Abstract:
:N(2)-(3,4-Dichlorobenzyl)-7-(2-[1-morpholinyl]ethyl)guanine (MorE-DCBG, 362E) is a synthetic purine that selectively inhibits the replication-specific DNA polymerase of Clostridium difficile. MorE-DCBG and its analogs strongly inhibited the growth of a wide variety of C. difficile strains. When administered orally in a hamster model of C. difficile-specific colitis, 362E was as effective as oral vancomycin, the current agent of choice for treating severe forms of the human disease.
journal_name
Antimicrob Agents Chemotherjournal_title
Antimicrobial agents and chemotherapyauthors
Dvoskin S,Xu WC,Brown NC,Yanachkov IB,Yanachkova M,Wright GEdoi
10.1128/AAC.06097-11subject
Has Abstractpub_date
2012-03-01 00:00:00pages
1624-6issue
3eissn
0066-4804issn
1098-6596pii
AAC.06097-11journal_volume
56pub_type
杂志文章abstract::The influence of five antibiotics (netilmicin, ceftriaxone, cefepime, fleroxacin, and ciprofloxacin) on capsular polysaccharide distribution and on opsonophagocytosis by human polymorphonuclear leukocytes of unencapsulated and encapsulated Escherichia coli strains was studied. Unencapsulated E. coli strains were readi...
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journal_title:Antimicrobial agents and chemotherapy
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