Antibiotic Substrate Selectivity of Pseudomonas aeruginosa MexY and MexB Efflux Systems Is Determined by a Goldilocks Affinity.

abstract：:Lung infections caused by Mycobacterium abscessus are emerging as a global threat to individuals with cystic fibrosis and to other patient groups. Recent evidence for human-to-human transmission worsens the situation. M. abscessus is an intrinsically multidrug-resistant pathogen showing resistance to even standard ant...

journal_title：Antimicrobial agents and chemotherapy

authors： Aziz DB,Low JL,Wu ML,Gengenbacher M,Teo JWP,Dartois V,Dick T

更新日期：2017-05-24 00:00:00

abstract：:Mycobacterium abscessus is increasingly recognized as an emerging opportunistic pathogen causing severe lung diseases. As it is intrinsically resistant to most conventional antibiotics, there is an unmet medical need for effective treatments. Repurposing of clinically validated pharmaceuticals represents an attractive...

journal_title：Antimicrobial agents and chemotherapy

authors： Johansen MD,Daher W,Roquet-Banères F,Raynaud C,Alcaraz M,Maurer FP,Kremer L

更新日期：2020-10-20 00:00:00

abstract：:Nikkomycins are nucleoside-peptide antibiotics produced by Streptomyces species with antifungal activities through the inhibition of chitin synthesis. We investigated the antifungal activities of nikkomycin Z alone and in combination with fluconazole and itraconazole. Checkerboard synergy studies were carried out by a...

journal_title：Antimicrobial agents and chemotherapy

authors： Li RK,Rinaldi MG

更新日期：1999-06-01 00:00:00

abstract：:The pathogenic yeast Candida albicans can exist in multiple morphological states, including budded, pseudohyphal, and true hyphal forms. The ability to convert between the budded and hyphal forms, termed the budded-to-hyphal-form transition, is important for virulence and is regulated by multiple environmental and cel...

journal_title：Antimicrobial agents and chemotherapy

authors： Toenjes KA,Munsee SM,Ibrahim AS,Jeffrey R,Edwards JE Jr,Johnson DI

更新日期：2005-03-01 00:00:00

abstract：:We administered 2 g of ceftazidime intravenously every 8 h to cancer patients for the empiric therapy of febrile episodes. Ceftazidime was administered as monotherapy for patients with granulocyte counts in excess of 1,000/microliter. Febrile, neutropenic patients were randomized to also receive either piperacillin or...

journal_title：Antimicrobial agents and chemotherapy

authors： Drusano GL,Joshi J,Forrest A,Ruxer R,Standiford H,Leslie J,Wade J,Schimpff S

更新日期：1985-04-01 00:00:00

abstract：:Remdesivir was recently approved by the Food and Drug Administration for the treatment of hospitalized patients with coronavirus disease 2019 (COVID-19). Remdesivir is the prodrug of an adenosine analogue that inhibits viral replication of several RNA virus families, including Coronaviridae Preclinical data in animal ...

journal_title：Antimicrobial agents and chemotherapy

authors： Aleissa MM,Silverman EA,Paredes Acosta LM,Nutt CT,Richterman A,Marty FM

更新日期：2020-12-16 00:00:00

abstract：:Dientamoeba fragilis is a commonly encountered trichomonad which has been implicated as a cause of gastrointestinal disease in humans. Despite the frequency of reports recording infections with this parasite, little research has been undertaken in terms of antimicrobial susceptibility. The aim of this study was to eva...

journal_title：Antimicrobial agents and chemotherapy

authors： Nagata N,Marriott D,Harkness J,Ellis JT,Stark D

更新日期：2012-01-01 00:00:00

abstract：:This report presents a fluorescent carboxyfluorescein diacetate (CFDA)-modified microdilution method used for the susceptibility testing of Candida albicans to amphotericin B, fluconazole, ketoconazole, itraconazole, voriconazole, and flucytosine. Four different broth microdilution susceptibility testing methods were ...

journal_title：Antimicrobial agents and chemotherapy

authors： Liao RS,Rennie RP,Talbot JA

更新日期：2002-10-01 00:00:00

abstract：:The stability of antipseudomonal beta-lactams in concentrated solutions was examined in view of their potential administration by continuous infusion with external pumps (for intensive care patients) or with portable pumps carried under clothing (for cystic fibrosis patients). Aztreonam (100 g/liter), piperacillin (12...

journal_title：Antimicrobial agents and chemotherapy

authors： Viaene E,Chanteux H,Servais H,Mingeot-Leclercq MP,Tulkens PM

更新日期：2002-08-01 00:00:00

abstract：:The emergence of clinical enterococcal isolates resistant to both ampicillin and vancomycin is a cause of great concern, as there are few therapeutic alternatives for treatment of infections caused by such organisms. We evaluated the effects of the combination of ampicillin with vancomycin against vancomycin-resistant...

journal_title：Antimicrobial agents and chemotherapy

authors： Cercenado E,Eliopoulos GM,Wennersten CB,Moellering RC Jr

更新日期：1992-10-01 00:00:00

abstract：:Against 443 aerobic and anaerobic bacteria isolated from diabetic foot infections, ceftobiprole MICs (microg/ml) at which 90% of the isolates tested were inhibited were as follows: methicillin-resistant Staphylococcus aureus, 1; methicillin-susceptible S. aureus and Staphylococcus lugdunensis, 0.5; Anaerococcus prevot...

journal_title：Antimicrobial agents and chemotherapy

authors： Goldstein EJ,Citron DM,Merriam CV,Warren YA,Tyrrell KL,Fernandez HT

更新日期：2006-11-01 00:00:00

abstract：:We have isolated in vitro fluoroquinolone-resistant mutants of the Lyme disease agent, Borrelia burgdorferi. Mutations in parC, which encodes a subunit of topoisomerase IV, were associated with loss of susceptibility to sparfloxacin, moxifloxacin, and Bay-Y3118, but not ciprofloxacin. This is the first description of ...

journal_title：Antimicrobial agents and chemotherapy

authors： Galbraith KM,Ng AC,Eggers BJ,Kuchel CR,Eggers CH,Samuels DS

更新日期：2005-10-01 00:00:00

abstract：:Two new antifungal triazoles, BAY n7133 and ICI 153,066, were compared with ketoconazole in treatment of mice challenged intraperitoneally with Cryptococcus neoformans. At high challenge doses, thymus-containing normal mice had prolonged survival after treatment with BAY n7133. Athymic mice, which have severely defici...

journal_title：Antimicrobial agents and chemotherapy

authors： Graybill JR,Kaster SR,Drutz DJ

更新日期：1983-12-01 00:00:00

abstract：:Omadacycline is an aminomethylcycline antibiotic with in vitro activity against pathogens causing community-acquired bacterial pneumonia (CABP). This study investigated the activity of omadacycline against Legionella pneumophila strains isolated between 1995 and 2014 from nosocomial or community-acquired respiratory i...

journal_title：Antimicrobial agents and chemotherapy

authors： Dubois J,Dubois M,Martel JF

更新日期：2020-04-21 00:00:00

abstract：:How HIV-1 resistant to small-molecule CCR5 antagonists uses the coreceptor for entry has been studied in a limited number of isolates. We characterized dependence on the N terminus (NT) and the second extracellular loop (ECL2) of CCR5 of three vicriviroc (VCV)-resistant clinical isolates broadly cross-resistant to oth...

journal_title：Antimicrobial agents and chemotherapy

authors： Henrich TJ,Lewine NR,Lee SH,Rao SS,Berro R,Gulick RM,Moore JP,Tsibris AM,Kuritzkes DR

更新日期：2012-04-01 00:00:00

abstract：:Forty years after the last endemic smallpox case, variola virus (VARV) is still considered a major threat to humans due to its possible use as a bioterrorism agent. For many years, the risk of disease reemergence was thought to solely be through deliberate misuse of VARV strains kept in clandestine laboratories. Howev...

journal_title：Antimicrobial agents and chemotherapy

authors： Delaune D,Iseni F

更新日期：2020-03-24 00:00:00

abstract：:Vancomycin is a renally excreted drug, and its body clearance correlates with creatinine clearance. However, the renal function estimation equation that best predicts vancomycin clearance has not been established yet. The objective of this study was to compare the abilities of different renal function estimation equat...

journal_title：Antimicrobial agents and chemotherapy

authors： Glatard A,Bourguignon L,Jelliffe RW,Maire P,Neely MN,Goutelle S

更新日期：2015-01-01 00:00:00

abstract：:The experimental pharmacoenhancer cobicistat (COBI), a potent mechanism-based inhibitor of cytochrome P450 3A enzymes, was found to inhibit the intestinal efflux transporters P-glycoprotein and breast cancer resistance protein. Consistent with its transporter inhibition, COBI significantly increased the absorptive flu...

journal_title：Antimicrobial agents and chemotherapy

authors： Lepist EI,Phan TK,Roy A,Tong L,Maclennan K,Murray B,Ray AS

更新日期：2012-10-01 00:00:00

abstract：:The basis of bactericidal versus bacteriostatic action of antibiotics and the mechanism of bacterial cell death are largely unknown. Related to this important issue is the essential invulnerability to killing of persisters: cells forming a small subpopulation largely responsible for the recalcitrance of biofilms to ch...

journal_title：Antimicrobial agents and chemotherapy

authors： Kaldalu N,Mei R,Lewis K

更新日期：2004-03-01 00:00:00

abstract：:Moxifloxacin has shown excellent activity against drug-sensitive as well as drug-resistant tuberculosis (TB), thus confirming DNA gyrase as a clinically validated target for discovering novel anti-TB agents. We have identified novel inhibitors in the pyrrolamide class which kill Mycobacterium tuberculosis through inhi...

journal_title：Antimicrobial agents and chemotherapy

authors： P SH,Solapure S,Mukherjee K,Nandi V,Waterson D,Shandil R,Balganesh M,Sambandamurthy VK,Raichurkar AK,Deshpande A,Ghosh A,Awasthy D,Shanbhag G,Sheikh G,McMiken H,Puttur J,Reddy J,Werngren J,Read J,Kumar M,R M,Chi

更新日期：2014-01-01 00:00:00

abstract：:We describe a novel method for isolating plasma-free peripheral blood mononuclear cells retaining intracellular efavirenz. Quantification of efavirenz in 13 human immunodeficiency virus-infected patients by liquid chromatography-tandem mass spectrometry showed a higher correlation of intracellular levels with unbound ...

journal_title：Antimicrobial agents and chemotherapy

authors： Tanaka R,Hanabusa H,Kinai E,Hasegawa N,Negishi M,Kato S

更新日期：2008-02-01 00:00:00

abstract：:Escherichia coli MRE 600 is a colicinogenic bacterium. Its colicinogenic activity may be ascribed mostly to colicin E1, although it produces a small amount of another, as yet unidentified, colicin. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Salaj-Smic E

更新日期：1978-11-01 00:00:00

abstract：:We tested the hypothesis that the bacterial load at the infection site could impact considerably on the pharmacokinetic/pharmacodynamic (PK/PD) parameters of fluoroquinolones. Using a rat lung infection model, we measured the influence of different marbofloxacin dosage regimens on selection of resistant bacteria after...

journal_title：Antimicrobial agents and chemotherapy

authors： Kesteman AS,Ferran AA,Perrin-Guyomard A,Laurentie M,Sanders P,Toutain PL,Bousquet-Mélou A

更新日期：2009-11-01 00:00:00

abstract：:The metabolic fate of the orally effective cephalosporin antibiotic cefaclor (Lilly 99638) has been studied in rats, mice, and dogs. Cefaclor is efficiently absorbed from the gastrointestinal tract as the intact antibiotic. In rats and mice, cefaclor, for the most part, escapes metabolism in the body and is eliminated...

journal_title：Antimicrobial agents and chemotherapy

authors： Sullivan HR,Due SL,Kau DL,Quay JF,Miller W

更新日期：1976-10-01 00:00:00

abstract：:Cystathionine gamma-lyase (EC 4.4.1.1) was purified from Streptomyces cattleya, an actinomycete which produces the unusual beta-lactam antibiotic thienamycin. The enzyme displays broad substrate specificity and is similar to gamma-lyases purified from other microorganisms. That the gamma-lyase functions in vivo to pro...

journal_title：Antimicrobial agents and chemotherapy

authors： Williamson JM,Meyer R,Inamine E

更新日期：1985-10-01 00:00:00

abstract：:The DNA sequences of two plasmids carrying vanA, pVEF1 (39,626 bp) and pVEF2 (39,714 bp), were determined. Forty-three shared coding sequences were identified, and the only nucleotide difference was an 88-bp indel. A postsegregational killing system was identified. This system possibly explains the persistence of the ...

journal_title：Antimicrobial agents and chemotherapy

authors： Sletvold H,Johnsen PJ,Simonsen GS,Aasnaes B,Sundsfjord A,Nielsen KM

更新日期：2007-02-01 00:00:00

abstract：:We found earlier that deferoxamine (DFO), a drug used for treatment of iron overload, is active against a rat model of Pneumocystis carinii pneumonia (PCP). We had assumed a mode of action by deprivation of nutritional iron; however, data here show that DFO penetrates P. carinii, causing irreversible damage, thus indi...

journal_title：Antimicrobial agents and chemotherapy

authors： Clarkson AB Jr,Turkel-Parrella D,Williams JH,Chen LC,Gordon T,Merali S

更新日期：2001-12-01 00:00:00

abstract：:This work reports, for the first time, the presence of New Delhi metallo-β-lactamase 1 (NDM-1) in Pseudomonas aeruginosa. Moreover, this is the first report of the NDM-1 presence in the Balkan region. Cosmid gene libraries of carbapenem-nonsusceptible Pseudomonas aeruginosa clinical isolates MMA83 and MMA533 were scre...

journal_title：Antimicrobial agents and chemotherapy

authors： Jovcic B,Lepsanovic Z,Suljagic V,Rackov G,Begovic J,Topisirovic L,Kojic M

更新日期：2011-08-01 00:00:00

abstract：:Multidrug resistance (MDR) is a major problem in the treatment of infectious diseases and cancer. Accumulating evidence suggests that the cyclooxygenase-2 (COX-2)-specific inhibitor celecoxib would not only inhibit COX-2 but also help in the reversal of drug resistance in cancers by inhibiting the MDR1 efflux pump. He...

journal_title：Antimicrobial agents and chemotherapy

authors： Kalle AM,Rizvi A

更新日期：2011-01-01 00:00:00

abstract：:β-Lactam antibiotics that inhibit penicillin-binding proteins (PBPs) have been widely used in the treatment of bacterial infections. However, the molecular basis underlying the different inhibitory potencies of β-lactams against specific PBPs is not fully understood. Here, we present the crystal structures of penicill...

journal_title：Antimicrobial agents and chemotherapy

authors： Jeong JH,Cha HJ,Kim YG

更新日期：2018-08-27 00:00:00