Novobiocin Susceptibility of MukBEF-Deficient Escherichia coli Is Combinatorial with Efflux and Resides in DNA Topoisomerases.

abstract：:Because macrolide antibiotics are hypothesized to possess immunomodulatory activity independent of their antimicrobial activity, we evaluated the immunomodulatory effect of clarithromycin in a murine model of lung inflammation induced by either live or UV-killed Mycoplasma pneumoniae. BALB/c mice were intranasally ino...

journal_title：Antimicrobial agents and chemotherapy

authors： Hardy RD,Rios AM,Chavez-Bueno S,Jafri HS,Hatfield J,Rogers BB,McCracken GH,Ramilo O

更新日期：2003-05-01 00:00:00

abstract：:Ga(3+) is a semimetal element that competes for the iron-binding sites of transporters and enzymes. We investigated the activity of gallium maltolate (GaM), an organic gallium salt with high solubility, against laboratory and clinical strains of methicillin-susceptible Staphylococcus aureus (MSSA), methicillin-resista...

journal_title：Antimicrobial agents and chemotherapy

authors： Baldoni D,Steinhuber A,Zimmerli W,Trampuz A

更新日期：2010-01-01 00:00:00

abstract：:RBx 11760, a bi-aryl oxazolidinone, was investigated for antibacterial activity against Gram-positive bacteria. The MIC90s of RBx 11760 and linezolid against Staphylococcus aureus were 2 and 4 mg/liter, against Staphylococcus epidermidis were 0.5 and 2 mg/liter, and against Enterococcus were 1 and 4 mg/liter, respecti...

journal_title：Antimicrobial agents and chemotherapy

authors： Barman TK,Kumar M,Mathur T,Chaira T,Ramkumar G,Kalia V,Rao M,Pandya M,Yadav AS,Das B,Upadhyay DJ,Hamidullah,Konwar R,Raj VS,Singh H

更新日期：2016-11-21 00:00:00

abstract：:We designed, synthesized, and characterized a novel nucleoside analog, (1S,3S,5S)-3-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-5-hydroxy-1-(hydroxymethyl)-2-methylene-cyclopentanecarbonitrile, or 4'-cyano-methylenecarbocyclic-2'-deoxyguanosine (CMCdG), and evaluated its anti-hepatitis B virus (anti-HBV) activity, safet...

journal_title：Antimicrobial agents and chemotherapy

authors： Higashi-Kuwata N,Hayashi S,Das D,Kohgo S,Murakami S,Hattori SI,Imoto S,Venzon DJ,Singh K,Sarafianos SG,Tanaka Y,Mitsuya H

更新日期：2019-03-27 00:00:00

abstract：:Staphylococcus epidermidis is one of the most frequent causes of device-associated infections, because it is known to cause biofilms that grow on catheters or other surgical implants. The persistent increasing resistance of S. epidermidis and other coagulase-negative staphylococci (CoNS) has driven the need for newer ...

journal_title：Antimicrobial agents and chemotherapy

authors： Hou Z,Da F,Liu B,Xue X,Xu X,Zhou Y,Li M,Li Z,Ma X,Meng J,Jia M,Wang Y,Luo X

更新日期：2013-10-01 00:00:00

abstract：:We characterized the genetic environment of mcr-1 in colistin-resistant Escherichia coli strains isolated in Switzerland during 2014 to 2016 from humans (n = 3) and chicken meat (n = 6). Whole-genome and plasmid sequencing identified the mcr-1 gene integrated in IncX4 (of which, one strain carried the mcr-1.2 variant)...

journal_title：Antimicrobial agents and chemotherapy

authors： Donà V,Bernasconi OJ,Pires J,Collaud A,Overesch G,Ramette A,Perreten V,Endimiani A

更新日期：2017-10-24 00:00:00

abstract：:The mecillinam resistance of Escherichia coli K-12 mutants deficient in the enzyme responsible for the synthesis of adenosine 3',5'-monophosphate, adenylate cyclase, has been investigated. The results suggest that resistance to this antibiotic may be a consequence of the slow growth rate of these mutants rather than a...

journal_title：Antimicrobial agents and chemotherapy

authors： Scott NW,Harwood CR

更新日期：1981-04-01 00:00:00

abstract：:The antimicrobial activities of BMY-28142, cefbuperazone (BMY-25182; formerly T-1982), and cefpiramide (WY-44635; formerly SM-1652) were compared with those of cefmenoxime, cefoperazone, cefotaxime, ceftizoxime, and moxalactam. BMY-28142 was the most active cephalosporin against the majority of aerobic and facultative...

journal_title：Antimicrobial agents and chemotherapy

authors： Khan NJ,Bihl JA,Schell RF,LeFrock JL,Weber SJ

更新日期：1984-10-01 00:00:00

abstract：:Oral administration of 2'-deoxy-3'-oxa-4'-thiocytidine (BCH-10652), a nucleoside analog structurally similar to lamivudine (3TC), caused dose-dependent inhibition of viral replication in SCID-hu Thy/Liv mice infected with human immunodeficiency virus type 1 NL4-3 and with an NL4-3 clone containing the M184V mutation i...

journal_title：Antimicrobial agents and chemotherapy

authors： Stoddart CA,Moreno ME,Linquist-Stepps VD,Bare C,Bogan MR,Gobbi A,Buckheit RW Jr,Bedard J,Rando RF,McCune JM

更新日期：2000-03-01 00:00:00

abstract：:The pharmacokinetics of an extended-release (XR) formulation of ciprofloxacin has been compared to that of the immediate-release (IR) product in healthy volunteers. The only significant difference in pharmacokinetic parameters between the two formulations was seen in the rate constant of absorption, which was approxim...

journal_title：Antimicrobial agents and chemotherapy

authors： Meagher AK,Forrest A,Dalhoff A,Stass H,Schentag JJ

更新日期：2004-06-01 00:00:00

abstract：:It has recently become apparent that inflammatory reactions including nitric oxide (NO) release contribute to the outcome of pulmonary infections. To investigate the effect of N(G)-monomethyl-L-arginine (L-NMMA), a NO synthase inhibitor, on the pathogenesis of pneumococcal pneumonia, we inoculated CD(1) Swiss mice wit...

journal_title：Antimicrobial agents and chemotherapy

authors： Bergeron Y,Ouellet N,Simard M,Olivier M,Bergeron MG

更新日期：1999-09-01 00:00:00

abstract：:A set of 20 nucleoside analogs were examined for their inhibitory effects on the cytopathogenicity and growth of influenza virus type A, B, and C strains in Madin-Darby canine kidney (MDCK) cells. Among the compounds evaluated, pyrazofurin, 3-deazaguanine, ribavirin, carbodine, and cyclopentenyl cytosine inhibited vir...

journal_title：Antimicrobial agents and chemotherapy

authors： Shigeta S,Konno K,Yokota T,Nakamura K,De Clercq E

更新日期：1988-06-01 00:00:00

abstract：:Combining voriconazole and flucloxacillin is indicated in patient cohorts experiencing both invasive aspergillosis and Gram-positive infections (e.g., patients with chronic granulomatous disease or postinfluenza pulmonary aspergillosis). We report a highly relevant interaction between voriconazole and flucloxacillin, ...

journal_title：Antimicrobial agents and chemotherapy

authors： Muilwijk EW,Dekkers BGJ,Henriet SSV,Verweij PE,Witjes B,Lashof AMLO,Groeneveld GH,van der Hoeven J,Alffenaar JWC,Russel FGM,van de Veerdonk F,Brüggemann RJM

更新日期：2017-08-24 00:00:00

abstract：:Replication complexes of hepatitis C virus synthesized two major species of viral RNA in vitro, double stranded and single stranded. NS5B nonnucleoside inhibitors inhibited dose dependently the synthesis of single-stranded RNA but not double-stranded RNA. Moreover, replication complexes carrying a mutation resistant t...

journal_title：Antimicrobial agents and chemotherapy

authors： Yang W,Sun Y,Phadke A,Deshpande M,Huang M

更新日期：2007-01-01 00:00:00

abstract：:The "HACEK" organisms are a group of fastidious Gram-negative bacteria that cause a variety of infections, including infective endocarditis. Antimicrobial susceptibility testing is not universally available, and therapy for these infections is often empirical. We report the antimicrobial susceptibilities of 70 clinica...

journal_title：Antimicrobial agents and chemotherapy

authors： Coburn B,Toye B,Rawte P,Jamieson FB,Farrell DJ,Patel SN

更新日期：2013-04-01 00:00:00

abstract：:Treating high-density bacterial infections is a challenging clinical problem. We have a paucity of new agents that can address this problem. Pseudomonas aeruginosa is a particularly difficult pathogen to treat effectively because of the plethora of resistance mechanisms it carries. Fosfomycin is an agent discovered ci...

journal_title：Antimicrobial agents and chemotherapy

authors： Drusano GL,Neely MN,Yamada WM,Duncanson B,Brown D,Maynard M,Vicchiarelli M,Louie A

更新日期：2018-11-26 00:00:00

abstract：:Numerous antibiotics have proven to be effective at ameliorating the clinical symptoms of urinary tract infections (UTIs), but recurrent and chronic infections continue to plague many individuals. Most UTIs are caused by strains of uropathogenic Escherichia coli (UPEC), which can form both extra- and intracellular bio...

journal_title：Antimicrobial agents and chemotherapy

authors： Blango MG,Mulvey MA

更新日期：2010-05-01 00:00:00

abstract：:Study of the antimicrobial spectrum of valinomycin revealed that, in addition to the gram-positive bacteria reported in literature, Streptococcus pyogenes and Clostridium sporogenes are also susceptible to this antibiotic. The minimal inhibitory concentrations (MIC) of the antibiotic for S. pyogenes grown aerobically ...

journal_title：Antimicrobial agents and chemotherapy

authors： Seshachalam D,Frahm DH,Ferraro FM

更新日期：1973-01-01 00:00:00

abstract：:The pharmacokinetics of gentamicin in 34 febrile neutropenic patients (40 courses) were compared with those in 40 nonneutropenic patients receiving the drug. No pharmacokinetic differences were seen in half-life, volume of distribution (liter per kilogram; total and ideal body weight), or clearance (milliliter per min...

journal_title：Antimicrobial agents and chemotherapy

authors： Bianco TM,Dwyer PN,Bertino JS Jr

更新日期：1989-11-01 00:00:00

abstract：:Intraoperative biliary cefamandole concentrations were determined in 16 patients with hepatobiliary pathology. These included seven patients with cholelithiasis, five with acute cholecystitis, two with recurrent ascending cholangitis, and two with liver abscesses. Bile collected 0.5 to 2.5 h after the last antibiotic ...

journal_title：Antimicrobial agents and chemotherapy

authors： Uwaydah M,Kantarjian H,Osseiran M,Bal'a F

更新日期：1982-12-01 00:00:00

abstract：:The binding of antibiotics to plasma (serum) proteins through hydrogen bonding can significantly influence the biological characteristics of these drugs. A rapid spectrophotometric assay has been developed that measures the level of free (unbound) penem antibiotic in serum ultrafiltrates. Whole human serum was adjuste...

journal_title：Antimicrobial agents and chemotherapy

authors： Gootz TD,Subashi TA,Lindner DL

更新日期：1988-02-01 00:00:00

abstract：:The motility of viable Trichomonas vaginalis organisms is readily demonstrable in a clinical wet mount or cultured specimens. We attempted to determine whether migration is a dynamic process such that the organisms move to avoid exposure to toxic antimicrobial agents. With the use of axenic cultures of T. vaginalis th...

journal_title：Antimicrobial agents and chemotherapy

authors： Sugarman B,Mummaw N

更新日期：1988-09-01 00:00:00

abstract：:Routine in vitro screening of a new synthetic series of 3,5-substituted 2-methylisoxazolidines revealed that three imidazole analogs (PR 967-248, PR 967-234, and PR 969-566) and, to a lesser extent, a triazole analog (PR 988-399) exerted rather potent antifungal activity against three systemic and four dermatophytic c...

journal_title：Antimicrobial agents and chemotherapy

authors： Palmer GC,Ordy MJ,Simmons RD,Strand JC,Radov LA,Mullen GB,Kinsolving CR,St Georgiev V,Mitchell JT,Allen SD

更新日期：1989-06-01 00:00:00

abstract：:The in vitro susceptibilities of 98 isolates of JK diphtheroids to teichomycin, vancomycin, and eight other antibiotics was investigated. Teichomycin and vancomycin were extremely active against all the isolates tested. The 90% minimal inhibitory concentrations for teichomycin and vancomycin were 1.56 and 0.78 microgr...

journal_title：Antimicrobial agents and chemotherapy

authors： Jadeja L,Fainstein V,LeBlanc B,Bodey GP

更新日期：1983-08-01 00:00:00

abstract：:The effectiveness of gatifloxacin therapy (15 mg/kg every 5 h [q5h]) was compared with that of meropenem (75 mg/kg q5h) and cefotaxime (75 mg/kg q5h) therapy in experimental meningitis caused by a beta-lactamase-producing strain of Escherichia coli. Gatifloxacin therapy was more rapidly bactericidal than cefotaxime bu...

journal_title：Antimicrobial agents and chemotherapy

authors： Lutsar I,Friedland IR,Jafri HS,Wubbel L,Ng W,Ghaffar F,McCracken GH Jr

更新日期：1999-07-01 00:00:00

abstract：:Levofloxacin is an antituberculosis drug with substantial interindividual pharmacokinetic variability; therapeutic drug monitoring (TDM) could therefore be helpful to improve treatment results. TDM would be more feasible with limited sampling strategies (LSSs), a method to estimate the area under the concentration cur...

journal_title：Antimicrobial agents and chemotherapy

authors： van den Elsen SHJ,Sturkenboom MGG,Van't Boveneind-Vrubleuskaya N,Skrahina A,van der Werf TS,Heysell SK,Mpagama S,Migliori GB,Peloquin CA,Touw DJ,Alffenaar JC

更新日期：2018-11-26 00:00:00

abstract：:Twenty-seven patients with advanced malignancies were given 200 mg of ketoconazole orally every 6 or 12 h. Blood samples were collected during these intervals and after the last dose to determine plasma concentrations and half-lives. The mean plasma concentrations measured after the initial dose were 1.7 +/- 1.1 micro...

journal_title：Antimicrobial agents and chemotherapy

authors： Maksymiuk AW,Levine HB,Bodey GP

更新日期：1982-07-01 00:00:00

abstract：:We performed the characterization of a multidrug-resistant (MDR) Enterobacter spp. isolate highlighting the genetic aspects of the antimicrobial resistance genes. An Enterobacter spp. isolate (Ec61) was recovered in 2014 from a transtracheal aspirate sample from a patient admitted to a Brazilian tertiary hospital and ...

journal_title：Antimicrobial agents and chemotherapy

authors： Martins WMBS,Martins ER,de Andrade LK,Farzana R,Walsh TR,Toleman MA,Nogueira MCL,Gales AC

更新日期：2020-12-14 00:00:00

abstract：:Increasingly frequent reports have described the in vivo loss of daptomycin susceptibility in association with clinical treatment failures. The mechanism(s) of daptomycin resistance is not well understood. We studied an isogenic set of Staphylococcus aureus isolates from the bloodstream of a daptomycin-treated patient...

journal_title：Antimicrobial agents and chemotherapy

authors： Jones T,Yeaman MR,Sakoulas G,Yang SJ,Proctor RA,Sahl HG,Schrenzel J,Xiong YQ,Bayer AS

更新日期：2008-01-01 00:00:00

abstract：:Sch 21420 is a new aminoglycoside synthesized from gentamicin B. Susceptibility tests with Sch 21420, amikacin, gentamicin, netilmicin, sisomicin, and tobramycin were performed on a variety of bacterial species including 44 with known mechanisms of resistance to aminoglycosides. Sch 21420 and amikacin had similar effe...

journal_title：Antimicrobial agents and chemotherapy

authors： Thornsberry C,Barry AL,Jones RN,Baker CN,Badal RE,Packer RR

更新日期：1980-08-01 00:00:00