Antibiotic-induced enterococcal expansion in the mouse intestine occurs throughout the small bowel and correlates poorly with suppression of competing flora.

abstract：:Candida parapsilosis isolates occasionally display resistance in vitro to echinocandins and cause breakthrough infections to echinocandins. The degree of the in vivo cross-resistance among echinocandins and the fitness loss associated with caspofungin (CAS) resistance of C. parapsilosis are not well studied. We compar...

journal_title：Antimicrobial agents and chemotherapy

authors： Dimopoulou D,Hamilos G,Tzardi M,Lewis RE,Samonis G,Kontoyiannis DP

更新日期：2014-01-01 00:00:00

abstract：:A strain of extensively drug-resistant (XDR) Salmonella enterica serovar Typhi has caused a large ongoing outbreak in Pakistan since 2016. In Ontario, Canada, 10 cases of mainly bloodstream infections (n = 9) were identified in patients who traveled to Pakistan. Whole-genome sequencing showed that Canadian cases were ...

journal_title：Antimicrobial agents and chemotherapy

authors： Eshaghi A,Zittermann S,Bharat A,Mulvey MR,Allen VG,Patel SN

更新日期：2020-04-21 00:00:00

abstract：:Previous studies have shown that various short- and medium-chain free fatty acids (FFAs) and their corresponding monoacylglycerol esters (MGs) have antibacterial activity in vitro against primarily gram-positive bacteria. More recent studies have also shown that the growth of Helicobacter spp. is inhibited by linoleic...

journal_title：Antimicrobial agents and chemotherapy

authors： Petschow BW,Batema RP,Ford LL

更新日期：1996-02-01 00:00:00

abstract：:Additional drugs are needed for the treatment of multidrug-resistant tuberculosis (TB). Sulfamethoxazole has been shown to have in vitro activity against Mycobacterium tuberculosis; however, there is concern about resistance given the widespread use of trimethoprim-sulfamethoxazole prophylaxis among HIV-infected patie...

journal_title：Antimicrobial agents and chemotherapy

authors： Ogwang S,Good CE,Okware B,Nsereko M,Jacobs MR,Boom WH,Bark CM

更新日期：2015-09-01 00:00:00

abstract：:A study was performed to determine the effect of parenteral treatment with four broad-spectrum cephalosporins (cefoperazone, ceftriaxone, ceftazidime, and cefepime) on the number of aerobic gram-negative rods and on the outgrowth of Candida albicans and a multiresistant strain of Citrobacter freundii in the feces of m...

journal_title：Antimicrobial agents and chemotherapy

authors： van Ogtrop ML,Guiot HF,Mattie H,van Furth R

更新日期：1991-05-01 00:00:00

abstract：:Invasive pulmonary aspergillosis is a life-threatening infection in lung transplant recipients; however, no studies of the pharmacokinetics and pharmacodynamics (PKPD) of echinocandins in transplanted lungs have been reported. We conducted a single-dose prospective study of the intrapulmonary and plasma PKPD of 150 mg...

journal_title：Antimicrobial agents and chemotherapy

authors： Walsh TJ,Goutelle S,Jelliffe RW,Golden JA,Little EA,DeVoe C,Mickiene D,Hayes M,Conte JE Jr

更新日期：2010-08-01 00:00:00

abstract：:GS-9160 is a novel and potent inhibitor of human immunodeficiency virus type 1 (HIV-1) integrase (IN) that specifically targets the process of strand transfer. It is an authentic inhibitor of HIV-1 integration, since treatment of infected cells results in an elevation of two-long terminal repeat circles and a decrease...

journal_title：Antimicrobial agents and chemotherapy

authors： Jones GS,Yu F,Zeynalzadegan A,Hesselgesser J,Chen X,Chen J,Jin H,Kim CU,Wright M,Geleziunas R,Tsiang M

更新日期：2009-03-01 00:00:00

abstract：:The etiological treatment of Chagas disease remains neglected. The compounds available show several limitations, mainly during the chronic phase. Lychnopholide encapsulated in polymeric nanocapsules (LYC-NC) was efficacious in mice infected with Trypanosoma cruzi and treated by intravenous administration during the ac...

journal_title：Antimicrobial agents and chemotherapy

authors： de Mello CG,Branquinho RT,Oliveira MT,Milagre MM,Saúde-Guimarães DA,Mosqueira VC,Lana Md

更新日期：2016-08-22 00:00:00

abstract：:Ten patients received a loading dose of tobramycin of 60 mg/m2 intravenously over 0.5 h followed immediately by 60 mg/m2 over 2 h every 4 h. The highest mean serum concentration (at the end of the loading dose) was 6.0 +/- 0.3 microgram/ml (range, 3.2 to 10.9 microgram/ml). The mean serum concentration 2 h after the e...

journal_title：Antimicrobial agents and chemotherapy

authors： Lawson RD,Bodey GP,Pan T,Smith TL

更新日期：1980-05-01 00:00:00

abstract：:Penicillin-binding protein 5 (PBP5) is one of the most abundant PBPs in Pseudomonas aeruginosa. Although its main function is that of a cell wall dd-carboxypeptidase, it possesses sufficient β-lactamase activity to contribute to the ability of P. aeruginosa to resist the antibiotic activity of the β-lactams. The study...

journal_title：Antimicrobial agents and chemotherapy

authors： Smith JD,Kumarasiri M,Zhang W,Hesek D,Lee M,Toth M,Vakulenko S,Fisher JF,Mobashery S,Chen Y

更新日期：2013-07-01 00:00:00

abstract：:Of five parenteral cephalosporins tested against 43 lactobacilli, cephaloridine, cefazolin, and cefamandole were the most active inhibitory and bactericidal agents. Timed-kill analysis revealed a slow bactericidal effect, with significant declines in mean minimal bactericidal concentration values at 48 h versus 24 h. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Bayer AS,Chow AW,Concepcion NF,Guze LB

更新日期：1979-07-01 00:00:00

abstract：:Catheter-associated urinary tract infections (CAUTIs) constitute the majority of nosocomial urinary tract infections (UTIs) and pose significant clinical challenges. These infections are polymicrobial in nature and are often associated with multidrug-resistant pathogens, including uropathogenic Escherichia coli (UPEC)...

journal_title：Antimicrobial agents and chemotherapy

authors： Guiton PS,Cusumano CK,Kline KA,Dodson KW,Han Z,Janetka JW,Henderson JP,Caparon MG,Hultgren SJ

更新日期：2012-09-01 00:00:00

abstract：:Pefloxacin mesylate is well absorbed by the oral route. The antimicrobial activity in dog, cynomolgus monkey, and human plasma was essentially due to unchanged drug which respectively accounted for 64, 94, and 84% of the total activity (ratios derived from relative area under the curve [AUC] values). Half-lives ranged...

journal_title：Antimicrobial agents and chemotherapy

authors： Montay G,Goueffon Y,Roquet F

更新日期：1984-04-01 00:00:00

abstract：:The objective of the present study was to test the hypothesis that treatment of schistosomiasis mansoni with praziquantel can alter significantly the immune response of patients and generate a reversal of the level of fibrosis. Peripheral blood mononuclear cell (PBMC) samples were collected from, and abdominal ultraso...

journal_title：Antimicrobial agents and chemotherapy

authors： Martins-Leite P,Gazzinelli G,Alves-Oliveira LF,Gazzinelli A,Malaquias LC,Correa-Oliveira R,Teixeira-Carvalho A,Silveira AM

更新日期：2008-08-01 00:00:00

abstract：:Daptomycin, a cyclic lipopeptide antibiotic, and 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors (statins) are commonly administered in the inpatient setting and are associated with creatine phosphokinase (CPK) elevations, myalgias, and muscle weakness. Safety data for coadministration of daptomyc...

journal_title：Antimicrobial agents and chemotherapy

authors： Bland CM,Bookstaver PB,Lu ZK,Dunn BL,Rumley KF,Southeastern Research Group Endeavor (SERGE-45).

更新日期：2014-10-01 00:00:00

abstract：:Depending on the spacing of their positive charges, ionenes, a class of quaternary ammonium polymers, increased the interferon-inducing activity of poly(inosinic acid).poly(cytidylic acid) in mouse L-929 cells, whereas they did not enhance poly(inosinic acid).poly(cytidylic acid) induced interferon production in prima...

journal_title：Antimicrobial agents and chemotherapy

authors： Clercq ED,Janik B,Sommer RG

更新日期：1977-04-01 00:00:00

abstract：:A portion of the Mycobacterium tuberculosis gene encoding the beta subunit of RNA polymerase (rpoB) was amplified by PCR using degenerate oligonucleotides and used as a hybridization probe to isolate plasmid clones carrying the entire rpoB gene of M. tuberculosis H37Rv, a virulent, rifampin-susceptible strain. Sequenc...

journal_title：Antimicrobial agents and chemotherapy

authors： Miller LP,Crawford JT,Shinnick TM

更新日期：1994-04-01 00:00:00

abstract：:The tuberactinomycin antibiotics are essential components in the drug arsenal against Mycobacterium tuberculosis infections and are specifically used for the treatment of multidrug-resistant tuberculosis. These antibiotics are also being investigated for their targeting of the catalytic RNAs involved in viral replicat...

journal_title：Antimicrobial agents and chemotherapy

authors： Thomas MG,Chan YA,Ozanick SG

更新日期：2003-09-01 00:00:00

abstract：:The occurrence of resistance to last-resort antibiotics was evaluated among Enterobacteriaceae isolates recovered from hospitalized children in a remote African archipelago, São Tomé and Príncipe, where there is limited access to those antibiotics. Fifty patients were screened for colonization by carbapenem-, pan-amin...

journal_title：Antimicrobial agents and chemotherapy

authors： Poirel L,Aires-de-Sousa M,Kudyba P,Kieffer N,Nordmann P

更新日期：2018-08-27 00:00:00

abstract：:A new procedure for determining the susceptibility of Treponema pallidum subsp. pallidum to antimicrobial agents was developed, utilizing a tissue culture system which promotes the in vitro multiplication of this organism. In the absence of antibiotics, T. pallidum (Nichols virulent strain) multiplied an average of 10...

journal_title：Antimicrobial agents and chemotherapy

authors： Norris SJ,Edmondson DG

更新日期：1988-01-01 00:00:00

abstract：:An observational study assessed the longitudinal use of a new line probe assay for the detection of protease mutations. Probe assays for detection of reverse transcriptase (Inno-LiPA HIV-1 RT; Innogenetics) and protease (prototype kit Inno-LiPA HIV Protease; Innogenetics) mutations gave results for 177 of 199 sequenti...

journal_title：Antimicrobial agents and chemotherapy

authors： Servais J,Lambert C,Plesséria JM,Fontaine E,Robert I,Arendt V,Staub T,Hemmer R,Schneider F,Schmit JC

更新日期：2002-06-01 00:00:00

abstract：:Among respiratory tract isolates of Streptococcus pneumoniae from children, resistance to penicillins, cephalosporins, macrolides, and trimethoprim-sulfamethoxazole (SXT) increases on an annual basis. Pediatric patients who do not respond to conventional therapy for respiratory tract infections someday may be treated ...

journal_title：Antimicrobial agents and chemotherapy

authors： Karlowsky JA,Thornsberry C,Critchley IA,Jones ME,Evangelista AT,Noel GJ,Sahm DF

更新日期：2003-06-01 00:00:00

abstract：:Aminoglycoside 2″-phosphotransferases are the major aminoglycoside-modifying enzymes in clinical isolates of enterococci and staphylococci. We describe a novel aminoglycoside 2″-phosphotransferase from the Gram-negative pathogen Campylobacter jejuni, which shares 78% amino acid sequence identity with the APH(2″)-Ia do...

journal_title：Antimicrobial agents and chemotherapy

authors： Toth M,Frase H,Antunes NT,Vakulenko SB

更新日期：2013-01-01 00:00:00

abstract：:Invasive pulmonary aspergillosis (IPA) is a devastating disease of immunocompromised patients. Pharmacodynamic (PD) examination of antifungal drug therapy in IPA is one strategy that may improve outcomes. The current study explored the PD target of posaconazole in an immunocompromised murine model of IPA against 10 A....

journal_title：Antimicrobial agents and chemotherapy

authors： Lepak AJ,Marchillo K,Vanhecker J,Andes DR

更新日期：2013-01-01 00:00:00

abstract：:Genes belonging to different erm DNA hybridization classes were selectively amplified by polymerase chain reaction with a pair of oligonucleotides that corresponded to conserved amino acid motifs in known ERM methylases. Identification of the resistance mechanism was possible despite substantial nucleotide sequence di...

journal_title：Antimicrobial agents and chemotherapy

authors： Arthur M,Molinas C,Mabilat C,Courvalin P

更新日期：1990-10-01 00:00:00

abstract：:To determine the influence of in vitro activity, pharmacokinetic properties, and therapeutic regimen on the antibacterial effect in vivo, we compared three cephalosporins, cefotiam, cefmenoxime, and ceftriaxone, in a rabbit model of experimental Escherichia coli endocarditis after 4 days of treatment. The MBCs of cefo...

journal_title：Antimicrobial agents and chemotherapy

authors： Pangon B,Joly V,Vallois JM,Abel L,Buré A,Brion N,Contrepois A,Carbon C

更新日期：1987-04-01 00:00:00

abstract：:Plazomicin is a new FDA-approved aminoglycoside antibiotic for complicated urinary tract infections (cUTI). In the product labeling, trough-based therapeutic drug management (TDM) is recommended for cUTI patients with renal impairment to prevent elevated trough concentrations associated with serum creatinine increases...

journal_title：Antimicrobial agents and chemotherapy

authors： Asempa TE,Kuti JL,Seroogy JD,Komirenko AS,Nicolau DP

更新日期：2019-09-23 00:00:00

abstract：:We use kinetic models to investigate how to design antimicrobial phage therapies to minimize emergence of resistant bacteria. We do this by modifying the "mutant selection window" hypothesis in a way that accounts for the ongoing self-replication of the phage. We show that components of combination phage therapies nee...

journal_title：Antimicrobial agents and chemotherapy

authors： Cairns BJ,Payne RJ

更新日期：2008-12-01 00:00:00

abstract：:Treatment of Escherichia coli K-10 with 100 mug of chloramphenicol per ml for periods greater than 30 min leads to progressive lysis and killing of cells. The bactericidal action of the antibiotic is dependent on cell growth and physiology; only rapidly dividing cells are susceptible to killing; resting or slowly grow...

journal_title：Antimicrobial agents and chemotherapy

authors： Guota RS

更新日期：1975-06-01 00:00:00

abstract：:Trimethoprim resistance dihydrofolate reductase genes from plasmids known to be exchanging between human and animal populations were mapped. The dihydrofolate reductase gene has been highly conserved in all plasmids, but differences in the flanking regions provide evidence that the most recent exchange of plasmids bet...

journal_title：Antimicrobial agents and chemotherapy

authors： Campbell IG,Mee BJ

更新日期：1987-09-01 00:00:00