Interpretive criteria for cefamandole and cephalothin disk diffusion susceptibility tests.

abstract：:The density of the biofilm layer produced on a plastic surface by 23 clinical isolates and 1 reference strain of slime-positive, coagulase-negative staphylococci was measured following growth in subinhibitory concentrations (sub-MICs) of cefamandole or vancomycin ranging from 2 to 0.008 micrograms/ml. All strains were...

journal_title：Antimicrobial agents and chemotherapy

authors： Dunne WM Jr

更新日期：1990-03-01 00:00:00

abstract：:C-8-methoxy fluoroquinolones were more lethal than C-8-bromine, C-8-ethoxy, and C-8-H derivatives for Staphylococcus aureus, especially when topoisomerase IV was resistant. The methoxy group also increased lethality against wild-type cells when protein synthesis was inhibited. These properties encourage refinement of ...

journal_title：Antimicrobial agents and chemotherapy

authors： Zhao X,Wang JY,Xu C,Dong Y,Zhou J,Domagala J,Drlica K

更新日期：1998-04-01 00:00:00

abstract：:An estimated 40 million women of reproductive age are infected with one of three species of the waterborne parasite Schistosoma spp. Treatment with praziquantel (PZQ) via mass drug administration (MDA) campaigns is the mainstay of schistosomiasis control for populations living in areas of endemicity. The World Health ...

journal_title：Antimicrobial agents and chemotherapy

authors： Bustinduy AL,Kolamunnage-Dona R,Mirochnick MH,Capparelli EV,Tallo V,Acosta LP,Olveda RM,Friedman JF,Hope WW

更新日期：2020-08-20 00:00:00

abstract：:We compared the inoculum effects for 109 recent clinical isolates of the Bacteroides fragilis group of cefoxitin, cefotetan, ceftizoxime, ceftriaxone, and three beta-lactamase inhibitors (clavulanic acid, sulbactam, and tazobactam) and their penicillin-derived components. Bactericidal activity was assayed and morpholo...

journal_title：Antimicrobial agents and chemotherapy

authors： Goldstein EJ,Citron DM,Cherubin CE

更新日期：1991-09-01 00:00:00

abstract：:Compound G2 isolated from alfalfa roots was applied topically to skin lesions of guinea pigs experimentally infected with the dermatophyte Trichophyton mentagrophytes var. granulare. After 12 to 15 applications, 80% of the infected lesions were cured, as judged by clinical and microbial criteria, compared with 20% of ...

journal_title：Antimicrobial agents and chemotherapy

authors： Evron R,Guizie M,Zehavi U,Polacheck I

更新日期：1990-08-01 00:00:00

abstract：:Simocyclinone D8, a coumarin derivative isolated from Streptomyces antibioticus Tü 6040, represents an interesting new antiproliferative agent. It was originally suggested that this drug recognizes the GyrA subunit and interferes with the gyrase catalytic cycle by preventing its binding to DNA. To further characterize...

journal_title：Antimicrobial agents and chemotherapy

authors： Sissi C,Vazquez E,Chemello A,Mitchenall LA,Maxwell A,Palumbo M

更新日期：2010-01-01 00:00:00

abstract：:Bisbenzamidines, such as pentamidine isethionate, are aromatic dicationic compounds that are active against Pneumocystis and other microbes but are oftentimes toxic to the host. To identify potential anti-Pneumocystis agents, we synthesized bisbenzamidine derivatives in which the parent compound pentamidine was modifi...

journal_title：Antimicrobial agents and chemotherapy

authors： Cushion MT,Walzer PD,Ashbaugh A,Rebholz S,Brubaker R,Vanden Eynde JJ,Mayence A,Huang TL

更新日期：2006-07-01 00:00:00

abstract：:We showed in a previous study that associations of antimicrobial peptides (AMPs), which are key components of the innate immune systems of all living species, with the fluoroquinolone enrofloxacin can successfully cure HeLa cell cultures of Mycoplasma fermentans and M. hyorhinis contamination. In the present work, the...

journal_title：Antimicrobial agents and chemotherapy

authors： Fassi Fehri L,Wróblewski H,Blanchard A

更新日期：2007-02-01 00:00:00

abstract：:Antagonism of antibiotic activity by peritoneal dialysate has been postulated to be a cause of failure of treatment of peritonitis complicating continuous ambulatory peritoneal dialysis. We evaluated by a case-control study whether unexpected treatment failure could be attributed to such antagonism. Bacteria isolated ...

journal_title：Antimicrobial agents and chemotherapy

authors： Ludlam H,Johnston L,Hopkins P

更新日期：1992-05-01 00:00:00

abstract：:Caspofungin acetate is an antifungal antibiotic that inhibits synthesis of 1,3-beta-D-glucan, an essential component of the fungal cell wall. While caspofungin causes cell death in yeasts and dimorphic fungi such as Candida albicans, its effect on Aspergillus fumigatus is less well understood. We used the fluorescent ...

journal_title：Antimicrobial agents and chemotherapy

authors： Bowman JC,Hicks PS,Kurtz MB,Rosen H,Schmatz DM,Liberator PA,Douglas CM

更新日期：2002-09-01 00:00:00

abstract：:A two-compartment pharmacokinetic (PK) population model of anidulafungin was fitted to PK data from 23 critically ill patients (age, 65 years [range, 28 to 81 years]; total body weight [TBW], 75 kg [range, 54 to 168 kg]). TBW was associated with clearance and incorporated into a final population PK model. Simulations ...

journal_title：Antimicrobial agents and chemotherapy

authors： Luque S,Hope W,Campillo N,Muñoz-Bermúdez R,Sorli L,Barceló-Vidal J,González-Colominas E,Alvarez-Lerma F,Masclans JR,Montero M,Horcajada JP,Grau S

更新日期：2019-06-24 00:00:00

abstract：:The purpose of this study was to compare the activity of HMR 1043 with those of daptomycin and teicoplanin against gram-positive isolates. Susceptibility tests were performed for 52 strains, 26 parental strains, including staphylococcal, streptococcal, enterococcal, and listerial strains, and 26 HMR 1043-resistant mut...

journal_title：Antimicrobial agents and chemotherapy

authors： Bemer P,Juvin ME,Bryskier A,Drugeon H

更新日期：2003-09-01 00:00:00

abstract：:Changes in plasmid DNA supercoiling were measured following treatment of Escherichia coli cells, carrying topoisomerase mutations, with the quinolone ciprofloxacin. In quinolone-susceptible cells (top+ gyr+) as well as in topA mutants and in gyrB mutants, plasmid DNA was relaxed after the addition of ciprofloxacin. In...

journal_title：Antimicrobial agents and chemotherapy

authors： Aleixandre V,Herrera G,Urios A,Blanco M

更新日期：1991-01-01 00:00:00

abstract：:Novel sulfonated derivatives of poly(allylamine hydrochloride) (NSPAHs) and N-sulfonated chitosan (NSCH) have been synthesized, and their activity against influenza A and B viruses has been studied and compared with that of a series of carrageenans, marine polysaccharides of well-documented anti-influenza activity. NS...

journal_title：Antimicrobial agents and chemotherapy

authors： Ciejka J,Milewska A,Wytrwal M,Wojarski J,Golda A,Ochman M,Nowakowska M,Szczubialka K,Pyrc K

更新日期：2016-03-25 00:00:00

abstract：:We assessed cutaneous ethanol (ETOH) and isopropanol (ISOP) absorption after intensive (30 times per h) use of alcohol-based hand-rub solutions by healthcare workers (HCWs). ETOH was detectable in the breath of 6/20 HCWs (0.001 to 0.0025%) at 1 to 2 min postexposure and in the serum of 2/20 HCWs at 5 to 7 min postexpo...

journal_title：Antimicrobial agents and chemotherapy

authors： Brown TL,Gamon S,Tester P,Martin R,Hosking K,Bowkett GC,Gerostamoulos D,Grayson ML

更新日期：2007-03-01 00:00:00

abstract：:To study whether the capability of horizontal DNA transfer is associated with metronidazole resistance in Helicobacter pylori, a total of 81 clinical isolates were tested for MICs of metronidazole (MTZ). The MIC assays were performed by using the E-test and reconfirmed by the agar dilution method. Natural competence a...

journal_title：Antimicrobial agents and chemotherapy

authors： Yeh YC,Chang KC,Yang JC,Fang CT,Wang JT

更新日期：2002-05-01 00:00:00

abstract：:We describe the pharmacokinetics of raltegravir of a preterm newborn after short-course treatment of the mother tested HIV + the day of delivery. At age 1 month, the circulating concentration of raltegravir in the newborn was 29 ng/ml (the IC95 of RAL against HIV-1 is 15 ng/ml). Raltegravir should therefore be conside...

journal_title：Antimicrobial agents and chemotherapy

authors： Clavel-Osorio C,Cazassus F,Stegmann S,Huc-Anaïs P,Lecam D,Peytavin G

更新日期：2013-12-01 00:00:00

abstract：:In this study, we synthesized antisense oligodeoxynucleotides (ODNs) with phosphodiester, phosphorothioate (S-ODNs), or methylphosphonate linkages complementary to the splicing acceptor site of immediate-early pre-mRNA 5 of herpes simplex virus type 1 (HSV-1). The antiviral activity of each analog on cytopathic effect...

journal_title：Antimicrobial agents and chemotherapy

authors： Shoji Y,Shimada J,Mizushima Y,Iwasawa A,Nakamura Y,Inouye K,Azuma T,Sakurai M,Nishimura T

更新日期：1996-07-01 00:00:00

abstract：:The quinolones inhibit the A subunit of DNA gyrase in the presence of Mg2+ by interrupting the DNA breakage and resealing steps, and the latter step is also retarded without quinolones if Mg2+ is replaced by Ca2+. Pyrimido[1,6-a]benzimidazoles have been found to represent a new class of potent DNA gyrase inhibitors wh...

journal_title：Antimicrobial agents and chemotherapy

authors： Gmünder H,Kuratli K,Keck W

更新日期：1995-01-01 00:00:00

abstract：:The activity of two cefoperazone-sulbactam combinations against anaerobic bacteria was tested and compared both with that of cefoperazone alone and with that of other commonly used antimicrobial agents. Imipenem was the most active of the tested agents, followed by chloramphenicol, metronidazole, and cefoperazone-sulb...

journal_title：Antimicrobial agents and chemotherapy

authors： Wexler HM,Finegold SM

更新日期：1988-03-01 00:00:00

abstract：:To investigate the occurrence of multinucleoside analog resistance during therapy failure, we surveyed the drug susceptibilities and genotypes of nearly 900 human immunodeficiency virus type 1 (HIV-1) samples. For 302 of these, the 50% inhibitory concentrations of at least four of the approved nucleoside analogs had f...

journal_title：Antimicrobial agents and chemotherapy

authors： Larder BA,Bloor S,Kemp SD,Hertogs K,Desmet RL,Miller V,Sturmer M,Staszewski S,Ren J,Stammers DK,Stuart DI,Pauwels R

更新日期：1999-08-01 00:00:00

abstract：:Microdialysis was applied to sample the unbound drug concentration in the extracellular fluid in brain and muscle of rats given zalcitabine (2',3'-dideoxycytidine; n = 4) or BEA005 (2', 3'-dideoxy-3'-hydroxymethylcytidine; n = 4) (50 mg/kg of body weight given subcutaneously). Zalcitabine and BEA005 were analyzed by h...

journal_title：Antimicrobial agents and chemotherapy

authors： Borg N,Ståhle L

更新日期：1998-09-01 00:00:00

abstract：:(-)-Beta-D-1',3'-Dioxolane guanosine (DXG) and 2,6-diaminopurine (DAPD) dioxolanyl nucleoside analogues have been reported to be potent inhibitors of human immunodeficiency virus type 1 (HIV-1). We have recently conducted experiments to more fully characterize their in vitro anti-HIV-1 profiles. Antiviral assays perfo...

journal_title：Antimicrobial agents and chemotherapy

authors： Gu Z,Wainberg MA,Nguyen-Ba N,L'Heureux L,de Muys JM,Bowlin TL,Rando RF

更新日期：1999-10-01 00:00:00

abstract：:We undertook a prospective, randomized open comparison of the broad-spectrum cephalosporins cefepime and ceftazidime in treatment of hospitalized subjects with skin or wound infections and complicated nosocomial urinary tract infections. Cefepime treatment (dosage, 2.0 g intravenously twice daily for 4 to 28 days) was...

journal_title：Antimicrobial agents and chemotherapy

authors： Gentry LO,Rodriguez-Gomez G

更新日期：1991-11-01 00:00:00

abstract：:Liposomal formulations of rifabutin were developed, and the effects of some parameters on the incorporation efficiency were studied. The antimycobacterial activity of rifabutin incorporated into liposomes prepared with phosphatidylcholine and phosphatidylserine (molar ratio, 7:3) was evaluated in a murine model of inf...

journal_title：Antimicrobial agents and chemotherapy

authors： Gaspar MM,Neves S,Portaels F,Pedrosa J,Silva MT,Cruz ME

更新日期：2000-09-01 00:00:00

abstract：:It has previously been shown that overexpression of the CdMDR1 gene is a major contributor to resistance in fluconazole-resistant isolates of Candida dubliniensis. However, since CdMdr1p does not mediate transport of other azole drugs such as itraconazole, we investigated the molecular mechanisms of stable resistance ...

journal_title：Antimicrobial agents and chemotherapy

authors： Pinjon E,Moran GP,Jackson CJ,Kelly SL,Sanglard D,Coleman DC,Sullivan DJ

更新日期：2003-08-01 00:00:00

abstract：:A "plasmid-curing effect" of multiresistant Escherichia coli by flavophospholipol, an antibiotic used as an antimicrobial growth promoter (AMGP) in animal feeds, has been reported to occur in vitro and in vivo under experimental conditions. In this study, the effect of flavophospholipol under field conditions was stud...

journal_title：Antimicrobial agents and chemotherapy

authors： van den Bogaard AE,Hazen M,Hoyer M,Oostenbach P,Stobberingh EE

更新日期：2002-01-01 00:00:00

abstract：:9-Deoxy-Delta(9),Delta(12)-13,14-dihydro-prostaglandin D(2) (Delta(12)-PGJ(2)), a natural cyclopentenone metabolite of prostaglandin D(2), is shown to possess therapeutic efficacy against influenza A virus A/PR8/34 (H1N1) infection in vitro and in vivo. The results indicate that the antiviral activity is associated wi...

journal_title：Antimicrobial agents and chemotherapy

authors： Pica F,Palamara AT,Rossi A,De Marco A,Amici C,Santoro MG

更新日期：2000-01-01 00:00:00

abstract：:A novel beta-lactamase gene, blaOXA-61, from Campylobacter jejuni GC015 was cloned and its nucleotide sequence determined. blaOXA-61 encodes a protein of 257 amino acids in which the active-site STFK tetrad and conserved class D beta-lactamase motifs YGN and KTG were identified. A conserved sequence upstream of blaOXA...

journal_title：Antimicrobial agents and chemotherapy

authors： Alfredson DA,Korolik V

更新日期：2005-06-01 00:00:00

abstract：:Pharmacokinetic modeling has often been applied to evaluate vancomycin pharmacokinetics in neonates. However, clinical application of the model-based personalized vancomycin therapy is still limited. The objective of the present study was to evaluate the clinical utility and safety of a model-based patient-tailored do...

journal_title：Antimicrobial agents and chemotherapy

authors： Leroux S,Jacqz-Aigrain E,Biran V,Lopez E,Madeleneau D,Wallon C,Zana-Taïeb E,Virlouvet AL,Rioualen S,Zhao W

更新日期：2016-03-25 00:00:00