The mef(A) gene predominates among seven macrolide resistance genes identified in gram-negative strains representing 13 genera, isolated from healthy Portuguese children.

abstract：UNLABELLED:Peramivir is an intravenous anti-influenza agent that inhibits viral growth by selectively inhibiting neuraminidase in human influenza A and B viruses. To characterize its pharmacokinetics, a population pharmacokinetic analysis of peramivir was performed using 3,199 plasma concentration data samples from 332...

journal_title：Antimicrobial agents and chemotherapy

authors： Matsuo Y,Ishibashi T,Hollister AS,Wajima T

更新日期：2015-11-01 00:00:00

abstract：:Sixteen clinical fungal isolates were tested for antibiotic susceptibility by using disks impregnated with growth medium and antibiotic. The procedure was easier to perform, less time consuming, and as reliable as other currently available methods. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Boyer JE

更新日期：1976-06-01 00:00:00

abstract：:Despite the availability of new antifungal compounds, invasive aspergillosis carries high morbidity and mortality in hematopoietic stem cell transplant recipients. In vitro studies and animal models suggest that the adoptive transfer of natural killer (NK) cells might be a promising immunotherapeutic option in this se...

journal_title：Antimicrobial agents and chemotherapy

authors： Schmidt S,Schubert R,Tramsen L,Lehrnbecher T

更新日期：2019-01-29 00:00:00

abstract：:Francisella tularensis, a bacterium which causes tularemia in humans, is classified as a CDC category A bioterrorism agent. In this study, we demonstrate that celecoxib, an anti-inflammatory cyclooxygenase-2 inhibitor in clinical use, exhibits activity against a type A strain of F. tularensis (Schu S4), the live vacci...

journal_title：Antimicrobial agents and chemotherapy

authors： Chiu HC,Yang J,Soni S,Kulp SK,Gunn JS,Schlesinger LS,Chen CS

更新日期：2009-07-01 00:00:00

abstract：:Cryptic species of Aspergillus fumigatus, including the Aspergillus viridinutans species complex, are increasingly reported to be causes of invasive aspergillosis. Their identification is clinically relevant, as these species frequently have intrinsic resistance to common antifungals. We evaluated the susceptibilities...

journal_title：Antimicrobial agents and chemotherapy

authors： Lyskova P,Hubka V,Svobodova L,Barrs V,Dhand NK,Yaguchi T,Matsuzawa T,Horie Y,Kolarik M,Dobias R,Hamal P

更新日期：2018-03-27 00:00:00

abstract：:para-Aminosalicylic acid (PAS) remains one of the drugs of last resort for the treatment of tuberculosis, but its mechanism of action is still not completely understood. The main aim of this project was to identify new potential mechanisms of action and resistance to PAS by performing whole-genome sequencing on PAS-re...

journal_title：Antimicrobial agents and chemotherapy

authors： Satta G,Witney AA,Begum N,Ortiz Canseco J,Boa AN,McHugh TD

更新日期：2020-08-20 00:00:00

abstract：:Positive carbon-containing electrodes conveying 5 or more microA of constant direct current per cm2 showed bactericidal activity on intact back skin of 13 human subjects. This effect increased with the duration of stimulation up to a total surface bacterial kill at 20 h. When total current and current density were var...

journal_title：Antimicrobial agents and chemotherapy

authors： Bolton L,Foleno B,Means B,Petrucelli S

更新日期：1980-07-01 00:00:00

abstract：:One hundred thirty nonimmune subjects living in Yaoundé, Cameroon, completed an 18-month prospective study on the efficacy and safety of weekly chloroquine and daily proguanil (chloroguanide) (Ch-P) in malaria prevention. A total of 9 of 78 Ch-P-treated subjects and 26 of 52 subjects who received no prophylaxis contra...

journal_title：Antimicrobial agents and chemotherapy

authors： Gozal D,Hengy C,Fadat G

更新日期：1991-02-01 00:00:00

abstract：:Vulvovaginal candidiasis (VVC) is a global health problem affecting ∼75% of women at least once in their lifetime. Here we examined the epidemiology of VVC in a patient cohort to identify the causative organisms associated with VVC. Biofilm-forming capacity and antifungal sensitivity profiles were also assessed. We re...

journal_title：Antimicrobial agents and chemotherapy

authors： Sherry L,Kean R,McKloud E,O'Donnell LE,Metcalfe R,Jones BL,Ramage G

更新日期：2017-08-24 00:00:00

abstract：:The in vitro susceptibilities of 151 unique clinical isolates of Mycoplasma pneumoniae, Mycoplasma hominis, Mycoplasma fermentans, Mycoplasma genitalium, and Ureaplasma species to DC-159a, an investigational fluoroquinolone, in comparison with those to other agents were determined. Macrolides were the most active agen...

journal_title：Antimicrobial agents and chemotherapy

authors： Waites KB,Crabb DM,Duffy LB

更新日期：2008-10-01 00:00:00

abstract：:Two hundred clinical isolates of Haemophilus influenzae were tested for tolerance (MBC/MIC greater than or equal to 32) to ampicillin and cefotaxime by broth dilution tests. Of 200 strains, 9 were tolerant to ampicillin, and 10 were tolerant to cefotaxime. Tolerant organisms were identified in both systemic and nonsys...

journal_title：Antimicrobial agents and chemotherapy

authors： Bergeron MG,Lavoie GY

更新日期：1985-08-01 00:00:00

abstract：:Pretomanid was approved by the U.S. FDA, via the limited population pathway for antibacterial and antifungal drugs, as part of a three-drug regimen with bedaquiline and linezolid for the treatment of extensively drug-resistant and treatment-intolerant or nonresponsive multidrug-resistant tuberculosis. The recommended ...

journal_title：Antimicrobial agents and chemotherapy

authors： Nedelman JR,Salinger DH,Subramoney V,Woolson R,Wade K,Li M,Everitt D,Mendel CM,Spigelman M

更新日期：2020-12-16 00:00:00

abstract：:Catheters and other indwelling devices placed inside human body are prone to bacterial infection, causing serious risk to patients. Infections associated with implants are difficult to resolve, and hence the prevention of bacterial colonization of such surfaces is quite appropriate. In this context, the development of...

journal_title：Antimicrobial agents and chemotherapy

authors： Dave RN,Joshi HM,Venugopalan VP

更新日期：2011-02-01 00:00:00

abstract：:Exposure of Staphylococcus aureus to cloxacillin at neutral pH rendered the bacteria more susceptible to subsequent lysis by lysostaphin. This sensitization effect also occurred at lower pH levels which were nonpermissive for the bactericidal action of cloxacillin, but the effect disappeared at pH 5.0. These findings ...

journal_title：Antimicrobial agents and chemotherapy

authors： Craven N,Anderson JC

更新日期：1982-04-01 00:00:00

abstract：:The objective of this study was to develop a population pharmacokinetic model and to determine a dosing regimen for caspofungin in critically ill patients. Nine blood samples were drawn per dosing occasion. Fifteen patients with (suspected) invasive candidiasis had one dosing occasion and five had two dosing occasions...

journal_title：Antimicrobial agents and chemotherapy

authors： Märtson AG,van der Elst KCM,Veringa A,Zijlstra JG,Beishuizen A,van der Werf TS,Kosterink JGW,Neely M,Alffenaar JW

更新日期：2020-08-20 00:00:00

abstract：:Receipt of parenteral nutrition (PN) remains an independent risk factor for developing catheter-related bloodstream infections (CR-BSI) caused by fungi, including by the polymorphic fungus Candida albicans, which is notoriously adept at forming drug-resistant biofilm structures. Among a variety of macronutrients, PN s...

journal_title：Antimicrobial agents and chemotherapy

authors： Willems HME,Stultz JS,Coltrane ME,Fortwendel JP,Peters BM

更新日期：2019-10-22 00:00:00

abstract：:Patterns of susceptibility of 45 Proteus penneri clinical isolates to 14 antimicrobial agents were evaluated by a macrobroth dilution method. All strains were highly susceptible to ceftizoxime, ceftazidime, moxalactam, cefoxitin, gentamicin, tobramycin, netilmicin, and, with few exceptions, to amikacin, piperacillin, ...

journal_title：Antimicrobial agents and chemotherapy

authors： Fuksa M,Krajden S,Lee A

更新日期：1984-09-01 00:00:00

abstract：:Mechanism-based inactivators of beta-lactamases are used to overcome the resistance of clinical pathogens to beta-lactam antibiotics. This strategy can itself be overcome by mutations of the beta-lactamase that compromise the effectiveness of their inactivation. We used PCR mutagenesis of the TEM-1 beta-lactamase gene...

journal_title：Antimicrobial agents and chemotherapy

authors： Vakulenko SB,Geryk B,Kotra LP,Mobashery S,Lerner SA

更新日期：1998-07-01 00:00:00

abstract：:The effects of trimethoprim, sulfadiazine, sulfamethoxazole, and sulfathiazole on the hemagglutination and adhesion by three Escherichia coli strains were studied. The strains were isolated from the urine of patients with acute pyelonephritis and carried P antigen-recognizing fimbriae (P fimbriae). At antimicrobial co...

journal_title：Antimicrobial agents and chemotherapy

authors： Väisänen V,Lounatmaa K,Korhonen TK

更新日期：1982-07-01 00:00:00

abstract：:A novel staphylococcal cassette chromosome mec (SCCmec) composite island (SCCmecAI16-SCCczrAI16-CI) was identified in Staphylococcus pseudintermedius. Four integration site sequences for SCC subdivided the 60,734-bp island into 41,232-bp SCCmecAI16, 19,400-bp SCCczrAI16, and 102-bp SCC-likeAI16 elements. SCCmecAI16 re...

journal_title：Antimicrobial agents and chemotherapy

authors： Chanchaithong P,Prapasarakul N,Perreten V,Schwendener S

更新日期：2015-12-07 00:00:00

abstract：:The pharmacokinetics of azlocillin were studied in 10 cystic fibrosis patients, ranging in age from 11 to 28 years. The patients received a 9- to 23-day course of 350 mg of azlocillin per kg in four or six divided daily doses in combination with am aminoglycoside. Blood and urine samples were collected at specified ti...

journal_title：Antimicrobial agents and chemotherapy

authors： Bosso JA,Saxon BA,Herbst JJ,Matsen JM

更新日期：1984-05-01 00:00:00

abstract：:We applied in vitro evolution to an Escherichia coli strain containing bla(CTX-M-2) and obtained 10 independent mutant bla(CTX-M-2) alleles that confer elevated resistance to ceftazidime (MIC > or = 32 microg/ml) but lost the ability to confer resistance to cefepime. All alleles had a Pro-to-Ser substitution at positi...

journal_title：Antimicrobial agents and chemotherapy

authors： Welsh KJ,Barlow M,Tenover FC,Biddle JW,Rasheed JK,Clark LA,McGowan JE Jr

更新日期：2005-03-01 00:00:00

abstract：:Mycobacterium tuberculosis, the causative agent of human tuberculosis (TB), has surpassed HIV/AIDS as the leading cause of death from a single infectious agent. The increasing occurrence of drug-resistant strains has become a major challenge for health care systems and, in some cases, has rendered TB untreatable. Howe...

journal_title：Antimicrobial agents and chemotherapy

authors： Meikle V,Mossberg AK,Mitra A,Hakansson AP,Niederweis M

更新日期：2019-01-29 00:00:00

abstract：:One hundred clinical isolates resistant to ceftazidime and/or cefotaxime were examined for susceptibility to cefepime. The most frequently encountered ceftazidime-cefotaxime-resistant strains belonged to the genera Enterobacter, Pseudomonas, and Citrobacter. Among these strains, 92% were resistant to cefoperazone, 91%...

journal_title：Antimicrobial agents and chemotherapy

authors： Fung-Tomc J,Dougherty TJ,DeOrio FJ,Simich-Jacobson V,Kessler RE

更新日期：1989-04-01 00:00:00

abstract：:Manogepix is a broad-spectrum antifungal agent that inhibits glycosylphosphatidylinositol (GPI) anchor biosynthesis. Using whole-genome sequencing, we characterized two efflux-mediated mechanisms in the fungal pathogens Candida albicans and Candida parapsilosis that resulted in decreased manogepix susceptibility. In C...

journal_title：Antimicrobial agents and chemotherapy

authors： Liston SD,Whitesell L,Kapoor M,Shaw KJ,Cowen LE

更新日期：2020-04-21 00:00:00

abstract：:Malaria is the third most significant cause of infectious disease in the world. The search for new antimalarial chemotherapy has become increasingly urgent due to parasite resistance to classical drugs. Trioxaquines are synthetic hybrid molecules containing a trioxane motif (which is responsible for the antimalarial a...

journal_title：Antimicrobial agents and chemotherapy

authors： Benoit-Vical F,Lelièvre J,Berry A,Deymier C,Dechy-Cabaret O,Cazelles J,Loup C,Robert A,Magnaval JF,Meunier B

更新日期：2007-04-01 00:00:00

abstract：:The objective of this study was to assess the association between previous antibiotic use, particularly long-term prophylaxis, and the occurrence of subsequent resistant infections in children with index infections due to extended-spectrum-cephalosporin-resistant Enterobacteriaceae We also investigated the concordance...

journal_title：Antimicrobial agents and chemotherapy

authors： Das S,Adler AL,Miles-Jay A,Kronman MP,Qin X,Weissman SJ,Burnham CA,Elward A,Newland JG,Selvarangan R,Sullivan KV,Zaoutis T,Zerr DM

更新日期：2017-04-24 00:00:00

abstract：:Win 41258-3 (4-[6-(2-chloro-4-methoxyphenoxy)hexyl]-3,5-diethyl-1H-pyrazole methane sulfonate) has in vitro and in vivo activity against herpes simplex virus types 1 and 2. In cell culture, a concentration of 2 microgram/ml produced a greater than 50% inhibition of plaque formation of herpes simplex virus type 2, and ...

journal_title：Antimicrobial agents and chemotherapy

authors： Pancic F,Steinberg BA,Diana GD,Carabateas PM,Gorman WG,Came PE

更新日期：1981-03-01 00:00:00

abstract：:An automated fluorescence polarization immunoassay for the determination of vancomycin levels in serum was evaluated. The vancomycin assay is a homogeneous competitive inhibition immunoassay based on changes in fluorescence polarization that occur with antibody binding. This assay was compared with a liquid chromatogr...

journal_title：Antimicrobial agents and chemotherapy

authors： Filburn BH,Shull VH,Tempera YM,Dick JD

更新日期：1983-08-01 00:00:00

abstract：:Fungal infections, especially infections caused by Candida albicans, remain a challenging problem in clinical settings. Despite the development of more-effective antifungal drugs, their application is limited for various reasons. Thus, alternative treatments with drugs aimed at novel targets in C. albicans are needed....

journal_title：Antimicrobial agents and chemotherapy

authors： Li X,Hou Y,Yue L,Liu S,Du J,Sun S

更新日期：2015-10-01 00:00:00