Evaluation of a loop-mediated isothermal amplification-based methodology to detect carbapenemase carriage in Acinetobacter clinical isolates.

abstract：:Cefazolin was added to dialysis fluid in nine patients with renal failure undergoing peritoneal dialysis with 2 liters/h per exchange. With 50 mg/liter (three patients), the first measurable mean serum concentration was 3.7 mug/ml (range, 2.4 to 4.9 mug/ml) after three exchanges and was 30.3 mug/ml (range, 13.3 to 44....

journal_title：Antimicrobial agents and chemotherapy

authors： Kaye D,Wenger N,Agarwal B

更新日期：1978-09-01 00:00:00

abstract：:The therapeutic effect of intranasally administered enviroxime was tested against naturally occurring common colds. The double-blind evaluation was carried out in Tecumseh, Mich., during a period when rhinoviruses are usually the principal pathogen. Rhinovirus transmission followed the typical pattern during this peri...

journal_title：Antimicrobial agents and chemotherapy

authors： Miller FD,Monto AS,DeLong DC,Exelby A,Bryan ER,Srivastava S

更新日期：1985-01-01 00:00:00

abstract：:Polysorbate 80 (PS80) is a nonionic surfactant and detergent that inhibits biofilm formation by Pseudomonas aeruginosa at concentrations as low as 0.001% and is well tolerated in human tissues. However, certain clinical and laboratory strains (PAO1) of P. aeruginosa are able to form biofilms in the presence of PS80. T...

journal_title：Antimicrobial agents and chemotherapy

authors： Zegans ME,Wozniak D,Griffin E,Toutain-Kidd CM,Hammond JH,Garfoot A,Lam JS

更新日期：2012-08-01 00:00:00

abstract：:Mice treated with antibiotics early or late after active infection had resolved were examined for chlamydial DNA in endocervical swabs. The early eradication of infection limited oviduct pathology, despite the continued detection of chlamydial DNA by nested PCR. Late antibiotic treatment had no effect on the ability t...

journal_title：Antimicrobial agents and chemotherapy

authors： Reeves DM,Nagarajan U,O'Connell C,Andrews CW Jr,Darville T

更新日期：2007-07-01 00:00:00

abstract：:A strain of Staphylococcus aureus was planted on filter membranes placed on Trypticase soy agar (BBL). After incubation, the membranes with growing staphylococci were transferred to Trypticase soy agar containing a subinhibitory concentration of penicillin (one-third minimal inhibitory concentration) and again incubat...

journal_title：Antimicrobial agents and chemotherapy

authors： Lorian V

更新日期：1975-06-01 00:00:00

abstract：:The pharmacokinetics and penetration into a cantharidine-induced inflammatory exudate of meropenem was studied in six volunteers following a single 1-g intravenous dose. Concentrations in plasma, urine, and the inflammatory exudate were determined by a microbiological assay. The mean elimination half-life of meropenem...

journal_title：Antimicrobial agents and chemotherapy

authors： Wise R,Logan M,Cooper M,Ashby JP,Andrews JM

更新日期：1990-08-01 00:00:00

abstract：:The dependence of microbial killing on chloride ions present in solutions undergoing iontophoresis is addressed. A 400-microA current was applied to vials containing synthetic urine or saline, and the production of chlorine-based substances (CBSs) was detected by the N,N-diethyl-p-phenylene diamine colorimetric method...

journal_title：Antimicrobial agents and chemotherapy

authors： Davis CP,Shirtliff ME,Trieff NM,Hoskins SL,Warren MM

更新日期：1994-12-01 00:00:00

abstract：:Previous studies on tetracycline transport into Staphylococcus aureus identified a high-affinity, saturable uptake system for the antibiotic (Km, 4.76 microM) (B.L. Hutchings, Biochim. Biophys. Acta 174:734-738, 1969). However, the earlier results could not be confirmed using conditions that permitted energy-dependent...

journal_title：Antimicrobial agents and chemotherapy

authors： Chopra I,Ismail S,Oliva B

更新日期：1991-12-01 00:00:00

abstract：:We present a 31-year-old female who had undergone an allogeneic bone marrow transplantation and who was started on intravenous posaconazole for pulmonary mycosis while undergoing continuous venovenous hemofiltration (CVVH). We performed steady-state pharmacokinetic evaluations for both posaconazole and sulfobutylether...

journal_title：Antimicrobial agents and chemotherapy

authors： Morris AA,Mueller SW,Rower JE,Washburn T,Kiser TH

更新日期：2015-10-01 00:00:00

abstract：:Coadministration of nevirapine-based antiretroviral therapy (ART) and artemether-lumefantrine is reported to result in variable changes in lumefantrine exposure. We conducted an intensive pharmacokinetic study with 11 HIV-infected adults who were receiving artemether-lumefantrine plus nevirapine-based ART, and we comp...

journal_title：Antimicrobial agents and chemotherapy

authors： Parikh S,Fehintola F,Huang L,Olson A,Adedeji WA,Darin KM,Morse GD,Murphy RL,Taiwo BO,Akinyinka OO,Adewole IF,Aweeka FT,Scarsi KK

更新日期：2015-12-01 00:00:00

abstract：:Acquiring iron (Fe) is critical to the metabolism and growth of Mycobacterium tuberculosis. Disruption of Fe metabolism is a potential approach for novel antituberculous therapy. Gallium (Ga) has many similarities to Fe. Biological systems are often unable to distinguish Ga(3+) from Fe(3+). Unlike Fe(3+), Ga(3+) canno...

journal_title：Antimicrobial agents and chemotherapy

authors： Olakanmi O,Kesavalu B,Pasula R,Abdalla MY,Schlesinger LS,Britigan BE

更新日期：2013-12-01 00:00:00

abstract：:The activities of sparfloxacin, azithromycin, temafloxacin, and rifapentine against two virulent strains of the Mycobacterium avium complex isolated from patients with AIDS were evaluated in a model of intracellular infection and were compared with that of clarithromycin. Human monocyte-derived macrophages were infect...

journal_title：Antimicrobial agents and chemotherapy

authors： Perronne C,Gikas A,Truffot-Pernot C,Grosset J,Vilde JL,Pocidalo JJ

更新日期：1991-07-01 00:00:00

abstract：:A comparative evaluation of daptomycin and eight other antimicrobial agents was performed by the agar dilution technique with 56 strains of vancomycin-resistant gram-positive bacteria, including Leuconostoc, Lactobacillus, and Pediococcus spp. Erythromycin, deptomycin, clindamycin, and gentamicin exhibited the greates...

journal_title：Antimicrobial agents and chemotherapy

authors： de la Maza L,Ruoff KL,Ferraro MJ

更新日期：1989-08-01 00:00:00

abstract：:Resistance-nodulation-division (RND) efflux pumps are important contributors to bacterial antibiotic resistance. In this study, we combined evolutionary sequence analyses, computational structural modeling, and ligand docking to develop a framework that can explain the known antibiotic substrate selectivity difference...

journal_title：Antimicrobial agents and chemotherapy

authors： Dey D,Kavanaugh LG,Conn GL

更新日期：2020-07-22 00:00:00

abstract：:Posaconazole (POS) is a new antifungal agent for prevention and therapy of mycoses in immunocompromised patients. Variable POS pharmacokinetics after oral dosing may influence efficacy: a trough threshold of 0.5 μg/ml has been recently proposed. Measurement of POS plasma concentrations by complex chromatographic techn...

journal_title：Antimicrobial agents and chemotherapy

authors： Rochat B,Pascual A,Pesse B,Lamoth F,Sanglard D,Decosterd LA,Bille J,Marchetti O

更新日期：2010-12-01 00:00:00

abstract：:β-Lactam antibiotics that inhibit penicillin-binding proteins (PBPs) have been widely used in the treatment of bacterial infections. However, the molecular basis underlying the different inhibitory potencies of β-lactams against specific PBPs is not fully understood. Here, we present the crystal structures of penicill...

journal_title：Antimicrobial agents and chemotherapy

authors： Jeong JH,Cha HJ,Kim YG

更新日期：2018-08-27 00:00:00

abstract：:Curcumin, a principal component of turmeric, acts as an immunomodulator regulating the host defenses in response to a diseased condition. The role of curcumin in controlling certain infectious diseases is highly controversial. It is known to alleviate symptoms of Helicobacter pylori infection and exacerbate that of Le...

journal_title：Antimicrobial agents and chemotherapy

authors： Marathe SA,Sen M,Dasgupta I,Chakravortty D

更新日期：2012-11-01 00:00:00

abstract：:The efficacy and safety of a novel once-daily extended-release ciprofloxacin (ciprofloxacin ER) 500-mg dose were compared with those of an immediate-release ciprofloxacin (ciprofloxacin IR) 250-mg twice-daily dose, each administered orally for 3 days in the treatment of acute uncomplicated urinary tract infection (uUT...

journal_title：Antimicrobial agents and chemotherapy

authors： Fourcroy JL,Berner B,Chiang YK,Cramer M,Rowe L,Shore N

更新日期：2005-10-01 00:00:00

abstract：:A series of quaternary ammonium compounds that are esters of betaine and fatty alcohols with hydrocarbon chain lengths of 10 to 18 carbon atoms were tested with respect to antimicrobial activities and rates of hydrolysis. When the tetradecyl derivative was tested against some selected microorganisms, the killing effec...

journal_title：Antimicrobial agents and chemotherapy

authors： Lindstedt M,Allenmark S,Thompson RA,Edebo L

更新日期：1990-10-01 00:00:00

abstract：:The two components of virginiamycin, virginiamycin M (VM) and virginiamycin S (VS), were used to explore the life cycle of symbiosis-dependent and -independent strains of Bdellovibrio bacteriovorus during multiplication in a two-membered system with either living or heat-inactivated Escherichia coli or in axenic cultu...

journal_title：Antimicrobial agents and chemotherapy

authors： Varon M,Cocito C,Seijffers J

更新日期：1976-01-01 00:00:00

abstract：:Clostridium difficile is a major nosocomial pathogen responsible for pseudomembranous colitis and many cases of antibiotic-associated diarrhea. Because of potential relapse of disease with current antimicrobial therapy protocols, there is a need for additional and/or alternative antimicrobial agents for the treatment ...

journal_title：Antimicrobial agents and chemotherapy

authors： Mahony DE,Lim-Morrison S,Bryden L,Faulkner G,Hoffman PS,Agocs L,Briand GG,Burford N,Maguire H

更新日期：1999-03-01 00:00:00

abstract：:Doravirine is a novel nonnucleoside reverse transcriptase inhibitor in development for use with other antiretroviral therapies to treat human immunodeficiency virus type 1 (HIV-1) infection. Doravirine metabolism predominantly occurs via cytochrome P450 3A with <10% of elimination occurring via the renal pathway. As s...

journal_title：Antimicrobial agents and chemotherapy

authors： Ankrom W,Yee KL,Sanchez RI,Adedoyin A,Fan L,Marbury T,Preston RA,Iwamoto M,Khalilieh SG

更新日期：2018-07-27 00:00:00

abstract：:The emergence of artemisinin-resistant Plasmodium falciparum poses a major threat to current frontline artemisinin combination therapies. Artemisinin resistance is widely associated with mutations in the P. falciparum Kelch13 (PfKelch13) propeller region, leading to delayed parasite clearance and increased survival of...

journal_title：Antimicrobial agents and chemotherapy

authors： Tong JX,Ang SEL,Tan EHN,Tan KSW

更新日期：2019-03-27 00:00:00

abstract：:Amphotericin B colloidal dispersion (ABCD) is a new formulation of conventional amphotericin B designed to minimize drug distribution in the kidney and reduce nephrotoxicity. We studied the safety and efficacy of ABCD in 133 renally compromised patients with invasive fungal infections. Patients had either nephrotoxici...

journal_title：Antimicrobial agents and chemotherapy

authors： Anaissie EJ,Mattiuzzi GN,Miller CB,Noskin GA,Gurwith MJ,Mamelok RD,Pietrelli LA

更新日期：1998-03-01 00:00:00

abstract：:Tested against 9,412 recent clinical isolates, cefotaxime exhibited 8 to 64 times greater activity against the Enterobacteriaceae than did cephalothin and two to four times greater activity against Pseudomonas aeruginosa, but only one-half to one-eighth the activity of cephalothin against staphylococci. Using 420 diff...

journal_title：Antimicrobial agents and chemotherapy

authors： Fuchs PC,Barry AL,Thornsberry C,Jones RN,Gavan TL,Gerlach EH,Sommers HM

更新日期：1980-07-01 00:00:00

abstract：:Ga(3+) is a semimetal element that competes for the iron-binding sites of transporters and enzymes. We investigated the activity of gallium maltolate (GaM), an organic gallium salt with high solubility, against laboratory and clinical strains of methicillin-susceptible Staphylococcus aureus (MSSA), methicillin-resista...

journal_title：Antimicrobial agents and chemotherapy

authors： Baldoni D,Steinhuber A,Zimmerli W,Trampuz A

更新日期：2010-01-01 00:00:00

abstract：:The in vitro and in vivo activities of a mixture of six oleane triterpene saponins, recovered from the methanolic extract of the leaves of the Vietnamese plant Maesa balansae (PX-6518), were evaluated against drug-sensitive visceral Leishmania strains. The in vitro 50% inhibitory concentration (IC(50)) against intrace...

journal_title：Antimicrobial agents and chemotherapy

authors： Maes L,Vanden Berghe D,Germonprez N,Quirijnen L,Cos P,De Kimpe N,Van Puyvelde L

更新日期：2004-01-01 00:00:00

abstract：:Three hundred ninety-four patients, aged 6 months to 12 years, entered a multicenter, randomized, controlled, investigator-blind study comparing cefdinir, 7 mg/kg of body weight twice a day, with cephalexin, 10 mg/kg four times a day, each given for 10 days. The most common infections treated were impetigo and seconda...

journal_title：Antimicrobial agents and chemotherapy

authors： Tack KJ,Keyserling CH,McCarty J,Hedrick JA

更新日期：1997-04-01 00:00:00

abstract：:When strains harboring R factor and showing ampicillin (APC) resistance were inoculated on plates containing various concentrations of APC, mutants carrying various levels of APC resistance occurred at high frequencies. Increases in the level of APC resistance were due to a quantitative increase in the formation of pe...

journal_title：Antimicrobial agents and chemotherapy

authors： Odakura Y,Tanaka T,Hashimoto H,Mitsuhashi S

更新日期：1973-03-01 00:00:00

abstract：:The in vitro activity of BMS-207147 against 80 clinical isolates of Aspergillus was compared with that of itraconazole and amphotericin B, using a validated microtiter method. Geometric mean MICs (in microg/ml) were as follows: 1.71 for BMS-207147, 0.67 for itraconazole, and 0.63 for amphotericin B. The range of conce...

journal_title：Antimicrobial agents and chemotherapy

authors： Moore CB,Walls CM,Denning DW

更新日期：2000-02-01 00:00:00