parC mutations in fluoroquinolone-resistant Borrelia burgdorferi.

Abstract:

:We have isolated in vitro fluoroquinolone-resistant mutants of the Lyme disease agent, Borrelia burgdorferi. Mutations in parC, which encodes a subunit of topoisomerase IV, were associated with loss of susceptibility to sparfloxacin, moxifloxacin, and Bay-Y3118, but not ciprofloxacin. This is the first description of fluoroquinolone resistance in the spirochete phylum.

authors

Galbraith KM,Ng AC,Eggers BJ,Kuchel CR,Eggers CH,Samuels DS

doi

10.1128/AAC.49.10.4354-4357.2005

subject

Has Abstract

pub_date

2005-10-01 00:00:00

pages

4354-7

issue

10

eissn

0066-4804

issn

1098-6596

pii

49/10/4354

journal_volume

49

pub_type

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