Activity of Simulated Human Dosage Regimens of Meropenem and Vaborbactam against Carbapenem-Resistant Enterobacteriaceae in an In Vitro Hollow-Fiber Model.

abstract：:Cell-free amino acid incorporation using ribosomes from strains of either Clostridium perfringens or Bacteroides fragilis was shown to be susceptible to inhibition by streptomycin and gentamicin. Ribosomes bound dihydrostreptomycin as effectively as ribosomes from Escherichia coli. No inactivation of streptomycin or g...

journal_title：Antimicrobial agents and chemotherapy

authors： Bryan LE,Kowand SK,Van Den Elzen HM

更新日期：1979-01-01 00:00:00

abstract：:The present study examined the efficacy of using multiple mechanisms as part of a topical microbicide to inactivate herpes simplex virus (HSV) by combining theaflavin-3,3'-digallate (TF-3) and lactic acid (LA) over the pH range of 4.0 to 5.7 to mimic conditions in the female reproductive tract. Six clinical isolates o...

journal_title：Antimicrobial agents and chemotherapy

authors： Isaacs CE,Xu W

更新日期：2013-08-01 00:00:00

abstract：:We previously showed that the mouse inorganic phosphate transporter Npt1 operates in the hepatic sinusoidal membrane transport of anionic drugs such as benzylpenicillin and mevalonic acid. In the present study, the mechanism of renal secretion of penem antibiotics was examined by using a Xenopus oocyte expression syst...

journal_title：Antimicrobial agents and chemotherapy

authors： Uchino H,Tamai I,Yabuuchi H,China K,Miyamoto K,Takeda E,Tsuji A

更新日期：2000-03-01 00:00:00

abstract：:The recent widespread emergence of carbapenem resistance in Enterobacteriaceae is a major public health concern, as carbapenems are a therapy of last resort against this family of common bacterial pathogens. Resistance genes can mobilize via various mechanisms, including conjugation and transposition; however, the imp...

journal_title：Antimicrobial agents and chemotherapy

authors： Sheppard AE,Stoesser N,Wilson DJ,Sebra R,Kasarskis A,Anson LW,Giess A,Pankhurst LJ,Vaughan A,Grim CJ,Cox HL,Yeh AJ,Modernising Medical Microbiology (MMM) Informatics Group.,Sifri CD,Walker AS,Peto TE,Crook DW,Mathers AJ

更新日期：2016-05-23 00:00:00

abstract：:This report presents a fluorescent carboxyfluorescein diacetate (CFDA)-modified microdilution method used for the susceptibility testing of Candida albicans to amphotericin B, fluconazole, ketoconazole, itraconazole, voriconazole, and flucytosine. Four different broth microdilution susceptibility testing methods were ...

journal_title：Antimicrobial agents and chemotherapy

authors： Liao RS,Rennie RP,Talbot JA

更新日期：2002-10-01 00:00:00

abstract：:PCR was used to amplify a 238-bp region from Helicobacter pylori which corresponded to the quinolone resistance-determining region in Escherichia coli. The gyrA gene of H. pylori was cloned and sequenced. An open reading frame of 2,478 nucleotides coded for a polypeptide of 826 amino acids with a calculated molecular ...

journal_title：Antimicrobial agents and chemotherapy

authors： Moore RA,Beckthold B,Wong S,Kureishi A,Bryan LE

更新日期：1995-01-01 00:00:00

abstract：:Daptomycin is a lipopeptide antibiotic with activity against gram-positive bacteria, including Staphylococcus aureus. We defined the pharmacodynamic parameters that determine the activity of daptomycin for S. aureus using in vitro methods and the Craig (W. A. Craig, J. Redington, and S. C. Ebert, J. Antimicrob. Chemot...

journal_title：Antimicrobial agents and chemotherapy

authors： Louie A,Kaw P,Liu W,Jumbe N,Miller MH,Drusano GL

更新日期：2001-03-01 00:00:00

abstract：:Mefloquine is widely used in combination with artemisinin derivatives for the treatment of falciparum malaria. Mefloquine resistance in Plasmodium falciparum has been related to increased copy numbers of multidrug-resistant gene 1 (pfmdr1). We studied the ex vivo dynamics of pfmdr1 gene amplification in culture-adapte...

journal_title：Antimicrobial agents and chemotherapy

authors： Preechapornkul P,Imwong M,Chotivanich K,Pongtavornpinyo W,Dondorp AM,Day NP,White NJ,Pukrittayakamee S

更新日期：2009-04-01 00:00:00

abstract：:VT-1161 and VT-1598 are promising investigational tetrazole antifungals that have shown in vitro and in vivo activity against Candida and other fungi. Candida glabrata is a problematic opportunistic pathogen that is associated with high mortality in invasive infection, as well as both intrinsic and rapidly acquired an...

journal_title：Antimicrobial agents and chemotherapy

authors： Nishimoto AT,Whaley SG,Wiederhold NP,Zhang Q,Yates CM,Hoekstra WJ,Schotzinger RJ,Garvey EP,Rogers PD

更新日期：2019-09-23 00:00:00

abstract：:We used the Tn10-encoded Tet repressor, which has a highly specific binding capacity for tetracycline, to probe contacts between the drug and protein by chemical interference studies of the antibiotic. For that purpose, the equilibrium association constants of modified tetracyclines with the Tet repressor and Mg2+ cat...

journal_title：Antimicrobial agents and chemotherapy

authors： Degenkolb J,Takahashi M,Ellestad GA,Hillen W

更新日期：1991-08-01 00:00:00

abstract：:The beta-lactamases in 154 clinical Mycobacterium tuberculosis strains were studied. Susceptibilities to beta-lactam antibiotics, their combination with clavulanate (2:1), and two fluoroquinolones were determined in 24 M. tuberculosis strains susceptible to antimycobacterial drugs and in nine multiresistant strains. A...

journal_title：Antimicrobial agents and chemotherapy

authors： Segura C,Salvadó M,Collado I,Chaves J,Coira A

更新日期：1998-06-01 00:00:00

abstract：:Sch 22591 (5-episisomicin), gentamicin, sisomicin, and tobramycin were compared for their ability to protect mice from lethal intraperitoneal challenge with 12 Pseudomonas strains, all susceptible to each of the aminoglycosides (minimal inhibitory concentrations and minimal bactericidal concentrations were

journal_title：Antimicrobial agents and chemotherapy

authors： Goering RV,Sanders CC,Sanders WE Jr

更新日期：1978-12-01 00:00:00

abstract：:Mutants with multiple low-level antibiotic resistance were isolated from virulent wild-type Aeromonas salmonicida strains exposed to a low concentration of any one of several low-molecular-mass (approximately 635 daltons or less) antibiotics. Multiple resistance was toward beta-lactam compounds (penicillin G, ampicill...

journal_title：Antimicrobial agents and chemotherapy

authors： Wood SC,McCashion RN,Lynch WH

更新日期：1986-06-01 00:00:00

abstract：:Rezafungin (CD101) is a novel echinocandin under development for once-weekly intravenous (i.v.) dosing. We evaluated the pharmacodynamics (PD) of rezafungin against 4 Candida tropicalis and 4 Candida dubliniensis strains, using the neutropenic mouse invasive candidiasis model. The area under the concentration-time cur...

journal_title：Antimicrobial agents and chemotherapy

authors： Lepak AJ,Zhao M,Andes DR

更新日期：2019-10-22 00:00:00

abstract：:Routine in vitro screening of a new synthetic series of 3,5-substituted 2-methylisoxazolidines revealed that three imidazole analogs (PR 967-248, PR 967-234, and PR 969-566) and, to a lesser extent, a triazole analog (PR 988-399) exerted rather potent antifungal activity against three systemic and four dermatophytic c...

journal_title：Antimicrobial agents and chemotherapy

authors： Palmer GC,Ordy MJ,Simmons RD,Strand JC,Radov LA,Mullen GB,Kinsolving CR,St Georgiev V,Mitchell JT,Allen SD

更新日期：1989-06-01 00:00:00

abstract：:Here, we report twoEnterobacter cloacaesequence type 231 isolates coproducing KPC-3 and NDM-1 that have caused lethal infections in a tertiary hospital in China. TheblaNDM-1-harboring plasmids carry IncA/C2and IncR replicons, showing a mosaic plasmid structure, and theblaNDM-1is harbored on a novel class I integron-li...

journal_title：Antimicrobial agents and chemotherapy

authors： Du H,Chen L,Chavda KD,Pandey R,Zhang H,Xie X,Tang YW,Kreiswirth BN

更新日期：2016-03-25 00:00:00

abstract：:Propolis, a resinous bee product, has been shown to inhibit the growth of oral microorganisms and the activity of bacterium-derived glucosyltransferases (GTFs). Several compounds, mainly polyphenolics, have been identified in this natural product. The present study evaluated the effects of distinct chemical groups fou...

journal_title：Antimicrobial agents and chemotherapy

authors： Koo H,Rosalen PL,Cury JA,Park YK,Bowen WH

更新日期：2002-05-01 00:00:00

abstract：:Protoplasts of the temperature-sensitive osmotic-1 mutant of Neurospora crassa grew and divided as cell wall-less cells when incubated under certain conditions at 37 degrees C. Each protoplast regenerated cell wall and formed a mycelium when the temperature was shifted to 22 degrees C. Cell wall regeneration, but not ...

journal_title：Antimicrobial agents and chemotherapy

authors： Selitrennikoff CP

更新日期：1983-05-01 00:00:00

abstract：:Gentamicin was successfully incorporated into neutral, anionic, and cationic liposomes, and the percentage of gentamicin incorporated was found to be a function of lipid concentration. Gentamicin did not leak out of the liposomes over a 3-week period at 4 degrees C. When liposome-associated gentamicin was administered...

journal_title：Antimicrobial agents and chemotherapy

authors： Morgan JR,Williams KE

更新日期：1980-04-01 00:00:00

abstract：:Current procedures for obtaining and measuring plasma concentrations of HIV protease inhibitors (PIs) are technically challenging. Dried blood spot (DBS) assays offer a way to overcome many of the obstacles. We sought to develop a DBS assay for quantitation of the PI atazanavir (ATV) and to compare this method with a ...

journal_title：Antimicrobial agents and chemotherapy

authors： Van Schooneveld T,Swindells S,Nelson SR,Robbins BL,Moore R,Fletcher CV

更新日期：2010-10-01 00:00:00

abstract：:The aim of this study was to investigate the variability of the voriconazole plasma level and its relationships with clinical outcomes and adverse events among liver transplant recipients to optimize the efficacy and safety of their treatment. Liver transplant recipients treated with voriconazole were included, and vo...

journal_title：Antimicrobial agents and chemotherapy

authors： Hashemizadeh Z,Badiee P,Malekhoseini SA,Raeisi Shahraki H,Geramizadeh B,Montaseri H

更新日期：2017-11-22 00:00:00

abstract：:Hypocrellins A and B were evaluated for in vitro antimicrobial and antileishmanial activities. Hypocrellin A exhibited promising activity against Candida albicans and moderate activity against Staphylococcus aureus, methicillin-resistant S. aureus, Pseudomonas aeruginosa, and Mycobacterium intracellulare. Hypocrellin ...

journal_title：Antimicrobial agents and chemotherapy

authors： Ma G,Khan SI,Jacob MR,Tekwani BL,Li Z,Pasco DS,Walker LA,Khan IA

更新日期：2004-11-01 00:00:00

abstract：:In vivo antiherpesvirus effects of 1-beta-D-arabinofuranosyl-E-5-(2-bromovinyl)uracil (brovavir) were tested in two mouse model infections with herpes simplex virus type 1 (HSV-1) strains which showed different degrees of virulence in mice. Successful efficacies of oral and intraperitoneal (i.p.) treatments with brova...

journal_title：Antimicrobial agents and chemotherapy

authors： Machida H,Takezawa J

更新日期：1990-05-01 00:00:00

abstract：:The biosynthetic gene cluster of lankamycin (LM), a 14-member macrolide antibiotic, is encoded on the 210-kb linear plasmid pSLA2-L in Streptomyces rochei 7434AN4. LM contains a 3-hydroxy-2-butyl group at the C-13 position, which is different from an ethyl group in erythromycin. The following two possibilities could b...

journal_title：Antimicrobial agents and chemotherapy

authors： Arakawa K,Kodama K,Tatsuno S,Ide S,Kinashi H

更新日期：2006-06-01 00:00:00

abstract：:Acanthamoeba keratitis is a severe ocular infection secondary to accidental macro- or microscopic trauma of the cornea. Starting in 1985, a dramatic increase of this infection was recorded along with the spread of contact lens use. This protozoal disease is difficult to treat because of the scarcity of efficacious top...

journal_title：Antimicrobial agents and chemotherapy

authors： Gatti S,Cevini C,Bruno A,Penso G,Rama P,Scaglia M

更新日期：1998-09-01 00:00:00

abstract：:Time-kill studies were used to examine the in vitro activities of penicillin G, RP 59500, erythromycin, ciprofloxacin, sparfloxacin, and vancomycin against 10 pneumococci expressing various degrees of susceptibility to penicillin and erythromycin. RP 59500 MICs for all strains were 0.5 to 2.0 micrograms/ml, while eryt...

journal_title：Antimicrobial agents and chemotherapy

authors： Pankuch GA,Jacobs MR,Appelbaum PC

更新日期：1994-09-01 00:00:00

abstract：:The pharmacokinetics of gentamicin in 34 febrile neutropenic patients (40 courses) were compared with those in 40 nonneutropenic patients receiving the drug. No pharmacokinetic differences were seen in half-life, volume of distribution (liter per kilogram; total and ideal body weight), or clearance (milliliter per min...

journal_title：Antimicrobial agents and chemotherapy

authors： Bianco TM,Dwyer PN,Bertino JS Jr

更新日期：1989-11-01 00:00:00

abstract：:This study was undertaken to investigate biochemical, genetic, and epidemiological aspects of resistance to aminoglycoside antibiotics among 650 consecutive isolates of Pseudomonas aeruginosa from Parkland Memorial Hospital, Dallas, Tex. In 364 strains, minimal inhibitory concentrations were 25 mug/ml or greater for g...

journal_title：Antimicrobial agents and chemotherapy

authors： Holmes RK,Minshew BH,Gould IK,Sanford JP

更新日期：1974-09-01 00:00:00

abstract：:Ribavirin (RBV) is a broad-spectrum antiviral agent that inhibits the production of infectious Hantaan virus (HTNV). Although the mechanism of action of RBV against HTNV is not understood, RBV is metabolized in human cells to both RBV-5'-monophosphate, which inhibits IMP dehydrogenase, resulting in a decrease in intra...

journal_title：Antimicrobial agents and chemotherapy

authors： Sun Y,Chung DH,Chu YK,Jonsson CB,Parker WB

更新日期：2007-01-01 00:00:00

abstract：:A series of twelve recently synthesized 6-substituted derivatives of 9-beta-d-ribofuranosylpurine 3',5'-cyclic phosphate (RPcMP) were evaluated for in vitro antiviral activity, using inhibition of viral cytopathogenic effect as the primary parameter for evaluation. Inhibition of the development of intra- and extracell...

journal_title：Antimicrobial agents and chemotherapy

authors： Sidwell RW,Huffman JH,Allen LB,Meyer RB Jr,Shuman DA,Simon LN,Robins RK

更新日期：1974-06-01 00:00:00