Susceptibility of gram-positive cocci to various antibiotics, including cefotaxime, moxalactam, and N-formimidoyl thienamycin.

abstract：:Condensins play a key role in the global organization of bacterial chromosomes. In Escherichia coli, the inactivation of its sole condensin MukBEF induces severe growth defects and renders cells hypersusceptible to novobiocin. We report here that this hypersusceptibility can be observed in TolC-deficient cells and is ...

journal_title：Antimicrobial agents and chemotherapy

authors： Petrushenko ZM,Zhao H,Zgurskaya HI,Rybenkov VV

更新日期：2016-04-22 00:00:00

abstract：:The in vitro activity of PD 127,391, a dihalogenated quinolone, was compared with those of ofloxacin, ciprofloxacin, nalidixic acid, gentamicin, and cefuroxime against 525 recent isolates and well-characterized antimicrobial agent-resistant strains. The MICs of PD 127,391 against 90% of members of the family Enterobac...

journal_title：Antimicrobial agents and chemotherapy

authors： Wise R,Ashby JP,Andrews JM

更新日期：1988-08-01 00:00:00

abstract：:We report on the cloning of the gene smeT, which encodes the transcriptional regulator of the Stenotrophomonas maltophilia efflux pump SmeDEF. SmeT belongs to the TetR and AcrR family of transcriptional regulators. The smeT gene is located upstream from the structural operon of the pump genes smeDEF and is divergently...

journal_title：Antimicrobial agents and chemotherapy

authors： Sánchez P,Alonso A,Martinez JL

更新日期：2002-11-01 00:00:00

abstract：:Kill-kinetic methods were used to provide data on the bactericidal activity of subinhibitory (0.5x MIC), inhibitory (1x MIC), and suprainhibitory (4x MIC) concentrations of LY146032 against methicillin-susceptible and -resistant Staphylococcus aureus and Staphylococcus epidermidis. These bactericidal activities were c...

journal_title：Antimicrobial agents and chemotherapy

authors： Stratton CW,Liu C,Weeks LS

更新日期：1987-08-01 00:00:00

abstract：:By means of a stepwise selection procedure, mutants capable of growing in the presence of relatively high multiplicities of a bacteriocin from Streptococcus mutans GS-5 were obtained from a sensitivie strain of Streptococcus pyogenes. Mutacin-neutralizing activity of cell extracts containing receptor protein was exami...

journal_title：Antimicrobial agents and chemotherapy

authors： Franker CK

更新日期：1980-02-01 00:00:00

abstract：:The outcome of Helicobacter pylori infection was analyzed in 114 dyspeptic patients treated with triple-drug therapy including clarithromycin. Clarithromycin resistance (in 20.2% of our isolates) was mainly caused by an A2142G mutation in the 23S rRNA gene of H. pylori. H. pylori eradication was obtained in all patien...

journal_title：Antimicrobial agents and chemotherapy

authors： Lee JH,Shin JH,Roe IH,Sohn SG,Lee JH,Kang GH,Lee HK,Jeong BC,Lee SH

更新日期：2005-04-01 00:00:00

abstract：:A "plasmid-curing effect" of multiresistant Escherichia coli by flavophospholipol, an antibiotic used as an antimicrobial growth promoter (AMGP) in animal feeds, has been reported to occur in vitro and in vivo under experimental conditions. In this study, the effect of flavophospholipol under field conditions was stud...

journal_title：Antimicrobial agents and chemotherapy

authors： van den Bogaard AE,Hazen M,Hoyer M,Oostenbach P,Stobberingh EE

更新日期：2002-01-01 00:00:00

abstract：:The effect of monocytopenia and granulocytopenia on the outgrowth of Staphylococcus aureus as well as on antibiotic efficacy was studied in an experimental thigh infection in mice. Pretreatment with etoposide reduced monocyte numbers in blood to 14% and those of granulocytes to 54% at the time of infection. Monocytope...

journal_title：Antimicrobial agents and chemotherapy

authors： Calame W,van der Waals R,Mattie H,van Furth R

更新日期：1989-06-01 00:00:00

abstract：:LpxC [UDP-3-O-(R-3-hydroxymyristoyl)-GlcNAc deacetylase] is a metalloamidase that catalyzes the first committed step in the biosynthesis of the lipid A component of lipopolysaccharide. A previous study (H. R. Onishi, B. A. Pelak, L. S. Gerckens, L. L. Silver, F. M. Kahan, M. H. Chen, A. A. Patchett, S. M. Galloway, S....

journal_title：Antimicrobial agents and chemotherapy

authors： Mdluli KE,Witte PR,Kline T,Barb AW,Erwin AL,Mansfield BE,McClerren AL,Pirrung MC,Tumey LN,Warrener P,Raetz CR,Stover CK

更新日期：2006-06-01 00:00:00

abstract：:Poly(DL-lactide-co-glycolide) (PLG) microparticles were developed as carriers for isoniazid and rifampin in order to improve compliance of tuberculous chemotherapy. Antitubercular drugs encapsulated in PLG polymers and injected in a single dose subcutaneously resulted in a sustained release (up to 6 weeks) of drugs in...

journal_title：Antimicrobial agents and chemotherapy

authors： Dutt M,Khuller GK

更新日期：2001-01-01 00:00:00

abstract：:Mutations in liaFSR, a three-component regulatory system controlling cell-envelope stress response, were recently linked with the emergence of daptomycin (DAP) resistance in enterococci. Our previous work showed that a liaF mutation increased the DAP MIC of a vancomycin-resistant Enterococcus faecalis strain from 1 to...

journal_title：Antimicrobial agents and chemotherapy

authors： Munita JM,Panesso D,Diaz L,Tran TT,Reyes J,Wanger A,Murray BE,Arias CA

更新日期：2012-08-01 00:00:00

abstract：:This study summarizes the linezolid susceptibility testing results for 7,429 Gram-positive pathogens from 60 U.S. sites collected during the 2012 sampling year for the LEADER Program. Linezolid showed potent activity when tested against 2,980 Staphylococcus aureus isolates, inhibiting all but 3 at ≤2 μg/ml. Similarly,...

journal_title：Antimicrobial agents and chemotherapy

authors： Mendes RE,Flamm RK,Hogan PA,Ross JE,Jones RN

更新日期：2014-01-01 00:00:00

abstract：:Upregulated expression of efflux pumps, lpxC target mutations, LpxC protein overexpression, and mutations in fabG were previously shown to mediate single-step resistance to the LpxC inhibitor CHIR-090 in P. aeruginosa Single-step selection experiments using three recently described LpxC inhibitors (compounds 2, 3, and...

journal_title：Antimicrobial agents and chemotherapy

authors： Jones AK,Caughlan RE,Woods AL,Uehara K,Xie L,Barnes SW,Walker JR,Thompson KV,Ranjitkar S,Lee PS,Dean CR

更新日期：2019-12-20 00:00:00

abstract：:An experiment was conducted in animal facilities to compare the impacts of four avian colibacillosis treatments-oxytetracycline (OTC), trimethoprim-sulfadimethoxine (SXT), amoxicillin (AMX), or enrofloxacin (ENR)-on the susceptibility of Escherichia coli in broiler intestinal tracts. Birds were first orally inoculated...

journal_title：Antimicrobial agents and chemotherapy

authors： Dheilly A,Le Devendec L,Mourand G,Bouder A,Jouy E,Kempf I

更新日期：2012-01-01 00:00:00

abstract：:The emergence of artemisinin-resistant Plasmodium falciparum poses a major threat to current frontline artemisinin combination therapies. Artemisinin resistance is widely associated with mutations in the P. falciparum Kelch13 (PfKelch13) propeller region, leading to delayed parasite clearance and increased survival of...

journal_title：Antimicrobial agents and chemotherapy

authors： Tong JX,Ang SEL,Tan EHN,Tan KSW

更新日期：2019-03-27 00:00:00

abstract：:The antibacterial activities of K-4619 (3-de-O-methylsporaricin A sulfate) were compared with those of sporaricin A, amikacin, dibekacin, and gentamicin. K-4619 exhibited a high order of activity against gram-positive and gram-negative bacteria, including Pseudomonas aeruginosa. Its activity against Providencia specie...

journal_title：Antimicrobial agents and chemotherapy

authors： Saino Y,Hattori Y,Koshi T,Kobayashi F,Oda T,Mitsuhashi S

更新日期：1984-08-01 00:00:00

abstract：:Robust determination of the concentration-time profile of anti-infective agents in certain specialized compartments is often limited by the inability to obtain more than a single sample from such a site in any one subject. Vitreous humor and cerebrospinal fluid are obvious examples for which the determination of conce...

journal_title：Antimicrobial agents and chemotherapy

authors： Drusano GL,Liu W,Perkins R,Madu A,Madu C,Mayers M,Miller MH

更新日期：1995-08-01 00:00:00

abstract：:The in vitro activities of magainin analogs against Blastocystis hominis, Entamoeba histolytica, and Trypanosoma cruzi were assessed by protozoan morphological integrity and motility. The antiprotozoan activities in descending order were magainin B greater than G greater than H, the same order as the alpha-helix conte...

journal_title：Antimicrobial agents and chemotherapy

authors： Huang CM,Chen HC,Zierdt CH

更新日期：1990-09-01 00:00:00

abstract：:Mutations in the kelch propeller domain (K13 propeller) of Plasmodium falciparum parasites from Southeast Asia are associated with reduced susceptibility to artemisinin. We exposed in vitro-cultured stage V gametocytes from Cambodian K13 propeller mutant parasites to dihydroartemisinin and evaluated the inhibition of ...

journal_title：Antimicrobial agents and chemotherapy

authors： Lozano S,Gamallo P,González-Cortés C,Presa Matilla JL,Fairhurst RM,Herreros E,Amaratunga C,Rodrigues J

更新日期：2018-11-26 00:00:00

abstract：:Acinetobacter baumannii is responsible for severe nosocomial pneumonia. To evaluate new therapeutic regimens for infections due to multiresistant strains and to study the pharmacodynamic properties of various antibiotics, we developed an experimental mouse model of acute A. baumannii pneumonia. C3H/HeN mice rendered t...

journal_title：Antimicrobial agents and chemotherapy

authors： Joly-Guillou ML,Wolff M,Pocidalo JJ,Walker F,Carbon C

更新日期：1997-02-01 00:00:00

abstract：:Burkholderia cepacia complex (Bcc) pulmonary infections in people living with cystic fibrosis (CF) are difficult to treat because of the extreme intrinsic resistance of most isolates to a broad range of antimicrobials. Fosmidomycin is an antibacterial and antiparasitic agent that disrupts the isoprenoid biosynthesis p...

journal_title：Antimicrobial agents and chemotherapy

authors： Malott RJ,Wu CH,Lee TD,Hird TJ,Dalleska NF,Zlosnik JE,Newman DK,Speert DP

更新日期：2014-09-01 00:00:00

abstract：:The binding of antibiotics to plasma (serum) proteins through hydrogen bonding can significantly influence the biological characteristics of these drugs. A rapid spectrophotometric assay has been developed that measures the level of free (unbound) penem antibiotic in serum ultrafiltrates. Whole human serum was adjuste...

journal_title：Antimicrobial agents and chemotherapy

authors： Gootz TD,Subashi TA,Lindner DL

更新日期：1988-02-01 00:00:00

abstract：:Nephrotoxicity is the primary adverse effect of the polymyxins. The relative rates of toxicity of polymyxin B and colistin have not been fully elucidated, especially in patients with cystic fibrosis (CF). A retrospective cohort study of adults treated with polymyxin B or colistin for at least 48 h was conducted. The p...

journal_title：Antimicrobial agents and chemotherapy

authors： Crass RL,Rutter WC,Burgess DR,Martin CA,Burgess DS

更新日期：2017-03-24 00:00:00

abstract：:The activity of gemifloxacin against Haemophilus influenzae and Moraxella catarrhalis was compared to those of 11 other agents. All quinolones were very active (MICs,

journal_title：Antimicrobial agents and chemotherapy

authors： Davies TA,Kelly LM,Hoellman DB,Ednie LM,Clark CL,Bajaksouzian S,Jacobs MR,Appelbaum PC

更新日期：2000-03-01 00:00:00

abstract：:A novel streptogramin A, pleuromutilin, and lincosamide resistance determinant, Vga(E), was identified in porcine methicillin-resistant Staphylococcus aureus (MRSA) ST398. The vga(E) gene encoded a 524-amino-acid protein belonging to the ABC transporter family. It was found on a multidrug resistance-conferring transpo...

journal_title：Antimicrobial agents and chemotherapy

authors： Schwendener S,Perreten V

更新日期：2011-10-01 00:00:00

abstract：:We investigated the antistaphylococcal activity of daptomycin, vancomycin, oxacillin, gentamicin, and rifampin in human monocyte-derived macrophages. Compared with vancomycin and oxacillin, daptomycin had the most rapid and greatest antibacterial activity, but that of oxacillin was most sustained. The combination of d...

journal_title：Antimicrobial agents and chemotherapy

authors： Baltch AL,Ritz WJ,Bopp LH,Michelsen PB,Smith RP

更新日期：2007-04-01 00:00:00

abstract：:Candida krusei ATCC 6258 was tested by eight laboratories using 96-well plates containing checkerboard pairwise combinations of amphotericin B (AMB), posaconazole (PSC), caspofungin (CSP), and voriconazole (VRC). The methodology led to reproducible results across the laboratories. All drug combinations yielded MICs lo...

journal_title：Antimicrobial agents and chemotherapy

authors： Chaturvedi V,Ramani R,Ghannoum MA,Killian SB,Holliday N,Knapp C,Ostrosky-Zeichner L,Messer SA,Pfaller MA,Iqbal NJ,Arthington-Skaggs BA,Vazquez JA,Sein T,Rex JH,Walsh TJ

更新日期：2008-04-01 00:00:00

abstract：:A major clinical challenge for treating infectious diseases is the duration of antimicrobial therapy required to eradicate the pathogen. We hypothesized that modulation of the bacterial replication rate in the context of an antimicrobial exposure is coupled with the rate and extent of bactericidal effects. Herein we d...

journal_title：Antimicrobial agents and chemotherapy

authors： Ambrose PG,VanScoy B,Conde H,McCauley J,Rubino CM,Bhavnani SM

更新日期：2016-12-27 00:00:00

abstract：:The antimicrobial activities of amphotericin B, itraconazole, and miconazole against 101 filamentous fungi from patients with cystic fibrosis were tested by a reproducible microdilution method. Itraconazole was very active against Aspergillus species and Scedosporium species (MIC at which 90% of the isolates were inhi...

journal_title：Antimicrobial agents and chemotherapy

authors： Hennequin C,Benailly N,Silly C,Sorin M,Scheinmann P,Lenoir G,Gaillard JL,Berche P

更新日期：1997-09-01 00:00:00

abstract：:Moxifloxacin (BAY12-8039) is a new 8-methoxyquinolone shown to be active against Mycobacterium tuberculosis in vitro. We tested moxifloxacin for activity in mice against M. tuberculosis CSU93, a highly virulent, recently isolated clinical strain. The MIC of moxifloxacin for the CSU93 strain was 0.25 microg/ml. The ser...

journal_title：Antimicrobial agents and chemotherapy

authors： Miyazaki E,Miyazaki M,Chen JM,Chaisson RE,Bishai WR

更新日期：1999-01-01 00:00:00