Comparative DNA analysis of two vanA plasmids from Enterococcus faecium strains isolated from poultry and a poultry farmer in Norway.

abstract：:The inhibition of Saccharomyces cerevisiae growth by amphotericin B and rifampin was studied. Rifampin alone had no effect on growth or macromolecular syntheses. Lethal amounts of amphotericin B produced a late inhibition of ribonucleic acid (RNA) synthesis simultaneous with the arrest of growth and protein synthesis....

journal_title：Antimicrobial agents and chemotherapy

authors： Battaner E,Kumar BV

更新日期：1974-04-01 00:00:00

abstract：:The 4,6-disubstituted 2-deoxystreptamines interfere with protein biosynthesis by specifically targeting the ribosomal A site. These drugs show subtle variations in the chemical groups of rings I, II, and III. In the present study we used site-directed mutagenesis to generate mutant strains of Mycobacterium smegmatis m...

journal_title：Antimicrobial agents and chemotherapy

authors： Hobbie SN,Pfister P,Brüll C,Westhof E,Böttger EC

更新日期：2005-12-01 00:00:00

abstract：:The antimicrobial susceptibility and mechanisms of resistance of 109 Shigella and 40 Salmonella isolates from children with diarrhea in southern Mozambique were assessed. The susceptibility to seven antimicrobial agents was tested by disk diffusion, and mechanisms of resistance were searched by PCR or colorimetric met...

journal_title：Antimicrobial agents and chemotherapy

authors： Mandomando I,Jaintilal D,Pons MJ,Vallès X,Espasa M,Mensa L,Sigaúque B,Sanz S,Sacarlal J,Macete E,Abacassamo F,Alonso PL,Ruiz J

更新日期：2009-06-01 00:00:00

abstract：:The candidacidal activity of nitric oxide (NO) as delivered by a class of compounds termed diazeniumdiolates has been investigated. Diazeniumdiolates are stable agents capable of releasing NO in a biologically usable form at a predicted rate, and three such compounds were examined for activity. One compound, (Z)-1-[N-...

journal_title：Antimicrobial agents and chemotherapy

authors： McElhaney-Feser GE,Raulli RE,Cihlar RL

更新日期：1998-09-01 00:00:00

abstract：:Condensins play a key role in the global organization of bacterial chromosomes. In Escherichia coli, the inactivation of its sole condensin MukBEF induces severe growth defects and renders cells hypersusceptible to novobiocin. We report here that this hypersusceptibility can be observed in TolC-deficient cells and is ...

journal_title：Antimicrobial agents and chemotherapy

authors： Petrushenko ZM,Zhao H,Zgurskaya HI,Rybenkov VV

更新日期：2016-04-22 00:00:00

abstract：:The design of novel integrase (IN) inhibitors has been aided by recent crystal structures revealing the binding mode of these compounds with a full-length prototype foamy virus (PFV) IN and synthetic viral DNA ends. Earlier docking studies relied on incomplete structures and did not include the contribution of the vir...

journal_title：Antimicrobial agents and chemotherapy

authors： Johnson BC,Métifiot M,Pommier Y,Hughes SH

更新日期：2012-01-01 00:00:00

abstract：:We studied the resistance mechanism and antimicrobial effects of β-lactams on imipenem-resistant Pseudomonas aeruginosa isolates that were susceptible to ceftazidime as detected by time-kill curve methods. Among 215 P. aeruginosa isolates from hospitalized patients in eight hospitals in the Republic of Korea, 18 isola...

journal_title：Antimicrobial agents and chemotherapy

authors： Wi YM,Choi JY,Lee JY,Kang CI,Chung DR,Peck KR,Song JH,Ko KS

更新日期：2017-05-24 00:00:00

abstract：:The treatment of dermatophytoses, including onychomycosis, has come a long way over the past few decades with the introduction of oral antifungals (e.g., terbinafine and itraconazole). However, with these advancements in oral therapies come several undesirable effects, such as kidney and liver toxicity, along with dru...

journal_title：Antimicrobial agents and chemotherapy

authors： Long L,Hager C,Ghannoum M

更新日期：2016-03-25 00:00:00

abstract：:The residual antibiotic concentration of vancomycin (2 mg/ml)- or ceftazidime (2 mg/ml)-heparin solutions instilled in ports in pediatric hematology-oncology patients 1 to 34 days earlier was measured. Antibiotic concentrations of > or = 100 microg of either antibiotic per ml persisted for at least 21 days. For treatm...

journal_title：Antimicrobial agents and chemotherapy

authors： Haimi-Cohen Y,Husain N,Meenan J,Karayalcin G,Lehrer M,Rubin LG

更新日期：2001-05-01 00:00:00

abstract：:An Escherichia coli strain with a plasmidic amikacin resistance has been selected for which the evidence strongly indicates that resistance is mediated by aminoglycoside phosphotransferase [APH(3')-II]: (i) this resistance was coupled with resistance against kanamycin and neomycin; (ii) partially purified APH(3')-II[A...

journal_title：Antimicrobial agents and chemotherapy

authors： Bongaerts GP,Kaptijn GM

更新日期：1981-09-01 00:00:00

abstract：:The recent widespread emergence of carbapenem resistance in Enterobacteriaceae is a major public health concern, as carbapenems are a therapy of last resort against this family of common bacterial pathogens. Resistance genes can mobilize via various mechanisms, including conjugation and transposition; however, the imp...

journal_title：Antimicrobial agents and chemotherapy

authors： Sheppard AE,Stoesser N,Wilson DJ,Sebra R,Kasarskis A,Anson LW,Giess A,Pankhurst LJ,Vaughan A,Grim CJ,Cox HL,Yeh AJ,Modernising Medical Microbiology (MMM) Informatics Group.,Sifri CD,Walker AS,Peto TE,Crook DW,Mathers AJ

更新日期：2016-05-23 00:00:00

abstract：:Mutations in liaFSR, a three-component regulatory system controlling cell-envelope stress response, were recently linked with the emergence of daptomycin (DAP) resistance in enterococci. Our previous work showed that a liaF mutation increased the DAP MIC of a vancomycin-resistant Enterococcus faecalis strain from 1 to...

journal_title：Antimicrobial agents and chemotherapy

authors： Munita JM,Panesso D,Diaz L,Tran TT,Reyes J,Wanger A,Murray BE,Arias CA

更新日期：2012-08-01 00:00:00

abstract：:The oxazolidinone linezolid represents a new antibacterial class of potential benefit in managing multidrug-resistant gram-positive infections, including those caused by Streptococcus pneumoniae. In a gerbil model of acute otitis media (AOM) induced by either penicillin-resistant S. pneumoniae (PRSP; amoxicillin MIC =...

journal_title：Antimicrobial agents and chemotherapy

authors： Humphrey WR,Shattuck MH,Zielinski RJ,Kuo MS,Biermacher JJ,Smith DP,Jensen JL,Schaadt RD,Zurenko GE,Richards IM

更新日期：2003-04-01 00:00:00

abstract：:Cryomicrotomy has been used as a new technique for removing gastric mucosae from adult guinea pigs for the study of amoxicillin secretion across gastric mucosae. This method allowed a very regular thickness of the removed surface layer of mucosa to be obtained with good reproducibility. Gastric superficial mucosa conc...

journal_title：Antimicrobial agents and chemotherapy

authors： Lozniewski A,Weber M,De Korwin JD,Conroy MC,Franck P,Floquet J,Le Faou A,Burdin JC

更新日期：1995-03-01 00:00:00

abstract：:Nine intubated patients were given a single, 2-g intravenous dose of aztreonam over 5 min. Samples of serum and bronchial secretion were obtained 2, 4, and 8 h after administration and assayed for aztreonam content. The mean concentrations in bronchial secretion ranged from 1.9 to 5.2 micrograms/ml and tended to be hi...

journal_title：Antimicrobial agents and chemotherapy

authors： Bechard DL,Hawkins SS,Dhruv R,Friedhoff LT

更新日期：1985-02-01 00:00:00

abstract：:Hepatotoxicity induced by antituberculosis drugs is a serious adverse reaction with significant morbidity and even, rarely, mortality. This form of toxicity potentially impacts the treatment outcome of tuberculosis in some patients. Covering only first-line antituberculosis drugs, this review addresses whether and how...

journal_title：Antimicrobial agents and chemotherapy

authors： Yew WW,Chang KC,Chan DP

更新日期：2018-07-27 00:00:00

abstract：:The epileptogenic activity of imipenem was investigated in rats with experimental renal failure induced by uranyl nitrate injection by using electroencephalogram (EEG) recording and a pharmacokinetic-pharmacodynamic model including an effect compartment. Results previously obtained with healthy rats were used to estim...

journal_title：Antimicrobial agents and chemotherapy

authors： Dupuis A,Limosin A,Paquereau J,Mimoz O,Couet W,Bouquet S

更新日期：2001-12-01 00:00:00

abstract：:Levels of roxithromycin in serum and tissue were investigated in 29 subjects undergoing tonsillectomy. A total of 13 subjects received a single oral dose of 300 mg, and 16 received four oral doses 12 h apart as follows: a 300-mg loading dose followed by three 150-mg doses. Measurable levels of roxithromycin were prese...

journal_title：Antimicrobial agents and chemotherapy

authors： Galioto GB,Ortisi G,Mevio E,Sassella D,Bartucci F,Privitera G

更新日期：1988-09-01 00:00:00

abstract：:The efficacy and safety of a novel once-daily extended-release ciprofloxacin (ciprofloxacin ER) 500-mg dose were compared with those of an immediate-release ciprofloxacin (ciprofloxacin IR) 250-mg twice-daily dose, each administered orally for 3 days in the treatment of acute uncomplicated urinary tract infection (uUT...

journal_title：Antimicrobial agents and chemotherapy

authors： Fourcroy JL,Berner B,Chiang YK,Cramer M,Rowe L,Shore N

更新日期：2005-10-01 00:00:00

abstract：:The entry of an antibiotic into phagocytes is a prerequisite for its intracellular bioactivity against susceptible facultative or obligatory intracellular microorganisms. Brodimoprim is a dimethoxybenzylpyrimidine that has recently entered into clinical use, and its uptake into and elimination from human polymorphonuc...

journal_title：Antimicrobial agents and chemotherapy

authors： Braga PC,Dal Sasso M,Maci S,Bondiolotti G,Fonti E,Reggio S

更新日期：1996-10-01 00:00:00

abstract：:Bioassay-guided fractionation of the extract from the fermentation broth of Streptomyces spectabilis BCC 4785 led to the isolation of three principle antimalarial agents, metacycloprodigiosin, bafilomycin A(1), and spectinabilin. Metacycloprodigiosin exhibited potent in vitro activity against Plasmodium falciparum K1,...

journal_title：Antimicrobial agents and chemotherapy

authors： Isaka M,Jaturapat A,Kramyu J,Tanticharoen M,Thebtaranonth Y

更新日期：2002-04-01 00:00:00

abstract：:Control of membrane permeability is a key step in regulating the intracellular concentration of antibiotics. Efflux pumps confer innate resistance to a wide range of toxic compounds such as antibiotics, dyes, detergents, and disinfectants in members of the Enterobacteriaceae. The AcrAB-TolC efflux pump is involved in ...

journal_title：Antimicrobial agents and chemotherapy

authors： Pérez A,Poza M,Aranda J,Latasa C,Medrano FJ,Tomás M,Romero A,Lasa I,Bou G

更新日期：2012-12-01 00:00:00

abstract：:The in vitro activities of sparfloxacin, temafloxacin, ciprofloxacin, ofloxacin, clarithromycin, erythromycin, tetracycline, cephalothin, penicillin G, and amoxicillin-clavulanic acid against 173 recent clinical bite wound isolates were determined by agar dilution. Sparfloxacin was active against all strains (MIC for ...

journal_title：Antimicrobial agents and chemotherapy

authors： Goldstein EJ,Citron DM

更新日期：1993-05-01 00:00:00

abstract：:Current treatment options for bacterial vaginosis (BV) have been shown to be inadequate at preventing recurrence and do not provide protection against associated infections, such as that with HIV. This study examines the feasibility of incorporating the antimicrobial peptide subtilosin within covalently cross-linked p...

journal_title：Antimicrobial agents and chemotherapy

authors： Sundara Rajan S,Cavera VL,Zhang X,Singh Y,Chikindas ML,Sinko PJ

更新日期：2014-05-01 00:00:00

abstract：:We investigated the efficacies of cefotaxime (CTX) and amoxicillin (AMX)-clavulanate (CLA) (AMC) against extended-spectrum-β-lactamase (ESBL)-producing Escherichia coli in vitro and in a murine model of urinary tract infection (UTI). MICs, the checkerboard dilution method, and time-kill curves were used to explore the...

journal_title：Antimicrobial agents and chemotherapy

authors： Rossi B,Soubirou JF,Chau F,Massias L,Dion S,Lepeule R,Fantin B,Lefort A

更新日期：2015-11-02 00:00:00

abstract：:A comparison was made of the in vitro activity of ciprofloxacin (Bay o 9867) with nine other antibiotics against isolates of Campylobacter jejuni, Salmonella spp., Shigella spp., Yersinia enterocolitica, Clostridium difficile, Vibrio spp., and Escherichia coli. Minimum inhibitory concentrations of ciprofloxacin were t...

journal_title：Antimicrobial agents and chemotherapy

authors： Goodman LJ,Fliegelman RM,Trenholme GM,Kaplan RL

更新日期：1984-04-01 00:00:00

abstract：:A-837093 is a potent and specific nonnucleoside inhibitor of the hepatitis C virus (HCV) nonstructural protein 5B (NS5B) RNA-dependent RNA polymerase. It possesses nanomolar potencies in both enzymatic and replicon-based cell culture assays. In rats and dogs this compound demonstrated an oral plasma half-life of great...

journal_title：Antimicrobial agents and chemotherapy

authors： Chen CM,He Y,Lu L,Lim HB,Tripathi RL,Middleton T,Hernandez LE,Beno DW,Long MA,Kati WM,Bosse TD,Larson DP,Wagner R,Lanford RE,Kohlbrenner WE,Kempf DJ,Pilot-Matias TJ,Molla A

更新日期：2007-12-01 00:00:00

abstract：:Adult AIDS Clinical Trials Group 5043 examined pharmacokinetic (PK) interactions between amprenavir (APV) and efavirenz (EFV) both by themselves and when nelfinavir (NFV), indinavir (IDV), ritonavir (RTV), or saquinavir (SQV) is added. A PK study was conducted after the administration of single doses of APV (day 0). S...

journal_title：Antimicrobial agents and chemotherapy

authors： Morse GD,Rosenkranz S,Para MF,Segal Y,Difrancesco R,Adams E,Brizz B,Yarasheski KE,Reichman RC

更新日期：2005-08-01 00:00:00

abstract：:The aminoglycoside Geneticin (G418) is known to inhibit cell culture proliferation, via virus-specific mechanisms, of two different virus genera from the family Flaviviridae. Here, we tried to determine whether Geneticin can selectively alter the switching of the nucleotide 1 to 570 RNA region of hepatitis C virus (HC...

journal_title：Antimicrobial agents and chemotherapy

authors： Ariza-Mateos A,Díaz-Toledano R,Block TM,Prieto-Vega S,Birk A,Gómez J

更新日期：2015-11-30 00:00:00

abstract：:Macrolide antibiotics are used as anti-inflammatory agents, e.g., for prevention of exacerbations in chronic obstructive pulmonary disease and cystic fibrosis. Several studies have shown improved outcomes after the addition of macrolides to β-lactam antibiotics for treatment of severe community-acquired pneumonia. How...

journal_title：Antimicrobial agents and chemotherapy

authors： Kasetty G,Bhongir RKV,Papareddy P,Herwald H,Egesten A

更新日期：2017-08-24 00:00:00