Preclinical evaluation of GS-9160, a novel inhibitor of human immunodeficiency virus type 1 integrase.

abstract：:Pyrosequencing was used to detect rapidly and estimate the number of 23S rRNA genes with a G2576T mutation in 43 linezolid-resistant and -susceptible clinical isolates of enterococci. The method showed 100% concordance with PCR-restriction fragment length polymorphism for detecting isolates homozygous for either G2576...

journal_title：Antimicrobial agents and chemotherapy

authors： Sinclair A,Arnold C,Woodford N

更新日期：2003-11-01 00:00:00

abstract：:In vitro interactions of ciprofloxacin with imipenem and amikacin were evaluated by the killing-curve technique against 26 Pseudomonas aeruginosa strains resistant to amikacin and resistant or moderately susceptible to ciprofloxacin and imipenem. Imipenem enhanced killing by ciprofloxacin in tests with 11 strains, whe...

journal_title：Antimicrobial agents and chemotherapy

authors： Giamarellou H,Petrikkos G

更新日期：1987-06-01 00:00:00

abstract：:Intestinal endogenous members of the family Enterobacteriaceae were eliminated in 12 human volunteers treated with 400 or 800 mg of oral norfloxacin per day for 5 days. No clones resistant to quinolone derivatives were isolated. Counts of aerotolerant streptococci were affected to various degrees, depending on their s...

journal_title：Antimicrobial agents and chemotherapy

authors： Pecquet S,Andremont A,Tancrède C

更新日期：1986-06-01 00:00:00

abstract：:The efficacy of voriconazole in 107 patients with scedosporiosis was analyzed. Principal infection sites were the lungs/sinuses (24%), central nervous system (CNS) (20%), and bone (18%), while 21% of patients had disseminated infection. Solid organ transplantation (22%), hematological malignancy (21%), and surgery/tra...

journal_title：Antimicrobial agents and chemotherapy

authors： Troke P,Aguirrebengoa K,Arteaga C,Ellis D,Heath CH,Lutsar I,Rovira M,Nguyen Q,Slavin M,Chen SC,Global Scedosporium Study Group.

更新日期：2008-05-01 00:00:00

abstract：:Replication complexes of hepatitis C virus synthesized two major species of viral RNA in vitro, double stranded and single stranded. NS5B nonnucleoside inhibitors inhibited dose dependently the synthesis of single-stranded RNA but not double-stranded RNA. Moreover, replication complexes carrying a mutation resistant t...

journal_title：Antimicrobial agents and chemotherapy

authors： Yang W,Sun Y,Phadke A,Deshpande M,Huang M

更新日期：2007-01-01 00:00:00

abstract：:Of 3,004 gram-negative bacilli collected from intra-abdominal infections in the Asia-Pacific region during 2007, 42.2% and 35.8% of Escherichia coli and Klebsiella spp., respectively, were extended-spectrum beta-lactamase (ESBL) positive. Moreover ESBL rates in India for E. coli, Klebsiella pneumoniae, and Klebsiella ...

journal_title：Antimicrobial agents and chemotherapy

authors： Hawser SP,Bouchillon SK,Hoban DJ,Badal RE,Hsueh PR,Paterson DL

更新日期：2009-08-01 00:00:00

abstract：:Hepatotoxicity induced by antituberculosis drugs is a serious adverse reaction with significant morbidity and even, rarely, mortality. This form of toxicity potentially impacts the treatment outcome of tuberculosis in some patients. Covering only first-line antituberculosis drugs, this review addresses whether and how...

journal_title：Antimicrobial agents and chemotherapy

authors： Yew WW,Chang KC,Chan DP

更新日期：2018-07-27 00:00:00

abstract：:We evaluated phage therapy in experimental infections due to S242, a fatal neonatal meningitis Escherichia coli strain belonging to the worldwide-distributed O25b:H4-ST131 clone that produces extended-spectrum beta-lactamase CTX-M-15. A lytic phage, EC200(PP), active against S242, was isolated from environmental water...

journal_title：Antimicrobial agents and chemotherapy

authors： Pouillot F,Chomton M,Blois H,Courroux C,Noelig J,Bidet P,Bingen E,Bonacorsi S

更新日期：2012-07-01 00:00:00

abstract：:According to recommendations of the 6th WHO Advisory Committee on Buruli ulcer, directly observed treatment with the combination of rifampin and streptomycin, administered daily for 8 weeks, was recommended to 310 patients diagnosed with Buruli ulcer in Pobè, Bénin. Among the 224 (72%) eligible patients for whom treat...

journal_title：Antimicrobial agents and chemotherapy

authors： Chauty A,Ardant MF,Adeye A,Euverte H,Guédénon A,Johnson C,Aubry J,Nuermberger E,Grosset J

更新日期：2007-11-01 00:00:00

abstract：:The endoperoxides are a new class of antimalarial agents, of which artemisinin (qinghaosu) is the prototype. We have previously shown that artemisinin is capable of alkylating proteins in model reactions. In the present study, we showed that when Plasmodium falciparum-infected erythrocytes are treated with a radiolabe...

journal_title：Antimicrobial agents and chemotherapy

authors： Asawamahasakda W,Ittarat I,Pu YM,Ziffer H,Meshnick SR

更新日期：1994-08-01 00:00:00

abstract：:A practical preclinical model for the hyperbilirubinemia produced by human immunodeficiency virus protease inhibitors has been developed. Indinavir and atazanavir produced significant hyperbilirubinemia, whereas amprenavir, the negative control, was indistinguishable from the ritonavir booster dose. This model was use...

journal_title：Antimicrobial agents and chemotherapy

authors： Kempf DJ,Waring JF,Morfitt DC,Werner P,Ebert B,Mitten M,Nguyen B,Randolph JT,DeGoey DA,Klein LL,Marsh K

更新日期：2006-02-01 00:00:00

abstract：:The objective of these studies was to evaluate the exposures of meropenem and vaborbactam that would produce antibacterial activity and prevent resistance development in carbapenem-resistant Klebsiella pneumoniae carbapenemase (KPC)-producing Enterobacteriaceae strains when tested at an inoculum of 108 CFU/ml. Thirtee...

journal_title：Antimicrobial agents and chemotherapy

authors： Sabet M,Tarazi Z,Rubio-Aparicio D,Nolan TG,Parkinson J,Lomovskaya O,Dudley MN,Griffith DC

更新日期：2018-01-25 00:00:00

abstract：:Two hundred and fifty-seven ampicillin-resistant clinical isolates of Haemophilus influenzae were tested by disk diffusion and MIC determination for susceptibility to aztreonam, imipenem, and amoxycillin combined with clavulanate. The modal MICs and MICs for 50 and 90% of isolates of all three antimicrobial agents for...

journal_title：Antimicrobial agents and chemotherapy

authors： Powell M,Williams JD

更新日期：1987-12-01 00:00:00

abstract：:The enterococcal peptide AS-48 exerts a concentration-dependent bactericidal effect on Enterococcus faecalis subsp. liquefaciens S-47; cell rescue by cardiolipin and trypsin can be effected only in the first few minutes after antibiotic addition. Gramicidin-exposed cells are protected from killing by AS-48. Long-term ...

journal_title：Antimicrobial agents and chemotherapy

authors： Galvez A,Valdivia E,Martinez M,Maqueda M

更新日期：1989-05-01 00:00:00

abstract：:We compared MICs and MBCs of various free- and liposome-incorporated antimicrobial agents against several patient isolates of Mycobacterium avium-M. intracellulare complex and certain American Type Culture Collection strains of M. avium, M. intracellulare, and Mycobacterium tuberculosis. Seven of 19 agents were select...

journal_title：Antimicrobial agents and chemotherapy

authors： Mehta RT,Keyhani A,McQueen TJ,Rosenbaum B,Rolston KV,Tarrand JJ

更新日期：1993-12-01 00:00:00

abstract：:The Michaelis-Menten inhibitory constants (Kis) and the concentrations required for 50% inhibition of the Plasmodium falciparum dihydropteroate synthetase were determined for six sulfa drugs. These drugs inhibited the in vitro growth of P. falciparum (50% lethal concentration) at concentrations of 30 to 500 nM; these ...

journal_title：Antimicrobial agents and chemotherapy

authors： Zhang Y,Meshnick SR

更新日期：1991-02-01 00:00:00

abstract：:Methicillin-resistant Staphylococcus aureus (MRSA) has acquired the mecA gene encoding a peptidoglycan transpeptidase, penicillin binding protein 2a (PBP2a), which has decreased affinity for β-lactams. Quickly spreading and highly virulent community-acquired (CA) MRSA strains recently emerged as a frequent cause of in...

journal_title：Antimicrobial agents and chemotherapy

authors： Bæk KT,Gründling A,Mogensen RG,Thøgersen L,Petersen A,Paulander W,Frees D

更新日期：2014-08-01 00:00:00

abstract：:A comparison was made of the in vitro activity of ciprofloxacin (Bay o 9867) with nine other antibiotics against isolates of Campylobacter jejuni, Salmonella spp., Shigella spp., Yersinia enterocolitica, Clostridium difficile, Vibrio spp., and Escherichia coli. Minimum inhibitory concentrations of ciprofloxacin were t...

journal_title：Antimicrobial agents and chemotherapy

authors： Goodman LJ,Fliegelman RM,Trenholme GM,Kaplan RL

更新日期：1984-04-01 00:00:00

abstract：:The antiviral effects of selenazofurin (2-beta-D-ribofuranosylselenazole-4-carboxamide, selenazole), ribavirin (1-beta-D-ribofuranosyl-1,2,4-triazole-3-carboxamide), and 3-deazaguanosine (6-amino-1-beta-D-ribofuranosylimidazo-[4.5-C]pyridin-4(5H)-one) were investigated separately and in various combinations in an in v...

journal_title：Antimicrobial agents and chemotherapy

authors： Kirsi JJ,McKernan PA,Burns NJ 3rd,North JA,Murray BK,Robins RK

更新日期：1984-10-01 00:00:00

abstract：:Eight unrelated clinical Acinetobacter baumannii isolates resistant to all commonly used antibiotics were subjected to three-dimensional checkerboard microtiter plate dilution and time-kill studies at one-fourth of their MICs of polymyxin B, imipenem, and rifampin. Synergy was demonstrated with combinations of polymyx...

journal_title：Antimicrobial agents and chemotherapy

authors： Yoon J,Urban C,Terzian C,Mariano N,Rahal JJ

更新日期：2004-03-01 00:00:00

abstract：:3-O-(3',3'-Dimethylsuccinyl) betulinic acid (DSB), also known as PA-457, bevirimat (BVM), or MPC-4326, is a novel HIV-1 maturation inhibitor. Unlike protease inhibitors, BVM blocks the cleavage of the Gag capsid precursor (CA-SP1) to mature capsid (CA) protein, resulting in the release of immature, noninfectious viral...

journal_title：Antimicrobial agents and chemotherapy

authors： Lu W,Salzwedel K,Wang D,Chakravarty S,Freed EO,Wild CT,Li F

更新日期：2011-07-01 00:00:00

abstract：:The effect of antichagasic benznidazole (BZL; 100 mg/kg body weight/day, 3 consecutive days, intraperitoneally) on biotransformation systems and ABC transporters was evaluated in rats. Expression of cytochrome P-450 (CYP3A), UDP-glucuronosyltransferase (UGT1A), glutathione S-transferases (alpha glutathione S-transfera...

journal_title：Antimicrobial agents and chemotherapy

authors： Perdomo VG,Rigalli JP,Villanueva SS,Ruiz ML,Luquita MG,Echenique CG,Catania VA

更新日期：2013-10-01 00:00:00

abstract：:A beta-lactamase was purified from Serratia marcescens GN16694; it hydrolyzed T-5575 and oxime-type cephalosporins, i.e., cefuroxime and ceftazidime. Its isoelectric point and molecular weight were 8.6 and 42,000, respectively. This enzyme was not inhibited by EDTA and clavulanic acid. This enzyme is an unusual beta-l...

journal_title：Antimicrobial agents and chemotherapy

authors： Matsumura N,Mitsuhashi S

更新日期：1995-09-01 00:00:00

abstract：:A new commercial low-density microarray which identifies common extended-spectrum β-lactamase plasmid-mediated cephalosporinase genes, as well as carbapenemase (bla(KPC) and bla(NDM)) genes, was evaluated. We tested 207 clinical and reference/collection isolates of the Enterobacteriaceae possessing different bla genes...

journal_title：Antimicrobial agents and chemotherapy

authors： Bogaerts P,Hujer AM,Naas T,de Castro RR,Endimiani A,Nordmann P,Glupczynski Y,Bonomo RA

更新日期：2011-09-01 00:00:00

abstract：:Mycobacterium avium complex (MAC) causes serious opportunistic infections in AIDS patients. Previous studies with MAC-infected beige mice have indicated that weekly administration of liposome-encapsulated streptomycin can reduce significantly the CFU in the liver and spleen. We examined whether streptomycin encapsulat...

journal_title：Antimicrobial agents and chemotherapy

authors： Gangadharam PR,Ashtekar DR,Flasher DL,Düzgüneş N

更新日期：1995-03-01 00:00:00

abstract：:Clinical isolates of the Bacteroides melaninogenicus and Bacteroides fragilis groups were tested for in vitro and in vivo susceptibility to penicillin, clindamycin, and metronidazole, used singly or in combination with gentamicin. The in vitro tests consisted of determinations of minimal inhibitory concentrations (MIC...

journal_title：Antimicrobial agents and chemotherapy

authors： Brook I,Coolbaugh JC,Walker RI,Weiss E

更新日期：1984-01-01 00:00:00

abstract：:Foscarnet (phosphonoformic acid) is a pyrophosphate analog that inhibits the replication of human immunodeficiency virus type 1 (HIV-1) in vitro and in patients with AIDS. HIV-1 resistance to foscarnet has not been reported despite long-term foscarnet therapy of AIDS patients with cytomegalovirus disease. We therefore...

journal_title：Antimicrobial agents and chemotherapy

authors： Mellors JW,Bazmi HZ,Schinazi RF,Roy BM,Hsiou Y,Arnold E,Weir J,Mayers DL

更新日期：1995-05-01 00:00:00

abstract：:The metabolic fate of the orally effective cephalosporin antibiotic cefaclor (Lilly 99638) has been studied in rats, mice, and dogs. Cefaclor is efficiently absorbed from the gastrointestinal tract as the intact antibiotic. In rats and mice, cefaclor, for the most part, escapes metabolism in the body and is eliminated...

journal_title：Antimicrobial agents and chemotherapy

authors： Sullivan HR,Due SL,Kau DL,Quay JF,Miller W

更新日期：1976-10-01 00:00:00

abstract：:The efficacy of a 5-day treatment with coumermycin A1 (hereafter referred to as coumermycin) (at three dosage regimens), with ciprofloxacin, or with coumermycin plus ciprofloxacin was tested in experimental aortic valve endocarditis induced in rats by a strain of methicillin-susceptible Staphylococcus aureus and was c...

journal_title：Antimicrobial agents and chemotherapy

authors： Perronne CM,Malinverni R,Glauser MP

更新日期：1987-04-01 00:00:00

abstract：:We evaluated the in vitro activities of anidulafungin, micafungin, and caspofungin against Candida krusei by determining MIC and minimum fungicidal concentration (MFC) measurements and by the time-kill method. The geometric mean (GM)-MIC/GM-MFC values were 0.1/0.34, 0.25/0.44, and 1/2.29, respectively. The mean times ...

journal_title：Antimicrobial agents and chemotherapy

authors： Cantón E,Pemán J,Valentín A,Espinel-Ingroff A,Gobernado M

更新日期：2009-07-01 00:00:00