Clinical correlates of antifungal macrodilution susceptibility test results for non-AIDS patients with severe Candida infections treated with fluconazole.

abstract：:The novel ATP synthase inhibitor bedaquiline recently received accelerated approval for treatment of multidrug-resistant tuberculosis and is currently being studied as a component of novel treatment-shortening regimens for drug-susceptible and multidrug-resistant tuberculosis. In a limited number of bedaquiline-treate...

journal_title：Antimicrobial agents and chemotherapy

authors： Almeida D,Ioerger T,Tyagi S,Li SY,Mdluli K,Andries K,Grosset J,Sacchettini J,Nuermberger E

更新日期：2016-07-22 00:00:00

abstract：:To investigate whether grapefruit juice inhibits the metabolism of clarithromycin, 12 healthy subjects were given water or grapefruit juice before and after a clarithromycin dose of 500 mg in a randomized crossover study. Administration of grapefruit juice increased the time to peak concentration of both clarithromyci...

journal_title：Antimicrobial agents and chemotherapy

authors： Cheng KL,Nafziger AN,Peloquin CA,Amsden GW

更新日期：1998-04-01 00:00:00

abstract：:A total of 6,991 unique patient isolates of Streptococcus pneumoniae were collected from October 1997 to June 2002 from 25 medical centers in 9 of the 10 Canadian provinces. Among these isolates, 20.2% were penicillin nonsusceptible, with 14.6% being penicillin intermediate (MIC, 0.12 to 1 microg/ml) and 5.6% being pe...

journal_title：Antimicrobial agents and chemotherapy

authors： Zhanel GG,Palatnick L,Nichol KA,Bellyou T,Low DE,Hoban DJ

更新日期：2003-06-01 00:00:00

abstract：:We have shown previously that high-dose lipid amphotericin preparations are not more efficacious than lower doses in aspergillosis. We studied toxicity, drug concentrations and localization, and quantitative infection concurrently, using a 4-day model of central nervous system (CNS) aspergillosis to assess early event...

journal_title：Antimicrobial agents and chemotherapy

authors： Clemons KV,Schwartz JA,Stevens DA

更新日期：2012-08-01 00:00:00

abstract：:Four large staphylococcal plasmids ranging in size from 31 to 82 kbp have been shown to mediate tetracycline resistance via an integrated copy of the tet(K)-encoding plasmid pT181 which was flanked by copies of the insertion element IS257. In two cases, IS257 elements interrupted the repC reading frame of pT181 and an...

journal_title：Antimicrobial agents and chemotherapy

authors： Werckenthin C,Schwarz S,Roberts MC

更新日期：1996-11-01 00:00:00

abstract：:Emtricitabine [(-)FTC] [(-)-beta-2', 3'-dideoxy-5-fluoro-3'-thiacytidine] has been shown to be an effective inhibitor of hepatitis B virus (HBV) in cell culture, with a potency and selectivity that are essentially identical to those of lamivudine. The antiviral activity of oral administration of (-)FTC against WHV rep...

journal_title：Antimicrobial agents and chemotherapy

authors： Korba BE,Schinazi RF,Cote P,Tennant BC,Gerin JL

更新日期：2000-06-01 00:00:00

abstract：:Amphotericin B (AMB) has been a mainstay therapy for fungal infections of the central nervous system, but its use has been limited by its poor penetration into the brain, the mechanism of which remains unclear. In this study, we aimed to investigate the role of P-glycoprotein (P-gp) in AMB crossing the blood-brain bar...

journal_title：Antimicrobial agents and chemotherapy

authors： Wu JQ,Shao K,Wang X,Wang RY,Cao YH,Yu YQ,Lou JN,Chen YQ,Zhao HZ,Zhang QQ,Weng XH,Jiang C,Zhu LP

更新日期：2014-08-01 00:00:00

abstract：:Unlike mammalian cells, malarial parasites are completely dependent on the de novo pyrimidine pathway and lack the enzymes to salvage preformed pyrimidines. In the present study, first, it is shown that 1843U89, even without polyglutamylation, is a potent folate-based inhibitor of purified malarial parasite thymidylat...

journal_title：Antimicrobial agents and chemotherapy

authors： Jiang L,Lee PC,White J,Rathod PK

更新日期：2000-04-01 00:00:00

abstract：:The human pathogen Giardia lamblia is an anaerobic protozoan parasite that causes giardiasis, one of the most common diarrheal diseases worldwide. Although several drugs are available for the treatment of giardiasis, drug resistance has been reported and is likely to increase, and recurrent infections are common. The ...

journal_title：Antimicrobial agents and chemotherapy

authors： Chen CZ,Kulakova L,Southall N,Marugan JJ,Galkin A,Austin CP,Herzberg O,Zheng W

更新日期：2011-02-01 00:00:00

abstract：:Azole antifungal resistance in Aspergillus fumigatus is a worldwide concern. As in most public hospitals in Brazil, antifungal susceptibility tests are not routinely performed for filamentous fungi at our institution. A 4-year retrospective azole antifungal resistance screening revealed two azole-resistant A. fumigatu...

journal_title：Antimicrobial agents and chemotherapy

authors： Pontes L,Beraquet CAG,Arai T,Pigolli GL,Lyra L,Watanabe A,Moretti ML,Schreiber AZ

更新日期：2020-02-21 00:00:00

abstract：:Activity of the new antiviral compound selenazofurin was compared with the known active compounds ribavirin and amantadine against influenza A and B viruses. In experiments with Madin Darby canine kidney cells, selenazofurin inhibited the cytopathic effect and yield of influenza A/NWS/33 virus, with 50% effective dose...

journal_title：Antimicrobial agents and chemotherapy

authors： Sidwell RW,Huffman JH,Call EW,Alaghamandan H,Cook PD,Robins RK

更新日期：1985-09-01 00:00:00

abstract：:DNA gyrase is a bacterial enzyme which catalyzes the ATP-dependent negative supercoiling of DNA. It is the accepted target of quinolones. The enzyme from Citrobacter freundii IID976 was purified by affinity chromatography on novobiocin-Sepharose and heparin-Sepharose. It had two subunits, designated A and B, which clo...

journal_title：Antimicrobial agents and chemotherapy

authors： Aoyama H,Sato K,Fujii T,Fujimaki K,Inoue M,Mitsuhashi S

更新日期：1988-01-01 00:00:00

abstract：:Doravirine (DOR, formerly known as MK-1439) is a human immunodeficiency type 1 virus (HIV-1) nonnucleoside reverse transcriptase inhibitor (NNRTI) that is currently in phase 2b clinical trials. In vitro resistance selection of subtype B virus (MT4-green fluorescent protein [GFP] cells), as well as subtype A and C viru...

journal_title：Antimicrobial agents and chemotherapy

authors： Feng M,Wang D,Grobler JA,Hazuda DJ,Miller MD,Lai MT

更新日期：2015-01-01 00:00:00

abstract：:The emergence in the United States of resistance to expanded-spectrum cephalosporin (e.g., ceftriaxone) within the salmonellae has been associated primarily with three large (>100-kb) plasmids (designated types A, B, and C) and one 10.1-kb plasmid (type D) that carry the blaCMY-2 gene. In the present study, the distri...

journal_title：Antimicrobial agents and chemotherapy

authors： Giles WP,Benson AK,Olson ME,Hutkins RW,Whichard JM,Winokur PL,Fey PD

更新日期：2004-08-01 00:00:00

abstract：:To evaluate maternal-fetal pharmacology of cefatrizine (BL-S 640), a new oral cephalosporin, a single oral 1,000-mg dose was administered to 33 gravidas (8 to 20 weeks' gestation) at varying intervals within 46 h of an elective therapeutic abortion by hysterectomy or intra-amniotic prostaglandin F(2a) induction. Mean ...

journal_title：Antimicrobial agents and chemotherapy

authors： Bernard B,Thielen P,Garcia-Cázares J,Ballard CA

更新日期：1977-08-01 00:00:00

abstract：:Accumulating data have brought the nonnucleoside reverse transcriptase (RT) inhibitors (NNRTIs) into the forefront of antiretroviral therapy. Among the emerging compounds in this class, a particularly attractive one is efavirenz (Sustiva), recently approved for clinical use by the U.S. Food and Drug Administration. In...

journal_title：Antimicrobial agents and chemotherapy

authors： Maga G,Ubiali D,Salvetti R,Pregnolato M,Spadari S

更新日期：2000-05-01 00:00:00

abstract：:We determined the pharmacodynamic parameter and the magnitude of that parameter that was predictive of the efficacy of fluconazole in the treatment of disseminated candidiasis. We used a neutropenic murine model of disseminated Candida albicans infection to characterize the time course of activity of fluconazole. Quan...

journal_title：Antimicrobial agents and chemotherapy

authors： Andes D,van Ogtrop M

更新日期：1999-09-01 00:00:00

abstract：:Penicillinase-producing Neisseria gonorrhoeae has increased in the Far East to the point that penicillin can no longer be recommended as the drug of choice, mandating a change to spectinomycin. As part of an ongoing surveillance of antibiotic susceptibilities, minimal inhibitory concentrations of penicillin, tetracycl...

journal_title：Antimicrobial agents and chemotherapy

authors： Piziak MV,Woodbury C,Berliner D,Takafuji E,Kirkpatrick J,Opal S,Tramont E

更新日期：1984-01-01 00:00:00

abstract：:Antibiotic resistance in bacteria is ever changing and adapting, as once-novel β-lactam antibiotics are losing their efficacy, primarily due to the production of β-lactamases. Metallo-β-lactamases (MBLs) efficiently inactivate a broad range of β-lactam antibiotics, including carbapenems, and are often coexpressed with...

journal_title：Antimicrobial agents and chemotherapy

authors： LaCuran AE,Pegg KM,Liu EM,Bethel CR,Ai N,Welsh WJ,Bonomo RA,Oelschlaeger P

更新日期：2015-12-01 00:00:00

abstract：:Antituberculosis drugs display large pharmacokinetic variability, which may be influenced by several factors, including body size, genetic differences, and drug-drug interactions. We set out to determine these factors, quantify their effect, and determine the dose adjustments necessary for optimal drug concentrations....

journal_title：Antimicrobial agents and chemotherapy

authors： Sekaggya-Wiltshire C,Chirehwa M,Musaazi J,von Braun A,Buzibye A,Muller D,Gutteck U,Motta I,Calcagno A,Fehr JS,Kambugu A,Castelnuovo B,Lamorde M,Denti P

更新日期：2019-05-24 00:00:00

abstract：:Free-living amoebae of the genus Acanthamoeba are causing serious chronic conditions such as destructive keratitis in contact lens wearers or granulomatous amoebic encephalitis in individuals with compromised immune systems. Both are characterized by the lack of availability of sufficiently effective and uncomplicated...

journal_title：Antimicrobial agents and chemotherapy

authors： Walochnik J,Duchêne M,Seifert K,Obwaller A,Hottkowitz T,Wiedermann G,Eibl H,Aspöck H

更新日期：2002-03-01 00:00:00

abstract：:There are limited long-term data on the trends in incidence and characteristics of methicillin-resistant Staphylococcus aureus (MRSA) bacteremia (MRSAB) in intensive care units (ICUs) in which infection control measures have been adopted. We evaluated the trend of incidence and changes in characteristics of MRSA bacte...

journal_title：Antimicrobial agents and chemotherapy

authors： Kim H,Kim ES,Lee SC,Yang E,Kim HS,Sung H,Kim MN,Jung J,Kim MJ,Kim SH,Lee SO,Choi SH,Woo JH,Kim YS,Chong YP

更新日期：2020-09-21 00:00:00

abstract：:Active efflux confers intrinsic resistance to multiple antibiotics in Pseudomonas aeruginosa, including old disused molecules. Beside resistance, intracellular survival is another reason for failure to eradicate bacteria with antibiotics. We evaluated the capacity of polyaminoisoprenyl potentiators (designed as efflux...

journal_title：Antimicrobial agents and chemotherapy

authors： Wang GW,Brunel JM,Bolla JM,Van Bambeke F

更新日期：2020-12-14 00:00:00

abstract：:An antibiotic-producing pseudomonad was isolated from a seawater sample from a La Jolla, Calif., tidepool. The pseudomonad produces two novel antibacterial compounds, 2-n-pentyl-4-quinolinol and 2-n-heptyl-4-quinolinol. It also synthesizes indole-3-carboxaldehyde, 6-bromoindole-3-carboxaldehyde, and the known antibiot...

journal_title：Antimicrobial agents and chemotherapy

authors： Wratten SJ,Wolfe MS,Andersen RJ,Faulkner DJ

更新日期：1977-03-01 00:00:00

abstract：:The pharmacokinetics of cefmenoxime were characterized in five healthy volunteers and in 15 subjects with various degrees of renal insufficiency after a single 10-mg/kg, 5-min intravenous infusion. Five of these subjects were studied both on hemodialysis and during an interdialytic period. Plasma, urine and dialysate ...

journal_title：Antimicrobial agents and chemotherapy

authors： Gambertoglio JG,Alexander DP,Barriere SL

更新日期：1984-12-01 00:00:00

abstract：:In vitro activities of erythromycin A, telithromycin, and two investigational ketolides, JNJ-17155437 and JNJ-17155528, were evaluated against clinical bacterial strains, including selected common respiratory tract pathogens. Against 46 macrolide-susceptible and -resistant Streptococcus pneumoniae strains, the MIC(90)...

journal_title：Antimicrobial agents and chemotherapy

authors： Abbanat D,Webb G,Foleno B,Li Y,Macielag M,Montenegro D,Wira E,Bush K

更新日期：2005-01-01 00:00:00

abstract：:The global control of tuberculosis (TB) is at risk by the spread of multidrug-resistant TB (MDR TB). Treatment of MDR TB is lengthy and involves injected drugs, such as capreomycin, that have severe side effects. It was previously reported that a single daily dose of inhaled capreomycin had a positive effect on the ba...

journal_title：Antimicrobial agents and chemotherapy

authors： Garcia-Contreras L,Muttil P,Fallon JK,Kabadi M,Gerety R,Hickey AJ

更新日期：2012-05-01 00:00:00

abstract：:At equivalent oral doses, cefadroxil has a longer serum half-life, slower urinary excretion rate, greater area under the serum level versus time curve than cephalexin or cephradine, and peak serum concentrations that are 75 to 80% those of cephalexin. The calculated, apparent in vivo volume of distribution of cefadrox...

journal_title：Antimicrobial agents and chemotherapy

authors： Pfeffer M,Jackson A,Ximenes J,de Menezes JP

更新日期：1977-02-01 00:00:00

abstract：:Piperaquine (PQ) is an important partner drug in antimalarial combination treatments, but the long half-life of PQ raises concerns about drug resistance. Our aim was to investigate the extended antimalarial effect of PQ in a study of drug efficacy, reinoculation outcomes, and parasite viability after the administratio...

journal_title：Antimicrobial agents and chemotherapy

authors： Moore BR,Ilett KF,Page-Sharp M,Jago JD,Batty KT

更新日期：2009-07-01 00:00:00

abstract：:Past studies conducted in Australian and American families have demonstrated that alpha 2b interferon (IFN) is effective in preventing rhinovirus-associated illnesses in exposed family members. IFN had been used by intranasal application for 7 days after exposure (5 x 10(6) IU/day). We used the same approach but with ...

journal_title：Antimicrobial agents and chemotherapy

authors： Monto AS,Schwartz SA,Albrecht JK

更新日期：1989-03-01 00:00:00