Effect of pyrimido[1,6-a]benzimidazoles, quinolones, and Ca2+ on the DNA gyrase-mediated cleavage reaction.

abstract：:The in vitro activities of luliconazole, amorolfine, ciclopirox, and terbinafine were determined against 320 dermatophyte isolates from large toenails of onychomycosis patients enrolled into an ongoing phase 2b/3 clinical study. The geometric mean MIC for luliconazole was 0.00022 μg/ml against all isolates, compared t...

journal_title：Antimicrobial agents and chemotherapy

authors： Wiederhold NP,Fothergill AW,McCarthy DI,Tavakkol A

更新日期：2014-06-01 00:00:00

abstract：:Bovicin HC5, a broad-spectrum lantibiotic produced by Streptococcus bovis HC5, catalyzed the efflux of intracellular potassium from Streptococcus bovis JB1, a sensitive strain. The level of ATP also decreased, but this decline appeared to be caused by the activity of the F(1)F(0) ATPase rather than efflux per se. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Mantovani HC,Russell JB

更新日期：2008-06-01 00:00:00

abstract：:Ceftaroline-avibactam and comparator agents were tested by the broth microdilution method against 20,089 isolates consecutively collected in 2010 and 2011 from 75 U.S. medical centers. Ceftaroline-avibactam was active against Enterobacteriaceae (4,908 strains; MIC90, 0.25 μg/ml; highest MIC, 4 μg/ml), including merope...

journal_title：Antimicrobial agents and chemotherapy

authors： Sader HS,Flamm RK,Jones RN

更新日期：2013-04-01 00:00:00

abstract：:The activity of MK-0826, a new carbapenem, against 309 Bacteroides fragilis group strains was investigated and compared with that of 11 other beta-lactam and 5 non-beta-lactam agents. MK-0826 showed excellent activity (MICs ranged from < or =0.06 to 4 microg/ml). The new carbapenem may be useful in the treatment of mi...

journal_title：Antimicrobial agents and chemotherapy

authors： Betriu C,Sánchez A,Palau ML,Gómez M,Picazo JJ

更新日期：2001-08-01 00:00:00

abstract：:We investigated the antistaphylococcal activity of daptomycin, vancomycin, oxacillin, gentamicin, and rifampin in human monocyte-derived macrophages. Compared with vancomycin and oxacillin, daptomycin had the most rapid and greatest antibacterial activity, but that of oxacillin was most sustained. The combination of d...

journal_title：Antimicrobial agents and chemotherapy

authors： Baltch AL,Ritz WJ,Bopp LH,Michelsen PB,Smith RP

更新日期：2007-04-01 00:00:00

abstract：:Ritonavir-boosted darunavir with efavirenz may be considered a nucleoside-sparing regimen for treatment-naïve HIV-infected patients. However, the pharmacokinetics of this combination administered once daily have not been studied. We conducted a three-period interaction study with healthy volunteers. The subjects were ...

journal_title：Antimicrobial agents and chemotherapy

authors： Soon GH,Shen P,Yong EL,Pham P,Flexner C,Lee L

更新日期：2010-07-01 00:00:00

abstract：:Given the greater than 90% lethality of clinical central nervous system (CNS) aspergillosis despite current therapies, there is a need for an animal model to study therapeutic strategies. We previously established a model of CNS aspergillosis by intracerebral infection and report here the results of treatment with the...

journal_title：Antimicrobial agents and chemotherapy

authors： Chiller TM,Sobel RA,Luque JC,Clemons KV,Stevens DA

更新日期：2003-02-01 00:00:00

abstract：:Our mutagenesis study has investigated all amino acid mutations in the penicillin-binding domain of PBP 1A from Hungarian pneumococcal isolate 3191 to determine the importance of every mutation in the development of penicillin and cefotaxime resistance. Our data reveal that mutations at amino acid positions 574 to 577...

journal_title：Antimicrobial agents and chemotherapy

authors： Smith AM,Klugman KP

更新日期：2003-01-01 00:00:00

abstract：:A new SHV-derived extended-spectrum beta-lactamase (SHV-24) conferring high-level resistance to ceftazidime but not cefotaxime and cefazolin was identified in Japan. This enzyme was encoded by a transferable 150-kb plasmid from an Escherichia coli clinical isolate. The pI and K(m) for CAZ of this enzyme were 7.5 and 3...

journal_title：Antimicrobial agents and chemotherapy

authors： Kurokawa H,Yagi T,Shibata N,Shibayama K,Kamachi K,Arakawa Y

更新日期：2000-06-01 00:00:00

abstract：:Pyrosequencing was used to detect rapidly and estimate the number of 23S rRNA genes with a G2576T mutation in 43 linezolid-resistant and -susceptible clinical isolates of enterococci. The method showed 100% concordance with PCR-restriction fragment length polymorphism for detecting isolates homozygous for either G2576...

journal_title：Antimicrobial agents and chemotherapy

authors： Sinclair A,Arnold C,Woodford N

更新日期：2003-11-01 00:00:00

abstract：:Lipopolysaccharide (LPS) samples isolated from a parent and two antibiotic-hypersusceptible mutant strains of Escherichia coli were analyzed for polycation affinity and level of binding. Purified salts of the LPSs from the parent strain, UB1005, and from one of the mutant strains, DC1, bound similar amounts of sodium ...

journal_title：Antimicrobial agents and chemotherapy

authors： Rocque WJ,Fesik SW,Haug A,McGroarty EJ

更新日期：1988-03-01 00:00:00

abstract：:The aminoglycoside Geneticin (G418) is known to inhibit cell culture proliferation, via virus-specific mechanisms, of two different virus genera from the family Flaviviridae. Here, we tried to determine whether Geneticin can selectively alter the switching of the nucleotide 1 to 570 RNA region of hepatitis C virus (HC...

journal_title：Antimicrobial agents and chemotherapy

authors： Ariza-Mateos A,Díaz-Toledano R,Block TM,Prieto-Vega S,Birk A,Gómez J

更新日期：2015-11-30 00:00:00

abstract：:We found a heterozygous C2857T mutation (R953C) in polymerase gamma (Pol-γ) in an HIV-infected patient with mitochondrial toxicity. The R953C Pol-γ mutant binding affinity for dCTP is 8-fold less than that of the wild type. The R953C mutant shows a 4-fold decrease in discrimination of analog nucleotides relative to th...

journal_title：Antimicrobial agents and chemotherapy

authors： Li M,Mislak AC,Foli Y,Agbosu E,Bose V,Bhandari S,Szymanski MR,Shumate CK,Yin YW,Anderson KS,Paintsil E

更新日期：2016-08-22 00:00:00

abstract：:The aim of the study was to evaluate the penetration of ciprofloxacin into bronchial secretions from mechanically ventilated patients with nosocomial bronchopneumonia. For this purpose, in each patient studied, simultaneous serial blood and bronchial secretion samples were obtained over a 12-h period on days 2 and 4. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Saux P,Martin C,Mallet MN,Papazian L,Bruguerolle B,De Micco P,Gouin F

更新日期：1994-04-01 00:00:00

abstract：:The single- and multiple-dose pharmacokinetics of and tolerability to a new microfluidized suspension of atovaquone were studied in human immunodeficiency virus-seropositive patients with CD4 counts of < or = 200 cells per mm3 in order to define a dosing regimen for the treatment of Pneumocystis carinii pneumonia. Thi...

journal_title：Antimicrobial agents and chemotherapy

authors： Dixon R,Pozniak AL,Watt HM,Rolan P,Posner J

更新日期：1996-03-01 00:00:00

abstract：:Isoxyl (ISO), a thiourea derivative that was successfully used for the clinical treatment of tuberculosis during the 1960s, is an inhibitor of the synthesis of oleic and mycolic acids in Mycobacterium tuberculosis. Its effect on oleic acid synthesis has been shown to be attributable to its inhibitory activity on the s...

journal_title：Antimicrobial agents and chemotherapy

authors： Korduláková J,Janin YL,Liav A,Barilone N,Dos Vultos T,Rauzier J,Brennan PJ,Gicquel B,Jackson M

更新日期：2007-11-01 00:00:00

abstract：:Lantibiotics such as nisin (NIS) are peptide antibiotics that may have a role in the chemotherapy of bacterial infections. A perceived benefit of lantibiotics for clinical use is their low propensity to select resistance, although detailed resistance studies with relevant bacterial pathogens are lacking. Here we exami...

journal_title：Antimicrobial agents and chemotherapy

authors： Blake KL,Randall CP,O'Neill AJ

更新日期：2011-05-01 00:00:00

abstract：:Hypermutation is a common feature of Pseudomonas aeruginosa isolates from chronically infected cystic fibrosis patients that is linked with antibiotic resistance development. In this work, using a large collection of sequential P. aeruginosa isolates from ICU patients, we found that despite the fact that mutational an...

journal_title：Antimicrobial agents and chemotherapy

authors： Gutiérrez O,Juan C,Pérez JL,Oliver A

更新日期：2004-09-01 00:00:00

abstract：:Bisbenzamidines, such as pentamidine isethionate, are aromatic dicationic compounds that are active against Pneumocystis and other microbes but are oftentimes toxic to the host. To identify potential anti-Pneumocystis agents, we synthesized bisbenzamidine derivatives in which the parent compound pentamidine was modifi...

journal_title：Antimicrobial agents and chemotherapy

authors： Cushion MT,Walzer PD,Ashbaugh A,Rebholz S,Brubaker R,Vanden Eynde JJ,Mayence A,Huang TL

更新日期：2006-07-01 00:00:00

abstract：:Adult AIDS Clinical Trials Group 5043 examined pharmacokinetic (PK) interactions between amprenavir (APV) and efavirenz (EFV) both by themselves and when nelfinavir (NFV), indinavir (IDV), ritonavir (RTV), or saquinavir (SQV) is added. A PK study was conducted after the administration of single doses of APV (day 0). S...

journal_title：Antimicrobial agents and chemotherapy

authors： Morse GD,Rosenkranz S,Para MF,Segal Y,Difrancesco R,Adams E,Brizz B,Yarasheski KE,Reichman RC

更新日期：2005-08-01 00:00:00

abstract：:The distribution of subclasses mefA and mefE of the mefA gene among 116 M-phenotype streptococci was as follows: pneumococci (38 strains had mefE and 4 mefA), viridans streptococci (49 mefE and 1 mefA), and Streptococcus pyogenes (24 mefA). Spain(9V)-3-14 and England(14)-9 clones of serotype 14 were dominant among pne...

journal_title：Antimicrobial agents and chemotherapy

authors： Ardanuy C,Tubau F,Liñares J,Domínguez MA,Pallarés R,Martín R,Spanish Pneumococcal Infection Study Network (G03\/103).

更新日期：2005-02-01 00:00:00

abstract：:Mefloquine shows a high capacity to bind plasma proteins, which influences the amount of drug in erythrocytes. The study investigated the association of lipids levels with plasma concentrations of mefloquine and carboxy-mefloquine in 85 Brazilian patients with uncomplicated falciparum malaria. There were no significan...

journal_title：Antimicrobial agents and chemotherapy

authors： Vieira JLF,Rivera JGB,de Sena LWP,Ferreira MVD

更新日期：2020-02-21 00:00:00

abstract：:Yersinia enterocolitica has emerged as an enteropathogen associated with several types of human infections that often require antimicrobial therapy, but little is known about the antimicrobial susceptibilities of pathogenic strains isolated from humans in Canada. To determine the present patterns of antimicrobial susc...

journal_title：Antimicrobial agents and chemotherapy

authors： Preston MA,Brown S,Borczyk AA,Riley G,Krishnan C

更新日期：1994-09-01 00:00:00

abstract：:Mycobacterium tuberculosis, the causative agent of human tuberculosis (TB), has surpassed HIV/AIDS as the leading cause of death from a single infectious agent. The increasing occurrence of drug-resistant strains has become a major challenge for health care systems and, in some cases, has rendered TB untreatable. Howe...

journal_title：Antimicrobial agents and chemotherapy

authors： Meikle V,Mossberg AK,Mitra A,Hakansson AP,Niederweis M

更新日期：2019-01-29 00:00:00

abstract：:High-level azole resistance in the Darlington strain of Candida albicans was investigated by gene replacement in C. albicans and expression in Saccharomyces cerevisiae. We sequenced the ERG11 gene, which encodes the sterol C(14)alpha-demethylase, from our copy of the Darlington strain. Both alleles contained the histi...

journal_title：Antimicrobial agents and chemotherapy

authors： Kakeya H,Miyazaki Y,Miyazaki H,Nyswaner K,Grimberg B,Bennett JE

更新日期：2000-11-01 00:00:00

abstract：:Polymorphisms and the overexpression of transporter genes, especially of the ATP-binding cassette superfamily, have been involved in antimalarial drug resistance. The objective of this study was to use 77 Senegalese Plasmodium falciparum isolates to evaluate the association between the number of Asn residues in the po...

journal_title：Antimicrobial agents and chemotherapy

authors： Gendrot M,Diawara S,Madamet M,Kounta MB,Briolant S,Wade KA,Fall M,Benoit N,Nakoulima A,Amalvict R,Diémé Y,Fall B,Wade B,Diatta B,Pradines B

更新日期：2017-02-23 00:00:00

abstract：:Penicillin-binding protein (PBP) 2 is the major PBP of five that have been identified in susceptible strains of Staphylococcus aureus. Beta-lactam antibiotic binding to PBP 2 is important for the antibacterial effect. Antibiotic binding to PBP 2 in strain 209P was examined with sodium dodecyl sulfate-polyacrylamide ge...

journal_title：Antimicrobial agents and chemotherapy

authors： Chambers HF,Miick C

更新日期：1992-03-01 00:00:00

abstract：:Enucleated human polymorphonuclear leukocytes (PMN cytoplasts), which have no nuclei and only a few granules, retain many of the functions of intact neutrophils. To better define the mechanisms and intracellular sites of antimicrobial agent accumulation in human neutrophils, we studied the antibiotic uptake process in...

journal_title：Antimicrobial agents and chemotherapy

authors： Hand WL,King-Thompson NL

更新日期：1990-06-01 00:00:00

abstract：:The semen-derived enhancer of viral infection (SEVI) is a positively charged amyloid fibril that is derived from a self-assembling proteolytic cleavage fragment of prostatic acid phosphatase (PAP(248-286)). SEVI efficiently facilitates HIV-1 infection in vitro, but its normal physiologic function remains unknown. In l...

journal_title：Antimicrobial agents and chemotherapy

authors： Easterhoff D,Ontiveros F,Brooks LR,Kim Y,Ross B,Silva JN,Olsen JS,Feng C,Hardy DJ,Dunman PM,Dewhurst S

更新日期：2013-06-01 00:00:00

abstract：:Between 1986 and 1988, the incidence of ampicillin-resistant enterococci increased sevenfold at a university-affiliated hospital. Forty-three patients acquired nosocomial infections with ampicillin-resistant enterococci, most of which were also resistant to mezlocillin, piperacillin, and imipenem. An analysis of plasm...

journal_title：Antimicrobial agents and chemotherapy

authors： Boyce JM,Opal SM,Potter-Bynoe G,LaForge RG,Zervos MJ,Furtado G,Victor G,Medeiros AA

更新日期：1992-05-01 00:00:00