Enhanced toxicity for mice of combinations of bacterial lipopolysaccharide and vincristine.

abstract：:Selection of resistance to cefamandole has been observed, and the drug has failed to protect animals lethally infected with certain Enterobacteriaceae that appeared to be highly susceptible in vitro. Using spectrophotometric assays, some of these organisms were found to produce beta-lactamases highly active against ce...

journal_title：Antimicrobial agents and chemotherapy

authors： Sanders CC,Sanders WE Jr

更新日期：1979-06-01 00:00:00

abstract：:We determined whether gyrA mutations were present in fluoroquinolone-resistant laboratory mutants derived from the Bacteroides fragilis reference strain ATCC 25285 and in clinical isolates of B. fragilis. The two first-step mutants selected on ciprofloxacin (CIP) were devoid of gyrA mutations, whereas two of the three...

journal_title：Antimicrobial agents and chemotherapy

authors： Bachoual R,Dubreuil L,Soussy CJ,Tankovic J

更新日期：2000-07-01 00:00:00

abstract：:We identified the carbapenemase gene blaOXA-499, a variant of blaOXA-143, from a clinical isolate of Acinetobacter pittii for the first time. OXA-499 shared 93.1% amino acid identity with OXA-143, and the gene was located on the chromosome. By cloning the OXA-499-encoding gene into the pWH1266 vector and transforming ...

journal_title：Antimicrobial agents and chemotherapy

authors： D'Souza R,Pinto NA,Higgins PG,Hwang I,Yong D,Choi J,Lee K,Chong Y

更新日期：2017-04-24 00:00:00

abstract：:Doravirine is a novel nonnucleoside reverse transcriptase inhibitor in development for use with other antiretroviral therapies to treat human immunodeficiency virus type 1 (HIV-1) infection. Doravirine metabolism predominantly occurs via cytochrome P450 3A with <10% of elimination occurring via the renal pathway. As s...

journal_title：Antimicrobial agents and chemotherapy

authors： Ankrom W,Yee KL,Sanchez RI,Adedoyin A,Fan L,Marbury T,Preston RA,Iwamoto M,Khalilieh SG

更新日期：2018-07-27 00:00:00

abstract：:Carbovir is a novel carbocyclic nucleoside which has been shown to have potent in vitro activity against human immunodeficiency virus, the causative agent of acquired immunodeficiency syndrome. Sprague-Dawley male rats were used to investigate the pharmacokinetics and bioavailability of carbovir. Six rats received car...

journal_title：Antimicrobial agents and chemotherapy

authors： Yeom YH,Remmel RP,Huang SH,Hua M,Vince R,Zimmerman CL

更新日期：1989-02-01 00:00:00

abstract：:In a randomized crossover trial, six volunteers received 200- and 400-mg doses of loracarbef (LY 163892), a new oral cephalosporin. Mean +/- standard error of the mean concentrations in serum obtained after 1.5 and 3 h were 13.2 +/- 2.8 and 4.3 +/- 0.7 mg/liter, respectively, after the 400-mg dose and 6.9 +/- 1.0 and ...

journal_title：Antimicrobial agents and chemotherapy

authors： Van der Auwera P

更新日期：1992-03-01 00:00:00

abstract：:Topical blockade of the gp41 fusogenic protein of HIV-1 is one possible strategy by which microbicides could prevent HIV transmission, working early against infection, by inhibiting viral entry into host cells. In this study, we examined the potential of gp41 fusion inhibitors (FIs) as candidate anti-HIV microbicides....

journal_title：Antimicrobial agents and chemotherapy

authors： Harman S,Herrera C,Armanasco N,Nuttall J,Shattock RJ

更新日期：2012-05-01 00:00:00

abstract：:To determine the influence of in vitro activity, pharmacokinetic properties, and therapeutic regimen on the antibacterial effect in vivo, we compared three cephalosporins, cefotiam, cefmenoxime, and ceftriaxone, in a rabbit model of experimental Escherichia coli endocarditis after 4 days of treatment. The MBCs of cefo...

journal_title：Antimicrobial agents and chemotherapy

authors： Pangon B,Joly V,Vallois JM,Abel L,Buré A,Brion N,Contrepois A,Carbon C

更新日期：1987-04-01 00:00:00

abstract：:The postantibiotic effect (PAE) (10 times the MIC of quinolones, 5 times the MIC of macrolides) and postantibiotic sub-MIC effect (PAE-SME) at 0.125, 0.25, and 0.5 times the MIC were determined for levofloxacin, ciprofloxacin, ofloxacin, erythromycin, azithromycin, and clarithromycin against 20 pneumococci. Quinolone ...

journal_title：Antimicrobial agents and chemotherapy

authors： Spangler SK,Lin G,Jacobs MR,Appelbaum PC

更新日期：1998-05-01 00:00:00

abstract：:Cationic antimicrobial peptides (CAPs) play important roles in host immune defenses. Plectasin is a defensin-like CAP isolated from the saprophytic fungus Pseudoplectania nigrella. NZ2114 is a novel variant of plectasin with potent activity against Gram-positive bacteria. In this study, we investigated (i) the in vivo...

journal_title：Antimicrobial agents and chemotherapy

authors： Xiong YQ,Hady WA,Deslandes A,Rey A,Fraisse L,Kristensen HH,Yeaman MR,Bayer AS

更新日期：2011-11-01 00:00:00

abstract：:Intestinal endogenous members of the family Enterobacteriaceae were eliminated in 12 human volunteers treated with 400 or 800 mg of oral norfloxacin per day for 5 days. No clones resistant to quinolone derivatives were isolated. Counts of aerotolerant streptococci were affected to various degrees, depending on their s...

journal_title：Antimicrobial agents and chemotherapy

authors： Pecquet S,Andremont A,Tancrède C

更新日期：1986-06-01 00:00:00

abstract：:The objective of the study was to measure antiretroviral exposures in four physiological compartments during pregnancy, delivery, and postpartum. This prospective, open-label, longitudinal study collected paired blood plasma (BP) and genital tract (GT) aspirates antepartum, at delivery, and up to 12 weeks postpartum. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Yeh RF,Rezk NL,Kashuba AD,Dumond JB,Tappouni HL,Tien HC,Chen YC,Vourvahis M,Horton AL,Fiscus SA,Patterson KB

更新日期：2009-06-01 00:00:00

abstract：:Resistance to macrolides and ketolides occurs mainly via alterations in RNA moieties of the drug-binding site. Using an A2058G mutant of Mycobacterium smegmatis, additional telithromycin resistance was acquired via deletion of 15 residues from protein L22. Molecular modeling, based on the crystal structure of the larg...

journal_title：Antimicrobial agents and chemotherapy

authors： Berisio R,Corti N,Pfister P,Yonath A,Böttger EC

更新日期：2006-11-01 00:00:00

abstract：:Mice infected with Plasmodium berghei served as donors of erythrocytes with a high level of parasitemia for the study of ferriprotoporphyrin IX (FP) polymerization. Six hours after treatment of these mice with 3 micromol of chloroquine per 25 g of body weight, there were significant losses of heme polymerase I (HPA I)...

journal_title：Antimicrobial agents and chemotherapy

authors： Fitch CD,Chou AC

更新日期：1997-11-01 00:00:00

abstract：:We reported previously that intraperitoneal administration of a bis(benzyl)polyamine analog, MDL 27,695, suppressed both pentavalent antimony (Sbv)-susceptible and -resistant Leishmania donovani in vivo. The present studies were performed to optimize parasite suppression by parenteral administration and to evaluate th...

journal_title：Antimicrobial agents and chemotherapy

authors： Baumann RJ,McCann PP,Bitonti AJ

更新日期：1991-07-01 00:00:00

abstract：:The in vitro activities of two new antimicrobial agents, apalcillin and cefpiramide (SM-1652), were evaluated against 324 strains of anaerobic bacteria. Apalcillin (a penicillin derivative) and cefpiramide (a semisynthetic cephalosporin) were compared with piperacillin, moxalactam, and cefoxitin. Organisms studied inc...

journal_title：Antimicrobial agents and chemotherapy

authors： Wexler H,Carter WT,Harris B,Finegold SM

更新日期：1984-02-01 00:00:00

abstract：:We used multiplex PCR to determine the agr group membership of 18 European glycopeptide heterointermediate and intermediate-resistant Staphylococcus aureus strains. Of the 15 agr group I strains, 13 were resistant and 2 were susceptible to methicillin. The remaining three strains, like the United States and Japanese c...

journal_title：Antimicrobial agents and chemotherapy

authors： Verdier I,Reverdy ME,Etienne J,Lina G,Bes M,Vandenesch F

更新日期：2004-03-01 00:00:00

abstract：:Invasive pulmonary aspergillosis (IPA) is a life-threatening disease of immunocompromised patients that requires aggressive therapy. Detection of the disease and monitoring of the therapeutic response during IPA are complex, and current molecular diagnostics are not suitably robust. Here, we explored proteomic profile...

journal_title：Antimicrobial agents and chemotherapy

authors： Krel M,Petraitis V,Petraitiene R,Jain MR,Zhao Y,Li H,Walsh TJ,Perlin DS

更新日期：2014-06-01 00:00:00

abstract：:The biosynthesis pathways of two anthracyclines, nogalamycin and aclacinomycin, were directed toward angucyclines by using an angucycline-specific cyclase, pgaF, isolated from a silent antibiotic biosynthesis gene cluster. Addition of pgaF to a gene cassette that harbored the early biosynthesis genes of nogalamycin re...

journal_title：Antimicrobial agents and chemotherapy

authors： Metsä-Ketelä M,Palmu K,Kunnari T,Ylihonko K,Mäntsälä P

更新日期：2003-04-01 00:00:00

abstract：:Fusidic acid (FA), which was approved in the 1960s in many European and Asian countries, has gained renewed interest due to its continued effectiveness against methicillin-resistant Staphylococcus aureus As rhabdomyolysis has been reported upon coadministration of FA with statins, we aimed to elucidate the underlying ...

journal_title：Antimicrobial agents and chemotherapy

authors： Gupta A,Harris JJ,Lin J,Bulgarelli JP,Birmingham BK,Grimm SW

更新日期：2016-09-23 00:00:00

abstract：:We previously demonstrated that the biguanide-based compound NB325 inhibits human immunodeficiency virus type 1 (HIV-1) infection by interacting with the CXCR4 viral coreceptor. This interaction also appeared to be persistent, since HIV-1 infection was inhibited even when the virus was introduced subsequent to the rem...

journal_title：Antimicrobial agents and chemotherapy

authors： Thakkar N,Pirrone V,Passic S,Keogan S,Zhu W,Kholodovych V,Welsh W,Rando R,Labib M,Wigdahl B,Krebs FC

更新日期：2010-05-01 00:00:00

abstract：:Linezolid is the first synthetic oxazolidone agent to treat infections caused by Gram-positive pathogens. Infected patients with liver dysfunction (LD) are more likely to suffer from adverse reactions, such as thrombocytopenia, when standard-dose linezolid is used than patients with LD who did not use linezolid. Curre...

journal_title：Antimicrobial agents and chemotherapy

authors： Zhang SH,Zhu ZY,Chen Z,Li Y,Zou Y,Yan M,Xu Y,Wang F,Liu MZ,Zhang M,Zhang BK

更新日期：2020-05-21 00:00:00

abstract：:The nucleotide sequence of pNL194, a VIM-1-encoding plasmid, is described in this study. pNL194 (79,307 bp) comprised an IncN-characteristic segment (38,940 bp) and a mosaic structure (40,367 bp) including bla(VIM-1), aacA7, aadA1, aadA2, dfrA1, dfrA12, aphA1, strA, strB, and sul1. Tn1000 or Tn5501 insertion within fi...

journal_title：Antimicrobial agents and chemotherapy

authors： Miriagou V,Papagiannitsis CC,Kotsakis SD,Loli A,Tzelepi E,Legakis NJ,Tzouvelekis LS

更新日期：2010-10-01 00:00:00

abstract：:The antimicrobial activity of CP-62,993 against four Chlamydia trachomatis isolates was compared with those of erythromycin, clindamycin, and tetracycline. The MIC of CP-62,993 was 0.26 to 1.02 micrograms/ml for 100% inclusion inhibition and 0.031 to 0.063 microgram/ml for 50% inclusion inhibition. With pharmacokineti...

journal_title：Antimicrobial agents and chemotherapy

authors： Walsh M,Kappus EW,Quinn TC

更新日期：1987-05-01 00:00:00

abstract：:The effect of antichagasic benznidazole (BZL; 100 mg/kg body weight/day, 3 consecutive days, intraperitoneally) on biotransformation systems and ABC transporters was evaluated in rats. Expression of cytochrome P-450 (CYP3A), UDP-glucuronosyltransferase (UGT1A), glutathione S-transferases (alpha glutathione S-transfera...

journal_title：Antimicrobial agents and chemotherapy

authors： Perdomo VG,Rigalli JP,Villanueva SS,Ruiz ML,Luquita MG,Echenique CG,Catania VA

更新日期：2013-10-01 00:00:00

abstract：:UK-18892 is a new aminoglycoside antibiotic, a derivative of kanamycin A structurally related to amikacin. It was found to be active against a wide range of pathogenic bacteria, including many gentamicin-resistant strains. The spectrum and degree of activity of UK-18892 were similar to those of amikacin, and differenc...

journal_title：Antimicrobial agents and chemotherapy

authors： Wise R,Andrews JM

更新日期：1978-08-01 00:00:00

abstract：:We developed a multiplex real-time SYBR green-based PCR assay for rapid detection of tet(X) and its variants, including tet(X1) and tet(X2) and high-level tigecycline resistance genes tet(X3), tet(X4), and tet(X5). We showed that the real-time PCR assay developed had high linearity (R2 ≥ 0.996), sensitivity (low detec...

journal_title：Antimicrobial agents and chemotherapy

authors： Fu Y,Liu D,Song H,Liu Z,Jiang H,Wang Y

更新日期：2020-03-24 00:00:00

abstract：:The mortality rate associated with Vibrio vulnificus sepsis remains high. An in vitro time-kill assay revealed synergism between tigecycline and ciprofloxacin. The survival rate was significantly higher in mice treated with tigecycline plus ciprofloxacin than in mice treated with cefotaxime plus minocycline. Thus, com...

journal_title：Antimicrobial agents and chemotherapy

authors： Kim SE,Kim HK,Choi SM,Yu Y,Kim UJ,Darboe KS,Kang SJ,Park KH,Kang G,Kim YR,Rhee JH,Jung SI,Jang HC

更新日期：2019-09-23 00:00:00

abstract：:Pefloxacin mesylate is well absorbed by the oral route. The antimicrobial activity in dog, cynomolgus monkey, and human plasma was essentially due to unchanged drug which respectively accounted for 64, 94, and 84% of the total activity (ratios derived from relative area under the curve [AUC] values). Half-lives ranged...

journal_title：Antimicrobial agents and chemotherapy

authors： Montay G,Goueffon Y,Roquet F

更新日期：1984-04-01 00:00:00

abstract：:A new reverse transcriptase (RT) inhibitor was extracted and purified from the red alga Schizymenia pacifica. The chromatographic behavior and chemical properties of this sea algal extract (SAE) suggest that it is a sulfated polysaccharide having a molecular weight of approximately 2,000,000. SAE is composed of galact...

journal_title：Antimicrobial agents and chemotherapy

authors： Nakashima H,Kido Y,Kobayashi N,Motoki Y,Neushul M,Yamamoto N

更新日期：1987-10-01 00:00:00