Boromycin has potent anti-Toxoplasma and anti-Cryptosporidium activity.

abstract：:Two optically active (100% enantiomeric excess) isomers of ofloxacin [(+/-)-ofloxacin; DL-8280; (+/-)-9-fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-7 H-pyrido[1,2,3-de] [1,4] benzoxazine-6-carboxylic acid] were prepared by use of their optically resolved synthetic intermediates. One of the isomers, (...

journal_title：Antimicrobial agents and chemotherapy

authors： Hayakawa I,Atarashi S,Yokohama S,Imamura M,Sakano K,Furukawa M

更新日期：1986-01-01 00:00:00

abstract：:Osteoarticular mucormycosis cases are quite rare and challenging infections that are mostly due to direct inoculation during traumatic injury among immunocompetent patients. Classic management includes a combination of aggressive surgical debridement, which may lead to amputation, and long-term systemic liposomal amph...

journal_title：Antimicrobial agents and chemotherapy

authors： Parize P,Mamez AC,Garcia-Hermoso D,Dumaine V,Poirée S,Kauffmann-Lacroix C,Jullien V,Lortholary O,Lanternier F

更新日期：2018-12-21 00:00:00

abstract：:Omadacycline is an effective therapy for community-acquired bacterial pneumonia (CABP). Given its potent activity against methicillin-susceptible Staphylococcus aureus (MSSA) and methicillin-resistant S. aureus (MRSA), we sought to determine the pharmacodynamic activity and target pharmacokinetic/pharmacodynamic (PK/P...

journal_title：Antimicrobial agents and chemotherapy

authors： Lepak AJ,Zhao M,Marchillo K,VanHecker J,Andes DR

更新日期：2020-01-27 00:00:00

abstract：:Agar and broth microdilution MICs of RP 74501-RP 74502, a mixture of streptogramin antimicrobial agents that inhibited 90% of 22 Legionella strains tested, were 0.64 and 0.08 microgram/ml, respectively; respective erythromycin values were 1.0 and 0.12 microgram/ml. RP 74501-RP 74502 at 1 microgram/ml was more active t...

journal_title：Antimicrobial agents and chemotherapy

authors： Edelstein PH,Edelstein MA

更新日期：1993-04-01 00:00:00

abstract：:A Staphylococcus aureus surveillance program was initiated in the United States to examine the in vitro activity of ceftaroline and epidemiologic trends. Susceptibility testing by Clinical and Laboratory Standards Institute broth microdilution was performed on 4,210 clinically significant isolates collected in 2009 fr...

journal_title：Antimicrobial agents and chemotherapy

authors： Richter SS,Heilmann KP,Dohrn CL,Riahi F,Costello AJ,Kroeger JS,Biek D,Critchley IA,Diekema DJ,Doern GV

更新日期：2011-09-01 00:00:00

abstract：:An increase in the incidence of rare but hard-to-treat invasive fungal pathogens as well as resistance to the currently available antifungal drugs calls for new broad-spectrum antifungals with a novel mechanism of action. Here we report the identification and characterization of two novel zinc-attenuating compounds, Z...

journal_title：Antimicrobial agents and chemotherapy

authors： Cohrt KAO,Marín L,Kjellerup L,Clausen JD,Dalby-Brown W,Calera JA,Winther AL

更新日期：2018-04-26 00:00:00

abstract：:As an obligate aerobe, Mycobacterium tuberculosis uses its electron transport chain (ETC) to produce energy via oxidative phosphorylation. This pathway has recently garnered a lot of attention and is a target for several new antimycobacterials. We tested the respiratory adaptation of M. tuberculosis to phenoxyalkylben...

journal_title：Antimicrobial agents and chemotherapy

authors： Berube BJ,Parish T

更新日期：2017-12-21 00:00:00

abstract：:In 24 patients with hepatitic C virus (HCV) infection who participated in a randomized trial with alpha 2B interferon, HCV RNA analysis by the polymerase chain reaction with two separate primer sets was performed at weeks 0, 4, and 24 and during a follow-up period of 6 to 9 months. Prior to therapy all patients were H...

journal_title：Antimicrobial agents and chemotherapy

authors： Kleter GE,Brouwer JT,Heijtink RA,Schalm SW,Quint WG

更新日期：1993-03-01 00:00:00

abstract：:Actithiazic acid and alpha-methyldethiobiotin inhibited the conversion of dethiobiotin to biotin resting-cell suspensions of Escherichia coli. The concentrations which effected 50% inhibition were 0.45 and 1.1 microM for actithiazic acid and alpha-methyldethiobiotin, respectively. Cells grown in low concentrations of ...

journal_title：Antimicrobial agents and chemotherapy

authors： Eisenberg MA,Hsiung SC

更新日期：1982-01-01 00:00:00

abstract：:To determine whether low concentrations of aminoglycosides in combination with penicillin could effectively kill enterococci in vitro, we tested penicillin (20 micrograms/ml) in combination with decreasing concentrations of either streptomycin (20, 10, 5, and 1 micrograms/ml) or gentamicin (5, 3, 1, and 0.5 micrograms...

journal_title：Antimicrobial agents and chemotherapy

authors： Matsumoto JY,Wilson WR,Wright AJ,Geraci JE,Washington JA 2nd

更新日期：1980-12-01 00:00:00

abstract：:Pharmacokinetic parameters were calculated from intravenous data based upon a two-compartment open model. These parameters were subsequently used to determine the absorption rates and bioavailability of cephradine administered intramuscularly and orally. The results indicate that cephradine obeys dose-independent kine...

journal_title：Antimicrobial agents and chemotherapy

authors： Rattie ES,Bernardo PD,Ravin JJ

更新日期：1976-08-01 00:00:00

abstract：:Lamivudine [beta-L-(-)-2',3'-dideoxy-3'-thiacytidine] is a potent inhibitor of hepadnavirus replication and is used both to treat chronic hepatitis B virus (HBV) infections and to prevent reinfection of transplanted livers. Unfortunately, lamivudine-resistant HBV variants do arise during prolonged therapy, indicating ...

journal_title：Antimicrobial agents and chemotherapy

authors： Walters KA,Tipples GA,Allen MI,Condreay LD,Addison WR,Tyrrell L

更新日期：2003-06-01 00:00:00

abstract：:The participation of trypanothione in clinical and experimental antimony (Sb) resistance in Leishmania panamensis was examined by using specific inhibitors. Buthionine sulfoximine (BSO) significantly reversed the resistance to trivalent Sb (Sb(III)) of promastigotes of experimentally derived Sb-resistant lines, suppor...

journal_title：Antimicrobial agents and chemotherapy

authors： Goyeneche-Patino DA,Valderrama L,Walker J,Saravia NG

更新日期：2008-12-01 00:00:00

abstract：:An a priori pharmacokinetic/pharmacodynamic (PK/PD) target of 40% daily time above the MIC (T >MIC; based on the MIC(90) of 0.06 microg/ml for Streptococcus pyogenes reported in the literature) was shown to be achievable in a phase 1 study of 23 children with a once-daily (QD) modified-release, multiparticulate formul...

journal_title：Antimicrobial agents and chemotherapy

authors： Pichichero ME,Casey JR,Block SL,Guttendorf R,Flanner H,Markowitz D,Clausen S

更新日期：2008-07-01 00:00:00

abstract：:The in vitro activity of HSR-903, an oral quinolone, against 196 recent clinical isolates of respiratory pathogens was evaluated. HSR-903 was 2 to 32 times more active than ofloxacin, ciprofloxacin, and sparfloxacin against Staphylococcus aureus, including methicillin-resistant strains, and Streptococcus pneumoniae an...

journal_title：Antimicrobial agents and chemotherapy

authors： Watanabe A,Tokue Y,Takahashi H,Kikuchi T,Kobayashi T,Gomi K,Fujimura S,Nukiwa T

更新日期：1999-07-01 00:00:00

abstract：:The purpose of this work was to evaluate the in vitro possibilities of ampicillin-ceftriaxone combinations for 10 Enterococcus faecalis strains with high-level resistance to aminoglycosides (HLRAg) and to assess the efficacy of ampicillin plus ceftriaxone, both administered with humanlike pharmacokinetics, for the tre...

journal_title：Antimicrobial agents and chemotherapy

authors： Gavaldà J,Torres C,Tenorio C,López P,Zaragoza M,Capdevila JA,Almirante B,Ruiz F,Borrell N,Gomis X,Pigrau C,Baquero F,Pahissa A

更新日期：1999-03-01 00:00:00

abstract：:We recently reported the chromosomal location of the staphylococcal beta-lactamase gene in four strains of Enterococcus faecalis. Transfer of this gene from strain CH19 to an enterococcal recipient was accompanied by transfer of numerous other antimicrobial resistance determinants in the absence of detectable plasmid ...

journal_title：Antimicrobial agents and chemotherapy

authors： Rice LB,Marshall SH

更新日期：1992-09-01 00:00:00

abstract：:To determine whether rifampin reduces concentrations of trimethoprim (TMP) and sulfamethoxazole (SMX) in serum of human immunodeficiency virus (HIV)-infected persons, levels of these agents were determined by high-performance liquid chromatography before and after more than 12 days of standard antituberculosis treatme...

journal_title：Antimicrobial agents and chemotherapy

authors： Ribera E,Pou L,Fernandez-Sola A,Campos F,Lopez RM,Ocaña I,Ruiz I,Pahissa A

更新日期：2001-11-01 00:00:00

abstract：:Topical blockade of the gp41 fusogenic protein of HIV-1 is one possible strategy by which microbicides could prevent HIV transmission, working early against infection, by inhibiting viral entry into host cells. In this study, we examined the potential of gp41 fusion inhibitors (FIs) as candidate anti-HIV microbicides....

journal_title：Antimicrobial agents and chemotherapy

authors： Harman S,Herrera C,Armanasco N,Nuttall J,Shattock RJ

更新日期：2012-05-01 00:00:00

abstract：:The emergence of resistance to antimicrobial agents within the salmonellas is a worldwide and severe problem. A case of treatment failure due to the emergence of resistance to ceftriaxone in Salmonella enterica serotype Anatum was studied. S. enterica serotype Anatum and Escherichia coli, both of which are susceptible...

journal_title：Antimicrobial agents and chemotherapy

authors： Su LH,Chiu CH,Chu C,Wang MH,Chia JH,Wu TL

更新日期：2003-02-01 00:00:00

abstract：:Mengo virus double-stranded ribonucleic acid (dsRNA) was obtained on a semi-industrial scale from infected cultures of BHK-21 cells grown in suspension. Yield of the extraction and purification operations was small (about 22 mg from 10(11) cells in a 100-liter culture). Physicochemical characterization of this dsRNA g...

journal_title：Antimicrobial agents and chemotherapy

authors： Falcoff E,Falcoff R,Cherby J,Florent J,Lunel J,Ninet L,De Ratuld Y,Tissier R,Vuillemin B,Werner GH

更新日期：1973-05-01 00:00:00

abstract：:Data on the effectiveness of ceftazidime-avibactam (CAZ-AVI) in critically ill, mechanically ventilated patients are limited. The present retrospective observational cohort study, which was conducted in two general intensive care units (ICUs) in central Greece, compared critically ill, mechanically ventilated patients...

journal_title：Antimicrobial agents and chemotherapy

authors： Tsolaki V,Mantzarlis K,Mpakalis A,Malli E,Tsimpoukas F,Tsirogianni A,Papagiannitsis C,Zygoulis P,Papadonta ME,Petinaki E,Makris D,Zakynthinos E

更新日期：2020-02-21 00:00:00

abstract：:Mycobacterium tuberculosis and the fast-growing species Mycobacterium abscessus are two important human pathogens causing persistent pulmonary infections that are difficult to cure and require long treatment times. The emergence of drug-resistant M. tuberculosis strains and the high level of intrinsic resistance of M....

journal_title：Antimicrobial agents and chemotherapy

authors： Gupta R,Rodrigues Felix C,Akerman MP,Akerman KJ,Slabber CA,Wang W,Adams J,Shaw LN,Tse-Dinh YC,Munro OQ,Rohde KH

更新日期：2018-04-26 00:00:00

abstract：:Echinocandins are recommended as the first-line drugs for the treatment of systemic candidiasis. Cas5 is a key transcription factor involved in the response to cell wall damage induced by echinocandins. In this study, through a genetic screen, we identified a second transcription factor, Efg1, that is also crucial for...

journal_title：Antimicrobial agents and chemotherapy

authors： Xiong K,Su C,Sun Q,Lu Y

更新日期：2021-01-20 00:00:00

abstract：:Ampicillin-resistant Enterococcus faecium (ARE) and vancomycin-resistant E. faecium (VRE) are important nosocomial pathogens. We quantified effects of probiotics and antibiotics on intestinal acquisition of ARE colonization in patients hospitalized in two non-intensive care unit (non-ICU) wards with high ARE prevalenc...

journal_title：Antimicrobial agents and chemotherapy

authors： de Regt MJ,Willems RJ,Hené RJ,Siersema PD,Verhaar HJ,Hopmans TE,Bonten MJ

更新日期：2010-07-01 00:00:00

abstract：:This study evaluated the pulmonary disposition of eravacycline in 20 healthy adult volunteers receiving 1.0 mg of eravacycline/kg intravenously every 12 h for a total of seven doses over 4 days. Plasma samples were collected at 0, 1, 2, 4, 6, and 12 h on day 4, with each subject randomized to undergo a single bronchoa...

journal_title：Antimicrobial agents and chemotherapy

authors： Connors KP,Housman ST,Pope JS,Russomanno J,Salerno E,Shore E,Redican S,Nicolau DP

更新日期：2014-01-01 00:00:00

abstract：:Lividomycin specifically inhibited bacterial protein synthesis and had codon misreading activity. Lividomycin, moreover, stimulated the binding of aminoacyl-transfer ribonucleic acid to ribosomes, but did not show any significant effects on the formation of aminoacyl-transfer ribonucleic acid and the puromycin reactio...

journal_title：Antimicrobial agents and chemotherapy

authors： Yamaguchi M,Eda J,Kobayashi F,Mitsuhashi S

更新日期：1973-09-01 00:00:00

abstract：:The outer membrane permeability to meropenem and imipenem in Escherichia coli K-12 was investigated, and its porin-deficient mutants were transformed with a constructed vector carrying the carbapenem-hydrolyzing CphA metallo-beta-lactamase gene. By using the method of Zimmermann and Rosselet, meropenem was shown to pe...

journal_title：Antimicrobial agents and chemotherapy

authors： Cornaglia G,Guan L,Fontana R,Satta G

更新日期：1992-09-01 00:00:00

abstract：:The in vitro susceptibility of 406 clinical isolates to BMY-28142, a new semisynthetic cephem, was evaluated and compared with cefpimizole, HR 810, ceftazidime, cefotaxime, moxalactam, and cefoperazone in a broth microdilution assay. On a weight basis, the activity of BMY-28142 against Escherichia coli, Proteus specie...

journal_title：Antimicrobial agents and chemotherapy

authors： Tsuji A,Maniatis A,Bertram MA,Young LS

更新日期：1985-04-01 00:00:00

abstract：:The resistance of Mycobacterium tuberculosis to isoniazid (INH) is largely linked to suppression of a catalase-peroxidase enzyme (KatG) that activates INH. In the absence of KatG, antioxidant protection is provided by enhanced expression of the peroxiredoxin AhpC, which is itself reduced by AhpD, a protein with low al...

journal_title：Antimicrobial agents and chemotherapy

authors： Koshkin A,Zhou XT,Kraus CN,Brenner JM,Bandyopadhyay P,Kuntz ID,Barry CE 3rd,Ortiz de Montellano PR

更新日期：2004-07-01 00:00:00