Reconstruction of an active integron recombination site after integration of a gene cassette at a secondary site.

abstract：:The carbapenem-hydrolyzing class D β-lactamase OXA-253 was identified in an Acinetobacter baumannii clinical isolate belonging to sequence type 113 (ST113) in Brazil. OXA-253 shares 93.8% amino acid identity with OXA-143. The blaOXA-253 gene is located on a ca. 20-kb plasmid. The genetic environment of the blaOXA-253 ...

journal_title：Antimicrobial agents and chemotherapy

authors： Girlich D,Damaceno QS,Oliveira AC,Nordmann P

更新日期：2014-05-01 00:00:00

abstract：:Triple antifungal combinations are used against refractory invasive aspergillosis without an adequate understanding of their pharmacodynamic interactions. We initially studied the in vitro triple combination of voriconazole, amphotericin B, and caspofungin against Aspergillus fumigatus, A. flavus, and A. terreus by a ...

journal_title：Antimicrobial agents and chemotherapy

authors： Meletiadis J,Stergiopoulou T,O'Shaughnessy EM,Peter J,Walsh TJ

更新日期：2007-06-01 00:00:00

abstract：:The increasing use of azole antifungals for the treatment of mucosal and systemic Candida glabrata infections has resulted in the selection and/or emergence of resistant strains. The main mechanisms of azole resistance include alterations in the C. glabrata ERG11 gene (CgERG11), which encodes the azole target enzyme, ...

journal_title：Antimicrobial agents and chemotherapy

authors： Sanguinetti M,Posteraro B,Fiori B,Ranno S,Torelli R,Fadda G

更新日期：2005-02-01 00:00:00

abstract：:Exposure of any of six clinical isolates of Staphylococcus aureus to daptomycin alone or in combination with vancomycin or oxacillin (compared with vancomycin or oxacillin alone) led to a dampened macrophage inflammatory response with diminished tumor necrosis factor secretion and reduced accumulation of inducible nit...

journal_title：Antimicrobial agents and chemotherapy

authors： English BK,Maryniw EM,Talati AJ,Meals EA

更新日期：2006-06-01 00:00:00

abstract：:Using an immunocompetent murine model of invasive aspergillosis (IA), we previously reported that the efficacy of liposomal amphotericin B (L-AmB) (Ambisome) is not hampered by the presence of azole resistance mutations in Aspergillus fumigatus (S. Seyedmousavi, W. J. G. Melchers, J. W. Mouton, and P. E. Verweij, Anti...

journal_title：Antimicrobial agents and chemotherapy

authors： Seyedmousavi S,Mouton JW,Melchers WJG,Verweij PE

更新日期：2017-05-24 00:00:00

abstract：:Candida albicans remains the leading causative agent of invasive fungal infection. Although the importance of filamentation in C. albicans pathogenesis has been extensively investigated, in vivo studies to date have been unable to dissect the role of this developmental process in the establishment of infection versus ...

journal_title：Antimicrobial agents and chemotherapy

authors： Saville SP,Lazzell AL,Bryant AP,Fretzen A,Monreal A,Solberg EO,Monteagudo C,Lopez-Ribot JL,Milne GT

更新日期：2006-10-01 00:00:00

abstract：:High-performance liquid chromatography was used to determine the penetration of 19 antimicrobial agents into human polymorphonuclear leukocytes. The ratios of the intracellular concentration to the extracellular concentration of ampicillin, piperacillin, cefazolin, ceftizoxime, cefpimizole, and ceftazidime were all le...

journal_title：Antimicrobial agents and chemotherapy

authors： Koga H

更新日期：1987-12-01 00:00:00

abstract：:A nationwide susceptibility survey of the Bacteroides fragilis group was continued at New England Medical Center in 1983. A total of 555 strains were obtained from eight centers in the United States. In addition to the nine antimicrobial agents studied in the two previous years, three other agents were added to the ev...

journal_title：Antimicrobial agents and chemotherapy

authors： Tally FP,Cuchural GJ Jr,Jacobus NV,Gorbach SL,Aldridge K,Cleary T,Finegold SM,Hill G,Iannini P,O'Keefe JP

更新日期：1985-11-01 00:00:00

abstract：:Prior investigators have reported a broad gram-negative spectrum and a marked anti-Pseudomonas activity in vitro with BL-P1654, 6-[R-alpha-(guanylureido)phenylacetamido]-penicillanic acid. An in vitro comparison of BL-P1654 to carbenicillin was performed against 84 strains of Pseudomonas and 39 strains of Enterobacter...

journal_title：Antimicrobial agents and chemotherapy

authors： Overturf GD,Ressler R,Wilkins J

更新日期：1974-11-01 00:00:00

abstract：:Mannopeptimycins alpha, beta, gamma, delta, and epsilon are new cyclic glycopeptide antibiotics produced by Streptomyces hygroscopicus LL-AC98. Mannopeptimycins gamma, delta, and epsilon, which have an isovaleryl substitution at various positions on the terminal mannose of the disaccharide moiety, demonstrated moderat...

journal_title：Antimicrobial agents and chemotherapy

authors： Singh MP,Petersen PJ,Weiss WJ,Janso JE,Luckman SW,Lenoy EB,Bradford PA,Testa RT,Greenstein M

更新日期：2003-01-01 00:00:00

abstract：:A proportion of patients with AIDS and toxoplasmic encephalitis (TE) sustain low plasma pyrimethamine concentrations during oral treatment, possibly because of incomplete and variable bioavailability. We wanted to develop a safe, practicable intravenous (i.v.) formulation of pyrimethamine and characterize its disposit...

journal_title：Antimicrobial agents and chemotherapy

authors： Almond DS,Szwandt IS,Edwards G,Lee MG,Winstanley PA

更新日期：2000-06-01 00:00:00

abstract：:The influence of inhibitors of P-glycoprotein (verapamil [VE], cyclosporine [CY], and GF120918 [GF]) on the cell handling of macrolides (erythromycin [ERY], clarithromycin [CLR], roxithromycin [ROX], azithromycin [AZM], and telithromycin [TEL]) was examined in J774 murine macrophages. The net influx rates of AZM and T...

journal_title：Antimicrobial agents and chemotherapy

authors： Seral C,Michot JM,Chanteux H,Mingeot-Leclercq MP,Tulkens PM,Van Bambeke F

更新日期：2003-03-01 00:00:00

abstract：:Viral entry inhibitors represent an emerging mode of therapy for human immunodeficiency virus type 1 (HIV-1) infection. PRO 542 (CD4-immunoglobulin G2) is a tetravalent CD4-immunoglobulin fusion protein that broadly neutralizes primary HIV-1 isolates. PRO 542 binds to the viral surface glycoprotein gp120 and blocks at...

journal_title：Antimicrobial agents and chemotherapy

authors： Jacobson JM,Israel RJ,Lowy I,Ostrow NA,Vassilatos LS,Barish M,Tran DN,Sullivan BM,Ketas TJ,O'Neill TJ,Nagashima KA,Huang W,Petropoulos CJ,Moore JP,Maddon PJ,Olson WC

更新日期：2004-02-01 00:00:00

abstract：:The in vitro activity of rosamicin and erythromycin was compared at various pH values against 311 strains of bacteria representing common urinary tract pathogens. Alkalinization of the media consistently and significantly increased the antibacterial activity of rosamicin against all of the organisms tested. This was a...

journal_title：Antimicrobial agents and chemotherapy

authors： Eickhoff TC,Ehret JM

更新日期：1979-07-01 00:00:00

abstract：:CMY-30, a Val211Gly mutant of CMY-2 cephalosporinase, was derived by mutagenesis. The hydrolytic efficiency of CMY-30 against expanded-spectrum cephalosporins was higher than that of CMY-2 due to increased k(cat) values. Findings indicate a role of the Omega loop residue 211 in determining the substrate specificities ...

journal_title：Antimicrobial agents and chemotherapy

authors： Kotsakis SD,Papagiannitsis CC,Tzelepi E,Tzouvelekis LS,Miriagou V

更新日期：2009-08-01 00:00:00

abstract：:One way to speed up the TB drug discovery process is to search for antitubercular activity among compound series that already possess some of the key properties needed in anti-infective drug discovery, such as whole-cell activity and oral absorption. Here, we present MGIs, a new series of Mycobacterium tuberculosis gy...

journal_title：Antimicrobial agents and chemotherapy

authors： Blanco D,Perez-Herran E,Cacho M,Ballell L,Castro J,González Del Río R,Lavandera JL,Remuiñán MJ,Richards C,Rullas J,Vázquez-Muñiz MJ,Woldu E,Zapatero-González MC,Angulo-Barturen I,Mendoza A,Barros D

更新日期：2015-04-01 00:00:00

abstract：:AG1343, a potent inhibitor of human immunodeficiency virus type 1 (HIV-1) protease (Ki = 2 nM), was designed by protein structure-based drug design techniques. AG1343 has potent antiviral activity (95% effective dose = 0.04 microgram/ml) against a number of HIV-1 strains in acute and chronic models of infection. As pa...

journal_title：Antimicrobial agents and chemotherapy

authors： Shetty BV,Kosa MB,Khalil DA,Webber S

更新日期：1996-01-01 00:00:00

abstract：:Structural analysis of two new beta-lactam antibiotics, A16884A and A16886B, indicated that they, like cephalosporin C, were composed of modified valine and cysteine residues, and alpha-aminoadipic acid. However, acid hydrolysis of A16886B and A16884A produced three times as much glycine as did hydrolysis of cephalosp...

journal_title：Antimicrobial agents and chemotherapy

authors： Brannon DR,Mabe JA,Ellis R,Whitney JG,Nagarajan R

更新日期：1972-03-01 00:00:00

abstract：:SM-8668 (Sch 39304) is a new oral antifungal agent which we evaluated in comparison with fluconazole in various fungal infection models. The prophylactic effect of SM-8668 was excellent against systemic candidiasis, aspergillosis, and cryptococcosis in mice. The 50% effective dose for SM-8668 was assessed at 10 days a...

journal_title：Antimicrobial agents and chemotherapy

authors： Tanio T,Ichise K,Nakajima T,Okuda T

更新日期：1990-06-01 00:00:00

abstract：:In most experiments when aminoglycoside antibiotic (AG) tissue levels are measured, the AG is extracted into buffered media. The data from this study reveal that buffer extraction results in only partial recovery of AG from tissues and that total recovery can be obtained after NaOH or trichloroacetic acid treatment. T...

journal_title：Antimicrobial agents and chemotherapy

authors： Fox KE

更新日期：1989-04-01 00:00:00

abstract：:Candida species are the cause of 60% of all mycoses in immunosuppressed individuals, leading to ∼150,000 deaths annually due to systemic infections, whereas the current antifungal therapies either have toxic side effects or are insufficiently efficient. We performed a screening of two compound libraries, the Enzo and ...

journal_title：Antimicrobial agents and chemotherapy

authors： Stylianou M,Kulesskiy E,Lopes JP,Granlund M,Wennerberg K,Urban CF

更新日期：2014-01-01 00:00:00

abstract：:The purpose of this study was to compare the activity of HMR 1043 with those of daptomycin and teicoplanin against gram-positive isolates. Susceptibility tests were performed for 52 strains, 26 parental strains, including staphylococcal, streptococcal, enterococcal, and listerial strains, and 26 HMR 1043-resistant mut...

journal_title：Antimicrobial agents and chemotherapy

authors： Bemer P,Juvin ME,Bryskier A,Drugeon H

更新日期：2003-09-01 00:00:00

abstract：:The in vitro activity of the investigational siderophore cephalosporin, cefiderocol (formerly S-649266), was determined against a 2014-2016, 52-country, worldwide collection of clinical isolates of carbapenem-nonsusceptible Enterobacteriaceae (n = 1,022), multidrug-resistant (MDR) Acinetobacter baumannii (n = 368), MD...

journal_title：Antimicrobial agents and chemotherapy

authors： Hackel MA,Tsuji M,Yamano Y,Echols R,Karlowsky JA,Sahm DF

更新日期：2018-01-25 00:00:00

abstract：:The activities of sparfloxacin, azithromycin, temafloxacin, and rifapentine against two virulent strains of the Mycobacterium avium complex isolated from patients with AIDS were evaluated in a model of intracellular infection and were compared with that of clarithromycin. Human monocyte-derived macrophages were infect...

journal_title：Antimicrobial agents and chemotherapy

authors： Perronne C,Gikas A,Truffot-Pernot C,Grosset J,Vilde JL,Pocidalo JJ

更新日期：1991-07-01 00:00:00

abstract：:We aimed to examine the effects of resistance mechanisms on several resistance phenotypes among carbapenem-resistant Klebsiella pneumoniae isolates with borderline carbapenem MICs. We compared carbapenemase-negative K. pneumoniae with carbapenemase-producing K. pneumoniae (CPKP) isolates with similar MICs. CPKP isolat...

journal_title：Antimicrobial agents and chemotherapy

authors： Adler A,Ben-Dalak M,Chmelnitsky I,Carmeli Y

更新日期：2015-08-01 00:00:00

abstract：:The objective of this study was to quantitate cefotaxime and its active metabolite, desacetyl cefotaxime, in the distal airways and to compare these levels to concentrations in plasma. Respiratory secretions were obtained from the subsegmental level in 17 adult patients undergoing fiber-optic bronchoscopy within 2 h a...

journal_title：Antimicrobial agents and chemotherapy

authors： Fick RB Jr,Alexander MR,Prince RA,Kasik JE

更新日期：1987-05-01 00:00:00

abstract：:A new natural TEM derivative, named TEM-87, was identified in a Proteus mirabilis isolate from an Italian hospital. Compared to TEM-1, TEM-87 contains the following mutations: E104K, R164C, and M182T. Kinetic analysis of TEM-87 revealed extended-spectrum activity against oxyimino cephalosporins (preferentially ceftazi...

journal_title：Antimicrobial agents and chemotherapy

authors： Perilli M,Segatore B,De Massis MR,Franceschini N,Bianchi C,Rossolini GM,Amicosante G

更新日期：2002-03-01 00:00:00

abstract：:The metabolic fate of the orally effective cephalosporin antibiotic cefaclor (Lilly 99638) has been studied in rats, mice, and dogs. Cefaclor is efficiently absorbed from the gastrointestinal tract as the intact antibiotic. In rats and mice, cefaclor, for the most part, escapes metabolism in the body and is eliminated...

journal_title：Antimicrobial agents and chemotherapy

authors： Sullivan HR,Due SL,Kau DL,Quay JF,Miller W

更新日期：1976-10-01 00:00:00

abstract：:Minimum inhibitory and bactericidal concentrations of four antibiotics and their combinations were determined for 38 strains of enterococci by a microtitration tube dilution technique. The drugs were ampicillin, vancomycin, gentamicin, and streptomycin; the combinations were ampicillin-gentamicin, ampicillin-streptomy...

journal_title：Antimicrobial agents and chemotherapy

authors： Harwick HJ,Kalmanson GM,Guze LB

更新日期：1973-10-01 00:00:00

abstract：:The efficacy and safety of amoxicillin-clavulanic acid were compared with those of co-trimoxazole in the treatment of acute urinary tract infections. A total of 104 patients (mean age, 52 years) with clinical and laboratory evidence of acute urinary tract infection were enrolled in the study. Characteristics and infec...

journal_title：Antimicrobial agents and chemotherapy

authors： Karachalios GN

更新日期：1985-11-01 00:00:00