Comparative evaluation of a new fluorescent carboxyfluorescein diacetate-modified microdilution method for antifungal susceptibility testing of Candida albicans isolates.

abstract：:Clarithromycin is compared with clindamycin for single-dose prophylaxis of streptococcal endocarditis in rats. Human-like kinetics of the two antibiotics prevented endocarditis in animals challenged with both small and large amounts of bacterial inocula. Clarithromycin was marginally superior to clindamycin against sm...

journal_title：Antimicrobial agents and chemotherapy

authors： Vermot D,Entenza JM,Vouillamoz J,Glauser MP,Moreillon P

更新日期：1996-03-01 00:00:00

abstract：:The mechanism of action of the fungicidal peptide auristatin PHE was investigated in Cryptococcus neoformans. Since auristatin PHE causes budding arrest in C. neoformans (T. Woyke, G. R. Pettit, G. Winkelmann, and R. K. Pettit, Antimicrob. Agents Chemother. 45:3580-3584, 2001), microtubule integrity and nuclear locali...

journal_title：Antimicrobial agents and chemotherapy

authors： Woyke T,Roberson RW,Pettit GR,Winkelmann G,Pettit RK

更新日期：2002-12-01 00:00:00

abstract：:The accumulation of norfloxacin by Bacteroides fragilis NCTC 9343 was determined by the modified fluorescence method. The time required to achieve a steady-state concentration (SSC) after allowing B. fragilis to accumulate norfloxacin in an aerobic or an anaerobic environment was approximately 2 min; the SSC achieved ...

journal_title：Antimicrobial agents and chemotherapy

authors： Ricci V,Piddock LJ

更新日期：2000-09-01 00:00:00

abstract：:NorC, a new efflux pump, like NorB, contributes to quinolone resistance that includes resistance to moxifloxacin and sparfloxacin in Staphylococcus aureus. norC expression, like that of norB and tet38, is negatively regulated by MgrA, and overexpression of both norC and norB contributes to the quinolone resistance phe...

journal_title：Antimicrobial agents and chemotherapy

authors： Truong-Bolduc QC,Strahilevitz J,Hooper DC

更新日期：2006-03-01 00:00:00

abstract：:Bacteria require at least one pathway to rescue ribosomes stalled at the ends of mRNAs. The primary pathway for ribosome rescue is trans-translation, which is conserved in >99% of sequenced bacterial genomes. Some species also have backup systems, such as ArfA or ArfB, which can rescue ribosomes in the absence of suff...

journal_title：Antimicrobial agents and chemotherapy

authors： Goralski TD,Dewan KK,Alumasa JN,Avanzato V,Place DE,Markley RL,Katkere B,Rabadi SM,Bakshi CS,Keiler KC,Kirimanjeswara GS

更新日期：2016-05-23 00:00:00

abstract：:All known DNA ligases catalyze the formation of a phosphodiester linkage between adjacent termini in double-stranded DNA via very similar mechanisms. The ligase family can, however, be divided into two classes: eubacterial ligases, which require NAD(+) as a cofactor, and other ligases, from viruses, archaea, and eukar...

journal_title：Antimicrobial agents and chemotherapy

authors： Ciarrocchi G,MacPhee DG,Deady LW,Tilley L

更新日期：1999-11-01 00:00:00

abstract：:Clinical isolates of Trichomonas vaginalis were obtained from women consecutively enrolled in a study of partner notification. Testing of susceptibility to metronidazole and tinidazole was performed. Resistance to metronidazole and tinidazole was present in 17/178 (9.6%) and 1/178 (0.56%) strains, respectively. In vit...

journal_title：Antimicrobial agents and chemotherapy

authors： Schwebke JR,Barrientes FJ

更新日期：2006-12-01 00:00:00

abstract：:Cytochrome aa3 concentrations in the cytoplasmic membrane of Bacillus subtilis were altered by growth conditions, and the effects on the membrane potential (delta psi) in whole cells were measured. When cytochrome aa3 was absent, the magnitude of delta psi was not diminished by comparison with the delta psi measured i...

journal_title：Antimicrobial agents and chemotherapy

authors： Arrow AS,Taber HW

更新日期：1986-01-01 00:00:00

abstract：:A total of 4,226 Spanish clinical isolates of Candida spp. were analyzed to assess resistance to voriconazole according to breakpoints established by the European Committee for Antimicrobial Susceptibility Testing (where susceptibility [S] to voriconazole corresponds to a MIC of ≤ 0.12 mg/liter). Resistance was uncomm...

journal_title：Antimicrobial agents and chemotherapy

authors： Cuenca-Estrella M,Gomez-Lopez A,Cuesta I,Zaragoza O,Mellado E,Rodriguez-Tudela JL,Antifungal Subcommittee of European Committee on Antimicrobial Susceptibility Testing.

更新日期：2011-04-01 00:00:00

abstract：:Significant increases in the MIC(90)s of linezolid in multidrug-resistant Mycobacterium tuberculosis isolates were seen between the baseline period of 2001 to 2003 (0.5 microg/ml) and 2004 (2 microg/ml). The MICs were 4 microg/ml in three strains. Both fluoroquinolones (except levofloxacin) and kanamycin were found to...

journal_title：Antimicrobial agents and chemotherapy

authors： Huang TS,Liu YC,Sy CL,Chen YS,Tu HZ,Chen BC

更新日期：2008-06-01 00:00:00

abstract：:The efficacy of intravenous peramivir against influenza A (H1N1) 2009 virus infection was evaluated in mice in which the immune system was suppressed by cyclophosphamide (CP) treatment. The mortality rate of the vehicle control group was 100%, and the mice lost 20% of their body weight on average by day 13 postinfecti...

journal_title：Antimicrobial agents and chemotherapy

authors： Kitano M,Kodama M,Itoh Y,Kanazu T,Kobayashi M,Yoshida R,Sato A

更新日期：2013-05-01 00:00:00

abstract：:ACH-702, a novel isothiazoloquinolone (ITQ), was assessed for antibacterial activity against a panel of Gram-positive and Gram-negative clinical isolates and found to possess broad-spectrum activity, especially against antibiotic-resistant Gram-positive strains, including methicillin-resistant Staphylococcus aureus (M...

journal_title：Antimicrobial agents and chemotherapy

authors： Pucci MJ,Podos SD,Thanassi JA,Leggio MJ,Bradbury BJ,Deshpande M

更新日期：2011-06-01 00:00:00

abstract：:Toxoplasma gondii and Cryptosporidium parvum, members of the phylum Apicomplexa, are significant pathogens of both humans and animals worldwide for which new and effective therapeutics are needed. Here we describe the activity of the antibiotic boromycin against Toxoplasma and Cryptosporidium Boromycin potently inhibi...

journal_title：Antimicrobial agents and chemotherapy

authors： Abenoja J,Cotto-Rosario A,O'Connor R

更新日期：2021-01-19 00:00:00

abstract：:Colistin is increasingly used as a salvage therapy for nosocomial infections caused by multidrug-resistant Gram-negative bacteria such as Pseudomonas aeruginosa and Acinetobacter baumannii. However, the available pharmacokinetic (PK) data for colistin are limited to guide dosing. The aim of this study was to develop a...

journal_title：Antimicrobial agents and chemotherapy

authors： Lee J,Han S,Jeon S,Hong T,Song W,Woo H,Yim DS

更新日期：2013-05-01 00:00:00

abstract：:The activities of cefotaxime, moxalactam, MK 0787 (N-formimidoyl thienamycin), ampicillin, oxacillin, vancomycin, and clindamycin were compared against gram-positive cocci. MK 0787 was the most active and moxalactam was the least active of these drugs, except against methicillin-resistant Staphylococcus aureus, where ...

journal_title：Antimicrobial agents and chemotherapy

authors： Cherubin CE,Corrado ML,Sierra MF,Gombert ME,Shulman M

更新日期：1981-10-01 00:00:00

abstract：:An in situ method for sensitive detection of differences in the action of chlorhexidine against subpopulations of cells in Candida albicans biofilms is described. Detection relies on monitoring the kinetics of propidium iodide (PI) penetration into the cytoplasm of individual cells during dosing with chlorhexidine. Ac...

journal_title：Antimicrobial agents and chemotherapy

authors： Suci PA,Tyler BJ

更新日期：2002-11-01 00:00:00

abstract：:The 54-kDa outer membrane protein (designated OprJ) of a norfloxacin-resistant nfxB mutant of Pseudomonas aeruginosa PAO1 was purified by ion-exchange high-performance liquid chromatography. Mobility of OprJ in sodium dodecyl sulfate-polyacrylamide gel electrophoresis was not affected by reduction and heating. A murin...

journal_title：Antimicrobial agents and chemotherapy

authors： Hosaka M,Gotoh N,Nishino T

更新日期：1995-08-01 00:00:00

abstract：:Production of a Klebsiella pneumoniae carbapenemase (KPC) is the most common mechanism of carbapenem resistance in the United States; however, until now, KPC-producing isolates have not been found in western Michigan. Molecular typing of two KPC-producing K. pneumoniae isolates from Michigan showed their similarity to...

journal_title：Antimicrobial agents and chemotherapy

authors： Kitchel B,Sundin DR,Patel JB

更新日期：2009-10-01 00:00:00

abstract：:Shiga toxin (Stx)-producing Escherichia coli (STEC) causes hemorrhagic colitis and hemolytic-uremic syndrome (HUS). The rates of STEC infection and complications, including death, are highest among young children and elderly individuals. There are no causal therapies. Because Stx is the primary pathological agent lead...

journal_title：Antimicrobial agents and chemotherapy

authors： Bitzan M,Poole R,Mehran M,Sicard E,Brockus C,Thuning-Roberson C,Rivière M

更新日期：2009-07-01 00:00:00

abstract：:A Staphylococcus aureus surveillance program was initiated in the United States to examine the in vitro activity of ceftaroline and epidemiologic trends. Susceptibility testing by Clinical and Laboratory Standards Institute broth microdilution was performed on 4,210 clinically significant isolates collected in 2009 fr...

journal_title：Antimicrobial agents and chemotherapy

authors： Richter SS,Heilmann KP,Dohrn CL,Riahi F,Costello AJ,Kroeger JS,Biek D,Critchley IA,Diekema DJ,Doern GV

更新日期：2011-09-01 00:00:00

abstract：:Clostridium difficile is a major nosocomial pathogen responsible for pseudomembranous colitis and many cases of antibiotic-associated diarrhea. Because of potential relapse of disease with current antimicrobial therapy protocols, there is a need for additional and/or alternative antimicrobial agents for the treatment ...

journal_title：Antimicrobial agents and chemotherapy

authors： Mahony DE,Lim-Morrison S,Bryden L,Faulkner G,Hoffman PS,Agocs L,Briand GG,Burford N,Maguire H

更新日期：1999-03-01 00:00:00

abstract：:The current recommendations for intravenous (i.v.) acyclovir dosing in obese patients suggest using ideal body weight (IBW) rather than total body weight (TBW). To our knowledge, no pharmacokinetic analysis has validated this recommendation. This single-dose pharmacokinetic study was conducted in an inpatient oncology...

journal_title：Antimicrobial agents and chemotherapy

authors： Turner RB,Cumpston A,Sweet M,Briggs F,Slain D,Wen S,Craig M,Hamadani M,Petros W

更新日期：2016-01-11 00:00:00

abstract：:Attenuated activity of echinocandin antifungals at high concentrations, known as the "paradoxical effect," is a well-established phenomenon in Candida albicans and Aspergillus fumigatus. In the yeast C. albicans, upregulation of chitin biosynthesis via the protein kinase C (PKC), high-osmolarity glycerol response (HOG...

journal_title：Antimicrobial agents and chemotherapy

authors： Fortwendel JR,Juvvadi PR,Perfect BZ,Rogg LE,Perfect JR,Steinbach WJ

更新日期：2010-04-01 00:00:00

abstract：:The clinical use of the neuraminidase inhibitor (NAI) oseltamivir is associated with the emergence of drug resistance resulting from subtype-specific neuraminidase (NA) mutations. The influenza A/Texas/12/2007 (H3N2) virus isolated from an oseltamivir-treated immunocompromised patient exhibited reduced susceptibility ...

journal_title：Antimicrobial agents and chemotherapy

authors： Okomo-Adhiambo M,Demmler-Harrison GJ,Deyde VM,Sheu TG,Xu X,Klimov AI,Gubareva LV

更新日期：2010-05-01 00:00:00

abstract：:Cryptosporidium parvum arginine aminopeptidase (RAP) was studied during in vitro excystation. Specific RAP inhibitors were identified by using C. parvum extracts. Amastatin, a series of alpha-aminoboronic acids, and the chelating agents EDTA and 1,10-phenanthrolene, but not endoproteinase inhibitors, blocked enzymatic...

journal_title：Antimicrobial agents and chemotherapy

authors： Okhuysen PC,Chappell CL,Kettner C,Sterling CR

更新日期：1996-12-01 00:00:00

abstract：:The effect of four macrolides against intracellular Toxoplasma gondii was determined in three different in vitro systems. Unactivated murine peritoneal macrophages were infected with the virulent RH strain of T. gondii. The activity of the macrolides was first measured with [3H]uracil, which is incorporated by the par...

journal_title：Antimicrobial agents and chemotherapy

authors： Chang HR,Pechère JC

更新日期：1988-04-01 00:00:00

abstract：:A new procedure for determining the susceptibility of Treponema pallidum subsp. pallidum to antimicrobial agents was developed, utilizing a tissue culture system which promotes the in vitro multiplication of this organism. In the absence of antibiotics, T. pallidum (Nichols virulent strain) multiplied an average of 10...

journal_title：Antimicrobial agents and chemotherapy

authors： Norris SJ,Edmondson DG

更新日期：1988-01-01 00:00:00

abstract：:Arylimidamides (AIAs) have been shown to have considerable biological activity against intracellular pathogens, includingTrypanosoma cruzi, which causes Chagas disease. In the present study, the activities of 12 novel bis-AIAs and 2 mono-AIAs against different strains ofT. cruziin vitroandin vivowere analyzed. The mos...

journal_title：Antimicrobial agents and chemotherapy

authors： Guedes-da-Silva FH,Batista DG,Meuser MB,Demarque KC,Fulco TO,Araújo JS,Da Silva PB,Da Silva CF,Patrick DA,Bakunova SM,Bakunov SA,Tidwell RR,Oliveira GM,Britto C,Moreira OC,Soeiro MN

更新日期：2016-03-25 00:00:00

abstract：:Study of the antimicrobial spectrum of valinomycin revealed that, in addition to the gram-positive bacteria reported in literature, Streptococcus pyogenes and Clostridium sporogenes are also susceptible to this antibiotic. The minimal inhibitory concentrations (MIC) of the antibiotic for S. pyogenes grown aerobically ...

journal_title：Antimicrobial agents and chemotherapy

authors： Seshachalam D,Frahm DH,Ferraro FM

更新日期：1973-01-01 00:00:00

abstract：:Viridans group streptococci (VGS) are part of the normal flora that may cause bacteremia, often leading to endocarditis. We evaluated daptomycin against four clinical strains of VGS (MICs = 1 or 2 μg/ml) using an in vitro-simulated endocardial vegetation model, a simulated bacteremia model, and kill curves. Daptomycin...

journal_title：Antimicrobial agents and chemotherapy

authors： Akins RL,Katz BD,Monahan C,Alexander D

更新日期：2015-04-01 00:00:00