Luliconazole demonstrates potent in vitro activity against dermatophytes recovered from patients with onychomycosis.

abstract：:The accumulation of quinolones by Escherichia coli JF568, Pseudomonas aeruginosa PAO1, and Staphylococcus aureus ATCC 29213 was measured by a modified fluorometric assay (J. S. Chapman and N. H. Georgopapadakou, Antimicrob. Agents Chemother. 33:27-29, 1989). The quinolones examined were fleroxacin, pefloxacin, norflox...

journal_title：Antimicrobial agents and chemotherapy

authors： McCaffrey C,Bertasso A,Pace J,Georgopapadakou NH

更新日期：1992-08-01 00:00:00

abstract：:Ethambutol [(S,S')-2,2'-(ethylenediimino)di-1-butanol; EMB], is a first-line drug used to treat tuberculosis. To gain insight into the molecular basis of EMB resistance, we characterized the 10-kb embCAB locus in 16 EMB-resistant and 3 EMB-susceptible genetically distinct Mycobacterium tuberculosis strains from divers...

journal_title：Antimicrobial agents and chemotherapy

authors： Sreevatsan S,Stockbauer KE,Pan X,Kreiswirth BN,Moghazeh SL,Jacobs WR Jr,Telenti A,Musser JM

更新日期：1997-08-01 00:00:00

abstract：:Previously published literature reports various impacts of food on the oral bioavailability of piperaquine. The aim of this study was to use a population modeling approach to investigate the impact of concomitant intake of a small amount of food on piperaquine pharmacokinetics. This was an open, randomized comparison ...

journal_title：Antimicrobial agents and chemotherapy

authors： Tarning J,Lindegardh N,Lwin KM,Annerberg A,Kiricharoen L,Ashley E,White NJ,Nosten F,Day NP

更新日期：2014-01-01 00:00:00

abstract：:As part of the CANCER Antimicrobial Surveillance Program in North America, a Pseudomonas aeruginosa isolate, strain 07-406, was shown to possess a metallo-beta-lactamase, designated VIM-7. bla(VIM-7) is located on a 24-kb plasmid which can be readily transferred into Enterobacteriaceae and other pseudomonads. This is ...

journal_title：Antimicrobial agents and chemotherapy

authors： Toleman MA,Rolston K,Jones RN,Walsh TR

更新日期：2004-01-01 00:00:00

abstract：:The present study confirms that CBA/J mice are susceptible to several clinical isolates of Streptococcus pneumoniae, including four of five penicillin-susceptible and all five penicillin-resistant strains tested, thus providing the first noncompromised animal model for penicillin-resistant S. pneumoniae pneumonia. In ...

journal_title：Antimicrobial agents and chemotherapy

authors： Tateda K,Takashima K,Miyazaki H,Matsumoto T,Hatori T,Yamaguchi K

更新日期：1996-06-01 00:00:00

abstract：:Fortimicins are bicyclic aminoglycoside antibiotics that contain a fortamine moiety instead of the deoxystreptamine found in other aminoglysides. Fortimicin A had a bactericidal effect on Escherichia coli and Staphylococcus epidermidis and was found to inhibit protein synthesis in vivo. In vitro, fortimicin A inhibite...

journal_title：Antimicrobial agents and chemotherapy

authors： Moreau N,Jaxel C,Le Goffic F

更新日期：1984-12-01 00:00:00

abstract：:ACH-702, a novel isothiazoloquinolone (ITQ), was assessed for antibacterial activity against a panel of Gram-positive and Gram-negative clinical isolates and found to possess broad-spectrum activity, especially against antibiotic-resistant Gram-positive strains, including methicillin-resistant Staphylococcus aureus (M...

journal_title：Antimicrobial agents and chemotherapy

authors： Pucci MJ,Podos SD,Thanassi JA,Leggio MJ,Bradbury BJ,Deshpande M

更新日期：2011-06-01 00:00:00

abstract：:Study of the antimicrobial spectrum of valinomycin revealed that, in addition to the gram-positive bacteria reported in literature, Streptococcus pyogenes and Clostridium sporogenes are also susceptible to this antibiotic. The minimal inhibitory concentrations (MIC) of the antibiotic for S. pyogenes grown aerobically ...

journal_title：Antimicrobial agents and chemotherapy

authors： Seshachalam D,Frahm DH,Ferraro FM

更新日期：1973-01-01 00:00:00

abstract：:We have previously shown that genetic disruption of Toxoplasma gondii calcium-dependent protein kinase 3 (TgCDPK3) affects calcium ionophore-induced egress. We examined whether Plasmodium falciparum CDPK1 (PfCDPK1), the closest homolog of TgCDPK3 in the malaria parasite P. falciparum, could complement a TgCDPK3 mutant...

journal_title：Antimicrobial agents and chemotherapy

authors： Gaji RY,Checkley L,Reese ML,Ferdig MT,Arrizabalaga G

更新日期：2014-05-01 00:00:00

abstract：:The in vitro activity of TR-700 (torezolid) was evaluated against a collection of 660 staphylococcal blood isolates. TR-700 showed excellent activity against all the staphylococci tested. The MIC(50) and MIC(90) values of TR-700, linezolid, daptomycin, and vancomycin against methicillin-resistant Staphylococcus aureus...

journal_title：Antimicrobial agents and chemotherapy

authors： Betriu C,Morales G,Rodríguez-Avial I,Culebras E,Gómez M,López-Fabal F,Picazo JJ

更新日期：2010-05-01 00:00:00

abstract：:Salmonella spp. are important food-borne pathogens that are demonstrating increasing antimicrobial resistance rates in isolates obtained from food animals and humans. In this study, 10 multidrug-resistant, cephalosporin-resistant Salmonella isolates from bovine, porcine, and human sources from a single geographic regi...

journal_title：Antimicrobial agents and chemotherapy

authors： Winokur PL,Brueggemann A,DeSalvo DL,Hoffmann L,Apley MD,Uhlenhopp EK,Pfaller MA,Doern GV

更新日期：2000-10-01 00:00:00

abstract：:The responses of 20 ampicillin-susceptible Haemophilus influenzae type b clinical isolates to the bactericidal action of ampicillin were studied by using a modified agar dilution plate count method. A well-defined paradoxical effect was observed in each of the 24-h killing curve patterns for 19 of the 20 isolates, the...

journal_title：Antimicrobial agents and chemotherapy

authors： Woolfrey BF,Gresser-Burns ME,Lally RT

更新日期：1987-11-01 00:00:00

abstract：:Macrolide-resistant Mycoplasma pneumoniae (MR M. pneumoniae) has been isolated from clinical specimens in Japan since 2000. A comparative study was carried out to determine whether or not macrolides are effective in treating patients infected with MR M. pneumoniae. The clinical courses of 11 patients with MR M. pneumo...

journal_title：Antimicrobial agents and chemotherapy

authors： Suzuki S,Yamazaki T,Narita M,Okazaki N,Suzuki I,Andoh T,Matsuoka M,Kenri T,Arakawa Y,Sasaki T

更新日期：2006-02-01 00:00:00

abstract：:We compared the efficacy of combination posaconazole-liposomal amphotericin B (LAmB) therapy to monotherapy with either drug in diabetic ketoacidotic or neutropenic mice with disseminated zygomycosis caused by Rhizopus oryzae. Combination therapy was no better than LAmB alone, and posaconazole monotherapy did not impr...

journal_title：Antimicrobial agents and chemotherapy

authors： Ibrahim AS,Gebremariam T,Schwartz JA,Edwards JE Jr,Spellberg B

更新日期：2009-02-01 00:00:00

abstract：:The increasing use of azole antifungals for the treatment of mucosal and systemic Candida glabrata infections has resulted in the selection and/or emergence of resistant strains. The main mechanisms of azole resistance include alterations in the C. glabrata ERG11 gene (CgERG11), which encodes the azole target enzyme, ...

journal_title：Antimicrobial agents and chemotherapy

authors： Sanguinetti M,Posteraro B,Fiori B,Ranno S,Torelli R,Fadda G

更新日期：2005-02-01 00:00:00

abstract：:In vitro susceptibility tests were performed on 84 strains of Clostridium difficile to 11 antimicrobial agents. All isolates were from the stools of patients with antibiotic-associated diarrhea or colitis in which there was a cytopathic toxin that was neutralized by Clostridium sordellii antitoxin. Over 95% of the str...

journal_title：Antimicrobial agents and chemotherapy

authors： Dzink J,Bartlett JG

更新日期：1980-04-01 00:00:00

abstract：:To test the hypothesis that establishing gastrointestinal colonization with multiresistant Enterococcus faecium (VRE) C68 results from expansion of the enterococcal population in the upper small bowel, we compared VRE quantities recovered from the proximal, middle, and distal segments of the small bowel from mice trea...

journal_title：Antimicrobial agents and chemotherapy

authors： Lakticová V,Hutton-Thomas R,Meyer M,Gurkan E,Rice LB

更新日期：2006-09-01 00:00:00

abstract：:The in vitro activity of cefaclor against 556 clinical isolates of gram-positive and gram-negative bacteria was compared with that of other cephalosporins. Cefaclor had activity similar to that of cephalexin against gram-positive bacteria. It showed greater activity against Haemophilus strains than did cephalexin and ...

journal_title：Antimicrobial agents and chemotherapy

authors： Neu HC,Fu KP

更新日期：1978-04-01 00:00:00

abstract：:Chloramphenicol acetyltransferases specified by fi(-) (F fertility-noninhibiting) R factors were compared with those specified by the fi(+) R factors R1, 222, and R6-S. Three classes of enzyme were distinguished: class I was determined by group N fi(-) R factors and was indistinguishable from the enzyme determined by ...

journal_title：Antimicrobial agents and chemotherapy

authors： Foster TJ,Shaw WV

更新日期：1973-01-01 00:00:00

abstract：:The aminoglycoside Geneticin (G418) is known to inhibit cell culture proliferation, via virus-specific mechanisms, of two different virus genera from the family Flaviviridae. Here, we tried to determine whether Geneticin can selectively alter the switching of the nucleotide 1 to 570 RNA region of hepatitis C virus (HC...

journal_title：Antimicrobial agents and chemotherapy

authors： Ariza-Mateos A,Díaz-Toledano R,Block TM,Prieto-Vega S,Birk A,Gómez J

更新日期：2015-11-30 00:00:00

abstract：:Ro 09-0179 (4',5-dihydroxy-3,3',7-trimethoxyflavone), isolated from a Chinese medicinal herb, was found to have potent antiviral activity. It selectively inhibited the replication of human picornaviruses, such as rhinoviruses and coxsackieviruses in tissue culture, but not other DNA and RNA viruses. Ro 09-0298 (4',5-d...

journal_title：Antimicrobial agents and chemotherapy

authors： Ishitsuka H,Ohsawa C,Ohiwa T,Umeda I,Suhara Y

更新日期：1982-10-01 00:00:00

abstract：:Two aminocyclitol-negative Micromonospora mutants representing two different species, M. purpurea and M. inyoensis, and blocked at different steps in the biosynthetic pathway were paired and cofermented for the synthesis of antibiotics. The two blocked mutants were incapable of producing antibiotics alone except when ...

journal_title：Antimicrobial agents and chemotherapy

authors： Lee BK,Nagabhushan TL,Condon RG,Cooper AB,Waitz JA

更新日期：1978-07-01 00:00:00

abstract：:We have recently cloned a DNA fragment containing a gene cluster that is responsible for the biosynthesis of an antituberculosis antibiotic, D-cycloserine. The gene cluster is composed of 10 open reading frames, designated dcsA to dcsJ. Judging from the sequence similarity between each putative gene product and known ...

journal_title：Antimicrobial agents and chemotherapy

authors： Uda N,Matoba Y,Kumagai T,Oda K,Noda M,Sugiyama M

更新日期：2013-06-01 00:00:00

abstract：:The mechanism of growth inhibition of Escherichia coli by thioglycerol was probed. The extent of growth inhibition depended on the ratio of thioglycerol to initial cell concentration. Exogenously added methionine and several methionine analogues reversed the inhibition of 2 to 40 mM thioglycerol. Exposure to thioglyce...

journal_title：Antimicrobial agents and chemotherapy

authors： Javor GT

更新日期：1983-12-01 00:00:00

abstract：:Eighty percent (21 of 26) of macrolide-resistant Peptostreptococcus strains studied harbored the ermTR gene. This methyltransferase gene is also the most frequently found gene among macrolide-lincosamide-streptogramin B-resistant Streptococcus pyogenes strains. Transfer of the ermTR gene from Peptostreptococcus magnus...

journal_title：Antimicrobial agents and chemotherapy

authors： Reig M,Galan J,Baquero F,Perez-Diaz JC

更新日期：2001-02-01 00:00:00

abstract：:The experimental model of infected fibrin clots in rabbits was used to study the penetration and in vivo activity of cefixime against Klebsiella pneumoniae, Escherichia coli, and Staphylococcus aureus. The respective MICs of cefixime against these strains were 0.25, 2, and 8 micrograms/ml. The clots were infected with...

journal_title：Antimicrobial agents and chemotherapy

authors： Bergeron MG,Turcotte A

更新日期：1986-12-01 00:00:00

abstract：:Clinical isolates of the Bacteroides melaninogenicus and Bacteroides fragilis groups were tested for in vitro and in vivo susceptibility to penicillin, clindamycin, and metronidazole, used singly or in combination with gentamicin. The in vitro tests consisted of determinations of minimal inhibitory concentrations (MIC...

journal_title：Antimicrobial agents and chemotherapy

authors： Brook I,Coolbaugh JC,Walker RI,Weiss E

更新日期：1984-01-01 00:00:00

abstract：:Human immunodeficiency virus (HIV) Tat and gp120 intriguingly share the feature of being basic peptides that, once released by HIV(+) cells, bind to polyanionic heparan sulfate proteoglycans (HSPGs) on target uninfected cells, contributing to the onset of AIDS-associated pathologies. To identify multitarget anti-HIV p...

journal_title：Antimicrobial agents and chemotherapy

authors： Bugatti A,Urbinati C,Ravelli C,De Clercq E,Liekens S,Rusnati M

更新日期：2007-07-01 00:00:00

abstract：:Visceral leishmaniasis is a neglected tropical disease that causes significant morbidity and mortality worldwide. Characterization of the pharmacokinetics and pharmacodynamics of antileishmanial drugs in preclinical models is important for drug development and use. Here we investigated the pharmacodynamics and drug di...

journal_title：Antimicrobial agents and chemotherapy

authors： Voak AA,Harris A,Qaiser Z,Croft SL,Seifert K

更新日期：2017-08-24 00:00:00

abstract：:Stenotrophomonas maltophilia is an opportunistic pathogen with increasing prevalence, which is able to cause infections in immunocompromised patients or in those with a previous pathology. The treatment of the infections caused by this bacterium is often complicated due to the several intrinsic antibiotic resistance m...

journal_title：Antimicrobial agents and chemotherapy

authors： Blanco P,Corona F,Sánchez MB,Martínez JL

更新日期：2017-04-24 00:00:00