Effects of ionenes on interferon induction by poly(inosinic acid) . poly(cytidylic acid).

abstract：:The emergence of human immunodeficiency virus type 1 (HIV-1) strains resistant to highly active antiretroviral therapy necessitates continued drug discovery for the treatment of HIV-1 infection. Most current drug discovery strategies focus upon a single aspect of HIV-1 replication. A virus-cell-based assay, which can ...

journal_title：Antimicrobial agents and chemotherapy

authors： Adelson ME,Pacchia AL,Kaul M,Rando RF,Ron Y,Peltz SW,Dougherty JP

更新日期：2003-02-01 00:00:00

abstract：:Mutants of attenuated Bacillus anthracis with high-level ciprofloxacin resistance were isolated using a three-step in vitro selection. Ciprofloxacin MICs were 0.5 micro g/ml for first-step mutants, which had one of two gyrA quinolone resistance-determining region (QRDR) mutations. Ciprofloxacin MICs were 8 and 16 micr...

journal_title：Antimicrobial agents and chemotherapy

authors： Price LB,Vogler A,Pearson T,Busch JD,Schupp JM,Keim P

更新日期：2003-07-01 00:00:00

abstract：:Ceftezole, a new cephalosporin derivative, was compared with cefazolin, cephaloridine, and cephalothin. Data obtained indicate that it is a broad-spectrum antibiotic, with almost identical antimicrobial activity against pathogenic organisms isolated from patients. The therapeutic effect of ceftezole on experimental in...

journal_title：Antimicrobial agents and chemotherapy

authors： Nishida M,Murakawa T,Kamimura T,Okada N,Sakamoto H,Fukada S,Nakamoto S,Yokota Y,Miki K

更新日期：1976-07-01 00:00:00

abstract：:The present study was designed to determine the temporal changes in tobramycin nephrotoxicity during the dark and the light periods of the day and to look for the mechanisms of such changes. Female Sprague-Dawley rats (9 to 11 weeks old) were housed in a 14-h-light-10-h-dark cycle (lights on 0600 to 2000 h). A bolus o...

journal_title：Antimicrobial agents and chemotherapy

authors： Lin L,Grenier L,Bergeron Y,Simard M,Bergeron MG,Labrecque G,Beauchamp D

更新日期：1994-01-01 00:00:00

abstract：:Clostridium difficile is the most frequently identified enteric pathogen in patients with nosocomially acquired, antibiotic-associated diarrhea. The drugs most commonly used to treat diseases associated with C. difficile are metronidazole and vancomycin. Most clinical laboratories assume that all C. difficile isolates...

journal_title：Antimicrobial agents and chemotherapy

authors： Peláez T,Alcalá L,Alonso R,Rodríguez-Créixems M,García-Lechuz JM,Bouza E

更新日期：2002-06-01 00:00:00

abstract：:During its intraerythrocytic phase, the most lethal human malarial parasite, Plasmodium falciparum, digests host cell hemoglobin as a source of some of the amino acids required for its own protein synthesis. A number of parasite endopeptidases (including plasmepsins and falcipains) process the globin into small peptid...

journal_title：Antimicrobial agents and chemotherapy

authors： Cunningham E,Drag M,Kafarski P,Bell A

更新日期：2008-09-01 00:00:00

abstract：:Two carbapenem-resistant isolates, one Escherichia coli isolate and one Klebsiella pneumoniae isolate, recovered from an Algerian patient expressed a novel VIM-type metallo-beta-lactamase (MBL). The identified bla(VIM-19) gene was located on a ca. 160-kb plasmid and located inside a class 1 integron in both isolates. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Rodriguez-Martinez JM,Nordmann P,Fortineau N,Poirel L

更新日期：2010-01-01 00:00:00

abstract：:We evaluated the antituberculosis (anti-TB) activity of five β-lactams alone or in combination with β-lactamase inhibitors against 41 clinical isolates of Mycobacterium tuberculosis, including multidrug-resistant and extensively drug-resistant strains. Of those, tebipenem, an oral carbapenem, showed the most potent an...

journal_title：Antimicrobial agents and chemotherapy

authors： Horita Y,Maeda S,Kazumi Y,Doi N

更新日期：2014-11-01 00:00:00

abstract：:Daptomycin is a lipopeptide antibiotic with activity against gram-positive bacteria, including Staphylococcus aureus. We defined the pharmacodynamic parameters that determine the activity of daptomycin for S. aureus using in vitro methods and the Craig (W. A. Craig, J. Redington, and S. C. Ebert, J. Antimicrob. Chemot...

journal_title：Antimicrobial agents and chemotherapy

authors： Louie A,Kaw P,Liu W,Jumbe N,Miller MH,Drusano GL

更新日期：2001-03-01 00:00:00

abstract：:The penicillin-binding proteins (PBPs) of helical (log-phase) Helicobacter pylori ATCC 43579 were identified by using biotinylated ampicillin. The major PBPs had apparent molecular masses of 47, 60, 63, and 66 kDa; an additional minor PBP of 95 to 100 kDa was also detected. The relative affinities of various beta-lact...

journal_title：Antimicrobial agents and chemotherapy

authors： DeLoney CR,Schiller NL

更新日期：1999-11-01 00:00:00

abstract：:Thirty-four infants and children ranging in age from 2.5 to 180 months (mean, 40 months) were treated with parenteral moxalactam (150 mg/kg per day) for suspected or proved bacterial infections outside the central nervous system. Six patients infected with Haemophilus influenzae b, nine infected with Staphylococcus au...

journal_title：Antimicrobial agents and chemotherapy

authors： Keyserling H,Feldman WE,Moffitt S,Manning N,Hollins M

更新日期：1982-06-01 00:00:00

abstract：:Antagonism of antibiotic activity by peritoneal dialysate has been postulated to be a cause of failure of treatment of peritonitis complicating continuous ambulatory peritoneal dialysis. We evaluated by a case-control study whether unexpected treatment failure could be attributed to such antagonism. Bacteria isolated ...

journal_title：Antimicrobial agents and chemotherapy

authors： Ludlam H,Johnston L,Hopkins P

更新日期：1992-05-01 00:00:00

abstract：:The pathogenic yeast Candida albicans can exist in multiple morphological states, including budded, pseudohyphal, and true hyphal forms. The ability to convert between the budded and hyphal forms, termed the budded-to-hyphal-form transition, is important for virulence and is regulated by multiple environmental and cel...

journal_title：Antimicrobial agents and chemotherapy

authors： Toenjes KA,Munsee SM,Ibrahim AS,Jeffrey R,Edwards JE Jr,Johnson DI

更新日期：2005-03-01 00:00:00

abstract：:The penam nucleus can assume two conformations; these are designated open and closed. The synthetic (2,3)-alpha- and (2,3)-beta-methylenepenams can be regarded as analogs of the open and closed conformations, respectively. It has been shown that the beta-methylenepenams are essentially inactive, suggesting that the cl...

journal_title：Antimicrobial agents and chemotherapy

authors： Christenson JG,Pruess DL,Talbot MK,Keith DD

更新日期：1988-07-01 00:00:00

abstract：:The potential of bacteriophage therapy to treat infections caused by antibiotic-resistant bacteria has now been well established using various animal models. While numerous newly isolated bacteriophages have been claimed to be potential therapeutic candidates on the basis of in vitro observations, the parameters used ...

journal_title：Antimicrobial agents and chemotherapy

authors： Henry M,Lavigne R,Debarbieux L

更新日期：2013-12-01 00:00:00

abstract：:The activity of methacycline against microbial L-forms and their parent bacteria was compared with that of oxytetracycline, chlortetracycline, tetracycline, and demethylchlortetracycline, as well as with that of 22 other antibiotics which included examples of major groups of antibiotics. The L-forms and bacteria used ...

journal_title：Antimicrobial agents and chemotherapy

authors： Hubert EG,Kalmanson GM,Montgomerie JZ,Guze LB

更新日期：1972-10-01 00:00:00

abstract：:We describe a primary high-throughput screen that uses the reporter strain Bacillus subtilis BAU-102 to identify antibiotics that induce autolysis. The screen measures autolysis in terms of the incipient release of recombinant Escherichia coli beta-galactosidase (beta-Gal) from the periplasmic space of B. subtilis owi...

journal_title：Antimicrobial agents and chemotherapy

authors： Falk SP,Noah JW,Weisblum B

更新日期：2010-09-01 00:00:00

abstract：:ABT-492 is a novel quinolone with potent activity against gram-positive, gram-negative, and atypical pathogens, making this compound an ideal candidate for the treatment of community-acquired pneumonia. We therefore compared the in vitro pharmacodynamic activity of ABT-492 to that of levofloxacin, an antibiotic common...

journal_title：Antimicrobial agents and chemotherapy

authors： Gunderson SM,Hayes RA,Quinn JP,Danziger LH

更新日期：2004-01-01 00:00:00

abstract：:The penetration of intravenously administered cefuroxime into ventricular fluid was assessed in five pediatric patients with ventriculoperitoneal shunt infections and in one with a ventriculostomy infection. Patients received a total dose of 200 to 230 mg of cefuroxime per kg of body weight per day administered at 8-h...

journal_title：Antimicrobial agents and chemotherapy

authors： Edwards MS,Baker CJ,Butler KM,Mason EO Jr,Laurent JP,Cheek WR

更新日期：1989-07-01 00:00:00

abstract：:Though the primary action of the cationic antibiotic polymyxin B is against the membrane of susceptible bacteria, severe morphological changes are detected in the cytoplasm. Using fluorescence microscopy and a mono-N-dansyl-polymyxin B derivative, we could demonstrate aggregations of the antibiotic with cellular mater...

journal_title：Antimicrobial agents and chemotherapy

authors： Schindler PR,Teuber M

更新日期：1975-07-01 00:00:00

abstract：:The 13-residue dermaseptin S4 derivative K(4)S4(1-13)a (P) was previously shown to kill intraerythrocytic malaria parasites through the lysis of the host cells. In this study, we have sought peptides that will kill the parasite without lysing the erythrocyte. To produce such peptides, 26 compounds of variable structur...

journal_title：Antimicrobial agents and chemotherapy

authors： Dagan A,Efron L,Gaidukov L,Mor A,Ginsburg H

更新日期：2002-04-01 00:00:00

abstract：:Susceptibility of pathogenic aerobic bacteria to moxalactam (LY127935) was compared by two methods, diffusion from 30-microgram disks and agar plate dilution. The two methods gave a satisfactory degree of correlation when compared by linear regression, but the slope of the linear regression was significantly steeper f...

journal_title：Antimicrobial agents and chemotherapy

authors： Hall WH,Opfer BJ

更新日期：1981-01-01 00:00:00

abstract：:The efficacy of ciprofloxacin for experimental aortic valve endocarditis in rabbits infected by either a methicillin-susceptible or a methicillin-resistant strain of Staphylococcus aureus was compared with standard therapy of nafcillin or vancomycin, respectively. After 4 days of therapy, ciprofloxacin reduced the cou...

journal_title：Antimicrobial agents and chemotherapy

authors： Carpenter TC,Hackbarth CJ,Chambers HF,Sande MA

更新日期：1986-09-01 00:00:00

abstract：:Vulvovaginal candidiasis (VVC) is a global health problem affecting ∼75% of women at least once in their lifetime. Here we examined the epidemiology of VVC in a patient cohort to identify the causative organisms associated with VVC. Biofilm-forming capacity and antifungal sensitivity profiles were also assessed. We re...

journal_title：Antimicrobial agents and chemotherapy

authors： Sherry L,Kean R,McKloud E,O'Donnell LE,Metcalfe R,Jones BL,Ramage G

更新日期：2017-08-24 00:00:00

abstract：:lacZ fusion strains were constructed using the promoters of five cell wall stress stimulon genes: pbp2, tcaA, vraSR, sgtB, and lytR. All fusion strains were induced only in the presence of cell wall-active antibiotics, suggesting the potential of these strains for use in high-throughput screening for new cell wall-act...

journal_title：Antimicrobial agents and chemotherapy

authors： Steidl R,Pearson S,Stephenson RE,Ledala N,Sitthisak S,Wilkinson BJ,Jayaswal RK

更新日期：2008-08-01 00:00:00

abstract：:A rapid (6-7 hr), modified Kirby-Bauer disk-susceptibility method, by which derivatives of tetrazolium dyes are used to enhance delineation between areas of growth and zones of inhibition, has been developed. Inoculated petri plates, prepared by the Kirby-Bauer method, were sprayed, after 6 to 7 hr of incubation (37 C...

journal_title：Antimicrobial agents and chemotherapy

authors： Boyle VJ,Fancher ME,Ross RW Jr

更新日期：1973-03-01 00:00:00

abstract：:Cephalosporins possessing a 1, 3-dithiolane, 1, 3-dithiane, or 1, 3-dithietane ring on their 7 beta-substituents showed potent inhibitory activity against cephaloridine hydrolysis by cephalosporinases purified from proteus morganii, Proteus rettgeri, and Proteus inconstans, which were not inhibited by clavulanic acid,...

journal_title：Antimicrobial agents and chemotherapy

authors： Ohya S,Miyadera T,Yamazaki M

更新日期：1982-04-01 00:00:00

abstract：:The capacity for intracellular growth is an important survival strategy for a large group of common pathogens. Helicobacter pylori, the etiological agent for gastritis and duodenal ulcer, has been shown by both in vivo and in vitro studies to have the capacity to invade epithelial cells. In vitro models are used to st...

journal_title：Antimicrobial agents and chemotherapy

authors： Hultén K,Rigo R,Gustafsson I,Engstrand L

更新日期：1996-12-01 00:00:00

abstract：:The prevalence of three plasmid-mediated quinolone resistance determinants, QnrA, QnrB, and QnrS, among 526 nonreplicate clinical isolates of Enterobacter cloacae collected at a Taiwanese university hospital in 2004 was determined by PCR and colony hybridization, and the association of Qnr with the IMP-8 metallo-beta-...

journal_title：Antimicrobial agents and chemotherapy

authors： Wu JJ,Ko WC,Tsai SH,Yan JJ

更新日期：2007-04-01 00:00:00

abstract：:Posaconazole (POS) is a new antifungal agent for prevention and therapy of mycoses in immunocompromised patients. Variable POS pharmacokinetics after oral dosing may influence efficacy: a trough threshold of 0.5 μg/ml has been recently proposed. Measurement of POS plasma concentrations by complex chromatographic techn...

journal_title：Antimicrobial agents and chemotherapy

authors： Rochat B,Pascual A,Pesse B,Lamoth F,Sanglard D,Decosterd LA,Bille J,Marchetti O

更新日期：2010-12-01 00:00:00