Trioxaquines are new antimalarial agents active on all erythrocytic forms, including gametocytes.

abstract：:We identified GRL-1388 and -1398, potent nonpeptidic human immunodeficiency virus type 1 (HIV-1) protease inhibitors (PIs) containing a bicyclic P2 functional moiety, tetrahydropyrano-tetrahydrofuran (Tp-THF). GRL-1388 was as potent as darunavir (DRV) against various drug-resistant HIV-1 laboratory strains with 50% ef...

journal_title：Antimicrobial agents and chemotherapy

authors： Ide K,Aoki M,Amano M,Koh Y,Yedidi RS,Das D,Leschenko S,Chapsal B,Ghosh AK,Mitsuya H

更新日期：2011-04-01 00:00:00

abstract：:Previous studies showed an increased prevalence of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) thumb subdomain polymorphisms Pro272, Arg277, and Thr286 in patients failing therapy with nucleoside analogue combinations. Interestingly, wild-type HIV-1(BH10) RT contains Pro272, Arg277, and Thr2...

journal_title：Antimicrobial agents and chemotherapy

authors： Betancor G,Puertas MC,Nevot M,Garriga C,Martínez MA,Martinez-Picado J,Menéndez-Arias L

更新日期：2010-11-01 00:00:00

abstract：:Hyperbaric oxygen exposures were evaluated for treatment of progressive liver abscesses produced by intraperitoneal injection of combined cultures of Fusobacterium necrophorum plus either Bacteroides fragilis subsp. fragilis or Fusobacterium nucleatum in a mouse model. Infected control and hyperbaric oxygen-exposed mi...

journal_title：Antimicrobial agents and chemotherapy

authors： Hill GB

更新日期：1976-02-01 00:00:00

abstract：:Eighteen patients developed abnormally low serum glutamic oxaloacetic transaminase values during metronidazole therapy. Metronidazole absorbs at 340 nm, simulating reduced nicotinamide adenine dinucleotide, which is the final colorimetric product of the serum glutamic oxaloacetic transaminase assay. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Rissing JP,Newman C,Moore WL Jr

更新日期：1978-10-01 00:00:00

abstract：:To investigate the effects of posaconazole (POS) and amphotericin B (AMB) combination therapy in cryptococcal infection, we established an experimental model of systemic cryptococcosis in CD1 mice by intravenous injection of three distinct clinical isolates of Cryptococcus neoformans. Therapy was started 24 h after th...

journal_title：Antimicrobial agents and chemotherapy

authors： Barchiesi F,Spreghini E,Schimizzi AM,Maracci M,Giannini D,Carle F,Scalise G

更新日期：2004-09-01 00:00:00

abstract：:GS-9160 is a novel and potent inhibitor of human immunodeficiency virus type 1 (HIV-1) integrase (IN) that specifically targets the process of strand transfer. It is an authentic inhibitor of HIV-1 integration, since treatment of infected cells results in an elevation of two-long terminal repeat circles and a decrease...

journal_title：Antimicrobial agents and chemotherapy

authors： Jones GS,Yu F,Zeynalzadegan A,Hesselgesser J,Chen X,Chen J,Jin H,Kim CU,Wright M,Geleziunas R,Tsiang M

更新日期：2009-03-01 00:00:00

abstract：:The anilinouracils (AUs) such as 6-(3-ethyl-4-methylanilino)uracil (EMAU) are a novel class of gram-positive, selective, bactericidal antibacterials which inhibit pol IIIC, the gram-positive-specific replicative DNA polymerase. We have linked various fluoroquinolones (FQs) to the N-3 position of EMAU to generate a var...

journal_title：Antimicrobial agents and chemotherapy

authors： Butler MM,Lamarr WA,Foster KA,Barnes MH,Skow DJ,Lyden PT,Kustigian LM,Zhi C,Brown NC,Wright GE,Bowlin TL

更新日期：2007-01-01 00:00:00

abstract：:Various Pseudomonas aeruginosa PAO1 NfxB mutants were isolated on agar plates containing cefpirome and ofloxacin. They were classified into type A and type B, based on the degrees of changes in their susceptibilities. Type A mutants were four to eight times more resistant to ofloxacin, erythromycin, and new zwitterion...

journal_title：Antimicrobial agents and chemotherapy

authors： Masuda N,Gotoh N,Ohya S,Nishino T

更新日期：1996-04-01 00:00:00

abstract：:The integrase inhibitor raltegravir (RAL) is currently used for the treatment of both treatment-naïve and treatment-experienced HIV-1-infected patients. Elvitegravir (EVG) is in late phases of clinical development. Since significant cross-resistance between RAL and EVG is observed, there is a need for second-generatio...

journal_title：Antimicrobial agents and chemotherapy

authors： Van Wesenbeeck L,Rondelez E,Feyaerts M,Verheyen A,Van der Borght K,Smits V,Cleybergh C,De Wolf H,Van Baelen K,Stuyver LJ

更新日期：2011-01-01 00:00:00

abstract：:Streptomycin binds to the bacterial ribosome and disrupts protein synthesis by promoting misreading of mRNA. Restrictive mutations on the ribosomal subunit protein S12 confer a streptomycin resistance (Strr) phenotype and concomitantly increase the accuracy of the decoding process and decrease the rate of translation....

journal_title：Antimicrobial agents and chemotherapy

authors： Chen C,Blumentritt CA,Curtis MM,Sperandio V,Torres AG,Dudley EG

更新日期：2013-09-01 00:00:00

abstract：:The activities of teicoplanin and vancomycin against 362 coagulase-negative staphylococci were determined by an agar dilution method. At the 4- and 32-micrograms/ml breakpoint levels of the National Committee for Clinical Laboratory Standards, 23.2% of the strains were intermediate and 1.7% were resistant to teicoplan...

journal_title：Antimicrobial agents and chemotherapy

authors： Goldstein FW,Coutrot A,Sieffer A,Acar JF

更新日期：1990-05-01 00:00:00

abstract：:A cluster of genes involved in antibiotic and heavy metal resistance has been characterized from a clinical isolate of the gram-negative bacterium Stenotrophomonas maltophilia. These genes include a macrolide phosphotransferase (mphBM) and a cadmium efflux determinant (cadA), together with the gene cadC coding for its...

journal_title：Antimicrobial agents and chemotherapy

authors： Alonso A,Sanchez P,Martínez JL

更新日期：2000-07-01 00:00:00

abstract：:Two bla(OXA-48)-like-positive isolates (Klebsiella pneumoniae and Enterobacter cloacae) were recovered in Argentina in 2008 as part of a large-scale survey focused on multidrug resistance in Enterobacteriaceae. In both cases, sequencing identified β-lactamase OXA-163, differing from OXA-48 by a single amino substituti...

journal_title：Antimicrobial agents and chemotherapy

authors： Poirel L,Castanheira M,Carrër A,Rodriguez CP,Jones RN,Smayevsky J,Nordmann P

更新日期：2011-06-01 00:00:00

abstract：:The biotransformation of the parenterally effective cephalosporin antibiotic cefamandole nafate (I) has been studied in rats and dogs. After rapid in vivo hydrolysis of the nafate pharmaceutical form to cefamandole (II), the antibiotic was found to be very resistant to metabolic degradation in both species. In dogs, c...

journal_title：Antimicrobial agents and chemotherapy

authors： Sullivan HR,Due SL,Kau DL,Quay JF,Miller WM

更新日期：1977-07-01 00:00:00

abstract：:Extended-infusion ceftolozane-tazobactam treatment at 1.5 g every 8 h was used to treat multidrug-resistant Pseudomonas aeruginosa in a critically ill patient on continuous venovenous hemofiltration. Serum drug concentrations were measured at 1, 4, 5, 6, and 8 h after the start of infusion. Prefilter levels of ceftolo...

journal_title：Antimicrobial agents and chemotherapy

authors： Oliver WD,Heil EL,Gonzales JP,Mehrotra S,Robinett K,Saleeb P,Nicolau DP

更新日期：2015-12-28 00:00:00

abstract：:It was previously found that certain nonnucleoside reverse transcriptase inhibitors (NNRTI) possess virucidal activity against human immunodeficiency virus type 1 (HIV-1), and it was suggested that the tight-binding mode of inhibition of reverse transcriptase might be important for this virucidal activity (Borkow et a...

journal_title：Antimicrobial agents and chemotherapy

authors： Motakis D,Parniak MA

更新日期：2002-06-01 00:00:00

abstract：:An outbreak due to extended-spectrum beta-lactamase-producing Klebsiella pneumoniae (ESBL-KP) was detected from May 1993 to June 1995. A total of 145 patients, particularly patients in intensive care units (ICUs) (107 patients [72%]), were colonized or infected. Infection developed in 92 (63%) patients, and primary ba...

journal_title：Antimicrobial agents and chemotherapy

authors： Peña C,Pujol M,Ardanuy C,Ricart A,Pallares R,Liñares J,Ariza J,Gudiol F

更新日期：1998-01-01 00:00:00

abstract：:Azoles are widely used antifungals; however, their efficacy is compromised by fungistatic activity and selection of resistant strains during treatment. Recent studies demonstrated roles for the protein kinase C and calcium signaling pathways in modulating azole activity. Here we explored a role for the signaling pathw...

journal_title：Antimicrobial agents and chemotherapy

authors： Jain P,Akula I,Edlind T

更新日期：2003-10-01 00:00:00

abstract：:In a retrospective review of 24 patients with histoplasmosis, blastomycosis, or coccidioidomycosis treated with voriconazole (most for salvage therapy), the outcome was favorable (improved or stable) for 22 (95.8%) within 2 months of starting voriconazole and for 20 (83.3%) at the last follow-up. Prospective studies a...

journal_title：Antimicrobial agents and chemotherapy

authors： Freifeld A,Proia L,Andes D,Baddour LM,Blair J,Spellberg B,Arnold S,Lentnek A,Wheat LJ

更新日期：2009-04-01 00:00:00

abstract：:Rift Valley fever virus (RVFV) is an emerging infectious pathogen that causes severe disease in humans and livestock and has the potential for global spread. There are currently no proven safe and effective treatment options for RVFV infection. Inhibition of RNA binding to RVFV nucleocapsid protein (N) represents an a...

journal_title：Antimicrobial agents and chemotherapy

authors： Ellenbecker M,Lanchy JM,Lodmell JS

更新日期：2014-12-01 00:00:00

abstract：:Candida biofilm infections pose an increasing threat in the health care setting due to the drug resistance associated with this lifestyle. Several mechanisms underlie the resistance phenomenon. In Candida albicans, one mechanism involves drug impedance by the biofilm matrix linked to β-1,3 glucan. Here, we show this i...

journal_title：Antimicrobial agents and chemotherapy

authors： Mitchell KF,Taff HT,Cuevas MA,Reinicke EL,Sanchez H,Andes DR

更新日期：2013-04-01 00:00:00

abstract：:Mycobacterium abscessus is an extensively drug-resistant opportunistic pathogen that can cause chronic otomastoiditis. There are no evidence-based treatment regimens for this severe infection. We treated four children with M. abscessus otomastoiditis with a structured regimen of topical imipenem and tigecycline, intra...

journal_title：Antimicrobial agents and chemotherapy

authors： van Wijk F,Waterval J,van Aerde K,Henriet SSV,Meijer FJA,Borra LC,Aarnoutse RE,van Ingen J

更新日期：2019-12-20 00:00:00

abstract：:Rationally designed synthetic inhibitors of retroviral proteases inhibit the processing of viral polyproteins in cultures of human immunodeficiency virus type 1 (HIV-1)-infected T lymphocytes and, as a result, inhibit the infectivity of HIV-1 for such cultures. The ability of HIV-1 protease inhibitors to suppress repl...

journal_title：Antimicrobial agents and chemotherapy

authors： Black PL,Downs MB,Lewis MG,Ussery MA,Dreyer GB,Petteway SR Jr,Lambert DM

更新日期：1993-01-01 00:00:00

abstract：:Meningococcal gyrA gene sequence data, MICs, and mouse infection were used to define the ciprofloxacin breakpoint for Neisseria meningitidis. Residue T91 or D95 of GyrA was altered in all meningococcal isolates with MICs of ≥ 0.064 μg/ml but not among isolates with MICs of ≤ 0.032 μg/ml. Experimental infection of cipr...

journal_title：Antimicrobial agents and chemotherapy

authors： Hong E,Thulin Hedberg S,Abad R,Fazio C,Enríquez R,Deghmane AE,Jolley KA,Stefanelli P,Unemo M,Vazquez JA,Veyrier FJ,Taha MK

更新日期：2013-04-01 00:00:00

abstract：:Prosthetic joint infections remain a major complication of arthroplasty. At present, local and international guidelines recommend cefazolin as a surgical antibiotic prophylaxis at the time of arthroplasty. This retrospective cohort study conducted across 10 hospitals over a 3-year period (January 2006 to December 2008...

journal_title：Antimicrobial agents and chemotherapy

authors： Peel TN,Cheng AC,Buising KL,Choong PF

更新日期：2012-05-01 00:00:00

abstract：:Streptococcus pneumoniae is a leading cause of pneumonia, meningitis, septicemia, and middle ear infections. The incidence of S. pneumoniae isolates that are not susceptible to penicillin has risen worldwide and may be above 20% in some countries. Beta-lactam antibiotic resistance in pneumococci is associated with sig...

journal_title：Antimicrobial agents and chemotherapy

authors： Jensen A,Valdórsson O,Frimodt-Møller N,Hollingshead S,Kilian M

更新日期：2015-01-01 00:00:00

abstract：:A clinical isolate of Pseudomonas aeruginosa recovered from the lower respiratory tract of an 81-year-old patient hospitalized in Belgium was sent to the national reference center to determine its resistance mechanism. PCR sequencing identified a new GES variant, GES-18, which differs from the carbapenem-hydrolyzing e...

journal_title：Antimicrobial agents and chemotherapy

authors： Bebrone C,Bogaerts P,Delbrück H,Bennink S,Kupper MB,Rezende de Castro R,Glupczynski Y,Hoffmann KM

更新日期：2013-01-01 00:00:00

abstract：:In a randomized crossover trial, six volunteers received 200- and 400-mg doses of loracarbef (LY 163892), a new oral cephalosporin. Mean +/- standard error of the mean concentrations in serum obtained after 1.5 and 3 h were 13.2 +/- 2.8 and 4.3 +/- 0.7 mg/liter, respectively, after the 400-mg dose and 6.9 +/- 1.0 and ...

journal_title：Antimicrobial agents and chemotherapy

authors： Van der Auwera P

更新日期：1992-03-01 00:00:00

abstract：:All cells need to protect themselves against the osmotic challenges of their environment by maintaining low permeability to ions across their cell membranes. This is a basic principle of cellular function, which is reflected in the interactions among ion transport and drug efflux genes that have arisen during cellular...

journal_title：Antimicrobial agents and chemotherapy

authors： Cohen BE

更新日期：2014-01-01 00:00:00

abstract：:Chikungunya virus (CHIKV; genus Alphavirus) is the causative agent of chikungunya fever. CHIKV replication can be inhibited by some broad-spectrum antiviral compounds; in contrast, there is very little information about compounds specifically inhibiting the enzymatic activities of CHIKV replication proteins. These pro...

journal_title：Antimicrobial agents and chemotherapy

authors： Das PK,Puusepp L,Varghese FS,Utt A,Ahola T,Kananovich DG,Lopp M,Merits A,Karelson M

更新日期：2016-11-21 00:00:00