Substrate specificity of Epstein-Barr virus thymidine kinase.

abstract：:SDZ MRL 953, a new synthetic monosaccharidic lipid A, was investigated in vitro and in vivo for immunopharmacological activities. In experimental models of microbial infections, the compound was highly protective when it was administered prophylactically either once or three times to myelosuppressed or immunocompetent...

journal_title：Antimicrobial agents and chemotherapy

authors： Lam C,Schütze E,Hildebrandt J,Aschauer H,Liehl E,Macher I,Stütz P

更新日期：1991-03-01 00:00:00

abstract：:We studied the DNA sequence variation of van genes of 34 isolates of Enterococcus spp. The isolates containing the vanB gene exhibited between 0 and 41 base pair changes per 801 bp studied when the vanB sequences were compared to that of the reference strain Enterococcus faecalis V583. The isolates carrying the vanC-2...

journal_title：Antimicrobial agents and chemotherapy

authors： Patel R,Uhl JR,Kohner P,Hopkins MK,Steckelberg JM,Kline B,Cockerill FR 3rd

更新日期：1998-01-01 00:00:00

abstract：:Ceftaroline fosamil is a cephalosporin with activity against Gram-positive pathogens, including methicillin-resistant Staphylococcus aureus (MRSA). The objective of this study was to characterize the dose-response relationship of ceftaroline fosamil against S. aureus in an immunocompromised murine pneumonia model, as ...

journal_title：Antimicrobial agents and chemotherapy

authors： Bhalodi AA,Crandon JL,Biek D,Nicolau DP

更新日期：2012-12-01 00:00:00

abstract：:Alternate therapies are needed for treatment of secondary bacterial pneumonia following influenza. The immunomodulatory peptide P4 has shown promise in mouse models of primary pneumococcal infection. Mice infected with influenza virus and then challenged with Streptococcus pneumoniae were treated with a combination of...

journal_title：Antimicrobial agents and chemotherapy

authors： Weeks JN,Boyd KL,Rajam G,Ades EW,McCullers JA

更新日期：2011-05-01 00:00:00

abstract：:LCB01-0371 is a new oxazolidinone with cyclic amidrazone. In vitro activity of LCB01-0371 against 624 clinical isolates was evaluated and compared with those of linezolid, vancomycin, and other antibiotics. LCB01-0371 showed good activity against Gram-positive pathogens. In vivo activity of LCB01-0371 against systemic...

journal_title：Antimicrobial agents and chemotherapy

authors： Jeong JW,Jung SJ,Lee HH,Kim YZ,Park TK,Cho YL,Chae SE,Baek SY,Woo SH,Lee HS,Kwak JH

更新日期：2010-12-01 00:00:00

abstract：:The prevailing resistance mechanism against glycopeptides in Gram-positive pathogens involves reprogramming the biosynthesis of peptidoglycan precursors, resulting in d-alanyl-d-lactate depsipeptide termini. Amycolatopsis balhimycina produces the vancomycin-like glycopeptide balhimycin and therefore has to protect its...

journal_title：Antimicrobial agents and chemotherapy

authors： Schäberle TF,Vollmer W,Frasch HJ,Hüttel S,Kulik A,Röttgen M,von Thaler AK,Wohlleben W,Stegmann E

更新日期：2011-09-01 00:00:00

abstract：:The 2-year follow-up results for a randomized placebo-controlled study of 47 patients with multidrug-resistant pulmonary tuberculosis treated with either the new diarylquinoline TMC207, recently renamed bedaquiline, or placebo, added to the first 8 weeks of a background regimen, are presented. Bedaquiline significantl...

journal_title：Antimicrobial agents and chemotherapy

authors： Diacon AH,Donald PR,Pym A,Grobusch M,Patientia RF,Mahanyele R,Bantubani N,Narasimooloo R,De Marez T,van Heeswijk R,Lounis N,Meyvisch P,Andries K,McNeeley DF

更新日期：2012-06-01 00:00:00

abstract：:Rifabutin pharmacokinetics were studied by the population approach (NONMEM) with 40 human immunodeficiency virus-infected patients receiving rifabutin at different doses for prophylaxis or therapy of mycobacterial infections. A two-compartment open model with first-order absorption was used as the structural pharmacok...

journal_title：Antimicrobial agents and chemotherapy

authors： Gatti G,Papa P,Torre D,Andreoni M,Poggio A,Bassetti M,Marone P

更新日期：1998-08-01 00:00:00

abstract：:The participation of trypanothione in clinical and experimental antimony (Sb) resistance in Leishmania panamensis was examined by using specific inhibitors. Buthionine sulfoximine (BSO) significantly reversed the resistance to trivalent Sb (Sb(III)) of promastigotes of experimentally derived Sb-resistant lines, suppor...

journal_title：Antimicrobial agents and chemotherapy

authors： Goyeneche-Patino DA,Valderrama L,Walker J,Saravia NG

更新日期：2008-12-01 00:00:00

abstract：:An agar dilution method was employed to test the susceptibility of 12 strains of Coccidioides immitis to polymyxin B (PB). After 3 days of incubation, eight strains were markedly inhibited by 5.0 mug of PB per ml and four strains did not grow. PB at 10 mug/ml inhibited the growth of all strains through 20 days of incu...

journal_title：Antimicrobial agents and chemotherapy

authors： Collins MS,Pappagianis D

更新日期：1976-08-01 00:00:00

abstract：:The two groups of chromosomal beta-lactamases from Klebsiella oxytoca (OXY-1 and OXY-2) can be overproduced 73- to 223-fold, due to point mutations in the consensus sequences of their promoters. The different versions of promoters from blaOXY-1 and blaOXY-2 were cloned upstream of the chloramphenicol acetyltransferase...

journal_title：Antimicrobial agents and chemotherapy

authors： Fournier B,Gravel A,Hooper DC,Roy PH

更新日期：1999-04-01 00:00:00

abstract：:Adult AIDS Clinical Trials Group 5043 examined pharmacokinetic (PK) interactions between amprenavir (APV) and efavirenz (EFV) both by themselves and when nelfinavir (NFV), indinavir (IDV), ritonavir (RTV), or saquinavir (SQV) is added. A PK study was conducted after the administration of single doses of APV (day 0). S...

journal_title：Antimicrobial agents and chemotherapy

authors： Morse GD,Rosenkranz S,Para MF,Segal Y,Difrancesco R,Adams E,Brizz B,Yarasheski KE,Reichman RC

更新日期：2005-08-01 00:00:00

abstract：:Nephrotoxicity was more marked in rats receiving isepamicin at midlight than at middark. And, the once-daily administration at middark induced a lesser degree of nephrotoxicity than the twice-daily injection, which indicates that the once-daily treatment therapy may have potential value in the clinical use of aminogly...

journal_title：Antimicrobial agents and chemotherapy

authors： Yoshiyama Y,Nishikawa S,Sugiyama T,Kobayashi T,Shimada H,Tomonaga F,Ohdo S,Ogawa N,Nakano S

更新日期：1993-09-01 00:00:00

abstract：:We investigated the occurrence of multidrug resistance in 44 Enterobacter aerogenes and Klebsiella pneumoniae clinical isolates. Efflux was involved in resistance in E. aerogenes isolates more frequently than in K. pneumoniae isolates (100 versus 38% of isolates) and was associated with the expression of phenylalanine...

journal_title：Antimicrobial agents and chemotherapy

authors： Tran QT,Dupont M,Lavigne JP,Chevalier J,Pagès JM,Sotto A,Davin-Regli A

更新日期：2009-04-01 00:00:00

abstract：:The gram-positive bacterium Streptomyces noursei ATCC 11455 produces a complex mixture of polyene macrolides generally termed nystatins. Although the structures for nystatins A(1) and A(3) have been reported, the identities of other components of the nystatin complex remain obscure. Analyses of the culture extract fro...

journal_title：Antimicrobial agents and chemotherapy

authors： Bruheim P,Borgos SE,Tsan P,Sletta H,Ellingsen TE,Lancelin JM,Zotchev SB

更新日期：2004-11-01 00:00:00

abstract：:The in vitro activities of GAR-936, the 9-t-butylglycylamido derivative of minocycline, were compared with those of doxycycline, minocycline, and tetracycline against 527 gram-positive clinical isolates. GAR-936 inhibited all strains, including those resistant to other tetracyclines, at concentrations of

journal_title：Antimicrobial agents and chemotherapy

authors： Boucher HW,Wennersten CB,Eliopoulos GM

更新日期：2000-08-01 00:00:00

abstract：:The clinical use of the neuraminidase inhibitor (NAI) oseltamivir is associated with the emergence of drug resistance resulting from subtype-specific neuraminidase (NA) mutations. The influenza A/Texas/12/2007 (H3N2) virus isolated from an oseltamivir-treated immunocompromised patient exhibited reduced susceptibility ...

journal_title：Antimicrobial agents and chemotherapy

authors： Okomo-Adhiambo M,Demmler-Harrison GJ,Deyde VM,Sheu TG,Xu X,Klimov AI,Gubareva LV

更新日期：2010-05-01 00:00:00

abstract：:The emergence of pneumococci resistant to penicillin and other agents prompted us to evaluate intravenous vancomycin for the therapy of pneumococcal meningitis, which has an overall mortality of 30%. Eleven consecutive adult patients with cerebrospinal fluid (CSF)-culture-proven pneumococcal meningitis and positive in...

journal_title：Antimicrobial agents and chemotherapy

authors： Viladrich PF,Gudiol F,Liñares J,Pallarés R,Sabaté I,Rufí G,Ariza J

更新日期：1991-12-01 00:00:00

abstract：:The human pathogen Giardia lamblia is an anaerobic protozoan parasite that causes giardiasis, one of the most common diarrheal diseases worldwide. Although several drugs are available for the treatment of giardiasis, drug resistance has been reported and is likely to increase, and recurrent infections are common. The ...

journal_title：Antimicrobial agents and chemotherapy

authors： Chen CZ,Kulakova L,Southall N,Marugan JJ,Galkin A,Austin CP,Herzberg O,Zheng W

更新日期：2011-02-01 00:00:00

abstract：:Pyrosequencing was used to detect rapidly and estimate the number of 23S rRNA genes with a G2576T mutation in 43 linezolid-resistant and -susceptible clinical isolates of enterococci. The method showed 100% concordance with PCR-restriction fragment length polymorphism for detecting isolates homozygous for either G2576...

journal_title：Antimicrobial agents and chemotherapy

authors： Sinclair A,Arnold C,Woodford N

更新日期：2003-11-01 00:00:00

abstract：:Fifty-seven cultures of Haemophilus influenzae were tested for production of beta-lactamase by use of a modified, 1-min test. Only the 24 cultures that were ampicillin resistant, whether type b or not, yielded positive results for the enzyme; all ampicillin-susceptible isolates were uniformly negative. The beta-lactam...

journal_title：Antimicrobial agents and chemotherapy

authors： Escamilla J

更新日期：1976-01-01 00:00:00

abstract：:The antimicrobial activity of CP-62,993 against four Chlamydia trachomatis isolates was compared with those of erythromycin, clindamycin, and tetracycline. The MIC of CP-62,993 was 0.26 to 1.02 micrograms/ml for 100% inclusion inhibition and 0.031 to 0.063 microgram/ml for 50% inclusion inhibition. With pharmacokineti...

journal_title：Antimicrobial agents and chemotherapy

authors： Walsh M,Kappus EW,Quinn TC

更新日期：1987-05-01 00:00:00

abstract：:As the site of insertion of the aadB gene cassette on pRAY, from a clinical isolate of Acinetobacter, is almost identical to the preferred site on integrons, the composite 59-base element (59-BE) associated with this cassette is potentially recombinationally active. By using a conduction assay to quantitate site activ...

journal_title：Antimicrobial agents and chemotherapy

authors： Segal H,Francia MV,Lobo JM,Elisha G

更新日期：1999-10-01 00:00:00

abstract：:We describe outcomes of patients with infections with carbapenem-resistant Klebsiella pneumoniae (CRKP) who received ertapenem-containing double-carbapenem therapy (ECDCT). Clinical success was observed in 7/18 (39%) patients overall: bloodstream infections, 3/7 (43%); pneumonia, 1/5 (20%); intraabdominal infections, ...

journal_title：Antimicrobial agents and chemotherapy

authors： Cprek JB,Gallagher JC

更新日期：2015-11-09 00:00:00

abstract：:Bactericidal activity in serum produced after administration of 1-g intravenous doses of cefoperazone, cefotaxime, ceftizoxime, and moxalactam was ascertained in six healthy subjects. The assay organisms were a strain of Staphylococcus aureus which was moderately susceptible to the drugs (MBC, 2 to 8 micrograms/ml) an...

journal_title：Antimicrobial agents and chemotherapy

authors： Barriere SL,Ozasa DC,Mordenti J

更新日期：1985-07-01 00:00:00

abstract：:Composite data describing ocular pharmacokinetics are unreliable because of intersubject variation. To address this problem, an animal model was developed in which multiple aqueous samples from single subjects were obtained. Following direct anterior chamber or intravenous administration of amikacin or chloramphenicol...

journal_title：Antimicrobial agents and chemotherapy

authors： Mayers M,Rush D,Madu A,Motyl M,Miller MH

更新日期：1991-09-01 00:00:00

abstract：:We present case histories of four patients treated with artemether-lumefantrine for falciparum malaria in UK hospitals in 2015 to 2016. Each subsequently presented with recurrent symptoms and Plasmodium falciparum parasitemia within 6 weeks of treatment with no intervening travel to countries where malaria is endemic....

journal_title：Antimicrobial agents and chemotherapy

authors： Sutherland CJ,Lansdell P,Sanders M,Muwanguzi J,van Schalkwyk DA,Kaur H,Nolder D,Tucker J,Bennett HM,Otto TD,Berriman M,Patel TA,Lynn R,Gkrania-Klotsas E,Chiodini PL

更新日期：2017-02-23 00:00:00

abstract：:The activity of nalidixic acid combined with each of 10 other antimicrobial agents on 95 strains of Enterobacteriaceae was studied. Synergism was found less often than antagonism, and the commonest outcome was indifference. Combinations of nalidixic acid with kanamycin, gentamicin, or colistin were more often synergis...

journal_title：Antimicrobial agents and chemotherapy

authors： Michel J,Luboshitzky R,Sacks T

更新日期：1973-09-01 00:00:00

abstract：:The two components of virginiamycin, virginiamycin M (VM) and virginiamycin S (VS), were used to explore the life cycle of symbiosis-dependent and -independent strains of Bdellovibrio bacteriovorus during multiplication in a two-membered system with either living or heat-inactivated Escherichia coli or in axenic cultu...

journal_title：Antimicrobial agents and chemotherapy

authors： Varon M,Cocito C,Seijffers J

更新日期：1976-01-01 00:00:00

abstract：:Alalevonadifloxacin (WCK 2349) is a novel l-alanine ester prodrug of levonadifloxacin that is being developed as an oral fluoroquinolone antibiotic. The primary objective of this study was to determine and compare plasma, epithelial lining fluid (ELF), and alveolar macrophage (AM) concentrations of levonadifloxacin fo...

journal_title：Antimicrobial agents and chemotherapy

authors： Rodvold KA,Gotfried MH,Chugh R,Gupta M,Yeole R,Patel A,Bhatia A

更新日期：2018-02-23 00:00:00