A Protein Complex from Human Milk Enhances the Activity of Antibiotics and Drugs against Mycobacterium tuberculosis.

abstract：:The effect of N-alkyl derivatives of saturated heterocyclic amine oxides on the growth and metabolism of microorganisms has been studied. 4-Dodecylmorpholine-N-oxide inhibited the differentiation and growth of Bacillus cereus, of different species of filamentous fungi, and of the yeast Saccharomyces cerevisiae. For ve...

journal_title：Antimicrobial agents and chemotherapy

authors： Subík J,Takácsová G,Psenák M,Devínsky F

更新日期：1977-08-01 00:00:00

abstract：:We examined the cerebrospinal fluid penetration of daptomycin after the addition of dexamethasone and its bactericidal efficacy with and without ceftriaxone in an experimental rabbit model of pneumococcal meningitis. The combination of daptomycin with ceftriaxone was the most efficacious regimen for pneumococcal menin...

journal_title：Antimicrobial agents and chemotherapy

authors： Egermann U,Stanga Z,Ramin A,Acosta F,Stucki A,Gerber P,Cottagnoud M,Cottagnoud P

更新日期：2009-07-01 00:00:00

abstract：:The accumulation of norfloxacin by Bacteroides fragilis NCTC 9343 was determined by the modified fluorescence method. The time required to achieve a steady-state concentration (SSC) after allowing B. fragilis to accumulate norfloxacin in an aerobic or an anaerobic environment was approximately 2 min; the SSC achieved ...

journal_title：Antimicrobial agents and chemotherapy

authors： Ricci V,Piddock LJ

更新日期：2000-09-01 00:00:00

abstract：:A total of 636 vancomycin-resistant Enterococcus faecium (VRE) isolates that had been obtained between 1994 and 1999 from the Medical School Hospital of the University of Michigan, Ann Arbor, were tested for bacteriocin production. Two hundred seventy-seven (44%) of the strains were bacteriocinogenic; and 193 of these...

journal_title：Antimicrobial agents and chemotherapy

authors： Inoue T,Tomita H,Ike Y

更新日期：2006-04-01 00:00:00

abstract：:Persistence of Mycobacterium tuberculosis remains a significant challenge for the effective treatment of tuberculosis in humans. In animals that develop necrotic lung lesions following infection with M. tuberculosis, drug-tolerant bacilli are present and persist in an extracellular microenvironment within the necrotic...

journal_title：Antimicrobial agents and chemotherapy

authors： Driver ER,Ryan GJ,Hoff DR,Irwin SM,Basaraba RJ,Kramnik I,Lenaerts AJ

更新日期：2012-06-01 00:00:00

abstract：:3-Decynoyl-N-acetylcystamine is known to inhibit the in vitro growth of Escherichia coli but not of yeasts or mammalian cells. Neither the free acid nor the 2 positional isomer is active (L. R. Kass, J. Biol. Chem. 243:3223-3228, 1968). Other studies have shown that 2-hexadecynoic acid is fungitoxic whereas most of th...

journal_title：Antimicrobial agents and chemotherapy

authors： Konthikamee W,Gilbertson JR,Langkamp H,Gershon H

更新日期：1982-11-01 00:00:00

abstract：:The frequencies of tetracycline resistance determinants of the classes A, B, C, and D were determined in 53 non-lactose-fermenting clinical isolates. The most frequent class of determinant in Salmonella typhimurium and Shigella flexneri strains was class B; however, the predominant determinant in Shigella sonnei strai...

journal_title：Antimicrobial agents and chemotherapy

authors： Martínez-Salazar JM,Alvarez G,Gómez-Eichelmann MC

更新日期：1986-10-01 00:00:00

abstract：:The activity of penicillin, alone and in combination with sulbactam, against a heterogeneously methicillin-resistant, penicillinase-producing clinical isolate of Staphylococcus aureus and its penicillinase-negative derivative was investigated in vitro and in a rabbit experimental endocarditis model. Penicillin was sig...

journal_title：Antimicrobial agents and chemotherapy

authors： Fantin B,Pierre J,Castéla-Papin N,Saint-Julien L,Drugeon H,Farinotti R,Carbon C

更新日期：1996-05-01 00:00:00

abstract：:Here, we report the isolation of 31 Acinetobacter baumannii strains producing OXA-253 in a single large Brazilian city. These strains belonged to five different sequence types (STs), including 4 STs not previously associated with blaOXA-253 In all strains, the blaOXA-253 gene was located in a plasmid within a genetic ...

journal_title：Antimicrobial agents and chemotherapy

authors： de Sá Cavalcanti FL,Mendes-Marques CL,Vasconcelos CR,de Lima Campos T,Rezende AM,Xavier DE,Leal NC,de-Melo-Neto OP,de Morais MM,Leal-Balbino TC

更新日期：2016-12-27 00:00:00

abstract：:Infection with multiple ganciclovir-resistant human cytomegalovirus mutants, containing different substitutions and deletions in the UL97 gene, was found in a patient with severe combined immunodeficiency (SCID) within 3 weeks of ganciclovir therapy. A novel 11-codon deletion at positions 590 to 600 was identified. Th...

journal_title：Antimicrobial agents and chemotherapy

authors： Wolf DG,Yaniv I,Ashkenazi S,Honigman A

更新日期：2001-02-01 00:00:00

abstract：:The global dissemination and increasing incidence of carbapenem-resistant, Gram-negative organisms have resulted in acute public health concerns. Here, we present a retrospective multicenter study on molecular characterization of metallo-β-lactamase (MBL)-producing clinical Escherichia coli isolates recovered from ext...

journal_title：Antimicrobial agents and chemotherapy

authors： Ranjan A,Shaik S,Mondal A,Nandanwar N,Hussain A,Semmler T,Kumar N,Tiwari SK,Jadhav S,Wieler LH,Ahmed N

更新日期：2016-10-21 00:00:00

abstract：:Among 730 Escherichia coli, 438 Klebsiella pneumoniae, and 141 Proteus mirabilis isolates obtained between September 2000 and September 2001 in seven hospitals in Ho Chi Minh City, Vietnam, 26.6% were resistant to ceftazidime, 30% were resistant to cefotaxime, 31.5% were resistant to ceftriaxone, 15.9% were resistant ...

journal_title：Antimicrobial agents and chemotherapy

authors： Cao V,Lambert T,Nhu DQ,Loan HK,Hoang NK,Arlet G,Courvalin P

更新日期：2002-12-01 00:00:00

abstract：:Penetration of fluconazole into female genital tissues was examined. Fluconazole was administered orally at a dose of 150 mg to patients undergoing total abdominal hysterectomy 1 to 151 h prior to surgery. During surgery, blood, uterus, ovary, and oviduct were sampled. Fluconazole concentrations in each tissue were de...

journal_title：Antimicrobial agents and chemotherapy

authors： Mikamo H,Kawazoe K,Sato Y,Izumi K,Ito T,Ito K,Tamaya T

更新日期：1999-01-01 00:00:00

abstract：:The antimicrobial activities of calcium-deficient apatite loaded with different concentrations (25, 100, and 500 microg/mg) of vancomycin as a filling biomaterial were evaluated in a methicillin-resistant Staphylococcus aureus (MRSA) rabbit acute osteomyelitis model. Bacterial counts in bone, bone marrow, and joint fl...

journal_title：Antimicrobial agents and chemotherapy

authors： Amador G,Gautier H,Le Mabecque V,Miegeville AF,Potel G,Bouler JM,Weiss P,Caillon J,Jacqueline C

更新日期：2010-02-01 00:00:00

abstract：:Spontaneous binding of infected erythrocytes to uninfected erythrocytes to form rosettes is a property of some strains of Plasmodium falciparum that is linked to severe complications of malaria. Curdlan sulfate (CRDS) is a sulfated glycoconjugate compound that is chemically similar to known rosette-inhibiting drugs su...

journal_title：Antimicrobial agents and chemotherapy

authors： Kyriacou HM,Steen KE,Raza A,Arman M,Warimwe G,Bull PC,Havlik I,Rowe JA

更新日期：2007-04-01 00:00:00

abstract：:Bacterial pathogens have specific virulence factors (e.g., toxins) that contribute significantly to the virulence and infectivity of microorganisms within the human hosts. Virulence factors are molecules expressed by pathogens that enable colonization, immunoevasion, and immunosuppression, obtaining nutrients from the...

journal_title：Antimicrobial agents and chemotherapy

authors： Jekle A,Yoon J,Zuck M,Najafi R,Wang L,Shiau T,Francavilla C,Rani SA,Eitzinger C,Nagl M,Anderson M,Debabov D

更新日期：2013-02-01 00:00:00

abstract：:Candida albicans remains the leading causative agent of invasive fungal infection. Although the importance of filamentation in C. albicans pathogenesis has been extensively investigated, in vivo studies to date have been unable to dissect the role of this developmental process in the establishment of infection versus ...

journal_title：Antimicrobial agents and chemotherapy

authors： Saville SP,Lazzell AL,Bryant AP,Fretzen A,Monreal A,Solberg EO,Monteagudo C,Lopez-Ribot JL,Milne GT

更新日期：2006-10-01 00:00:00

abstract：:Racemic 2'-deoxy-3'-thiacytidine (BCH 189) is a dideoxycytidine analog having a sulfur atom in place of the 3' carbon. The enantiomers of BCH 189 have been resolved and found to be equipotent in antiviral activity against human immunodeficiency virus types 1 and 2. However, the (-)-enantiomer (3TC) is considerably les...

journal_title：Antimicrobial agents and chemotherapy

authors： Coates JA,Cammack N,Jenkinson HJ,Mutton IM,Pearson BA,Storer R,Cameron JM,Penn CR

更新日期：1992-01-01 00:00:00

abstract：:Liquid cultures of a Pseudomonas aeruginosa strain in Mueller-Hinton broth diluted at rates higher than the bacterial growth rate showed the expected decrease in CFU only for 1 to 2 h. Later the CFU started to increase. This phenomenon can be explained by a hypothesis that assumes that the bacteria multiply in two dif...

journal_title：Antimicrobial agents and chemotherapy

authors： Haag R,Lexa P,Werkhäuser I

更新日期：1986-05-01 00:00:00

abstract：:Using the techniques of gap misrepair mutagenesis and site-directed mutagenesis, we have generated two novel quinolone resistance mutations of the Escherichia coli DNA gyrase A protein. DNA sequencing showed these mutations to be Ser-83----Ala and Gln-106----Arg. The mutant proteins were overproduced and purified, and...

journal_title：Antimicrobial agents and chemotherapy

authors： Hallett P,Maxwell A

更新日期：1991-02-01 00:00:00

abstract：:It remains controversial whether combination therapy, given empirically or as definitive treatment, for Pseudomonas aeruginosa bacteremia is associated with a better outcome than monotherapy. The aim of the present study was to compare the rates of survival among patients who received either combination therapy or mon...

journal_title：Antimicrobial agents and chemotherapy

authors： Chamot E,Boffi El Amari E,Rohner P,Van Delden C

更新日期：2003-09-01 00:00:00

abstract：:The rabbit kidney cell line LLC-RK1 was tested for its ability to discriminate the toxicities of six cephalosporin antibiotics according to their in vivo nephrotoxic potentials in rabbits. With the exception of cephalothin, which was markedly toxic to kidney cells in vitro, a good correlation between in vitro toxicity...

journal_title：Antimicrobial agents and chemotherapy

authors： Williams PD,Laska DA,Tay LK,Hottendorf GH

更新日期：1988-03-01 00:00:00

abstract：:Histatin 5 (Hst 5) is a salivary human antimicrobial peptide that is toxic to the opportunistic yeast Candida albicans. Fungicidal activity of Hst 5 requires intracellular translocation and accumulation to a threshold concentration for it to disrupt cellular processes. Previously, we observed that total cytosolic leve...

journal_title：Antimicrobial agents and chemotherapy

authors： Li R,Kumar R,Tati S,Puri S,Edgerton M

更新日期：2013-04-01 00:00:00

abstract：:We have studied the interference of roxithromycin with NADPH oxidase, the key enzymatic system for oxidant production by human neutrophils. Roxithromycin alters the reconstitution of an active enzyme and impairs the translocation to the outer membrane of the cytosolic components p47-phox and p67-phox. Interestingly, i...

journal_title：Antimicrobial agents and chemotherapy

authors： Abdelghaffar H,Babin-Chevaye C,Labro MT

更新日期：2005-07-01 00:00:00

abstract：:Violacein is a violet pigment extracted from the gram-negative bacterium Chromobacterium violaceum. It presents bactericidal, tumoricidal, trypanocidal, and antileishmanial activities. We show that micromolar concentrations efficiently killed chloroquine-sensitive and -resistant Plasmodium falciparum strains in vitro;...

journal_title：Antimicrobial agents and chemotherapy

authors： Lopes SC,Blanco YC,Justo GZ,Nogueira PA,Rodrigues FL,Goelnitz U,Wunderlich G,Facchini G,Brocchi M,Duran N,Costa FT

更新日期：2009-05-01 00:00:00

abstract：:Highly active antiretroviral therapy (HAART) involves combination treatment with three or more antiretroviral agents. The antiviral effects of combinations of emtricitabine (FTC) plus tenofovir (TFV) plus antiretroviral agents of all the major drug classes were investigated. Combinations of FTC and TFV with a nonnucle...

journal_title：Antimicrobial agents and chemotherapy

authors： Kulkarni R,Hluhanich R,McColl DM,Miller MD,White KL

更新日期：2014-10-01 00:00:00

abstract：:We found a heterozygous C2857T mutation (R953C) in polymerase gamma (Pol-γ) in an HIV-infected patient with mitochondrial toxicity. The R953C Pol-γ mutant binding affinity for dCTP is 8-fold less than that of the wild type. The R953C mutant shows a 4-fold decrease in discrimination of analog nucleotides relative to th...

journal_title：Antimicrobial agents and chemotherapy

authors： Li M,Mislak AC,Foli Y,Agbosu E,Bose V,Bhandari S,Szymanski MR,Shumate CK,Yin YW,Anderson KS,Paintsil E

更新日期：2016-08-22 00:00:00

abstract：:The mechanism of colistin resistance (Col(r)) in Acinetobacter baumannii was studied by selecting in vitro Col(r) derivatives of the multidrug-resistant A. baumannii isolate AB0057 and the drug-susceptible strain ATCC 17978, using escalating concentrations of colistin in liquid culture. DNA sequencing identified mutat...

journal_title：Antimicrobial agents and chemotherapy

authors： Adams MD,Nickel GC,Bajaksouzian S,Lavender H,Murthy AR,Jacobs MR,Bonomo RA

更新日期：2009-09-01 00:00:00

abstract：:Clostridium difficile causes antibiotic-associated diarrhea and is a major public health concern. Current therapies disrupt the protective intestinal flora, do not reliably prevent recurrent infections, and will be decreasingly effective should less susceptible strains emerge. CRS3123 is an oral agent that inhibits ba...

journal_title：Antimicrobial agents and chemotherapy

authors： Nayak SU,Griffiss JM,Blumer J,O'Riordan MA,Gray W,McKenzie R,Jurao RA,An AT,Le M,Bell SJ,Ochsner UA,Jarvis TC,Janjic N,Zenilman JM

更新日期：2017-07-25 00:00:00

abstract：:S. aureus combats cell wall antibiotic stress by altered gene expression mediated by various environmental signal sensors. In this study, we examined the transcriptional regulation of trfA, a gene related to mecA of Bacillus subtilis encoding an adaptor protein implicated in multiple roles, notably, proteolysis and ge...

journal_title：Antimicrobial agents and chemotherapy

authors： Jousselin A,Kelley WL,Barras C,Lew DP,Renzoni A

更新日期：2013-07-01 00:00:00