In vitro activities of novel 2-fluoro-naphthyridine-containing ketolides.

abstract：:Therapeutic treatment for systemic mycoses is severely hampered by the extremely limited number of antifungals. The difficulty of treatment of fungal infections in the central nervous system is further compounded by the poor central nervous system (CNS) penetration of most antifungals due to the blood-brain barrier. O...

journal_title：Antimicrobial agents and chemotherapy

authors： Zhai B,Wu C,Wang L,Sachs MS,Lin X

更新日期：2012-07-01 00:00:00

abstract：:Previous studies have shown that various short- and medium-chain free fatty acids (FFAs) and their corresponding monoacylglycerol esters (MGs) have antibacterial activity in vitro against primarily gram-positive bacteria. More recent studies have also shown that the growth of Helicobacter spp. is inhibited by linoleic...

journal_title：Antimicrobial agents and chemotherapy

authors： Petschow BW,Batema RP,Ford LL

更新日期：1996-02-01 00:00:00

abstract：:Fungal infections are a leading cause of morbidity and death for hospitalized patients, mainly because they remain difficult to diagnose and to treat. Diseases range from widespread superficial infections such as vulvovaginal infections to life-threatening systemic candidiasis. For systemic mycoses, only a restricted ...

journal_title：Antimicrobial agents and chemotherapy

authors： Keller P,Müller C,Engelhardt I,Hiller E,Lemuth K,Eickhoff H,Wiesmüller KH,Burger-Kentischer A,Bracher F,Rupp S

更新日期：2015-10-01 00:00:00

abstract：:Dialyzed extracts of the gentamicin producer Micromonospora purpurea catalyze reactions which represent transaminations proposed for 2-deoxystreptamine biosynthesis. To determine whether these transaminations were catalyzed by a single aminotransferase or by multiple enzymes, we purified and characterized an L-glutami...

journal_title：Antimicrobial agents and chemotherapy

authors： Lucher LA,Chen YM,Walker JB

更新日期：1989-04-01 00:00:00

abstract：:Staphylococcus aureus is a bacterial pathogen responsible for the majority of skin and soft tissue infections. Antibiotics are losing their efficacy as treatment for skin and soft tissue infections as a result of increased resistance in a variety of pathogens, including S. aureus It is thus imperative to explore alter...

journal_title：Antimicrobial agents and chemotherapy

authors： van Staden Adu P,Heunis T,Smith C,Deane S,Dicks LM

更新日期：2016-06-20 00:00:00

abstract：:The in vitro activities of penicillin, clindamycin, chloramphenicol, metronidazole, piperacillin, piperacillin-tazobactam, ticarcillin, ticarcillin-clavulanate, ampicillin-sulbactam, cefoxitin, ceftizoxime, cefotetan, moxalactam, and imipenem against 348 Bacteroides fragilis group isolates collected from six Canadian ...

journal_title：Antimicrobial agents and chemotherapy

authors： Bourgault AM,Lamothe F,Hoban DJ,Dalton MT,Kibsey PC,Harding G,Smith JA,Low DE,Gilbert H

更新日期：1992-02-01 00:00:00

abstract：:Colistin resistance, although uncommon, is increasingly being reported among Gram-negative clinical pathogens, and an understanding of its impact on the activity of antimicrobials is now evolving. We evaluated the potential for synergy of colistin plus trimethoprim, trimethoprim-sulfamethoxazole (1/19 ratio), or vanco...

journal_title：Antimicrobial agents and chemotherapy

authors： Vidaillac C,Benichou L,Duval RE

更新日期：2012-09-01 00:00:00

abstract：:Intraoperative biliary cefamandole concentrations were determined in 16 patients with hepatobiliary pathology. These included seven patients with cholelithiasis, five with acute cholecystitis, two with recurrent ascending cholangitis, and two with liver abscesses. Bile collected 0.5 to 2.5 h after the last antibiotic ...

journal_title：Antimicrobial agents and chemotherapy

authors： Uwaydah M,Kantarjian H,Osseiran M,Bal'a F

更新日期：1982-12-01 00:00:00

abstract：:Using an isogenic system, we have determined the impact that the four promoters known to control bla(TEM) gene expression have on beta-lactamase activity. For both TEM-1 and TEM-30, this activity gradually increased in relation to the presence of promoters P3, Pa/Pb, and P4 upstream of the corresponding gene. Promoter...

journal_title：Antimicrobial agents and chemotherapy

authors： Lartigue MF,Leflon-Guibout V,Poirel L,Nordmann P,Nicolas-Chanoine MH

更新日期：2002-12-01 00:00:00

abstract：:Two carbapenem-resistant isolates, one Escherichia coli isolate and one Klebsiella pneumoniae isolate, recovered from an Algerian patient expressed a novel VIM-type metallo-beta-lactamase (MBL). The identified bla(VIM-19) gene was located on a ca. 160-kb plasmid and located inside a class 1 integron in both isolates. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Rodriguez-Martinez JM,Nordmann P,Fortineau N,Poirel L

更新日期：2010-01-01 00:00:00

abstract：:(-)-Beta-D-1',3'-Dioxolane guanosine (DXG) and 2,6-diaminopurine (DAPD) dioxolanyl nucleoside analogues have been reported to be potent inhibitors of human immunodeficiency virus type 1 (HIV-1). We have recently conducted experiments to more fully characterize their in vitro anti-HIV-1 profiles. Antiviral assays perfo...

journal_title：Antimicrobial agents and chemotherapy

authors： Gu Z,Wainberg MA,Nguyen-Ba N,L'Heureux L,de Muys JM,Bowlin TL,Rando RF

更新日期：1999-10-01 00:00:00

abstract：:Rosmarinic acid (RA) reduced the mortality of mice infected with Japanese encephalitis virus (JEV). Significant decreases in viral loads (P < 0.001) and proinflammatory cytokine levels (P < 0.001) were observed in JEV-infected animals treated with RA compared to levels in infected mice without treatment, at 8 to 9 day...

journal_title：Antimicrobial agents and chemotherapy

authors： Swarup V,Ghosh J,Ghosh S,Saxena A,Basu A

更新日期：2007-09-01 00:00:00

abstract：:The topical delivery of liposomally encapsulated interferon was evaluated in the cutaneous herpes simplex virus guinea pig model. Application of liposomally entrapped interferon caused a reduction of lesion scores, whereas application of interferon formulated as a solution or as an emulsion was ineffective. The method...

journal_title：Antimicrobial agents and chemotherapy

authors： Weiner N,Williams N,Birch G,Ramachandran C,Shipman C Jr,Flynn G

更新日期：1989-08-01 00:00:00

abstract：:Mutations in the Plasmodium falciparum genes pfcrt and pfmdr1 are selected by amodiaquine treatment in Africa. To examine the importance of these mutations in amodiaquine-treated Asian parasites, we determined pre- and posttreatment genotypes for amodiaquine treatment failures from a clinical trial in Afghanistan. The...

journal_title：Antimicrobial agents and chemotherapy

authors： Beshir K,Sutherland CJ,Merinopoulos I,Durrani N,Leslie T,Rowland M,Hallett RL

更新日期：2010-09-01 00:00:00

abstract：:Epidemiological data on carbapenemase-producing Gram-negative bacteria on the African continent are limited. Here, we report the identification of VIM-2-producing Pseudomonas aeruginosa isolates in Tanzania. Eight out of 90 clinical isolates of P. aeruginosa from a tertiary care hospital in Dar es Salaam were shown to...

journal_title：Antimicrobial agents and chemotherapy

authors： Moyo S,Haldorsen B,Aboud S,Blomberg B,Maselle SY,Sundsfjord A,Langeland N,Samuelsen Ø

更新日期：2015-01-01 00:00:00

abstract：:Spontaneous mutants of susceptible clinical and laboratory isolates of Streptococcus pneumoniae exhibiting reduced susceptibility to evernimicin (SCH27899; MIC, 0.5 to 4.0 mg/liter) were selected on plates containing evernimicin. Four isolates that did not harbor mutations in rplP (which encodes ribosomal protein L16)...

journal_title：Antimicrobial agents and chemotherapy

authors： Adrian PV,Mendrick C,Loebenberg D,McNicholas P,Shaw KJ,Klugman KP,Hare RS,Black TA

更新日期：2000-11-01 00:00:00

abstract：:Maribavir (1263W94, VP-41263) is an oral anticytomegalovirus agent under clinical development. The pharmacokinetics and safety of maribavir and the effects of maribavir on the activities of cytochrome P450 (CYP) 1A2, CYP 2C9, CYP 2C19, CYP 2D6, CYP 3A, N-acetyltransferase-2 (NAT-2), and xanthine oxidase (XO) were eval...

journal_title：Antimicrobial agents and chemotherapy

authors： Ma JD,Nafziger AN,Villano SA,Gaedigk A,Bertino JS Jr

更新日期：2006-04-01 00:00:00

abstract：:A mouse model of cystitis caused by uropathogenic Escherichia coli was used to study the distribution of gallium in bladder tissue following oral administration of gallium maltolate during urinary tract infection. The median concentration of gallium in homogenized bladder tissue from infected mice was 1.93 μg/g after ...

journal_title：Antimicrobial agents and chemotherapy

authors： Ball KR,Sampieri F,Chirino M,Hamilton DL,Blyth RI,Sham TK,Dowling PM,Thompson J

更新日期：2013-11-01 00:00:00

abstract：:Nocardia farcinica, one of the most frequent pathogenic species responsible for nocardiosis, is characterized by frequent brain involvement and resistance to β-lactams mediated by a class A β-lactamase. Kinetic parameters for hydrolysis of various β-lactams by FARIFM10152 from strain IFM 10152 were determined by spect...

journal_title：Antimicrobial agents and chemotherapy

authors： Lebeaux D,Ourghanlian C,Dorchène D,Soroka D,Edoo Z,Compain F,Arthur M

更新日期：2020-01-27 00:00:00

abstract：:The effect of 19 antimicrobial agents on human polymorphonuclear leukocyte function was evaluated by chemiluminescence assays, yeast phagocytosis and killing, and lactate dehydrogenase release. Tetracycline and trimethoprim inhibited chemiluminescence and reduced killing at therapeutic concentrations of 2 microgram/ml...

journal_title：Antimicrobial agents and chemotherapy

authors： Welch WD,Davis D,Thrupp LD

更新日期：1981-07-01 00:00:00

abstract：:Duck hepatitis B virus (DHBV) replication in primary duck hepatocytes was monitored by examining the synthesis of both DHBV DNA and DHBV core antigen. Several nucleoside analogs which were previously shown to inhibit the replication of DNA viruses (i.e., herpesviruses) and retroviruses were examined for their inhibito...

journal_title：Antimicrobial agents and chemotherapy

authors： Yokota T,Konno K,Chonan E,Mochizuki S,Kojima K,Shigeta S,de Clercq E

更新日期：1990-07-01 00:00:00

abstract：:R plasmids identified in Pseudomonas aeruginosa strains isolated in our laboratories were classified by their incompatibility characters by using intraspecies conjugation in P. aeruginosa. The fertility factor, FP2, was compatible with R plasmids belonging to all groups, and was classified in a new group. From these d...

journal_title：Antimicrobial agents and chemotherapy

authors： Sagai H,Hasuda K,Iyobe S,Bryan LE,Holloway BW,Mitsuhashi S

更新日期：1976-10-01 00:00:00

abstract：:Clostridioides difficile causes severe antibiotic-associated diarrhea and colitis. C. difficile is an anaerobic, Gram-positive sporeformer that is highly resistant to β-lactams, the most commonly prescribed antibiotics. The resistance of C. difficile to β-lactam antibiotics allows the pathogen to replicate and cause d...

journal_title：Antimicrobial agents and chemotherapy

authors： Sandhu BK,Edwards AN,Anderson SE,Woods EC,McBride SM

更新日期：2019-12-20 00:00:00

abstract：:With the aim of investigating home therapy for enterococcal endocarditis, we compared the efficacy of teicoplanin combined with gentamicin given once a day or in three daily doses (t.i.d.) with the standard treatment, ampicillin plus gentamicin administered t.i.d., for treating experimental enterococcal endocarditis. ...

journal_title：Antimicrobial agents and chemotherapy

authors： López P,Gavaldà J,Martin MT,Almirante B,Gomis X,Azuaje C,Borrell N,Pou L,Falcó V,Pigrau C,Pahissa A

更新日期：2001-05-01 00:00:00

abstract：:A self-transferable plasmid of ca. 80 kb, pIP1204, conferred multiple-antibiotic resistance to Klebsiella pneumoniae BM4536, which was isolated from a urinary tract infection. Resistance to beta-lactams was due to the bla(TEM1) and bla(CTX-M) genes, resistance to trimethroprim was due to the dhfrXII gene, resistance t...

journal_title：Antimicrobial agents and chemotherapy

authors： Galimand M,Courvalin P,Lambert T

更新日期：2003-08-01 00:00:00

abstract：:The plasma elimination rates of serial 2-g intravenous injections of ceftriaxone were studied in a patient who also was treated with therapeutic plasma exchange pheresis. Plasmapheresis had negligible influence on the total clearance of ceftriaxone. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Bakken JS,Cavalieri SJ,Gangeness D

更新日期：1990-06-01 00:00:00

abstract：:The postantibiotic effect (PAE) (10 times the MIC of quinolones, 5 times the MIC of macrolides) and postantibiotic sub-MIC effect (PAE-SME) at 0.125, 0.25, and 0.5 times the MIC were determined for levofloxacin, ciprofloxacin, ofloxacin, erythromycin, azithromycin, and clarithromycin against 20 pneumococci. Quinolone ...

journal_title：Antimicrobial agents and chemotherapy

authors： Spangler SK,Lin G,Jacobs MR,Appelbaum PC

更新日期：1998-05-01 00:00:00

abstract：:The pharmacokinetic properties of an everninomicin antibiotic (SCH27899; Ziracin) were studied with healthy Japanese male volunteers by single (1, 3, 6, and 9 mg/kg of body weight) and multiple 60-min intravenous infusions (3, 6, and 9 mg/kg once daily for 10 consecutive days following a 2-day interval after the initi...

journal_title：Antimicrobial agents and chemotherapy

authors： Kozawa O,Uematsu T,Matsuno H,Niwa M,Kohno K,Kawato A,Takahashi K,Nagashima S,Kanamaru M

更新日期：2001-03-01 00:00:00

abstract：:Helicobacter pylori is a major etiological agent in gastroduodenal disorders. The adhesion of H. pylori to human gastric epithelial cells is the initial step of H. pylori infection. Inhibition of H. pylori adhesion is thus a therapeutic target in the prevention of H. pylori infection. Experiments were performed to eva...

journal_title：Antimicrobial agents and chemotherapy

authors： Hayashi S,Sugiyama T,Amano K,Isogai H,Isogai E,Aihara M,Kikuchi M,Asaka M,Yokota K,Oguma K,Fujii N,Hirai Y

更新日期：1998-08-01 00:00:00

abstract：:Macrolides are the antimicrobials of choice for treating human campylobacteriosis. The recent emergence of erm(B) in Campylobacter bacteria threatens the utility of this class of antibiotics. Here we report the constitutive and inducible expression of erm(B) in Campylobacter isolates derived from diarrheal patients an...

journal_title：Antimicrobial agents and chemotherapy

authors： Deng F,Shen J,Zhang M,Wu C,Zhang Q,Wang Y

更新日期：2015-10-01 00:00:00