Treatment of invasive fungal infections in renally impaired patients with amphotericin B colloidal dispersion.

abstract：:Bloodstream infection (BSI) due to multidrug-resistant Klebsiella is associated with high rates of morbidity and mortality. The aim of this study was to identify predictors of in-hospital mortality among patients with BSI due to ceftazidime-resistant (CAZ-R) Klebsiella pneumoniae at a tertiary care medical center. Pat...

journal_title：Antimicrobial agents and chemotherapy

authors： Anderson DJ,Engemann JJ,Harrell LJ,Carmeli Y,Reller LB,Kaye KS

更新日期：2006-05-01 00:00:00

abstract：:Oral doses of norfloxacin (80 mg/kg of body weight per day) and ciprofloxacin (25 and 80 mg/kg/day) and intramuscular doses of teicoplanin (5 mg/kg/day), all administered once a day for 10 days, were evaluated as a means of preventing encrusted cystitis caused by Corynebacterium group D2. Zinc disks dipped into a 24-h...

journal_title：Antimicrobial agents and chemotherapy

authors： Soriano F,Rodriguez-Tudela JL,Castilla C,Avilés P

更新日期：1991-12-01 00:00:00

abstract：:Amphotericin B lipid complex for injection (ABLC) is a suspension of amphotericin B complexed with the lipids L-alpha-dimyristoylphosphatidylcholine (DMPC) and L-alpha-dimyristoylphosphatidylglycerol. ABLC is less toxic than amphotericin B deoxycholate (AmB-d), while it maintains the antifungal activity of AmB-d. Acti...

journal_title：Antimicrobial agents and chemotherapy

authors： Swenson CE,Perkins WR,Roberts P,Ahmad I,Stevens R,Stevens DA,Janoff AS

更新日期：1998-04-01 00:00:00

abstract：:A novel streptogramin A, pleuromutilin, and lincosamide resistance determinant, Vga(E), was identified in porcine methicillin-resistant Staphylococcus aureus (MRSA) ST398. The vga(E) gene encoded a 524-amino-acid protein belonging to the ABC transporter family. It was found on a multidrug resistance-conferring transpo...

journal_title：Antimicrobial agents and chemotherapy

authors： Schwendener S,Perreten V

更新日期：2011-10-01 00:00:00

abstract：:The in vitro activities of GAR-936, the 9-t-butylglycylamido derivative of minocycline, were compared with those of doxycycline, minocycline, and tetracycline against 527 gram-positive clinical isolates. GAR-936 inhibited all strains, including those resistant to other tetracyclines, at concentrations of

journal_title：Antimicrobial agents and chemotherapy

authors： Boucher HW,Wennersten CB,Eliopoulos GM

更新日期：2000-08-01 00:00:00

abstract：:The in vitro activities of luliconazole, amorolfine, ciclopirox, and terbinafine were determined against 320 dermatophyte isolates from large toenails of onychomycosis patients enrolled into an ongoing phase 2b/3 clinical study. The geometric mean MIC for luliconazole was 0.00022 μg/ml against all isolates, compared t...

journal_title：Antimicrobial agents and chemotherapy

authors： Wiederhold NP,Fothergill AW,McCarthy DI,Tavakkol A

更新日期：2014-06-01 00:00:00

abstract：:Enterococcus faecium has emerged as a major opportunistic pathogen for 2 decades with the spread of hospital-adapted multidrug-resistant clones. As members of the intestinal microbiota, they are subjected to numerous bacterial stresses, including antibiotics at subinhibitory concentrations (SICs). Since fluoroquinolon...

journal_title：Antimicrobial agents and chemotherapy

authors： Sinel C,Cacaci M,Meignen P,Guérin F,Davies BW,Sanguinetti M,Giard JC,Cattoir V

更新日期：2017-04-24 00:00:00

abstract：:We asked whether beta-lactamase inhibitors (BLIs) increased the activity of daptomycin (DAP) against methicillin-resistant Staphylococcus aureus (MRSA), the peptide antibiotic colistin (COL) against the emerging Gram-negative nosocomial pathogen Acinetobacter baumannii, and the human host defense peptide cathelicidin ...

journal_title：Antimicrobial agents and chemotherapy

authors： Sakoulas G,Rose W,Berti A,Olson J,Munguia J,Nonejuie P,Sakoulas E,Rybak MJ,Pogliano J,Nizet V

更新日期：2017-01-24 00:00:00

abstract：:The EmbCAB proteins have been considered a target for ethambutol (EMB). Mutations in embCAB are known to confer most EMB resistance. However, the knowledge about the effects of embCAB mutations on the EMB resistance level and about the role of mutation-mutation interactions is limited in China. Here, we sequenced embC...

journal_title：Antimicrobial agents and chemotherapy

authors： Sun Q,Xiao TY,Liu HC,Zhao XQ,Liu ZG,Li YN,Zeng H,Zhao LL,Wan KL

更新日期：2017-12-21 00:00:00

abstract：:Vancomycin is a renally excreted drug, and its body clearance correlates with creatinine clearance. However, the renal function estimation equation that best predicts vancomycin clearance has not been established yet. The objective of this study was to compare the abilities of different renal function estimation equat...

journal_title：Antimicrobial agents and chemotherapy

authors： Glatard A,Bourguignon L,Jelliffe RW,Maire P,Neely MN,Goutelle S

更新日期：2015-01-01 00:00:00

abstract：:The carbapenem-hydrolyzing class D β-lactamase OXA-253 was identified in an Acinetobacter baumannii clinical isolate belonging to sequence type 113 (ST113) in Brazil. OXA-253 shares 93.8% amino acid identity with OXA-143. The blaOXA-253 gene is located on a ca. 20-kb plasmid. The genetic environment of the blaOXA-253 ...

journal_title：Antimicrobial agents and chemotherapy

authors： Girlich D,Damaceno QS,Oliveira AC,Nordmann P

更新日期：2014-05-01 00:00:00

abstract：:To compare the in vitro antibacterial efficacies and resistance profiles of rifampin-based combinations against methicillin-resistant Staphylococcus aureus (MRSA) in a biofilm model, the antibacterial activities of vancomycin, teicoplanin, daptomycin, minocycline, linezolid, fusidic acid, fosfomycin, and tigecycline a...

journal_title：Antimicrobial agents and chemotherapy

authors： Tang HJ,Chen CC,Cheng KC,Wu KY,Lin YC,Zhang CC,Weng TC,Yu WL,Chiu YH,Toh HS,Chiang SR,Su BA,Ko WC,Chuang YC

更新日期：2013-11-01 00:00:00

abstract：:The activities of trimethoprim (TMP) and sulfamethoxazole (SMZ), alone and in combination (SMZ-TMP), and of the following antibiotics were tested against 115 clinical isolates of nontyphoid Salmonella species: tobramycin, gentamicin, ampicillin, amoxicillin, neomycin, kanamycin, chloramphenicol, and tetracycline. The ...

journal_title：Antimicrobial agents and chemotherapy

authors： Marks MI,Kazemi M,MacKay E

更新日期：1973-11-01 00:00:00

abstract：:We sought to determine whether there was an interaction between aminoglycoside use and shock in their effect on renal function among seriously ill patients suspected of having gram-negative sepsis. Serial serum creatinine determinations were used to estimate changes in creatinine clearance rates in 179 patients entere...

journal_title：Antimicrobial agents and chemotherapy

authors： Ambinder RF,Moore RD,Smith CR,Mellits ED,Lietman PS

更新日期：1985-02-01 00:00:00

abstract：:The accumulation of quinolones by Escherichia coli JF568, Pseudomonas aeruginosa PAO1, and Staphylococcus aureus ATCC 29213 was measured by a modified fluorometric assay (J. S. Chapman and N. H. Georgopapadakou, Antimicrob. Agents Chemother. 33:27-29, 1989). The quinolones examined were fleroxacin, pefloxacin, norflox...

journal_title：Antimicrobial agents and chemotherapy

authors： McCaffrey C,Bertasso A,Pace J,Georgopapadakou NH

更新日期：1992-08-01 00:00:00

abstract：:We previously demonstrated that the biguanide-based compound NB325 inhibits human immunodeficiency virus type 1 (HIV-1) infection by interacting with the CXCR4 viral coreceptor. This interaction also appeared to be persistent, since HIV-1 infection was inhibited even when the virus was introduced subsequent to the rem...

journal_title：Antimicrobial agents and chemotherapy

authors： Thakkar N,Pirrone V,Passic S,Keogan S,Zhu W,Kholodovych V,Welsh W,Rando R,Labib M,Wigdahl B,Krebs FC

更新日期：2010-05-01 00:00:00

abstract：:To evaluate maternal-fetal pharmacology of cefatrizine (BL-S 640), a new oral cephalosporin, a single oral 1,000-mg dose was administered to 33 gravidas (8 to 20 weeks' gestation) at varying intervals within 46 h of an elective therapeutic abortion by hysterectomy or intra-amniotic prostaglandin F(2a) induction. Mean ...

journal_title：Antimicrobial agents and chemotherapy

authors： Bernard B,Thielen P,Garcia-Cázares J,Ballard CA

更新日期：1977-08-01 00:00:00

abstract：:There is significant interest in the development of mass spectrometry (MS) methods for antimicrobial resistance protein detection, given the ability of these methods to confirm protein expression. In this work, we studied the performance of a liquid chromatography, tandem MS multiple-reaction monitoring (LC-MS/MS MRM)...

journal_title：Antimicrobial agents and chemotherapy

authors： Wang H,Strich JR,Drake SK,Chen Y,Youn JH,Rosenberg AZ,Gucek M,Dekker JP,Suffredini AF

更新日期：2019-08-23 00:00:00

abstract：:The minimal inhibitory concentrations of 45 antimicrobial agents were determined for 14 strains of Bacterium actinomycetem comitans (Actinobacillus actinomycetem-comitans). All the strains showed good susceptibility to tetracyclines and chloramphenicol, but not to lincomycins. Some strains were clearly resistant to pe...

journal_title：Antimicrobial agents and chemotherapy

authors： Höffler U,Niederau W,Pulverer G

更新日期：1980-06-01 00:00:00

abstract：:Various fluoroquinolones (norfloxacin, enoxacin, ofloxacin, levofloxacin, and sparfloxacin) induce DnaK and GroEL heat shock proteins in Escherichia coli. The induction is transient, consistent with the kinetics of cellular DNA relaxation. The concentrations of fluoroquinolones required for induction are similar to th...

journal_title：Antimicrobial agents and chemotherapy

authors： Mizushima T,Matsuo M,Sekimizu K

更新日期：1997-01-01 00:00:00

abstract：:In 1891 Guttmann and Ehrlich (P. Guttmann and P. Ehrlich, Berlin Klin. Wochenschr. 28:953-956, 1891) were the first to report the antimalarial properties of a synthetic, rather than a natural, material when they described the clinical cure of two patients after oral administration of a thiazine dye, methylene blue. Si...

journal_title：Antimicrobial agents and chemotherapy

authors： Vennerstrom JL,Makler MT,Angerhofer CK,Williams JA

更新日期：1995-12-01 00:00:00

abstract：:Beta-lactamase-negative ampicillin-resistant (BLNAR) isolates of Haemophilus influenzae have been emerging in some countries, including Japan. The Clinical and Laboratory Standards Institute has only a susceptible MIC breakpoint (< or = 1 microg/ml) for piperacillin-tazobactam and a disclaimer comment that BLNAR H. in...

journal_title：Antimicrobial agents and chemotherapy

authors： Hirakata Y,Ohmori K,Mikuriya M,Saika T,Matsuzaki K,Hasegawa M,Hatta M,Yamamoto N,Kunishima H,Yano H,Kitagawa M,Arai K,Kawakami K,Kobayashi I,Jones RN,Kohno S,Yamaguchi K,Kaku M

更新日期：2009-10-01 00:00:00

abstract：:Antimicrobial resistance (AMR) is an ever-growing public health problem worldwide. The low rate of antibiotic discovery coupled with the rapid spread of drug-resistant bacterial pathogens is causing a global health crisis. To facilitate the drug discovery processes, we present a large-scale study of reference antibiot...

journal_title：Antimicrobial agents and chemotherapy

authors： O'Rourke A,Beyhan S,Choi Y,Morales P,Chan AP,Espinoza JL,Dupont CL,Meyer KJ,Spoering A,Lewis K,Nierman WC,Nelson KE

更新日期：2020-02-21 00:00:00

abstract：:Targeting dormant Mycobacterium tuberculosis represents a challenge to antituberculosis drug discovery programs. We previously reported and validated the use of the streptomycin (STR)-dependent M. tuberculosis 18b strain as a tool for assessing drug potency against nonreplicating bacteria both in vitro and in vivo. In...

journal_title：Antimicrobial agents and chemotherapy

authors： Vocat A,Hartkoorn RC,Lechartier B,Zhang M,Dhar N,Cole ST,Sala C

更新日期：2015-07-01 00:00:00

abstract：:The capacity for intracellular growth is an important survival strategy for a large group of common pathogens. Helicobacter pylori, the etiological agent for gastritis and duodenal ulcer, has been shown by both in vivo and in vitro studies to have the capacity to invade epithelial cells. In vitro models are used to st...

journal_title：Antimicrobial agents and chemotherapy

authors： Hultén K,Rigo R,Gustafsson I,Engstrand L

更新日期：1996-12-01 00:00:00

abstract：:The antiviral effects of four compounds, phosphonoacetate, phosphonoformate, acycloguanosine, and purified human lymphoblastic interferon, were tested against two neurotropic herpesviruses, herpesvirus platyrrhine and herpes simplex virus, and two oncogenic herpesviruses, herpesvirus saimiri and herpesvirus ateles. Al...

journal_title：Antimicrobial agents and chemotherapy

authors： Daniel MD,Falk LA,King NW,Tamulevich R,Holland JS,Bekesi JG

更新日期：1980-10-01 00:00:00

abstract：:The high intrinsic penem resistance of Pseudomonas aeruginosa is due to the interplay among the outer membrane barrier, the active efflux system MexAB-OprM, and AmpC beta-lactamase. We studied the roles of two other efflux systems, MexCD-OprJ and MexXY-OprM, in penem resistance by overexpressing each system in an AmpC...

journal_title：Antimicrobial agents and chemotherapy

authors： Okamoto K,Gotoh N,Nishino T

更新日期：2002-08-01 00:00:00

abstract：:TEM-1 hyperproduction in two ampicillin-sulbactam-resistant Shigella flexneri strains was studied. In both strains the blaTEM gene was encoded as a single copy on a large conjugatively transferable plasmid. A single G-->T transversion at position 1 of the -10 consensus sequence was identified to be the mechanism of TE...

journal_title：Antimicrobial agents and chemotherapy

authors： Siu LK,Ho PL,Yuen KY,Wong SS,Chau PY

更新日期：1997-02-01 00:00:00

abstract：:The tight packing of six fatty acids in the lipid A constituent of lipopolysaccharide (LPS) has been proposed to contribute to the unusually low permeability of the outer membrane of gram-negative enteric bacteria to hydrophobic antibiotics. Here it is shown that the Escherichia coli msbB mutant, which elaborates defe...

journal_title：Antimicrobial agents and chemotherapy

authors： Vaara M,Nurminen M

更新日期：1999-06-01 00:00:00

abstract：:Hepatitis C virus (HCV) is the major cause of non-A, non-B hepatitis worldwide. Current treatments are not curative for most infected individuals, and there is an urgent need for both novel therapeutic agents and small-animal models which can be used to evaluate candidate drugs. A small-animal model of HCV gene expres...

journal_title：Antimicrobial agents and chemotherapy

authors： Zhang H,Hanecak R,Brown-Driver V,Azad R,Conklin B,Fox MC,Anderson KP

更新日期：1999-02-01 00:00:00