Polyethylene glycol-based hydrogels for controlled release of the antimicrobial subtilosin for prophylaxis of bacterial vaginosis.

abstract：:WCK 5222 consists of cefepime combined with zidebactam, a bicyclo-acyl hydrazide β-lactam enhancer antibiotic with a dual action involving binding to Gram-negative bacterial PBP2 and β-lactamase inhibition. We evaluated the in vitro activity of cefepime-zidebactam against 7,876 contemporary (2015) clinical isolates of...

journal_title：Antimicrobial agents and chemotherapy

authors： Sader HS,Castanheira M,Huband M,Jones RN,Flamm RK

更新日期：2017-04-24 00:00:00

abstract：:We compared the in vitro activity of gemifloxacin, a new quinolone antibiotic, to the activities of levofloxacin, moxifloxacin, trovafloxacin, erythromycin, and doxycycline against 20 isolates of Chlamydia pneumoniae. Gemifloxacin was the most active quinolone tested, with a MIC at which 90% of the isolates are inhibi...

journal_title：Antimicrobial agents and chemotherapy

authors： Roblin PM,Reznik T,Kutlin A,Hammerschlag MR

更新日期：1999-11-01 00:00:00

abstract：:Norfloxacin is a quinolone (pyridonecarboxylic acid derivative) effective against Pseudomonas aeruginosa infections. We studied the effects of this drug on DNA metabolism in P. aeruginosa. Norfloxacin inhibits DNA replication immediately on its addition to a logarithmically growing culture of P. aeruginosa. It inhibit...

journal_title：Antimicrobial agents and chemotherapy

authors： Benbrook DM,Miller RV

更新日期：1986-01-01 00:00:00

abstract：:The susceptibility of 4,929 unselected clinical isolates of bacteria to cefoxitin and cephalothin was determined by the single-disk method, using a computer-associated electronic zone analyzer to obtain, record, and process measurements of sizes of zones of inhibition. Both cefoxitin and cephalothin were effective aga...

journal_title：Antimicrobial agents and chemotherapy

authors： Moellering RC Jr,Dray M,Kunz LJ

更新日期：1974-09-01 00:00:00

abstract：:The objective of this study was to develop a population pharmacokinetic model and to determine a dosing regimen for caspofungin in critically ill patients. Nine blood samples were drawn per dosing occasion. Fifteen patients with (suspected) invasive candidiasis had one dosing occasion and five had two dosing occasions...

journal_title：Antimicrobial agents and chemotherapy

authors： Märtson AG,van der Elst KCM,Veringa A,Zijlstra JG,Beishuizen A,van der Werf TS,Kosterink JGW,Neely M,Alffenaar JW

更新日期：2020-08-20 00:00:00

abstract：:18F-labeled fleroxacin was used to measure the pharmacokinetics of fleroxacin in healthy and infected animals by positron emission tomography (PET) and tissue radioactivity measurements. In all experiments, a pharmacological dose of unlabeled drug (10 mg/kg) was coinjected with the tracer. The pharmacokinetics of [18F...

journal_title：Antimicrobial agents and chemotherapy

authors： Fischman AJ,Livni E,Babich J,Alpert NM,Liu YY,Thom E,Cleeland R,Prosser BL,Callahan RJ,Correia JA

更新日期：1992-10-01 00:00:00

abstract：:Compound G2 isolated from alfalfa roots was applied topically to skin lesions of guinea pigs experimentally infected with the dermatophyte Trichophyton mentagrophytes var. granulare. After 12 to 15 applications, 80% of the infected lesions were cured, as judged by clinical and microbial criteria, compared with 20% of ...

journal_title：Antimicrobial agents and chemotherapy

authors： Evron R,Guizie M,Zehavi U,Polacheck I

更新日期：1990-08-01 00:00:00

abstract：:One hundred clinical isolates resistant to ceftazidime and/or cefotaxime were examined for susceptibility to cefepime. The most frequently encountered ceftazidime-cefotaxime-resistant strains belonged to the genera Enterobacter, Pseudomonas, and Citrobacter. Among these strains, 92% were resistant to cefoperazone, 91%...

journal_title：Antimicrobial agents and chemotherapy

authors： Fung-Tomc J,Dougherty TJ,DeOrio FJ,Simich-Jacobson V,Kessler RE

更新日期：1989-04-01 00:00:00

abstract：:The influence of inhibitors of P-glycoprotein (verapamil [VE], cyclosporine [CY], and GF120918 [GF]) on the cell handling of macrolides (erythromycin [ERY], clarithromycin [CLR], roxithromycin [ROX], azithromycin [AZM], and telithromycin [TEL]) was examined in J774 murine macrophages. The net influx rates of AZM and T...

journal_title：Antimicrobial agents and chemotherapy

authors： Seral C,Michot JM,Chanteux H,Mingeot-Leclercq MP,Tulkens PM,Van Bambeke F

更新日期：2003-03-01 00:00:00

abstract：:The in vitro susceptibility of Mycobacterium fortuitum and Mycobacterium chelonei to cefmetazole was studied by the agar dilution method. At a concentration of 16 micrograms/ml or lower, 44 isolates (96%) of M. fortuitum and 8 isolates (40%) of M. chelonei were inhibited. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Casal MJ,Rodriguez FC,Benavente MC

更新日期：1985-02-01 00:00:00

abstract：:At least four broad-spectrum efflux pumps (Mex) are involved in elevated intrinsic antibiotic resistance as well as in acquired multidrug resistance in Pseudomonas aeruginosa. Substrate specificity of the Mex pumps has been shown to be determined by the cytoplasmic membrane component (MexB, MexD, MexF, and MexY) of th...

journal_title：Antimicrobial agents and chemotherapy

authors： Aires JR,Pechère JC,Van Delden C,Köhler T

更新日期：2002-07-01 00:00:00

abstract：:Similar to Neisseria gonorrhoeae, tetracycline-resistant isolates of N. meningitidis, Kingella denitrificans, and Eikenella corrodens contained 25.2-megadalton plasmids carrying the TetM determinant. In contrast, tetracycline-resistant N. subflava biovar perflava-N. sicca and N. mucosa isolates carried the TetM determ...

journal_title：Antimicrobial agents and chemotherapy

authors： Knapp JS,Johnson SR,Zenilman JM,Roberts MC,Morse SA

更新日期：1988-05-01 00:00:00

abstract：:Clinical isolates of the Bacteroides melaninogenicus and Bacteroides fragilis groups were tested for in vitro and in vivo susceptibility to penicillin, clindamycin, and metronidazole, used singly or in combination with gentamicin. The in vitro tests consisted of determinations of minimal inhibitory concentrations (MIC...

journal_title：Antimicrobial agents and chemotherapy

authors： Brook I,Coolbaugh JC,Walker RI,Weiss E

更新日期：1984-01-01 00:00:00

abstract：:We have previously identified a target site in HIV-1 RNA that was particularly accessible to a ribozyme and a short hairpin RNA (shRNA). To design small interfering RNAs (siRNAs) targeting this site, we evaluated the effects of siRNAs with different lengths on HIV-1 production. The potency and efficacy of these siRNAs...

journal_title：Antimicrobial agents and chemotherapy

authors： Scarborough RJ,Adams KL,Daher A,Gatignol A

更新日期：2015-09-01 00:00:00

abstract：:Despite the documented benefit of voriconazole therapeutic drug monitoring, nonlinear pharmacokinetics make the timing of steady-state trough sampling and appropriate dose adjustments unpredictable by conventional methods. We developed a nonparametric population model with data from 141 previously richly sampled child...

journal_title：Antimicrobial agents and chemotherapy

authors： Neely M,Margol A,Fu X,van Guilder M,Bayard D,Schumitzky A,Orbach R,Liu S,Louie S,Hope W

更新日期：2015-01-01 00:00:00

abstract：:A series of quaternary ammonium compounds that are esters of betaine and fatty alcohols with hydrocarbon chain lengths of 10 to 18 carbon atoms were tested with respect to antimicrobial activities and rates of hydrolysis. When the tetradecyl derivative was tested against some selected microorganisms, the killing effec...

journal_title：Antimicrobial agents and chemotherapy

authors： Lindstedt M,Allenmark S,Thompson RA,Edebo L

更新日期：1990-10-01 00:00:00

abstract：:Passive antibody administration is a potentially useful approach for the therapy of human Cryptococcus neoformans infections. To evaluate the efficacy of the human immunoglobulin G1 (IgG1) constant region against C. neoformans and to construct murine antibody derivatives with reduced immunogenicities and longer half-l...

journal_title：Antimicrobial agents and chemotherapy

authors： Zebedee SL,Koduri RK,Mukherjee J,Mukherjee S,Lee S,Sauer DF,Scharff MD,Casadevall A

更新日期：1994-07-01 00:00:00

abstract：:Fifty strains of Mycoplasma pneumoniae in L cells were tested for susceptibility to macrolide antibiotics. Rokitamycin, a new macrolide antibiotic, was most active against these organisms, with an MIC for 90% of strains of 0.007 microgram/ml. The MICs of erythromycin, josamycin, and kitasamycin for 90% of strains were...

journal_title：Antimicrobial agents and chemotherapy

authors： Misu T,Arai S,Furukawa M,Yamamoto Y,Miyazaki T

更新日期：1987-11-01 00:00:00

abstract：:We examined an E-test-based strategy for testing the combination of itraconazole and amphotericin B, the latter given either sequentially or concomitantly, in isolates of Aspergillus fumigatus. An antagonistic interaction between the two drugs was noted, especially with the sequential administration of amphotericin B....

journal_title：Antimicrobial agents and chemotherapy

authors： Kontoyiannis DP,Lewis RE,Sagar N,May G,Prince RA,Rolston KV

更新日期：2000-10-01 00:00:00

abstract：:Quinolones, in addition to their antibacterial activities, act as immunomodulators. Osteopontin (OPN), a member of the extracellular matrix proteins, was found to play a role in the immune and inflammatory response. We found that quinolones significantly enhanced OPN secretion, namely, garenoxacin (220%), moxifloxacin...

journal_title：Antimicrobial agents and chemotherapy

authors： Shiratori B,Zhang J,Usami O,Chagan-Yasutan H,Suzuki Y,Nakajima C,Uede T,Hattori T

更新日期：2012-06-01 00:00:00

abstract：:The in vitro activity of cefazolin was assessed by continuous turbidimetric monitoring of cultures of gram-negative bacilli and the results were compared with those previously obtained with other beta-lactam agents using the same strains and methods. Cefazolin was found to induce rapid lysis of ampicillin-susceptible ...

journal_title：Antimicrobial agents and chemotherapy

authors： Greenwood D,Chan-Teoh CH,O'Grady F

更新日期：1975-02-01 00:00:00

abstract：:The long-term therapeutic and toxic effects of 9-[2-(phosphonomethoxy)propyl]adenine (PMPA) were evaluated in simian immunodeficiency virus (SIV)-infected newborn rhesus macaques. Four untreated SIV-infected newborn macaques developed persistently high levels of viremia, and three of the four animals had rapidly fatal...

journal_title：Antimicrobial agents and chemotherapy

authors： Van Rompay KK,Cherrington JM,Marthas ML,Berardi CJ,Mulato AS,Spinner A,Tarara RP,Canfield DR,Telm S,Bischofberger N,Pedersen NC

更新日期：1996-11-01 00:00:00

abstract：:The activity of four antifungal agents against 15 systemic (blood and vascular catheter) and 10 superficial (skin) Malassezia furfur isolates was evaluated. MIC ranges were similar for the two groups of organisms: amphotericin B, 0.3 to 2.5 micrograms/ml; flucytosine, greater than 100 micrograms/ml; miconazole, 0.4 to...

journal_title：Antimicrobial agents and chemotherapy

authors： Marcon MJ,Durrell DE,Powell DA,Buesching WJ

更新日期：1987-06-01 00:00:00

abstract：:Resistance to metronidazole, clarithromycin, and amoxicillin (amoxicilline) was found in 82, 3.8, and 1.9% of 106 Helicobacter pylori isolates, respectively. No tetracycline-resistant isolates were found. In all of the clarithromycin-resistant isolates, only one point mutation was present, either A2143G or A2142G. Our...

journal_title：Antimicrobial agents and chemotherapy

authors： Alvarez A,Moncayo JI,Santacruz JJ,Santacoloma M,Corredor LF,Reinosa E

更新日期：2009-09-01 00:00:00

abstract：:Linezolid is the first synthetic oxazolidone agent to treat infections caused by Gram-positive pathogens. Infected patients with liver dysfunction (LD) are more likely to suffer from adverse reactions, such as thrombocytopenia, when standard-dose linezolid is used than patients with LD who did not use linezolid. Curre...

journal_title：Antimicrobial agents and chemotherapy

authors： Zhang SH,Zhu ZY,Chen Z,Li Y,Zou Y,Yan M,Xu Y,Wang F,Liu MZ,Zhang M,Zhang BK

更新日期：2020-05-21 00:00:00

abstract：:Properties of a population of carbenicillin- and gentamicin-resistant, tobramycin-susceptible Pseudomonas aeruginosa at Veteran's Administration Hospital, Cincinnati, Ohio, have been followed during a 16-month period. As originally described, the strains were isolated from patients with urinary tract colonizations and...

journal_title：Antimicrobial agents and chemotherapy

authors： Korfhagen TR,Ferrel JA,Menefee CL,Loper JC

更新日期：1976-05-01 00:00:00

abstract：:We have quantified the biological cost of VanA-type glycopeptide resistance due to the acquisition of the resistance operon by methicillin-resistant Staphylococcus aureus (MRSA) from Enterococcus sp. Exponential growths of recipient strain HIP11713, its transconjugant VRSA-1, VRSA-5, and VRSA-6 were compared in the ab...

journal_title：Antimicrobial agents and chemotherapy

authors： Foucault ML,Courvalin P,Grillot-Courvalin C

更新日期：2009-06-01 00:00:00

abstract：:The biological activity of a new intravenous (i.v.) preparation of human vaccinia immune globulin (VIGIV) was evaluated in two mouse models of vaccinia virus (VV) infection. In a mouse tail lesion model, female CD-1 mice were inoculated i.v. with 7 x 10(4) PFU of VV to produce >10 lesions per tail 8 days later. In a m...

journal_title：Antimicrobial agents and chemotherapy

authors： Shearer JD,Siemann L,Gerkovich M,House RV

更新日期：2005-07-01 00:00:00

abstract：:Two types of transmissible plasmids which encode resistance to trimethoprim-sulfamethoxazole were found among five animal isolates of Salmonella krefeld. This is the first report of plasmid-mediated resistance to trimethoprim-sulfamethoxazole in Salmonella strains isolated in the United States. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Mathewson JJ,Murray BE

更新日期：1983-03-01 00:00:00

abstract：:Etest susceptibilities to amoxicillin, chloramphenicol, and trimethoprim-sulfamethoxazole of 240 invasive isolates of Haemophilus influenzae cultured from children in rural Kenya were 66%, 66%, and 38%, respectively. Resistance increased markedly over 9 years and was concentrated among serotype b isolates. In Africa, ...

journal_title：Antimicrobial agents and chemotherapy

authors： Scott JA,Mwarumba S,Ngetsa C,Njenga S,Lowe BS,Slack MP,Berkley JA,Mwangi I,Maitland K,English M,Marsh K

更新日期：2005-07-01 00:00:00