Effect of oral administration of emtricitabine on woodchuck hepatitis virus replication in chronically infected woodchucks.

abstract：:Strains of Aspergillus fumigatus, Aspergillus flavus, and Aspergillus niger were tested for in vitro susceptibility to amphotericin B alone and in combination with fixed concentrations of tetracycline, doxycycline, or minocycline, using buffered minimal essential medium in microtiter plates. Enhanced inhibitory activi...

journal_title：Antimicrobial agents and chemotherapy

authors： Hughes CE,Harris C,Peterson LR,Gerding DN

更新日期：1984-12-01 00:00:00

abstract：:A mouse model of cystitis caused by uropathogenic Escherichia coli was used to study the distribution of gallium in bladder tissue following oral administration of gallium maltolate during urinary tract infection. The median concentration of gallium in homogenized bladder tissue from infected mice was 1.93 μg/g after ...

journal_title：Antimicrobial agents and chemotherapy

authors： Ball KR,Sampieri F,Chirino M,Hamilton DL,Blyth RI,Sham TK,Dowling PM,Thompson J

更新日期：2013-11-01 00:00:00

abstract：:In both scid and BALB/c mouse-Leishmania donovani models, hexadecyphosphocholine (miltefosine) and AmBisome had similar levels of activity. In contrast, sodium stibogluconate (Pentostam) was significantly less active against L. donovani in scid mice than in BALB/c mice. The in vitro anti-leishmanial activity of miltef...

journal_title：Antimicrobial agents and chemotherapy

authors： Escobar P,Yardley V,Croft SL

更新日期：2001-06-01 00:00:00

abstract：:Bay 12-8039, a new 8-methoxy quinolone, was compared with other agents for activity against clinically relevant anaerobes. Bay 12-8039 inhibited 91 and 96% of the 410 test isolates at 2 and 4 micrograms/ml, respectively. Bay 12-8039 had activity comparable to that metronidazole and overall was at least 16-fold more ac...

journal_title：Antimicrobial agents and chemotherapy

authors： Aldridge KE,Ashcraft DS

更新日期：1997-03-01 00:00:00

abstract：:Among hospitalized adults who received vancomycin for their skin and skin structure infection (SSSI), patients who experienced acute kidney injury (AKI) had considerably higher 30-day readmission rates. Nearly half of the observed 30-day readmissions were due to non-SSSI-related reasons, which is consistent with the p...

journal_title：Antimicrobial agents and chemotherapy

authors： Patel N,Stornelli N,Sangiovanni RJ,Huang DB,Lodise TP

更新日期：2020-09-21 00:00:00

abstract：:Although obesity is prevalent among children in the United States, pharmacokinetic (PK) data for obese children are limited. Clindamycin is a commonly used antibiotic that may require dose adjustment in obese children due to its lipophilic properties. We performed a clindamycin population PK analysis using data from t...

journal_title：Antimicrobial agents and chemotherapy

authors： Smith MJ,Gonzalez D,Goldman JL,Yogev R,Sullivan JE,Reed MD,Anand R,Martz K,Berezny K,Benjamin DK Jr,Smith PB,Cohen-Wolkowiez M,Watt K,Best Pharmaceuticals for Children Act—Pediatric Trials Network Steering Committee.

更新日期：2017-03-24 00:00:00

abstract：:Multidrug-resistant clinical isolate Klebsiella pneumoniae BM4686 was highly resistant to 4,6-disubstituted 2-deoxystreptamines and to fortimicin. Resistance was due to the presence, on the 40-kb non-self-transferable plasmid pIP849, of the rmtF gene which was cotranscribed with the upstream aac(6')-Ib gene. The deduc...

journal_title：Antimicrobial agents and chemotherapy

authors： Galimand M,Courvalin P,Lambert T

更新日期：2012-07-01 00:00:00

abstract：:In 18 male healthy subjects, artesunate (200 mg)-azithromycin (1,500 mg) daily for 3 days was found to be well tolerated, with only mild gastrointestinal disturbances reported. The pharmacokinetic properties of artesunate-azithromycin given in combination are comparable to those of the drugs given alone. Artesunate an...

journal_title：Antimicrobial agents and chemotherapy

authors： Chinh NT,Quang NN,Anh CX,Thanh NX,Dai B,Birrell GW,Chavchich M,Edstein MD

更新日期：2011-09-01 00:00:00

abstract：:Serratia marcescens S-95, which displayed an unusually high degree of resistance to aminoglycosides, including kanamycins and gentamicins, was isolated in 2002 from a patient in Japan. The resistance was mediated by a large plasmid which was nonconjugative but transferable to an Escherichia coli recipient by transform...

journal_title：Antimicrobial agents and chemotherapy

authors： Doi Y,Yokoyama K,Yamane K,Wachino J,Shibata N,Yagi T,Shibayama K,Kato H,Arakawa Y

更新日期：2004-02-01 00:00:00

abstract：:Replication complexes of hepatitis C virus synthesized two major species of viral RNA in vitro, double stranded and single stranded. NS5B nonnucleoside inhibitors inhibited dose dependently the synthesis of single-stranded RNA but not double-stranded RNA. Moreover, replication complexes carrying a mutation resistant t...

journal_title：Antimicrobial agents and chemotherapy

authors： Yang W,Sun Y,Phadke A,Deshpande M,Huang M

更新日期：2007-01-01 00:00:00

abstract：:Intravenous ampicillin-sulbactam is effective in the treatment of various infections in adults, but little is known about the pharmacokinetics (PK) of ampicillin-sulbactam in children. The objective of this study was to determine the PK of ampicillin and sulbactam in pediatric patients with intra-abdominal infection, ...

journal_title：Antimicrobial agents and chemotherapy

authors： Nahata MC,Vashi VI,Swanson RN,Messig MA,Chung M

更新日期：1999-05-01 00:00:00

abstract：:SM-8668 (Sch 39304) is a new oral antifungal agent which we evaluated in comparison with fluconazole in various fungal infection models. The prophylactic effect of SM-8668 was excellent against systemic candidiasis, aspergillosis, and cryptococcosis in mice. The 50% effective dose for SM-8668 was assessed at 10 days a...

journal_title：Antimicrobial agents and chemotherapy

authors： Tanio T,Ichise K,Nakajima T,Okuda T

更新日期：1990-06-01 00:00:00

abstract：:The in vitro activities of CG400549, a novel FabI inhibitor, were compared to those of linezolid and commonly used antimicrobials against recent bacterial isolates. CG400549 had an MIC(90) of 0.5 microg/ml for Staphylococcus aureus strains and was more potent than either linezolid or vancomycin. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Yum JH,Kim CK,Yong D,Lee K,Chong Y,Kim CM,Kim JM,Ro S,Cho JM

更新日期：2007-07-01 00:00:00

abstract：:Resistance-nodulation-division (RND) efflux pumps are important contributors to bacterial antibiotic resistance. In this study, we combined evolutionary sequence analyses, computational structural modeling, and ligand docking to develop a framework that can explain the known antibiotic substrate selectivity difference...

journal_title：Antimicrobial agents and chemotherapy

authors： Dey D,Kavanaugh LG,Conn GL

更新日期：2020-07-22 00:00:00

abstract：:The objective of these studies was to evaluate the exposures of meropenem and vaborbactam that would produce antibacterial activity and prevent resistance development in carbapenem-resistant Klebsiella pneumoniae carbapenemase (KPC)-producing Enterobacteriaceae strains when tested at an inoculum of 108 CFU/ml. Thirtee...

journal_title：Antimicrobial agents and chemotherapy

authors： Sabet M,Tarazi Z,Rubio-Aparicio D,Nolan TG,Parkinson J,Lomovskaya O,Dudley MN,Griffith DC

更新日期：2018-01-25 00:00:00

abstract：:Extended-spectrum class C β-lactamases have evolved to rapidly inactivate expanded-spectrum cephalosporins, a class of antibiotics designed to be resistant to hydrolysis by β-lactamase enzymes. To better understand the mechanism by which Acinetobacter-derived cephalosporinase-7 (ADC-7), a chromosomal AmpC enzyme, hydr...

journal_title：Antimicrobial agents and chemotherapy

authors： Curtis BN,Smolen KA,Barlow SJ,Caselli E,Prati F,Taracila MA,Bonomo RA,Wallar BJ,Powers RA

更新日期：2020-11-17 00:00:00

abstract：:Concomitant treatment of tuberculosis (TB) and HIV is recommended and improves outcomes. Bedaquiline is a novel drug for the treatment of multidrug-resistant (MDR) TB; combined use with antiretroviral drugs, nevirapine, or ritonavir-boosted lopinavir (LPV/r) is anticipated, but no clinical data from coinfected patient...

journal_title：Antimicrobial agents and chemotherapy

authors： Svensson EM,Dooley KE,Karlsson MO

更新日期：2014-11-01 00:00:00

abstract：:A portion of the Mycobacterium tuberculosis gene encoding the beta subunit of RNA polymerase (rpoB) was amplified by PCR using degenerate oligonucleotides and used as a hybridization probe to isolate plasmid clones carrying the entire rpoB gene of M. tuberculosis H37Rv, a virulent, rifampin-susceptible strain. Sequenc...

journal_title：Antimicrobial agents and chemotherapy

authors： Miller LP,Crawford JT,Shinnick TM

更新日期：1994-04-01 00:00:00

abstract：:BEL-1 is an acquired class A extended-spectrum β-lactamase (ESBL) found in Pseudomonas aeruginosa clinical isolates from Belgium which is divergent from other ESBLs (maximum identity of 54% with GES-type enzymes). This enzyme is efficiently inhibited by clavulanate, imipenem, and moxalactam. Crystals of BEL-1 were obt...

journal_title：Antimicrobial agents and chemotherapy

authors： Pozzi C,De Luca F,Benvenuti M,Poirel L,Nordmann P,Rossolini GM,Mangani S,Docquier JD

更新日期：2016-11-21 00:00:00

abstract：:Herpes simplex ocular infection is a major cause of corneal blindness. Local antiviral treatments exist but are associated with corneal toxicity, and resistance has become an issue. We evaluated the biodistribution and efficacy of a humanized anti-herpes simplex virus (anti-HSV) IgG FAb fragment (AC-8; 53 kDa) followi...

journal_title：Antimicrobial agents and chemotherapy

authors： Berdugo M,Larsen IV,Abadie C,Deloche C,Kowalczuk L,Touchard E,Dubielzig R,Brandt CR,Behar-Cohen F,Combette JM

更新日期：2012-03-01 00:00:00

abstract：:The in vitro susceptibility of Brucella melitensis was examined vis-a-vis the clinical outcome in 75 patients with brucellosis. The initial MICs for Brucella isolates from patients who relapsed and from those who did not were similar. Furthermore, the MICs for isolates from patients whose infections relapsed were no d...

journal_title：Antimicrobial agents and chemotherapy

authors： Ariza J,Bosch J,Gudiol F,Liñares J,Viladrich PF,Martín R

更新日期：1986-12-01 00:00:00

abstract：:The report describes the establishment and characterization of a mouse xenograft transplantation model for the study of papillomavirus infection of bovine skin. Calf scrotal skin was inoculated with bovine papillomavirus type 2 before grafting it to the dorsum of severe combined immunodeficient mice. The grafted skin ...

journal_title：Antimicrobial agents and chemotherapy

authors： Pawellek A,Hewlett G,Kreuter J,Rübsamen-Waigmann H,Weber O

更新日期：2001-04-01 00:00:00

abstract：:Carbapenem-resistant Enterobacteriaceae (CRE) are resistant to most antibiotics, making CRE infections extremely difficult to treat with available agents. Klebsiella pneumoniae carbapenemases (KPC-2 and KPC-3) are predominant carbapenemases in CRE in the United States. Nacubactam is a bridged diazabicyclooctane (DBO) ...

journal_title：Antimicrobial agents and chemotherapy

authors： Barnes MD,Taracila MA,Good CE,Bajaksouzian S,Rojas LJ,van Duin D,Kreiswirth BN,Jacobs MR,Haldimann A,Papp-Wallace KM,Bonomo RA

更新日期：2019-07-25 00:00:00

abstract：:Vaborbactam (formerly RPX7009) is a member of a new class of β-lactamase inhibitor with pharmacokinetic properties similar to those of many β-lactams, including carbapenems. The pharmacokinetics and safety of vaborbactam were evaluated in 80 healthy adult subjects in a first-in-human randomized, placebo-controlled, do...

journal_title：Antimicrobial agents and chemotherapy

authors： Griffith DC,Loutit JS,Morgan EE,Durso S,Dudley MN

更新日期：2016-09-23 00:00:00

abstract：:A rapid-flow cytofluorometric susceptibility test for in vitro amphotericin B testing of yeasts was evaluated and compared to the National Committee for Clinical Laboratory Standards (NCCLS) M27-T reference broth macrodilution method. The flow cytofluorometric method is based on the detection of decreased green fluore...

journal_title：Antimicrobial agents and chemotherapy

authors： Peyron F,Favel A,Guiraud-Dauriac H,El Mzibri M,Chastin C,Dumenil G,Regli P

更新日期：1997-07-01 00:00:00

abstract：:Genome studies suggest that DNA gyrase is the sole type II topoisomerase and likely the unique target of quinolones in Mycobacterium tuberculosis. Despite the emerging importance of quinolones in the treatment of mycobacterial disease, the slow growth and high pathogenicity of M. tuberculosis have precluded direct pur...

journal_title：Antimicrobial agents and chemotherapy

authors： Aubry A,Pan XS,Fisher LM,Jarlier V,Cambau E

更新日期：2004-04-01 00:00:00

abstract：:The in vitro and in vivo activity of FR-31564 [sodium hydrogen 3-(N-hydroxyformamido)propylphosphate] against gram-positive and -negative aerobic and anaerobic bacteria was investigated and compared with that of fosfomycin, cephalexin, carbenicillin, and trimethoprim-sulfamethoxazole. The in vitro activity of FR-31564...

journal_title：Antimicrobial agents and chemotherapy

authors： Neu HC,Kamimura T

更新日期：1981-06-01 00:00:00

abstract：:Various steroids were tested for their effects upon gonococcal O2 consumption and glucose catabolism. The ability to inhibit gonococcal O2 uptake appeared to be related to the molecular configuration of the steroid. The presence of lipophilic groups enhanced inhibition, whereas the addition of hydrophilic groups marke...

journal_title：Antimicrobial agents and chemotherapy

authors： Lysko PG,Morse SA

更新日期：1980-08-01 00:00:00

abstract：:The efficacy of ciprofloxacin for experimental aortic valve endocarditis in rabbits infected by either a methicillin-susceptible or a methicillin-resistant strain of Staphylococcus aureus was compared with standard therapy of nafcillin or vancomycin, respectively. After 4 days of therapy, ciprofloxacin reduced the cou...

journal_title：Antimicrobial agents and chemotherapy

authors： Carpenter TC,Hackbarth CJ,Chambers HF,Sande MA

更新日期：1986-09-01 00:00:00

abstract：:Mammalian cathelicidins are a class of innate antimicrobial peptides isolated from leukocytes and epithelial cells that aid host defense against bacterial infections. Synthetic analogs of cathelicidins offer the promise of potent broad-spectrum antimicrobial efficacy. We developed a combined lung infection and ex vivo...

journal_title：Antimicrobial agents and chemotherapy

authors： Bartlett KH,McCray PB Jr,Thorne PS

更新日期：2003-12-01 00:00:00