Selective antimicrobial modulation of the intestinal tract by norfloxacin in human volunteers and in gnotobiotic mice associated with a human fecal flora.

abstract：:Pseudomonas aeruginosa 455, isolated in Ankara, Turkey, produced a pI 6.2 beta-lactamase determined by plasmid pMLH53 and resisted all beta-lactams except carbapenems. This beta-lactamase, named OXA-14, corresponded to OXA-10 (PSE-2) except that aspartate replaced glycine at position 157 and thus is intermediate betwe...

journal_title：Antimicrobial agents and chemotherapy

authors： Danel F,Hall LM,Gur D,Livermore DM

更新日期：1995-08-01 00:00:00

abstract：:The influence of reduced susceptibilities to glycopeptides on the activities of vancomycin and teicoplanin against an isogenic pair of clinical Staphylococcus aureus strains in experimental endocarditis was investigated. While vancomycin was similarly active against both strains, teicoplanin was approximately 100-fold...

journal_title：Antimicrobial agents and chemotherapy

authors： Pavie J,Lefort A,Ploy MC,Massias L,Chau F,Garry L,Denis F,Fantin B

更新日期：2003-06-01 00:00:00

abstract：:The human and veterinary disease complex known as African trypanosomiasis continues to inflict significant global morbidity, mortality, and economic hardship. Drug resistance and toxic side effects of old drugs call for novel and unorthodox strategies for new and safe treatment options. We designed methyltriazenyl pur...

journal_title：Antimicrobial agents and chemotherapy

authors： Rodenko B,Wanner MJ,Alkhaldi AA,Ebiloma GU,Barnes RL,Kaiser M,Brun R,McCulloch R,Koomen GJ,de Koning HP

更新日期：2015-11-01 00:00:00

abstract：:Seventy-one strains of 15 species of rapidly growing mycobacteria were studied for their susceptibilities to fatty acids with 2 to 20 carbons by the agar dilution method at pH 7.0. Most mycobacteria other than potential pathogens (Mycobacterium fortuitum and Mycobacterium chelonei) were resistant to saturated fatty ac...

journal_title：Antimicrobial agents and chemotherapy

authors： Saito H,Tomioka H,Yoneyama T

更新日期：1984-08-01 00:00:00

abstract：:Combination antiretroviral therapy has achieved dramatic reductions in the mortality and morbidity in people with HIV-1 infection. Darunavir (DRV) represents a most efficacious and well-tolerated protease inhibitor (PI) with a high genetic barrier to the emergence of drug-resistant HIV-1. However, highly DRV-resistant...

journal_title：Antimicrobial agents and chemotherapy

authors： Takamatsu Y,Aoki M,Bulut H,Das D,Amano M,Sheri VR,Kovari LC,Hayashi H,Delino NS,Ghosh AK,Mitsuya H

更新日期：2019-07-25 00:00:00

abstract：:Fifty-six strains, representing eight species of salmonellae of diverse geographic origin and possessing a variety of antimicrobial resistance profiles, were tested for susceptibility to niridazole by the agar dilution method. Calculated MICs for 50 and 90% of strains were 4.8 and 16.0 mg/liter, respectively, with a s...

journal_title：Antimicrobial agents and chemotherapy

authors： Bannatyne RM,Jackowski J,Grant RB

更新日期：1986-05-01 00:00:00

abstract：:The emergence of pneumococci resistant to penicillin and other agents prompted us to evaluate intravenous vancomycin for the therapy of pneumococcal meningitis, which has an overall mortality of 30%. Eleven consecutive adult patients with cerebrospinal fluid (CSF)-culture-proven pneumococcal meningitis and positive in...

journal_title：Antimicrobial agents and chemotherapy

authors： Viladrich PF,Gudiol F,Liñares J,Pallarés R,Sabaté I,Rufí G,Ariza J

更新日期：1991-12-01 00:00:00

abstract：:The inhibition of the lymphadenopathy-associated virus strain of human immunodeficiency virus (HIV) by alternating regimens of two dideoxynucleosides, 3'-azido-3'-deoxythymidine (AZT) (zidovudine) and 2',3'-dideoxycytidine (ddC), was determined in CEM cells. Cultures infected with virus for 2 h were treated with clini...

journal_title：Antimicrobial agents and chemotherapy

authors： Spector SA,Ripley D,Hsia K

更新日期：1989-06-01 00:00:00

abstract：:Seventy nine strains of Yersinia enterocolitica resistant to one or more antimicrobials were analyzed for integrons. Only class 1 sul1 integrons containing aadA1a (28 strains), aadA1a-dfr1-sat1 (2 strains), and dfr1-aadA1a (1 strain) gene cassettes were found. The first two types were found in clinical isolates belong...

journal_title：Antimicrobial agents and chemotherapy

authors： Soto SM,Lobato MJ,Mendoza MC

更新日期：2003-01-01 00:00:00

abstract：:Amphotericin B (AMB) has been a mainstay therapy for fungal infections of the central nervous system, but its use has been limited by its poor penetration into the brain, the mechanism of which remains unclear. In this study, we aimed to investigate the role of P-glycoprotein (P-gp) in AMB crossing the blood-brain bar...

journal_title：Antimicrobial agents and chemotherapy

authors： Wu JQ,Shao K,Wang X,Wang RY,Cao YH,Yu YQ,Lou JN,Chen YQ,Zhao HZ,Zhang QQ,Weng XH,Jiang C,Zhu LP

更新日期：2014-08-01 00:00:00

abstract：:A multi-center study of 1,838 clinical isolates established the accuracy of diffusion susceptibility tests with 30-mug cephalothin disks and 30-mug cefamandole disks. The same interpretive zone standards can be applied to tests with either disk but the two drugs cannot be tested interchangeably. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Barry AL,Schoenknecht FD,Shadomy S,Sherris JC,Thornsberry C,Washington JA,Kammer RB

更新日期：1979-01-01 00:00:00

abstract：:A total of 295 ceftiofur-resistant Escherichia coli isolates were obtained from 489 cloacal samples collected at five different Belgian broiler farms with the aim to evaluate the diversity of this resistance at the farm level. Strains were examined for resistance against beta-lactam antibiotics and other antimicrobial...

journal_title：Antimicrobial agents and chemotherapy

authors： Smet A,Martel A,Persoons D,Dewulf J,Heyndrickx M,Catry B,Herman L,Haesebrouck F,Butaye P

更新日期：2008-04-01 00:00:00

abstract：:Viridin B, a bacteriocin produced by Streptococcus mitis, copurified with the alpha-hemolysin after ammonium sulfate precipitation and gel filtration on Sephadex G-200. The bacteriocin and hemolysin were separated in some instances by ion-exchange chromatography on diethylaminoethyl-Sephadex A-50, but the two substanc...

journal_title：Antimicrobial agents and chemotherapy

authors： Apelgren LD,Dajani AS

更新日期：1979-03-01 00:00:00

abstract：:The results of treatment of 10 patients with anaerobic infections with metronidazole are presented. Six patients were cured, three showed initial good response but circumstances required a change to another drug, and one patient did not respond. The unique spectrum of the drug, its pharmacology, and limitations are di...

journal_title：Antimicrobial agents and chemotherapy

authors： Tally FP,Sutter VL,Finegold SM

更新日期：1975-05-01 00:00:00

abstract：:Chronic infection with hepatitis C virus (HCV) is a major global health burden and is associated with an increased risk of liver cirrhosis and hepatocellular carcinoma. Current therapy for HCV infection has limited efficacy, particularly against genotype 1 virus, and is hampered by a range of adverse effects. Therefor...

journal_title：Antimicrobial agents and chemotherapy

authors： Berke JM,Vijgen L,Lachau-Durand S,Powdrill MH,Rawe S,Sjuvarsson E,Eriksson S,Götte M,Fransen E,Dehertogh P,Van den Eynde C,Leclercq L,Jonckers TH,Raboisson P,Nilsson M,Samuelsson B,Rosenquist Å,Fanning GC,Lin TI

更新日期：2011-08-01 00:00:00

abstract：:Human macrophage inflammatory protein 3alpha (MIP-3alpha), also known as CCL20, is a 70-amino-acid chemokine which exclusively binds to chemokine receptor 6. In addition, the protein also has direct antimicrobial, antifungal, and antiviral activities. The solution structure of MIP-3alpha was solved by the use of two-d...

journal_title：Antimicrobial agents and chemotherapy

authors： Chan DI,Hunter HN,Tack BF,Vogel HJ

更新日期：2008-03-01 00:00:00

abstract：:The capacity for intracellular growth is an important survival strategy for a large group of common pathogens. Helicobacter pylori, the etiological agent for gastritis and duodenal ulcer, has been shown by both in vivo and in vitro studies to have the capacity to invade epithelial cells. In vitro models are used to st...

journal_title：Antimicrobial agents and chemotherapy

authors： Hultén K,Rigo R,Gustafsson I,Engstrand L

更新日期：1996-12-01 00:00:00

abstract：:Histatin 5 (Hst 5) is a salivary human antimicrobial peptide that is toxic to the opportunistic yeast Candida albicans. Fungicidal activity of Hst 5 requires intracellular translocation and accumulation to a threshold concentration for it to disrupt cellular processes. Previously, we observed that total cytosolic leve...

journal_title：Antimicrobial agents and chemotherapy

authors： Li R,Kumar R,Tati S,Puri S,Edgerton M

更新日期：2013-04-01 00:00:00

abstract：:The mechanism of action of the fungicidal peptide auristatin PHE was investigated in Cryptococcus neoformans. Since auristatin PHE causes budding arrest in C. neoformans (T. Woyke, G. R. Pettit, G. Winkelmann, and R. K. Pettit, Antimicrob. Agents Chemother. 45:3580-3584, 2001), microtubule integrity and nuclear locali...

journal_title：Antimicrobial agents and chemotherapy

authors： Woyke T,Roberson RW,Pettit GR,Winkelmann G,Pettit RK

更新日期：2002-12-01 00:00:00

abstract：:Chlorhexidine (Hibiscrub; ICI) is generally accepted to be effective as an antiseptic hand wash for methicillin-susceptible Staphylococcus aureus (MSSA), but there is dispute whether the chlorhexidine MIC for methicillin-resistant S. aureus (MRSA) strains is higher than that for MSSA strains and, indeed, whether it is...

journal_title：Antimicrobial agents and chemotherapy

authors： Cookson BD,Bolton MC,Platt JH

更新日期：1991-10-01 00:00:00

abstract：:4,4'-Isopropylidine-bis[2-isopropyl]phenol was found to possess antimicrobial activity against gram-positive bacteria and some fungi, whereas it had no effect on gram-negative organisms. The drug has a potent inhibitory action on the synthesis of cell wall mucopeptides of Bacillus subtilis by inhibiting the enzyme d-g...

journal_title：Antimicrobial agents and chemotherapy

authors： Shimi IR,Shoukry S,Zaki Z

更新日期：1976-04-01 00:00:00

abstract：:The effects of binding and the bactericidal action of vancomycin on the arrangement and mobilities of cell wall polymers in Bacillus licheniformis were investigated by (15)N nuclear magnetic resonance spectroscopy. The bactericidal action of vancomycin led to reduced mobilities of cell wall teichoic acid and teichuron...

journal_title：Antimicrobial agents and chemotherapy

authors： Irving CS,Lapidot A

更新日期：1978-11-01 00:00:00

abstract：:We sought to determine whether there was an interaction between aminoglycoside use and shock in their effect on renal function among seriously ill patients suspected of having gram-negative sepsis. Serial serum creatinine determinations were used to estimate changes in creatinine clearance rates in 179 patients entere...

journal_title：Antimicrobial agents and chemotherapy

authors： Ambinder RF,Moore RD,Smith CR,Mellits ED,Lietman PS

更新日期：1985-02-01 00:00:00

abstract：:In an effort to discover novel, noncarbohydrate inhibitors of influenza virus neuraminidase we hypothesized that compounds which contain positively charged amino groups in an appropriate position to interact with the Asp 152 or Tyr 406 side chains might be bound tightly by the enzyme. Testing of 300 alpha- and beta-am...

journal_title：Antimicrobial agents and chemotherapy

authors： Kati WM,Montgomery D,Maring C,Stoll VS,Giranda V,Chen X,Laver WG,Kohlbrenner W,Norbeck DW

更新日期：2001-09-01 00:00:00

abstract：:Colistin is increasingly being utilized against Gram-negative pathogens, including Pseudomonas aeruginosa, resistant to all other antibiotics. Since limited data exist regarding killing by colistin at different initial inocula (CFUo), we evaluated killing of Pseudomonas aeruginosa by colistin at several CFUo and devel...

journal_title：Antimicrobial agents and chemotherapy

authors： Bulitta JB,Yang JC,Yohonn L,Ly NS,Brown SV,D'Hondt RE,Jusko WJ,Forrest A,Tsuji BT

更新日期：2010-05-01 00:00:00

abstract：:Because of the rising incidence of failures in the treatment of oropharyngeal candidosis in the case of severely immunosuppressed patients (mostly human immunodeficiency virus [HIV]-infected patients), there is need for the development of new, more effective agents and/or compounds that support the activity of the com...

journal_title：Antimicrobial agents and chemotherapy

authors： Kuipers ME,de Vries HG,Eikelboom MC,Meijer DK,Swart PJ

更新日期：1999-11-01 00:00:00

abstract：:Ramoplanin is an actinomycetes-derived antibiotic with broad-spectrum activity against Gram-positive bacteria that has been evaluated in clinical trials for the treatment of gastrointestinal vancomycin-resistant enterococci (VRE) and Clostridium difficile infections. Recent studies have proposed that ramoplanin binds ...

journal_title：Antimicrobial agents and chemotherapy

authors： Cheng M,Huang JX,Ramu S,Butler MS,Cooper MA

更新日期：2014-11-01 00:00:00

abstract：:Diabetic foot ulcer treatment currently focuses on targeting bacterial biofilms, while dismissing fungi. To investigate this, we used an in vitro biofilm model containing bacteria and fungi, reflective of the wound environment, to test the impact of antimicrobials. Here we showed that while monotreatment approaches in...

journal_title：Antimicrobial agents and chemotherapy

authors： Townsend EM,Sherry L,Kean R,Hansom D,Mackay WG,Williams C,Butcher J,Ramage G

更新日期：2017-08-24 00:00:00

abstract：:Because macrolide antibiotics are hypothesized to possess immunomodulatory activity independent of their antimicrobial activity, we evaluated the immunomodulatory effect of clarithromycin in a murine model of lung inflammation induced by either live or UV-killed Mycoplasma pneumoniae. BALB/c mice were intranasally ino...

journal_title：Antimicrobial agents and chemotherapy

authors： Hardy RD,Rios AM,Chavez-Bueno S,Jafri HS,Hatfield J,Rogers BB,McCracken GH,Ramilo O

更新日期：2003-05-01 00:00:00

abstract：:Ten patients with acquired immunodeficiency syndrome with newly diagnosed cytomegalovirus (CMV) retinitis were treated with an induction regimen of intravenous foscarnet, 60 mg/kg of body weight, administered as a 2-h infusion and repeated every 8 h for 14 days. At the end of induction, 9 of 10 patients had stabilized...

journal_title：Antimicrobial agents and chemotherapy

authors： Jacobson MA,O'Donnell JJ,Mills J

更新日期：1989-05-01 00:00:00