In vitro efficacies and resistance profiles of rifampin-based combination regimens for biofilm-embedded methicillin-resistant Staphylococcus aureus.


:To compare the in vitro antibacterial efficacies and resistance profiles of rifampin-based combinations against methicillin-resistant Staphylococcus aureus (MRSA) in a biofilm model, the antibacterial activities of vancomycin, teicoplanin, daptomycin, minocycline, linezolid, fusidic acid, fosfomycin, and tigecycline alone or in combination with rifampin against biofilm-embedded MRSA were measured. The rifampin-resistant mutation frequencies were evaluated. Of the rifampin-based combinations, rifampin enhances the antibacterial activities of and even synergizes with fusidic acid, tigecycline, and, to a lesser extent, linezolid, fosfomycin, and minocycline against biofilm-embedded MRSA. Such combinations with weaker rifampin resistance induction activities may provide a therapeutic advantage in MRSA biofilm-related infections.


Tang HJ,Chen CC,Cheng KC,Wu KY,Lin YC,Zhang CC,Weng TC,Yu WL,Chiu YH,Toh HS,Chiang SR,Su BA,Ko WC,Chuang YC




Has Abstract


2013-11-01 00:00:00














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    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Pfaller MA,Flamm RK,Jones RN,Farrell DJ,Mendes RE

    更新日期:2016-08-22 00:00:00

  • Assessment of the Potential for Inducing Resistance in Multidrug-Resistant Organisms from Exposure to Minocycline, Rifampin, and Chlorhexidine Used To Treat Intravascular Devices.

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    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Rosenblatt J,Vargas-Cruz N,Reitzel RA,Raad II

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    journal_title:Antimicrobial agents and chemotherapy

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    authors: Fourel I,Hantz O,Watanabe KA,Jacquet C,Chomel B,Fox JJ,Trepo C

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  • Novel Protease Inhibitors Containing C-5-Modified bis-Tetrahydrofuranylurethane and Aminobenzothiazole as P2 and P2' Ligands That Exert Potent Antiviral Activity against Highly Multidrug-Resistant HIV-1 with a High Genetic Barrier against the Emergence of

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    journal_title:Antimicrobial agents and chemotherapy

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    authors: Takamatsu Y,Aoki M,Bulut H,Das D,Amano M,Sheri VR,Kovari LC,Hayashi H,Delino NS,Ghosh AK,Mitsuya H

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    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Jadeja L,Bolivar R,Fainstein V,Keating M,McCredie K,Hay M,Bodey GP

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  • Effects of penicillin, ceftriaxone, and doxycycline on morphology of Borrelia burgdorferi.

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    authors: Kersten A,Poitschek C,Rauch S,Aberer E

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  • Role of Interleukin-12 in Protection against Pulmonary Infection with Methicillin-Resistant Staphylococcus aureus.

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    journal_title:Antimicrobial agents and chemotherapy

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    journal_title:Antimicrobial agents and chemotherapy

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    authors: Sarig H,Rotem S,Ziserman L,Danino D,Mor A

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    journal_title:Antimicrobial agents and chemotherapy

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    authors: Credito KL,Ednie LM,Jacobs MR,Appelbaum PC

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    authors: Rusconi S,La Seta Catamancio S,Citterio P,Kurtagic S,Violin M,Balotta C,Moroni M,Galli M,d'Arminio-Monforte A

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    authors: Fevre C,Jbel M,Passet V,Weill FX,Grimont PA,Brisse S

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    authors: Shemonsky NK,Carrizosa J,Levison ME

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    authors: Rocque WJ,Fesik SW,Haug A,McGroarty EJ

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    pub_type: 杂志文章


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    pub_type: 杂志文章


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    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Beauchamp D,Pettigrew M

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    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Barry AL,Fuchs PC

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    更新日期:2010-01-01 00:00:00