Resistance of Pseudomonas aeruginosa to gentamicin and related aminoglycoside antibiotics.

abstract：:There remains an unmet need to address the substantial morbidity and mortality associated with severe community-acquired pneumonia (sCAP). Recombinant human plasma gelsolin (rhu-pGSN) improves disease outcomes in diverse animal models of infectious and noninfectious inflammation. This blinded dose-escalation safety st...

journal_title：Antimicrobial agents and chemotherapy

authors： Tannous A,Levinson SL,Bolognese J,Opal SM,DiNubile MJ

更新日期：2020-09-21 00:00:00

abstract：:Eighty group G streptococcal stains were collected from Chinese children. Susceptibility testing was done by a double-dilution and a disk diffusion method. PCR was used to test drug-resistant genes, and the χ(2) test and definite probability methods were used to test for statistically significant differences among the...

journal_title：Antimicrobial agents and chemotherapy

authors： Yin J,Yu S,Liu X,Li Y,Gao W,Ma X,Yang Y

更新日期：2011-01-01 00:00:00

abstract：:The antibiotic tolerances of bacterial persisters have been attributed to transient dormancy. While persisters have been observed to be growth inhibited prior to antibiotic exposure, we sought to determine whether such a trait was essential to the phenotype. Furthermore, we sought to provide direct experimental eviden...

journal_title：Antimicrobial agents and chemotherapy

authors： Orman MA,Brynildsen MP

更新日期：2013-07-01 00:00:00

abstract：:Colistin resistance, although uncommon, is increasingly being reported among Gram-negative clinical pathogens, and an understanding of its impact on the activity of antimicrobials is now evolving. We evaluated the potential for synergy of colistin plus trimethoprim, trimethoprim-sulfamethoxazole (1/19 ratio), or vanco...

journal_title：Antimicrobial agents and chemotherapy

authors： Vidaillac C,Benichou L,Duval RE

更新日期：2012-09-01 00:00:00

abstract：:Consideration of existing compounds always simplifies and shortens the long and difficult process of discovering new drugs specifically for diseases of developing countries, an approach that may add to the significant potential cost savings. This study focused on improving the biological characteristics of the already...

journal_title：Antimicrobial agents and chemotherapy

authors： El-Feky GS,Mohamed WS,Nasr HE,El-Lakkany NM,Seif El-Din SH,Botros SS

更新日期：2015-01-01 00:00:00

abstract：:All known DNA ligases catalyze the formation of a phosphodiester linkage between adjacent termini in double-stranded DNA via very similar mechanisms. The ligase family can, however, be divided into two classes: eubacterial ligases, which require NAD(+) as a cofactor, and other ligases, from viruses, archaea, and eukar...

journal_title：Antimicrobial agents and chemotherapy

authors： Ciarrocchi G,MacPhee DG,Deady LW,Tilley L

更新日期：1999-11-01 00:00:00

abstract：:(1,3)Beta-D-glucan synthase (EC 2.4.1.34. UDP-glucose: 1,3-beta-D-glucan 3-beta-glucosyltransferase) uses UDP-glucose as substrate and catalyzes the polymerization of glucose ([1,3]-beta-linkages) to form the major carbohydrate component of the fungal cell wall. We have optimized in vitro assay conditions for (1,3)bet...

journal_title：Antimicrobial agents and chemotherapy

authors： Maligie MA,Selitrennikoff CP

更新日期：2005-07-01 00:00:00

abstract：:The antifolate activity and the transport characteristics of isoaminopterin (IA) in HeLa cells were studied and compared with those of methotrexate (MTX). Both IA and MTX inhibited the incorporation of [2-(14)C]deoxyuridine into HeLa cell DNA by 50% at a concentration of 0.09 muM by 8 h postaddition of the compounds. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Rosemond-Hornbeak H,Nair MG

更新日期：1979-05-01 00:00:00

abstract：:The penetration of intravenously administered cefuroxime into ventricular fluid was assessed in five pediatric patients with ventriculoperitoneal shunt infections and in one with a ventriculostomy infection. Patients received a total dose of 200 to 230 mg of cefuroxime per kg of body weight per day administered at 8-h...

journal_title：Antimicrobial agents and chemotherapy

authors： Edwards MS,Baker CJ,Butler KM,Mason EO Jr,Laurent JP,Cheek WR

更新日期：1989-07-01 00:00:00

abstract：:We identified GRL-1388 and -1398, potent nonpeptidic human immunodeficiency virus type 1 (HIV-1) protease inhibitors (PIs) containing a bicyclic P2 functional moiety, tetrahydropyrano-tetrahydrofuran (Tp-THF). GRL-1388 was as potent as darunavir (DRV) against various drug-resistant HIV-1 laboratory strains with 50% ef...

journal_title：Antimicrobial agents and chemotherapy

authors： Ide K,Aoki M,Amano M,Koh Y,Yedidi RS,Das D,Leschenko S,Chapsal B,Ghosh AK,Mitsuya H

更新日期：2011-04-01 00:00:00

abstract：:Mycobacterium abscessus is a major nontuberculous mycobacterial (NTM) pathogen and is responsible for about 80% of all pulmonary infections caused by rapidly growing mycobacteria. Clofazimine is an effective drug active against M. abscessus, but the mechanism of resistance to clofazimine in M. abscessus is unknown. To...

journal_title：Antimicrobial agents and chemotherapy

authors： Chen Y,Chen J,Zhang S,Shi W,Zhang W,Zhu M,Zhang Y

更新日期：2018-06-26 00:00:00

abstract：:We report the first description of the metallo-β-lactamase VIM-31, a new variant of VIM-2 with Tyr224His and His252Arg mutations, in Enterobacter cloacae 11236, which was isolated from blood specimens of a patient with colonic adenocarcinoma in Belgium. bla(VIM-31) was found on a class 1 integron located on a self-tra...

journal_title：Antimicrobial agents and chemotherapy

authors： Bogaerts P,Bebrone C,Huang TD,Bouchahrouf W,Degheldre Y,Deplano A,Hoffmann K,Glupczynski Y

更新日期：2012-06-01 00:00:00

abstract：:The discovery of antibiotics in the last century is considered one of the most important achievements in the history of medicine. Antibiotic usage has significantly reduced morbidity and mortality associated with bacterial infections. However, inappropriate use of antibiotics has led to emergence of antibiotic resista...

journal_title：Antimicrobial agents and chemotherapy

authors： Ghosh D,Veeraraghavan B,Elangovan R,Vivekanandan P

更新日期：2020-01-27 00:00:00

abstract：:Targeted antisense and gene replacement mutagenesis experiments demonstrate that only the murA1 gene and not the murA2 gene is required for the normal cellular growth of Bacillus anthracis. Antisense-based modulation of murA1 gene expression hypersensitizes cells to the MurA-specific antibiotic fosfomycin despite the ...

journal_title：Antimicrobial agents and chemotherapy

authors： Kedar GC,Brown-Driver V,Reyes DR,Hilgers MT,Stidham MA,Shaw KJ,Finn J,Haselbeck RJ

更新日期：2008-06-01 00:00:00

abstract：:It remains controversial whether combination therapy, given empirically or as definitive treatment, for Pseudomonas aeruginosa bacteremia is associated with a better outcome than monotherapy. The aim of the present study was to compare the rates of survival among patients who received either combination therapy or mon...

journal_title：Antimicrobial agents and chemotherapy

authors： Chamot E,Boffi El Amari E,Rohner P,Van Delden C

更新日期：2003-09-01 00:00:00

abstract：:Sparfloxacin, a new fluorinated quinolone, exhibits higher in vitro activity against pneumococci than do ciprofloxacin and ofloxacin. Since up to 30% of cases of pneumococcal pneumonia are associated with bacteremia, and since an increasing percentage of pneumococci are resistant against penicillin, we studied the ser...

journal_title：Antimicrobial agents and chemotherapy

authors： Trautmann M,Ruhnke M,Borner K,Wagner J,Koeppe P

更新日期：1996-03-01 00:00:00

abstract：:Genome editing using zinc finger nucleases (ZFNs) has been successfully applied to disrupt CCR5 or CXCR4 host factors and inhibit viral entry and infection. Gene therapy using ZFNs to modify the PSIP1 gene, which encodes the lens epithelium-derived growth factor (LEDGF) protein, might restrain an early step of the vir...

journal_title：Antimicrobial agents and chemotherapy

authors： Badia R,Pauls E,Riveira-Munoz E,Clotet B,Esté JA,Ballana E

更新日期：2014-08-01 00:00:00

abstract：:The MICs and MBCs of the new difluorinated quinolone drug sparfloxacin against type strains belonging to 21 species of mycobacteria were screened. The MICs and MBCs were within the range of 0.1 to 2.0 and 0.1 to 4.0 micrograms/ml, respectively (with an MBC/MIC ratio of 1 to 2), and against 18 of the 21 species tested,...

journal_title：Antimicrobial agents and chemotherapy

authors： Rastogi N,Labrousse V,Goh KS,De Sousa JP

更新日期：1991-12-01 00:00:00

abstract：:The single- and multiple-dose pharmacokinetics of and tolerability to a new microfluidized suspension of atovaquone were studied in human immunodeficiency virus-seropositive patients with CD4 counts of < or = 200 cells per mm3 in order to define a dosing regimen for the treatment of Pneumocystis carinii pneumonia. Thi...

journal_title：Antimicrobial agents and chemotherapy

authors： Dixon R,Pozniak AL,Watt HM,Rolan P,Posner J

更新日期：1996-03-01 00:00:00

abstract：:The efficacy and safety of oral LY217896 for prevention of experimental influenza A/Kawasaki/86 (H1N1) virus infection were assessed in susceptible males randomly assigned to receive LY217896 (75 mg) or placebo once daily for 7 days beginning 24 h prior to viral challenge. The rates of virus shedding (100% in both gro...

journal_title：Antimicrobial agents and chemotherapy

authors： Hayden FG,Tunkel AR,Treanor JJ,Betts RF,Allerheiligen S,Harris J

更新日期：1994-05-01 00:00:00

abstract：:In a previous work, we described the possible relationship between a defect of purine-cytosine permease and the acquisition of a cross-resistance to the antifungal combination flucytosine (5FC) and fluconazole (FLC) in Candida lusitaniae (T. Noël, F. François, P. Paumard, C. Chastin, D. Brethes, and J. Villard, Antimi...

journal_title：Antimicrobial agents and chemotherapy

authors： Chapeland-Leclerc F,Bouchoux J,Goumar A,Chastin C,Villard J,Noël T

更新日期：2005-08-01 00:00:00

abstract：:The efficacy of a new class of drugs for Pneumocystis carinii pneumonitis was demonstrated. 566C80, a hydroxynaphthoquinone, administered orally in a dose of greater than or equal to 100 mg/kg of body weight per day prophylactically prevented P. carinii pneumonitis in 90% or more of rats, while all untreated control a...

journal_title：Antimicrobial agents and chemotherapy

authors： Hughes WT,Gray VL,Gutteridge WE,Latter VS,Pudney M

更新日期：1990-02-01 00:00:00

abstract：:Since beta-lactam antibiotics have concentration-independent killing, bacterial eradication is a function of the time the serum drug concentration remains above the drug's MIC (T > MIC). We compared the serum bactericidal titers (SBTs) of ceftazidime given by continuous infusion (CI) or by intermittent bolus dosing (B...

journal_title：Antimicrobial agents and chemotherapy

authors： Nicolau DP,Nightingale CH,Banevicius MA,Fu Q,Quintiliani R

更新日期：1996-01-01 00:00:00

abstract：:After inducing mutagenesis with nitrosoguanidine, we used vancomycin enrichment in isolating auxotrophic mutants of Mycobacterium smegmatis. Compared with cycloserine and penicillin G, which are also cell wall inhibitors, vancomycin, with 24 h of exposure, produced less cell lysis and a greater reduction in viable cel...

journal_title：Antimicrobial agents and chemotherapy

authors： Woodley CL,Baldwin JN,Greenberg J

更新日期：1981-04-01 00:00:00

abstract：:An open, randomized comparison of ofloxacin (200 mg, every 12 h) given orally for 5 days and ceftriaxone (3 g, once daily) given intravenously for 3 days in the treatment of uncomplicated enteric fever was conducted in Ho Chi Minh City, Vietnam. Salmonella paratyphi type A was isolated from six patients. Salmonella ty...

journal_title：Antimicrobial agents and chemotherapy

authors： Smith MD,Duong NM,Hoa NT,Wain J,Ha HD,Diep TS,Day NP,Hien TT,White NJ

更新日期：1994-08-01 00:00:00

abstract：:The P450 enzyme, CYP3A4, extensively metabolizes both amprenavir and clarithromycin. To determine if an interaction exists when these two drugs are coadministered, the pharmacokinetics of amprenavir and clarithromycin were investigated in healthy adult male volunteers. This was a Phase I, open-label, randomized, balan...

journal_title：Antimicrobial agents and chemotherapy

authors： Brophy DF,Israel DS,Pastor A,Gillotin C,Chittick GE,Symonds WT,Lou Y,Sadler BM,Polk RE

更新日期：2000-04-01 00:00:00

abstract：:The activity of cefotaxime, either alone or combined with an aminoglycoside, was determined against 50 isolates of Pseudomonas aeruginosa, of which 50, 33, and 10 were resistant to gentamicin, tobramycin, and amikacin, respectively. Cefotaxime inhibited 34 isolates at a concentration of 16 microgram/ml and all isolate...

journal_title：Antimicrobial agents and chemotherapy

authors： Murray PR

更新日期：1980-03-01 00:00:00

abstract：:Sixty-three consecutive streptococcal blood isolates from neutropenic patients, represented mainly by viridans group streptococci, were evaluated in vitro for antibiotic susceptibility. Of these isolates, 79.3% were highly susceptible to penicillin (MIC, less than or equal to 0.12 microgram/ml). Overall, imipenem was ...

journal_title：Antimicrobial agents and chemotherapy

authors： Venditti M,Baiocchi P,Santini C,Brandimarte C,Serra P,Gentile G,Girmenia C,Martino P

更新日期：1989-04-01 00:00:00

abstract：:The aim of this analysis was to identify therapeutic micafungin regimens for children that produce the same micafungin exposures known to be effective for the prevention and treatment of Candida infections in adults. Pediatric pharmacokinetic data from 229 patients between the ages of 4 months and <17 years were obtai...

journal_title：Antimicrobial agents and chemotherapy

authors： Hope WW,Kaibara A,Roy M,Arrieta A,Azie N,Kovanda LL,Benjamin DK Jr

更新日期：2015-02-01 00:00:00

abstract：:Tested against 9,412 recent clinical isolates, cefotaxime exhibited 8 to 64 times greater activity against the Enterobacteriaceae than did cephalothin and two to four times greater activity against Pseudomonas aeruginosa, but only one-half to one-eighth the activity of cephalothin against staphylococci. Using 420 diff...

journal_title：Antimicrobial agents and chemotherapy

authors： Fuchs PC,Barry AL,Thornsberry C,Jones RN,Gavan TL,Gerlach EH,Sommers HM

更新日期：1980-07-01 00:00:00