Therapeutic efficacy of liposomal rifabutin in a Mycobacterium avium model of infection.

abstract：:We evaluated the diffusion of pefloxacin into the cerebrospinal fluid (CSF) in 15 patients with bacterial meningitis or ventriculitis, 14 of whom were treated with other antibiotics. Three doses of pefloxacin were administered at 12-h intervals to 11 patients intravenously and to 4 patients orally. Individual doses we...

journal_title：Antimicrobial agents and chemotherapy

authors： Wolff M,Regnier B,Daldoss C,Nkam M,Vachon F

更新日期：1984-09-01 00:00:00

abstract：:Previous studies on tetracycline transport into Staphylococcus aureus identified a high-affinity, saturable uptake system for the antibiotic (Km, 4.76 microM) (B.L. Hutchings, Biochim. Biophys. Acta 174:734-738, 1969). However, the earlier results could not be confirmed using conditions that permitted energy-dependent...

journal_title：Antimicrobial agents and chemotherapy

authors： Chopra I,Ismail S,Oliva B

更新日期：1991-12-01 00:00:00

abstract：:Ajoene (4,5,9-trithiadodeca-1,6,11-triene 9-oxide), a product initially isolated from extracts of garlic (Allium sativum), was tested for its antimalarial activity in vivo in a well-characterized murine model. A single ajoene dose of 50 mg/kg, on the day of infection, suppressed the development of parasitemia; there w...

journal_title：Antimicrobial agents and chemotherapy

authors： Perez HA,De la Rosa M,Apitz R

更新日期：1994-02-01 00:00:00

abstract：:Sulfide production has been proposed to be a universal defense mechanism against antibiotics in bacteria (K. Shatalin, E. Shatalina, A. Mironov, and E. Nudler, Science 334:986-990, 2011, doi:10.1126/science.1209855). To gain insight into the mechanism underlying sulfide protection, we systematically and comparatively ...

journal_title：Antimicrobial agents and chemotherapy

authors： Weikum J,Ritzmann N,Jelden N,Klöckner A,Herkersdorf S,Josten M,Sahl HG,Grein F

更新日期：2018-09-24 00:00:00

abstract：:Previously, we reported potent activity of a novel spiropyrimidinetrione, zoliflodacin, against N. gonorrhoeae isolates from symptomatic men in Nanjing, China, collected in 2013. Here, we investigated trends of susceptibilities of zoliflodacin in 986 isolates collected from men between 2014 and 2018. N. gonorrhoeae is...

journal_title：Antimicrobial agents and chemotherapy

authors： Le W,Su X,Lou X,Li X,Gong X,Wang B,Genco CA,Mueller JP,Rice PA

更新日期：2020-12-14 00:00:00

abstract：:A randomized, prospective, double-blind, double-dummy, multicenter study investigated the efficacy and safety of 10 days of oral therapy with grepafloxacin at 400 mg once daily, grepafloxacin at 600 mg once daily, or ciprofloxacin at 500 mg twice daily in 624 patients with acute bacterial exacerbations of chronic bron...

journal_title：Antimicrobial agents and chemotherapy

authors： Chodosh S,Lakshminarayan S,Swarz H,Breisch S

更新日期：1998-01-01 00:00:00

abstract：:Dientamoeba fragilis is a commonly encountered trichomonad which has been implicated as a cause of gastrointestinal disease in humans. Despite the frequency of reports recording infections with this parasite, little research has been undertaken in terms of antimicrobial susceptibility. The aim of this study was to eva...

journal_title：Antimicrobial agents and chemotherapy

authors： Nagata N,Marriott D,Harkness J,Ellis JT,Stark D

更新日期：2012-01-01 00:00:00

abstract：:This is a substudy of a larger randomized controlled trial on HIV-infected Zambian children, which revealed that cotrimoxazole prophylaxis reduced morbidity and mortality despite a background of high cotrimoxazole resistance. The impact of cotrimoxazole on the carriage and antibiotic resistance of Streptococcus pneumo...

journal_title：Antimicrobial agents and chemotherapy

authors： Mwenya DM,Charalambous BM,Phillips PP,Mwansa JC,Batt SL,Nunn AJ,Walker S,Gibb DM,Gillespie SH

更新日期：2010-09-01 00:00:00

abstract：:Occidiofungin is produced by the soil bacterium Burkolderia contaminans MS14 and is structurally similar or identical to the burkholdines, xylocandins, and cepacidines. This study identified the primary cellular target of occidiofungin, which was determined to be actin. The modification of occidiofungin with a functio...

journal_title：Antimicrobial agents and chemotherapy

authors： Ravichandran A,Geng M,Hull KG,Li J,Romo D,Lu SE,Albee A,Nutter C,Gordon DM,Ghannoum MA,Lockless SW,Smith L

更新日期：2018-12-21 00:00:00

abstract：:Nephrotoxicity was more marked in rats receiving isepamicin at midlight than at middark. And, the once-daily administration at middark induced a lesser degree of nephrotoxicity than the twice-daily injection, which indicates that the once-daily treatment therapy may have potential value in the clinical use of aminogly...

journal_title：Antimicrobial agents and chemotherapy

authors： Yoshiyama Y,Nishikawa S,Sugiyama T,Kobayashi T,Shimada H,Tomonaga F,Ohdo S,Ogawa N,Nakano S

更新日期：1993-09-01 00:00:00

abstract：:Acyclovir reduced mortality and organ virus titers in mice inoculated intraperitoneally with 10 50% lethal doses of mouse cytomegalovirus. This susceptibility to acyclovir of a herpesvirus which lacks thymidine kinase is surprising. Alternative phosphorylating enzymes may account for this susceptibility. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Wingard JR,Bender WJ,Saral R,Burns WH

更新日期：1981-08-01 00:00:00

abstract：:Two Klebsiella pneumoniae isolates of the same strain, identified in Poland, produced either TEM-47 or TEM-68, which differed by the Arg275Leu substitution. They harbored a few virulence factors, including an iron-chelating factor and capsule overproduction, suggesting that these factors were sufficient to enhance the...

journal_title：Antimicrobial agents and chemotherapy

authors： Robin F,Hennequin C,Gniadkowski M,Beyrouthy R,Empel J,Gibold L,Bonnet R

更新日期：2012-02-01 00:00:00

abstract：:Accurate antibiotic susceptibility testing is essential for successful tuberculosis treatment. Recent studies have highlighted the limitations of minimum inhibitory concentrations (MIC) based phenotypic susceptibility methods in detecting other aspects of antibiotic susceptibilities in bacteria. Duration and peak of a...

journal_title：Antimicrobial agents and chemotherapy

authors： Vijay S,Nhung HN,Bao NLH,Thu DDA,Trieu LPT,Phu NH,Thwaites GE,Javid B,Thuong NTT

更新日期：2020-11-30 00:00:00

abstract：:The efficacy of a 5-day treatment with coumermycin A1 (hereafter referred to as coumermycin) (at three dosage regimens), with ciprofloxacin, or with coumermycin plus ciprofloxacin was tested in experimental aortic valve endocarditis induced in rats by a strain of methicillin-susceptible Staphylococcus aureus and was c...

journal_title：Antimicrobial agents and chemotherapy

authors： Perronne CM,Malinverni R,Glauser MP

更新日期：1987-04-01 00:00:00

abstract：:Although ampicillin has been suggested as a useful agent for the treatment of nocardiosis in man, little is known regarding the presence of beta-lactamase in Nocardia or its possible role in determining resistance to ampicillin and the other beta-lactam antibiotics. We have evaluated 55 isolates of Nocardia for suscep...

journal_title：Antimicrobial agents and chemotherapy

authors： Wallace RJ Jr,Vance P,Weissfeld A,Martin RR

更新日期：1978-11-01 00:00:00

abstract：:The pharmacokinetics of cefepime were studied in 12 adult patients in intensive care units during continuous venovenous hemofiltration (CVVH) or continuous venovenous hemodiafiltration (CVVHDF) with a Multiflow60 AN69HF 0.60-m(2) polyacrylonitrile hollow-fiber membrane (Hospal Industrie, Meyzieu, France). Patients (me...

journal_title：Antimicrobial agents and chemotherapy

authors： Malone RS,Fish DN,Abraham E,Teitelbaum I

更新日期：2001-11-01 00:00:00

abstract：:The aim of this study was to determine the penetration of doripenem administered intravenously into the rabbit aqueous and vitreous humors. Nineteen New Zealand White rabbits received a 20-mg dose of doripenem intravenously over 60 min. Specimens of aqueous humor, vitreous humor, and blood were obtained 30 min (n = 5)...

journal_title：Antimicrobial agents and chemotherapy

authors： Semoun O,Marchand S,Grégoire N,Lamarche I,Adier C,Laroche L,Goldschmidt P,Couet W

更新日期：2012-07-01 00:00:00

abstract：:Invasive pulmonary aspergillosis is a major life-threatening complication among transplant recipients and patients receiving cancer chemotherapy. In a rat model of progressive pulmonary aspergillosis that is characterized by hyphal bronchopneumonia, aerosol amphotericin B (aero-AmB; 1.6 mg/kg given 2 days before infec...

journal_title：Antimicrobial agents and chemotherapy

authors： Schmitt HJ,Bernard EM,Häuser M,Armstrong D

更新日期：1988-11-01 00:00:00

abstract：:To date, the majority of pharmacokinetic/pharmacodynamic (PK/PD) discussions have focused on PK/PD relationships evaluated at steady-state drug concentrations. However, a concern with reliance upon steady-state drug concentrations is that it ignores events occurring while the pathogen is exposed to intermittent subopt...

journal_title：Antimicrobial agents and chemotherapy

authors： Martinez MN,Papich MG,Drusano GL

更新日期：2012-06-01 00:00:00

abstract：:Therapy with nucleoside reverse transcriptase inhibitors (NRTIs) can be associated with mitochondrial toxicity. In vitro studies have been used to predict the predisposition for and characterize the mechanisms causing mitochondrial toxicity. Entecavir (ETV) is an approved deoxyguanosine nucleoside for the treatment of...

journal_title：Antimicrobial agents and chemotherapy

authors： Mazzucco CE,Hamatake RK,Colonno RJ,Tenney DJ

更新日期：2008-02-01 00:00:00

abstract：:Of the 176 randomly selected, commensal, gram-negative bacteria isolated from healthy children with low exposure to antibiotics, 138 (78%) carried one or more of the seven macrolide resistance genes tested in this study. These isolates included 79 (91%) isolates from the oral cavity and 59 (66%) isolates from urine sa...

journal_title：Antimicrobial agents and chemotherapy

authors： Ojo KK,Ulep C,Van Kirk N,Luis H,Bernardo M,Leitao J,Roberts MC

更新日期：2004-09-01 00:00:00

abstract：:Heat shock protein 90 (Hsp90) is an essential chaperone involved in the fungal stress response that can be harnessed as a novel antifungal target for the treatment of invasive aspergillosis. We previously showed that genetic repression of Hsp90 reduced Aspergillus fumigatus virulence and potentiated the effect of the ...

journal_title：Antimicrobial agents and chemotherapy

authors： Lamoth F,Juvvadi PR,Soderblom EJ,Moseley MA,Asfaw YG,Steinbach WJ

更新日期：2014-01-01 00:00:00

abstract：:Using a new rabbit model of methicillin-susceptible Staphylococcus aureus knee prosthesis infection, we compared the efficacies of sparfloxacin (50 mg/kg of body weight subcutaneously, twice a day) and pefloxacin (50 mg/kg subcutaneously, twice a day). A partial knee replacement was performed with a silicone implant f...

journal_title：Antimicrobial agents and chemotherapy

authors： Crémieux AC,Mghir AS,Bleton R,Manteau M,Belmatoug N,Massias L,Garry L,Sales N,Mazière B,Carbon C

更新日期：1996-09-01 00:00:00

abstract：:Receipt of parenteral nutrition (PN) remains an independent risk factor for developing catheter-related bloodstream infections (CR-BSI) caused by fungi, including by the polymorphic fungus Candida albicans, which is notoriously adept at forming drug-resistant biofilm structures. Among a variety of macronutrients, PN s...

journal_title：Antimicrobial agents and chemotherapy

authors： Willems HME,Stultz JS,Coltrane ME,Fortwendel JP,Peters BM

更新日期：2019-10-22 00:00:00

abstract：:The clinical use of the neuraminidase inhibitor (NAI) oseltamivir is associated with the emergence of drug resistance resulting from subtype-specific neuraminidase (NA) mutations. The influenza A/Texas/12/2007 (H3N2) virus isolated from an oseltamivir-treated immunocompromised patient exhibited reduced susceptibility ...

journal_title：Antimicrobial agents and chemotherapy

authors： Okomo-Adhiambo M,Demmler-Harrison GJ,Deyde VM,Sheu TG,Xu X,Klimov AI,Gubareva LV

更新日期：2010-05-01 00:00:00

abstract：:Pairs of 11 antimicrobial agents were tested in vitro for their ability to act synergistically against three strains of Mycobacterium avium complex isolated from patients with acquired immune deficiency syndrome. From the combinations tested, four drugs (ethambutol, rifampin, ciprofloxacin, and erythromycin) were sele...

journal_title：Antimicrobial agents and chemotherapy

authors： Yajko DM,Kirihara J,Sanders C,Nassos P,Hadley WK

更新日期：1988-09-01 00:00:00

abstract：:The site of localization of [(3)H]gentamicin within mouse kidney is shown to be the proximal renal tubule by coincidence of the radioactivity, as visualized by autoradiography, and the mucopolysaccharide-rich microvilli characteristic of proximal convoluted tubules, as visualized by histochemical staining. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Kuhar MJ,Mak LL,Lietman PS

更新日期：1979-01-01 00:00:00

abstract：:Ten penicillinase-producing Neisseria gonorrhoeae (PPNG) strains isolated from 2000 to 2008 were characterized by multilocus sequence typing, multiantigen sequence typing, and plasmid typing. Sequence analysis showed that 8 strains contained a TEM-1 beta-lactamase gene. However, two other genetically distinct PPNG str...

journal_title：Antimicrobial agents and chemotherapy

authors： Ohnishi M,Ono E,Shimuta K,Watanabe H,Okamura N

更新日期：2010-07-01 00:00:00

abstract：:The mechanism of action of quinolones was investigated by use of various DNA gyrases reconstituted from wild-type and mutant GyrA and GyrB proteins of Escherichia coli. The quinolone sensitivities of the DNA supercoiling activity of the gyrases were generally parallel to the quinolone susceptibilities of strains havin...

journal_title：Antimicrobial agents and chemotherapy

authors： Yoshida H,Nakamura M,Bogaki M,Ito H,Kojima T,Hattori H,Nakamura S

更新日期：1993-04-01 00:00:00

abstract：:Two aminocyclitol-negative Micromonospora mutants representing two different species, M. purpurea and M. inyoensis, and blocked at different steps in the biosynthetic pathway were paired and cofermented for the synthesis of antibiotics. The two blocked mutants were incapable of producing antibiotics alone except when ...

journal_title：Antimicrobial agents and chemotherapy

authors： Lee BK,Nagabhushan TL,Condon RG,Cooper AB,Waitz JA

更新日期：1978-07-01 00:00:00