In vitro efficacies and resistance profiles of rifampin-based combination regimens for biofilm-embedded methicillin-resistant Staphylococcus aureus.


:To compare the in vitro antibacterial efficacies and resistance profiles of rifampin-based combinations against methicillin-resistant Staphylococcus aureus (MRSA) in a biofilm model, the antibacterial activities of vancomycin, teicoplanin, daptomycin, minocycline, linezolid, fusidic acid, fosfomycin, and tigecycline alone or in combination with rifampin against biofilm-embedded MRSA were measured. The rifampin-resistant mutation frequencies were evaluated. Of the rifampin-based combinations, rifampin enhances the antibacterial activities of and even synergizes with fusidic acid, tigecycline, and, to a lesser extent, linezolid, fosfomycin, and minocycline against biofilm-embedded MRSA. Such combinations with weaker rifampin resistance induction activities may provide a therapeutic advantage in MRSA biofilm-related infections.


Tang HJ,Chen CC,Cheng KC,Wu KY,Lin YC,Zhang CC,Weng TC,Yu WL,Chiu YH,Toh HS,Chiang SR,Su BA,Ko WC,Chuang YC




Has Abstract


2013-11-01 00:00:00














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    abstract::Group B streptococci are common causative agents of early-onset neonatal sepsis (EOS). Pharmacokinetic (PK) data for penicillin G have been described for extremely preterm neonates but have been poorly described for late-preterm and term neonates. Thus, evidence-based dosing recommendations are lacking. We describe th...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Padari H,Metsvaht T,Germovsek E,Barker CI,Kipper K,Herodes K,Standing JF,Oselin K,Tasa T,Soeorg H,Lutsar I

    更新日期:2018-04-26 00:00:00

  • Profiling of PDR1 and MSH2 in Candida glabrata Bloodstream Isolates from a Multicenter Study in China.

    abstract::Among 158 Candida glabrata bloodstream isolates collected from numerous centers in China, a resistance to fluconazole was seen in 8.9%. Three isolates (1.9%) were resistant to all echinocandins. Multilocus sequence typing (MLST) revealed that sequence type 7 ([ST7] 65.8%) was the most common type, followed by ST3 (7.6...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章,多中心研究


    authors: Hou X,Xiao M,Wang H,Yu SY,Zhang G,Zhao Y,Xu YC

    更新日期:2018-05-25 00:00:00

  • Effect of anthrax immune globulin on response to BioThrax (anthrax vaccine adsorbed) in New Zealand white rabbits.

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    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Malkevich NV,Basu S,Rudge TL Jr,Clement KH,Chakrabarti AC,Aimes RT,Nabors GS,Skiadopoulos MH,Ionin B

    更新日期:2013-11-01 00:00:00

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    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Ancelin ML,Vial HJ

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  • Daptomycin may attenuate experimental tobramycin nephrotoxicity by electrostatic complexation to tobramycin.

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    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Couture M,Simard M,Gourde P,Lessard C,Gurnani K,Lin L,Carrier D,Bergeron MG,Beauchamp D

    更新日期:1994-04-01 00:00:00

  • Surveillance of community-based reservoirs reveals the presence of CTX-M, imported AmpC, and OXA-30 beta-lactamases in urine isolates of Klebsiella pneumoniae and Escherichia coli in a U.S. community.

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    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Hanson ND,Moland ES,Hong SG,Propst K,Novak DJ,Cavalieri SJ

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    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 临床试验,杂志文章,随机对照试验


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    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Zasowski E,Butterfield JM,McNutt LA,Cohen J,Cosler L,Pai MP,Gottwald J,Chen WZ,Lodise TP

    更新日期:2014-07-01 00:00:00

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    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Hackel MA,Tsuji M,Yamano Y,Echols R,Karlowsky JA,Sahm DF

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  • blaVIM-7, an evolutionarily distinct metallo-beta-lactamase gene in a Pseudomonas aeruginosa isolate from the United States.

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    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Toleman MA,Rolston K,Jones RN,Walsh TR

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    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Dabbs ER,Yazawa K,Mikami Y,Miyaji M,Morisaki N,Iwasaki S,Furihata K

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  • Renal glycosuria as a novel early sign of colistin-induced kidney damage in mice.

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    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


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    pub_type: 临床试验,杂志文章,随机对照试验


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  • Antimicrobial susceptibility patterns of Streptococcus pneumoniae.

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    pub_type: 杂志文章,多中心研究


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    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


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    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 临床试验,杂志文章


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  • Cyanovirin-N, a potent human immunodeficiency virus-inactivating protein, blocks both CD4-dependent and CD4-independent binding of soluble gp120 (sgp120) to target cells, inhibits sCD4-induced binding of sgp120 to cell-associated CXCR4, and dissociates bo

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    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


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    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


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    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


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    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Franklin K,Clarke AJ

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    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Rolain JM,Diene SM,Kempf M,Gimenez G,Robert C,Raoult D

    更新日期:2013-01-01 00:00:00

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    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Chau AS,Mendrick CA,Sabatelli FJ,Loebenberg D,McNicholas PM

    更新日期:2004-06-01 00:00:00

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    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Hayden FG,Tunkel AR,Treanor JJ,Betts RF,Allerheiligen S,Harris J

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    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Butler MM,Lamarr WA,Foster KA,Barnes MH,Skow DJ,Lyden PT,Kustigian LM,Zhi C,Brown NC,Wright GE,Bowlin TL

    更新日期:2007-01-01 00:00:00

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    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Black PL,Downs MB,Lewis MG,Ussery MA,Dreyer GB,Petteway SR Jr,Lambert DM

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