Influence of P-glycoprotein inhibitors on accumulation of macrolides in J774 murine macrophages.

abstract：:Mycobactin biosynthesis in Mycobacterium tuberculosis facilitates iron acquisition, which is required for growth and virulence. The mycobactin biosynthesis inhibitor salicyl-AMS [5'-O-(N-salicylsulfamoyl)adenosine] inhibits M. tuberculosis growth in vitro under iron-limited conditions. Here, we conducted a single-dose...

journal_title：Antimicrobial agents and chemotherapy

authors： Lun S,Guo H,Adamson J,Cisar JS,Davis TD,Chavadi SS,Warren JD,Quadri LE,Tan DS,Bishai WR

更新日期：2013-10-01 00:00:00

abstract：:The aims of the study were to investigate the prevalence of azole resistance among Aspergillus fumigatus clinical isolates. A total of 533 clinical isolates that had been collected between 1995 and 2006, from 441 patients, were screened. No resistance was detected in isolates collected between 1995 and 1997. Starting ...

journal_title：Antimicrobial agents and chemotherapy

authors： Lazzarini C,Esposto MC,Prigitano A,Cogliati M,De Lorenzis G,Tortorano AM

更新日期：2015-11-09 00:00:00

abstract：:No studies have investigated whether discontinuation of ethambutol (EMB) based on the susceptibility to isoniazid and rifampin as determined by the GenoType MTBDRplus assay would be appropriate. We aimed to determine the feasibility of discontinuing EMB before the end of intensive phase treatment based on the result o...

journal_title：Antimicrobial agents and chemotherapy

authors： Jo KW,Kim M,Kim YJ,Lee HK,Kim HK,Jeon D,Lyu J,Park HK,Mok J,Kim JS,Heo EY,Choi SB,Yim JJ,Shim TS

更新日期：2019-09-16 00:00:00

abstract：:Sublethal doses of vincristine (VNC) and bacterial lipopolysaccharide (LPS) administered simultaneously to adult male mice resulted in markedly enhanced mortality. All of 10 strains of Pseudomonas aeruginosa tested, 4 of 7 strains of Bacteroides, and 6 of 10 strains of Listeria monocytogenes were able to substitute fo...

journal_title：Antimicrobial agents and chemotherapy

authors： Munson AE,Drummond DC,Adams AC,Bradley SG

更新日期：1976-05-01 00:00:00

abstract：:The intestinal elimination of ciprofloxacin in the large bowel was studied in a rabbit model. Segments from the cecum, colon, and sigmoid colon along with their intact blood vessels were isolated and perfused, and their contents were collected over a 90-min period following the administration of a single parenteral do...

journal_title：Antimicrobial agents and chemotherapy

authors： Ramon J,Dautrey S,Farinoti R,Carbon C,Rubinstein E

更新日期：1996-01-01 00:00:00

abstract：:Interactions between bacterial biofilms formed by Pseudomonas aeruginosa and clarithromycin, a macrolide having no anti-P. aeruginosa activity, were investigated. P. aeruginosa incubated for 10 days on membrane filters formed biofilms on the surfaces of the filters. The biofilms were characterized by dense colonizatio...

journal_title：Antimicrobial agents and chemotherapy

authors： Yasuda H,Ajiki Y,Koga T,Kawada H,Yokota T

更新日期：1993-09-01 00:00:00

abstract：:N(2)-(3,4-Dichlorobenzyl)-7-(2-[1-morpholinyl]ethyl)guanine (MorE-DCBG, 362E) is a synthetic purine that selectively inhibits the replication-specific DNA polymerase of Clostridium difficile. MorE-DCBG and its analogs strongly inhibited the growth of a wide variety of C. difficile strains. When administered orally in ...

journal_title：Antimicrobial agents and chemotherapy

authors： Dvoskin S,Xu WC,Brown NC,Yanachkov IB,Yanachkova M,Wright GE

更新日期：2012-03-01 00:00:00

abstract：:A novel plasmid-mediated metallo-beta-lactamase (IMP-9) is described in seven isolates of Pseudomonas aeruginosa from Guangzhou, China, isolated in 2000. The gene was carried on a large (approximately 450-kb) IncP-2 conjugative plasmid. This is the first report of carriage of bla(IMP) genes on such large plasmids. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Xiong J,Hynes MF,Ye H,Chen H,Yang Y,M'zali F,Hawkey PM

更新日期：2006-01-01 00:00:00

abstract：:The main aim of this study was to develop a standardized experimental assay to enable differential antimicrobial comparisons of test biocidal aerosols. This study represents the first chlorine-matched comparative assessment of the antimicrobial activities of aerosolized sodium hypochlorite, chlorine dioxide, and elect...

journal_title：Antimicrobial agents and chemotherapy

authors： Thorn RM,Robinson GM,Reynolds DM

更新日期：2013-05-01 00:00:00

abstract：:A number of compounds, as exemplified by verapamil and desipramine, have been shown to enhance the susceptibility of resistant malaria parasites to chloroquine. The mechanism by which these agents reverse resistance is still controversial but is though to involve alterations in drug transport causing an increase in st...

journal_title：Antimicrobial agents and chemotherapy

authors： Ndifor AM,Howells RE,Bray PG,Ngu JL,Ward SA

更新日期：1993-06-01 00:00:00

abstract：:A nationwide susceptibility survey of the Bacteroides fragilis group was continued at New England Medical Center in 1983. A total of 555 strains were obtained from eight centers in the United States. In addition to the nine antimicrobial agents studied in the two previous years, three other agents were added to the ev...

journal_title：Antimicrobial agents and chemotherapy

authors： Tally FP,Cuchural GJ Jr,Jacobus NV,Gorbach SL,Aldridge K,Cleary T,Finegold SM,Hill G,Iannini P,O'Keefe JP

更新日期：1985-11-01 00:00:00

abstract：:Preclinical animal models of infection are employed to develop new agents but also to screen among molecules to rank them. There are often major differences between human pharmacokinetic (PK) profiles and those developed by animal models of infection, and these may lead to substantial differences in efficacy relative ...

journal_title：Antimicrobial agents and chemotherapy

authors： Drusano GL,Duncanson B,Scanga CA,Kim S,Schmidt S,Neely MN,Yamada WM,Vicchiarelli M,Peloquin CA,Louie A

更新日期：2020-11-17 00:00:00

abstract：:A new reverse transcriptase (RT) inhibitor was extracted and purified from the red alga Schizymenia pacifica. The chromatographic behavior and chemical properties of this sea algal extract (SAE) suggest that it is a sulfated polysaccharide having a molecular weight of approximately 2,000,000. SAE is composed of galact...

journal_title：Antimicrobial agents and chemotherapy

authors： Nakashima H,Kido Y,Kobayashi N,Motoki Y,Neushul M,Yamamoto N

更新日期：1987-10-01 00:00:00

abstract：:In both scid and BALB/c mouse-Leishmania donovani models, hexadecyphosphocholine (miltefosine) and AmBisome had similar levels of activity. In contrast, sodium stibogluconate (Pentostam) was significantly less active against L. donovani in scid mice than in BALB/c mice. The in vitro anti-leishmanial activity of miltef...

journal_title：Antimicrobial agents and chemotherapy

authors： Escobar P,Yardley V,Croft SL

更新日期：2001-06-01 00:00:00

abstract：:We collected 1,353 strains of beta-hemolytic streptococci of groups A, B, C, and G (1,176 strains of which were group A) isolated in 26 institutions throughout Japan in 1972-1974. The strains were grouped and T-typed by our specific group-and T-factor sera, and the minimal inhibitory concentrations of 10 antibiotics w...

journal_title：Antimicrobial agents and chemotherapy

authors： Miyamoto Y,Takizawa K,Matsushima A,Asai Y,Nakatsuka S

更新日期：1978-03-01 00:00:00

abstract：:Eighty-five patients with cystic fibrosis who were experiencing an acute infectious exacerbation of their disease were randomized in double-blind fashion to receive either 50 or 75 mg of ceftazidime per kg (body weight) per dose administered intravenously every 8 h for 14 days. Three patients were dropped from the stu...

journal_title：Antimicrobial agents and chemotherapy

authors： Reed MD,Stern RC,O'Brien CA,Crenshaw DA,Blumer JL

更新日期：1987-05-01 00:00:00

abstract：:The human fungal pathogen Candida albicans releases a large glycofragment of the Msb2 surface protein (Msb2*) into the growth environment, which protects against the action of human antimicrobial peptides (AMPs) LL-37 and histatin-5. Quantitation of Msb2*/LL-37 interactions by microscale thermophoresis revealed high-a...

journal_title：Antimicrobial agents and chemotherapy

authors： Swidergall M,Ernst AM,Ernst JF

更新日期：2013-08-01 00:00:00

abstract：:A new natural TEM derivative with extended-spectrum beta-lactamase activity, TEM-134, was identified in a ceftazidime-resistant clinical isolate of Citrobacter koseri. Compared to TEM-1, TEM-134 contains the following mutations: Q39K, E104K, R164H, and G238S. The bla(TEM-134) gene was not transferable by conjugation a...

journal_title：Antimicrobial agents and chemotherapy

authors： Perilli M,Mugnaioli C,Luzzaro F,Fiore M,Stefani S,Rossolini GM,Amicosante G

更新日期：2005-04-01 00:00:00

abstract：:The rapid and global emergence of azole resistance in the human pathogen Aspergillus fumigatus has drawn attention. Thus, a thorough understanding of its mechanisms of drug resistance requires extensive exploration. In this study, we found that the loss of the putative calcium-dependent protein-encoding gene algA caus...

journal_title：Antimicrobial agents and chemotherapy

authors： Wei X,Chen P,Gao R,Li Y,Zhang A,Liu F,Lu L

更新日期：2016-12-27 00:00:00

abstract：:Gatifloxacin pneumococcal, staphylococcal and enterococcal postantibiotic effects (PAEs) were 0.5 to 4.0 h, respectively. For Escherichia coli and Pseudomonas aeruginosa, PAEs were 2.2 to 4.8 h. Pneumococcal, staphylococcal, and enterococcal postantibiotic sub-MIC effects (PA-SMEs) (four times the MICs) were 3.7 to 8....

journal_title：Antimicrobial agents and chemotherapy

authors： Pankuch GA,Jacobs MR,Appelbaum PC

更新日期：1999-10-01 00:00:00

abstract：:New drugs are needed to shorten the duration of tuberculosis treatment. R207910, a diarylquinoline, is very active against Mycobacterium tuberculosis both in vitro and in mice. In healthy volunteers, the coadministration of R207910 and rifampin induced the increased metabolism of R207910, resulting in a 50% reduction ...

journal_title：Antimicrobial agents and chemotherapy

authors： Lounis N,Gevers T,Van Den Berg J,Andries K

更新日期：2008-10-01 00:00:00

abstract：:Weak mutators are common among clinical isolates of Escherichia coli. We show that the relative mutation rate and the "evolvability of fluoroquinolone resistance" are related by a power law slope of 1.2 over 3 orders of magnitude. Thus, even weak mutators can drive the evolution of fluoroquinolone resistance under sel...

journal_title：Antimicrobial agents and chemotherapy

authors： Orlén H,Hughes D

更新日期：2006-10-01 00:00:00

abstract：:Disk susceptibility tests with two structurally related aminoglycosides (amikacin and Sch 21420) were evaluated. Tests with 10- and 30-micrograms amikacin disks confirmed previous recommendations for interpretive zone standards; 30-micrograms disks are preferred. Tests with 10-, 20-, and 30-micrograms Sch 21420 disks ...

journal_title：Antimicrobial agents and chemotherapy

authors： Barry AL,Thornsberry C,Jones RN,Gerlach EH

更新日期：1980-10-01 00:00:00

abstract：:The antiviral activity of a new series of thymidine analogs was determined against vaccinia virus (VV), cowpox virus (CV), herpes simplex virus, and varicella-zoster virus. Several compounds were identified that had good activity against each of the viruses, including a set of novel 5-substituted deoxyuridine analogs....

journal_title：Antimicrobial agents and chemotherapy

authors： Prichard MN,Keith KA,Johnson MP,Harden EA,McBrayer A,Luo M,Qiu S,Chattopadhyay D,Fan X,Torrence PF,Kern ER

更新日期：2007-05-01 00:00:00

abstract：:The anilinouracils (AUs) such as 6-(3-ethyl-4-methylanilino)uracil (EMAU) are a novel class of gram-positive, selective, bactericidal antibacterials which inhibit pol IIIC, the gram-positive-specific replicative DNA polymerase. We have linked various fluoroquinolones (FQs) to the N-3 position of EMAU to generate a var...

journal_title：Antimicrobial agents and chemotherapy

authors： Butler MM,Lamarr WA,Foster KA,Barnes MH,Skow DJ,Lyden PT,Kustigian LM,Zhi C,Brown NC,Wright GE,Bowlin TL

更新日期：2007-01-01 00:00:00

abstract：:Penciclovir (PCV) and acyclovir are acyclic guanine analogs which inhibit herpes simplex virus (HSV) DNA polymerase. Their 50% infective doses were 0.5 to 0.8 microgram/ml for clinical isolates of HSV-1 and 1.3 to 2.2 micrograms/ml for HSV-2. Furthermore, HSV-infected cultures receiving 2-h pulses of PCV had 2- to 50-...

journal_title：Antimicrobial agents and chemotherapy

authors： Weinberg A,Bate BJ,Masters HB,Schneider SA,Clark JC,Wren CG,Allaman JA,Levin MJ

更新日期：1992-09-01 00:00:00

abstract：:Bloodstream infection (BSI) due to multidrug-resistant Klebsiella is associated with high rates of morbidity and mortality. The aim of this study was to identify predictors of in-hospital mortality among patients with BSI due to ceftazidime-resistant (CAZ-R) Klebsiella pneumoniae at a tertiary care medical center. Pat...

journal_title：Antimicrobial agents and chemotherapy

authors： Anderson DJ,Engemann JJ,Harrell LJ,Carmeli Y,Reller LB,Kaye KS

更新日期：2006-05-01 00:00:00

abstract：:There has been major interest by the scientific community in antivirulence approaches against bacterial infections. However, partly due to a lack of viable lead compounds, antivirulence therapeutics have yet to reach the clinic. Here we investigate the development of an antivirulence lead targeting quorum sensing sign...

journal_title：Antimicrobial agents and chemotherapy

authors： Todd DA,Parlet CP,Crosby HA,Malone CL,Heilmann KP,Horswill AR,Cech NB

更新日期：2017-07-25 00:00:00

abstract：:A novel plasmid-borne resistance gene cluster comprising the genes erm(T) for macrolide-lincosamide-streptogramin B resistance, dfrK for trimethoprim resistance, and tet(L) for tetracycline resistance was identified in a porcine methicillin-resistant Staphylococcus aureus sequence type 398 (ST398) strain. This erm(T)-...

journal_title：Antimicrobial agents and chemotherapy

authors： Kadlec K,Schwarz S

更新日期：2010-02-01 00:00:00

abstract：:A rapid (6-7 hr), modified Kirby-Bauer disk-susceptibility method, by which derivatives of tetrazolium dyes are used to enhance delineation between areas of growth and zones of inhibition, has been developed. Inoculated petri plates, prepared by the Kirby-Bauer method, were sprayed, after 6 to 7 hr of incubation (37 C...

journal_title：Antimicrobial agents and chemotherapy

authors： Boyle VJ,Fancher ME,Ross RW Jr

更新日期：1973-03-01 00:00:00