Comparison of in vitro activity of Sch 21420, a gentamicin B derivative, with those of amikacin, gentamicin, netilmicin, sisomicin, and tobramycin.

abstract：:Methionine gamma-lyase, the enzyme which catalyzes the single-step conversion of methionine to alpha-ketobutyrate, ammonia, and methanethiol, is highly active in many anaerobic pathogenic microorganisms but has no counterpart in mammals. This study tested the hypothesis that this pathogen-specific enzyme can be exploi...

journal_title：Antimicrobial agents and chemotherapy

authors： Coombs GH,Mottram JC

更新日期：2001-06-01 00:00:00

abstract：:We describe a novel method for isolating plasma-free peripheral blood mononuclear cells retaining intracellular efavirenz. Quantification of efavirenz in 13 human immunodeficiency virus-infected patients by liquid chromatography-tandem mass spectrometry showed a higher correlation of intracellular levels with unbound ...

journal_title：Antimicrobial agents and chemotherapy

authors： Tanaka R,Hanabusa H,Kinai E,Hasegawa N,Negishi M,Kato S

更新日期：2008-02-01 00:00:00

abstract：:Histatin 5 (Hst 5) is a salivary human antimicrobial peptide that is toxic to the opportunistic yeast Candida albicans. Fungicidal activity of Hst 5 requires intracellular translocation and accumulation to a threshold concentration for it to disrupt cellular processes. Previously, we observed that total cytosolic leve...

journal_title：Antimicrobial agents and chemotherapy

authors： Li R,Kumar R,Tati S,Puri S,Edgerton M

更新日期：2013-04-01 00:00:00

abstract：:DNA microarrays were used to analyze Candida glabrata oropharyngeal isolates from seven hematopoietic stem cell transplant recipients whose isolates developed azole resistance while the recipients received fluconazole prophylaxis. Transcriptional profiling of the paired isolates revealed 19 genes upregulated in the ma...

journal_title：Antimicrobial agents and chemotherapy

authors： Tsai HF,Sammons LR,Zhang X,Suffis SD,Su Q,Myers TG,Marr KA,Bennett JE

更新日期：2010-08-01 00:00:00

abstract：:Standardized direct disk diffusion antibiotic susceptibility testing on monomicrobial urine specimens is compared with the Food and Drug Administration method. The direct procedure yields acceptable data and may conserve 24 h in reporting results. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Wegner DL,Neblett TR

更新日期：1976-12-01 00:00:00

abstract：:Although controversial, it has been suggested that antibiotic treatment of laboratory animals infected with Borrelia burgdorferi often leads to the persistence of residual spirochetes that are claimed to be viable but noncultivable. If viable cells of B. burgdorferi do persist following antibiotic therapy, one possibl...

journal_title：Antimicrobial agents and chemotherapy

authors： Pavia CS,Wormser GP

更新日期：2014-11-01 00:00:00

abstract：:A total of 6,991 unique patient isolates of Streptococcus pneumoniae were collected from October 1997 to June 2002 from 25 medical centers in 9 of the 10 Canadian provinces. Among these isolates, 20.2% were penicillin nonsusceptible, with 14.6% being penicillin intermediate (MIC, 0.12 to 1 microg/ml) and 5.6% being pe...

journal_title：Antimicrobial agents and chemotherapy

authors： Zhanel GG,Palatnick L,Nichol KA,Bellyou T,Low DE,Hoban DJ

更新日期：2003-06-01 00:00:00

abstract：:Acquiring iron (Fe) is critical to the metabolism and growth of Mycobacterium tuberculosis. Disruption of Fe metabolism is a potential approach for novel antituberculous therapy. Gallium (Ga) has many similarities to Fe. Biological systems are often unable to distinguish Ga(3+) from Fe(3+). Unlike Fe(3+), Ga(3+) canno...

journal_title：Antimicrobial agents and chemotherapy

authors： Olakanmi O,Kesavalu B,Pasula R,Abdalla MY,Schlesinger LS,Britigan BE

更新日期：2013-12-01 00:00:00

abstract：:Though the primary action of the cationic antibiotic polymyxin B is against the membrane of susceptible bacteria, severe morphological changes are detected in the cytoplasm. Using fluorescence microscopy and a mono-N-dansyl-polymyxin B derivative, we could demonstrate aggregations of the antibiotic with cellular mater...

journal_title：Antimicrobial agents and chemotherapy

authors： Schindler PR,Teuber M

更新日期：1975-07-01 00:00:00

abstract：:The bioavailabilities of orally administered drugs depend to a great extent on their capability of being transported across the intestinal mucosa. In an attempt to develop an in vitro model for studying the intestinal transport of drugs, we used an intestinal epithelial cell line (Caco 2) derived from a human colon ad...

journal_title：Antimicrobial agents and chemotherapy

authors： Ranaldi G,Islam K,Sambuy Y

更新日期：1992-07-01 00:00:00

abstract：:Meropenem is a broad-spectrum carbapenem antibacterial agent. In order to optimize levels in plasma relative to the MICs, the ideal dose level and dosage regimen need to be determined. The pharmacokinetics of meropenem were studied in two groups, each comprising eight healthy volunteers who received the following dose...

journal_title：Antimicrobial agents and chemotherapy

authors： Krueger WA,Bulitta J,Kinzig-Schippers M,Landersdorfer C,Holzgrabe U,Naber KG,Drusano GL,Sörgel F

更新日期：2005-05-01 00:00:00

abstract：:Phosphorothioate oligonucleotides complementary to mRNA of the human cytomegalovirus (HCMV) DNA polymerase gene or to RNA transcripts of the major immediate-early regions 1 and 2 (IE1 and IE2) of HCMV were evaluated for antiviral activity in a 96-well immunoassay with primary human dermal fibroblasts as host cells. Ol...

journal_title：Antimicrobial agents and chemotherapy

authors： Azad RF,Driver VB,Tanaka K,Crooke RM,Anderson KP

更新日期：1993-09-01 00:00:00

abstract：:Isavuconazole is a novel, broad-spectrum, antifungal azole. In order to evaluate its interactions with known azole resistance mechanisms, isavuconazole susceptibility among different yeast models and clinical isolates expressing characterized azole resistance mechanisms was tested and compared to those of fluconazole,...

journal_title：Antimicrobial agents and chemotherapy

authors： Sanglard D,Coste AT

更新日期：2015-10-19 00:00:00

abstract：:Recent Food and Drug Administration (FDA) guidance endorses the use of an early clinical response endpoint as the primary outcome for community-acquired bacterial pneumonia (CABP) trials. While antibiotics will now be approved for CABP, in practice they will primarily be used to treat patients with community-acquired ...

journal_title：Antimicrobial agents and chemotherapy

authors： Zasowski E,Butterfield JM,McNutt LA,Cohen J,Cosler L,Pai MP,Gottwald J,Chen WZ,Lodise TP

更新日期：2014-07-01 00:00:00

abstract：:Analysis of the evolution of drug target genes under changing drug policy is needed to assist monitoring of Plasmodium falciparum drug resistance in the field. Here we genotype Pfcrt and Pfdmr1 of 700 isolates collected in French Guiana from 2000 (5 years after withdrawal of chloroquine) to 2008, i.e., the period when...

journal_title：Antimicrobial agents and chemotherapy

authors： Legrand E,Yrinesi J,Ekala MT,Péneau J,Volney B,Berger F,Bouchier C,Bertani S,Musset L,Meynard JB,Mercereau-Puijalon O

更新日期：2012-03-01 00:00:00

abstract：:Chromatographic fractionation of streptovaricin complex yields two stable components enriched (4- to 16-fold) in activity directed against the polycythemic strain of Friend virus; both components apparently contain no streptovaricins. When compared with their unfractionated parent streptovaricin complex, eight individ...

journal_title：Antimicrobial agents and chemotherapy

authors： Horoszewicz JS,Rinehart KL Jr,Leong SS,Carter WA

更新日期：1975-03-01 00:00:00

abstract：:The efficacy of a new class of drugs for Pneumocystis carinii pneumonitis was demonstrated. 566C80, a hydroxynaphthoquinone, administered orally in a dose of greater than or equal to 100 mg/kg of body weight per day prophylactically prevented P. carinii pneumonitis in 90% or more of rats, while all untreated control a...

journal_title：Antimicrobial agents and chemotherapy

authors： Hughes WT,Gray VL,Gutteridge WE,Latter VS,Pudney M

更新日期：1990-02-01 00:00:00

abstract：:The apparent body clearance of chloramphenicol was investigated in 21 hospitalized adult patients on 27 occasions. Apparent body clearance was found to be significantly lower (1.99 +/- 1.49 ml/min per kg) in patients with total serum bilirubin concentrations of >1.5 mg/100 ml than in patients with serum bilirubin conc...

journal_title：Antimicrobial agents and chemotherapy

authors： Koup JR,Lau AH,Brodsky B,Slaughter RL

更新日期：1979-05-01 00:00:00

abstract：:The 2-year follow-up results for a randomized placebo-controlled study of 47 patients with multidrug-resistant pulmonary tuberculosis treated with either the new diarylquinoline TMC207, recently renamed bedaquiline, or placebo, added to the first 8 weeks of a background regimen, are presented. Bedaquiline significantl...

journal_title：Antimicrobial agents and chemotherapy

authors： Diacon AH,Donald PR,Pym A,Grobusch M,Patientia RF,Mahanyele R,Bantubani N,Narasimooloo R,De Marez T,van Heeswijk R,Lounis N,Meyvisch P,Andries K,McNeeley DF

更新日期：2012-06-01 00:00:00

abstract：:Drug repurposing affords the implementation of new treatments at a moderate cost and under a faster time-scale. Most of the clinical drugs against Leishmania share this origin. The antidepressant sertraline has been successfully assayed in a murine model of visceral leishmaniasis. Nevertheless, sertraline targets in L...

journal_title：Antimicrobial agents and chemotherapy

authors： Lima ML,Abengózar MA,Nácher-Vázquez M,Martínez-Alcázar MP,Barbas C,Tempone AG,López-Gonzálvez Á,Rivas L

更新日期：2018-11-26 00:00:00

abstract：:We recently identified a novel plasmid-mediated RND-type efflux pump gene cluster, tmexCD1-toprJ1 in Klebsiella pneumoniae, that conferred resistance to multiple antimicrobials, including tigecycline. While homologs of tmexCD1-toprJ1 were found encoded in many other bacterial species in GenBank, their function and tra...

journal_title：Antimicrobial agents and chemotherapy

authors： Wang CZ,Gao X,Yang QW,Lv LC,Wan M,Yang J,Cai ZP,Liu JH

更新日期：2021-01-25 00:00:00

abstract：:Ten patients received a loading dose of tobramycin of 60 mg/m2 intravenously over 0.5 h followed immediately by 60 mg/m2 over 2 h every 4 h. The highest mean serum concentration (at the end of the loading dose) was 6.0 +/- 0.3 microgram/ml (range, 3.2 to 10.9 microgram/ml). The mean serum concentration 2 h after the e...

journal_title：Antimicrobial agents and chemotherapy

authors： Lawson RD,Bodey GP,Pan T,Smith TL

更新日期：1980-05-01 00:00:00

abstract：:Lung infections caused by Mycobacterium abscessus are emerging as a global threat to individuals with cystic fibrosis and to other patient groups. Recent evidence for human-to-human transmission worsens the situation. M. abscessus is an intrinsically multidrug-resistant pathogen showing resistance to even standard ant...

journal_title：Antimicrobial agents and chemotherapy

authors： Aziz DB,Low JL,Wu ML,Gengenbacher M,Teo JWP,Dartois V,Dick T

更新日期：2017-05-24 00:00:00

abstract：:This study was undertaken to investigate biochemical, genetic, and epidemiological aspects of resistance to aminoglycoside antibiotics among 650 consecutive isolates of Pseudomonas aeruginosa from Parkland Memorial Hospital, Dallas, Tex. In 364 strains, minimal inhibitory concentrations were 25 mug/ml or greater for g...

journal_title：Antimicrobial agents and chemotherapy

authors： Holmes RK,Minshew BH,Gould IK,Sanford JP

更新日期：1974-09-01 00:00:00

abstract：:Carbapenem-resistant Acinetobacter baumannii is a major source of nosocomial infections worldwide and is mainly associated with the acquisition of OXA-type carbapenemases and, to a lesser extent, metallo-β-lactamases (MBLs). In this study, 82 nonepidemiologically related Acinetobacter strains carrying different types ...

journal_title：Antimicrobial agents and chemotherapy

authors： Vergara A,Zboromyrska Y,Mosqueda N,Morosini MI,García-Fernández S,Roca I,Cantón R,Marco F,Vila J

更新日期：2014-12-01 00:00:00

abstract：:The EmbCAB proteins have been considered a target for ethambutol (EMB). Mutations in embCAB are known to confer most EMB resistance. However, the knowledge about the effects of embCAB mutations on the EMB resistance level and about the role of mutation-mutation interactions is limited in China. Here, we sequenced embC...

journal_title：Antimicrobial agents and chemotherapy

authors： Sun Q,Xiao TY,Liu HC,Zhao XQ,Liu ZG,Li YN,Zeng H,Zhao LL,Wan KL

更新日期：2017-12-21 00:00:00

abstract：:The in vitro antibacterial activity of AM-1155 against a wide variety of clinical isolates was compared with those of other fluoroquinolones. The MICs of AM-1155 for 90% of Staphylococcus aureus, Streptococcus pneumoniae, and Enterococcus faecalis isolates tested were 0.10, 0.39, and 0.78 microgram/ml, respectively. T...

journal_title：Antimicrobial agents and chemotherapy

authors： Wakabayashi E,Mitsuhashi S

更新日期：1994-03-01 00:00:00

abstract：:Currently, CTX-M β-lactamases are among the most prevalent and most heterogeneous extended-spectrum β-lactamases (ESBLs). In general, CTX-M enzymes are susceptible to inhibition by β-lactamase inhibitors. However, it is unknown if the pathway to inhibition by β-lactamase inhibitors for CTX-M ESBLs is similar to TEM an...

journal_title：Antimicrobial agents and chemotherapy

authors： Bethel CR,Taracila M,Shyr T,Thomson JM,Distler AM,Hujer KM,Hujer AM,Endimiani A,Papp-Wallace K,Bonnet R,Bonomo RA

更新日期：2011-07-01 00:00:00

abstract：:The effects of sub-MICs of certain antibiotics, namely, penicillin G, tetracycline, and trimethoprim-sulfamethoxazole, on the cell surface characteristics and the virulences of two toxigenic isolates of Pasteurella multocida representing capsular types A and D were evaluated. Expression of proteins, in particular, out...

journal_title：Antimicrobial agents and chemotherapy

authors： Lebrun A,Caya M,Jacques M

更新日期：1992-10-01 00:00:00

abstract：:Analysis of two clonally related multiresistant Pseudomonas aeruginosa isolates led to the identification of a novel IMP-type metallo-β-lactamase. IMP-29 was significantly different from the other IMP variants (the closest variant being IMP-5 with 93% amino acid identity). The bla(IMP-29) gene cassette was carried by ...

journal_title：Antimicrobial agents and chemotherapy

authors： Jeannot K,Poirel L,Robert-Nicoud M,Cholley P,Nordmann P,Plésiat P

更新日期：2012-04-01 00:00:00