title：Antimicrobial agents and chemotherapy

authors： Marchand S,Dahyot C,Lamarche I,Plan E,Mimoz O,Couet W

更新日期：2005-12-01 00:00:00

abstract：:An inhibitor-resistant beta-lactamase (SHV-10), derived from an SHV-5 variant (SHV-9), was found in an Escherichia coli clinical isolate. In SHV-10, Ser-130 was replaced by Gly. The enzyme partially retained its ability to hydrolyze penicillins, but its activity against cephalosporins was drastically reduced. A Ser-13...

journal_title：Antimicrobial agents and chemotherapy

authors： Prinarakis EE,Miriagou V,Tzelepi E,Gazouli M,Tzouvelekis LS

更新日期：1997-04-01 00:00:00

abstract：:Pharmaceutical differences between the reference listed drug (RLD) and generic formulations of piperacillin-tazobactam may impact the reconstitution process for intravenous administration. This study evaluated the RLD against three generic formulations and measured their reconstitution times using a standardized proce...

journal_title：Antimicrobial agents and chemotherapy

authors： Zheng H,Truong J,Carroll F,Pai MP

更新日期：2015-03-01 00:00:00

abstract：:A preliminary study was conducted with netilmicin, a new aminoglycoside antibiotic. Its effectiveness was evaluated in vitro against 546 strains of Enterobacteriaceae and Pseudomonas aeruginosa isolated from clinical material. Its effectiveness against gentamicin-susceptible strains was roughly similar to that of gent...

journal_title：Antimicrobial agents and chemotherapy

authors： Klastersky J,Meunier-Carpentier F,Coppens-Kahan L,Daneau D,Prevost JM

更新日期：1977-10-01 00:00:00

abstract：:The distributions of tet(M) and conjugative transposons related to Tn1545 were studied by hybridization in 47 clinical isolates of Streptococcus pneumoniae resistant to tetracycline. Resistance to tetracycline was always associated with resistance to minocycline and was due to the presence of the tet(M) gene. Associat...

journal_title：Antimicrobial agents and chemotherapy

authors： Poyart-Salmeron C,Trieu-Cuot P,Carlier C,Courvalin P

更新日期：1991-08-01 00:00:00

abstract：:Two carbapenem-resistant isolates, one Escherichia coli isolate and one Klebsiella pneumoniae isolate, recovered from an Algerian patient expressed a novel VIM-type metallo-beta-lactamase (MBL). The identified bla(VIM-19) gene was located on a ca. 160-kb plasmid and located inside a class 1 integron in both isolates. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Rodriguez-Martinez JM,Nordmann P,Fortineau N,Poirel L

更新日期：2010-01-01 00:00:00

abstract：:We have discovered a remarkable synergistic antimalarial interaction between rufigallol and the structurally similar compound exifone. The synergistic effects were produced in chloroquine-susceptible and chloroquine-resistant clones of Plasmodium falciparum. The degree of potentiation as estimated by standard isobolar...

journal_title：Antimicrobial agents and chemotherapy

authors： Winter RW,Cornell KA,Johnson LL,Ignatushchenko M,Hinrichs DJ,Riscoe MK

更新日期：1996-06-01 00:00:00

abstract：:Intranasal inoculation of newborn mice with Herpesvirus hominis (HVH) type 2 provides a model for disseminated herpesvirus infections of human newborn infants. Treatment of this experimental infection with polyinosinic-polycytidylic acid [poly(I:C)] significantly increased the mean survival time and markedly altered t...

journal_title：Antimicrobial agents and chemotherapy

authors： Kern ER,Overall JC Jr,Glasgow LA

更新日期：1975-06-01 00:00:00

abstract：:This study explored metronidazole and hydroxymetronidazole distribution in the cerebrospinal fluid (CSF) of brain-injured patients. Four brain-injured patients with external ventricular drain received 500 mg of metronidazole over 0.5 h every 8 h. CSF and blood samples were collected at steady state over 8 h, and the m...

journal_title：Antimicrobial agents and chemotherapy

authors： Frasca D,Dahyot-Fizelier C,Adier C,Mimoz O,Debaene B,Couet W,Marchand S

更新日期：2014-01-01 00:00:00

abstract：:In vitro studies of zidovudine (ZDV) phosphorylation may not accurately reflect the in vivo dose-response relationship, which is crucial to determining the relationship between ZDV exposure, efficacy, and toxicity. However, measurement of ZDV phosphorylated anabolites in peripheral blood mononuclear cells (PBMCs) from...

journal_title：Antimicrobial agents and chemotherapy

authors： Slusher JT,Kuwahara SK,Hamzeh FM,Lewis LD,Kornhauser DM,Lietman PS

更新日期：1992-11-01 00:00:00

abstract：:The residual antibiotic concentration of vancomycin (2 mg/ml)- or ceftazidime (2 mg/ml)-heparin solutions instilled in ports in pediatric hematology-oncology patients 1 to 34 days earlier was measured. Antibiotic concentrations of > or = 100 microg of either antibiotic per ml persisted for at least 21 days. For treatm...

journal_title：Antimicrobial agents and chemotherapy

authors： Haimi-Cohen Y,Husain N,Meenan J,Karayalcin G,Lehrer M,Rubin LG

更新日期：2001-05-01 00:00:00

abstract：:Minimum inhibitory concentrations (MICs) of six penicillins against 95 strains of Neisseria gonorrhoeae from patients with uncomplicated anogenital infections and 22 strains from women with pelvic inflammatory disease were determined by an agar plate dilution method, using an inocula replicator. Against all 117 strain...

journal_title：Antimicrobial agents and chemotherapy

authors： Sackel SG,Alpert S,Rosner B,McCormack WM,Finland M

更新日期：1977-07-01 00:00:00

abstract：:Caseinomacropeptide (CMP) is a heterogeneous C-terminal fragment (residues 106 to 169) of bovine milk kappa-casein composed of glycosylated and phosphorylated forms of different genetic variants. We have demonstrated that CMP has growth-inhibitory activity against the oral opportunistic pathogens Streptococcus mutans ...

journal_title：Antimicrobial agents and chemotherapy

authors： Malkoski M,Dashper SG,O'Brien-Simpson NM,Talbo GH,Macris M,Cross KJ,Reynolds EC

更新日期：2001-08-01 00:00:00

abstract：:A beta-lactamase was purified from Serratia marcescens GN16694; it hydrolyzed T-5575 and oxime-type cephalosporins, i.e., cefuroxime and ceftazidime. Its isoelectric point and molecular weight were 8.6 and 42,000, respectively. This enzyme was not inhibited by EDTA and clavulanic acid. This enzyme is an unusual beta-l...

journal_title：Antimicrobial agents and chemotherapy

authors： Matsumura N,Mitsuhashi S

更新日期：1995-09-01 00:00:00

abstract：:Three mer transposons from the Murray collection of preantibiotic enterobacteria show >99% sequence identity to current isolates. Tn5073 is most closely related to Tn5036 and Tn1696, and Tn5074 is most closely related to Tn5053. Tn5075 is most closely related to Tn21 but lacks integron In2 and is flanked by insertion ...

journal_title：Antimicrobial agents and chemotherapy

authors： Essa AM,Julian DJ,Kidd SP,Brown NL,Hobman JL

更新日期：2003-03-01 00:00:00