Oxidative Stress and First-Line Antituberculosis Drug-Induced Hepatotoxicity.

abstract：:As an obligate aerobe, Mycobacterium tuberculosis uses its electron transport chain (ETC) to produce energy via oxidative phosphorylation. This pathway has recently garnered a lot of attention and is a target for several new antimycobacterials. We tested the respiratory adaptation of M. tuberculosis to phenoxyalkylben...

journal_title：Antimicrobial agents and chemotherapy

authors： Berube BJ,Parish T

更新日期：2017-12-21 00:00:00

abstract：:Among hospitalized adults who received vancomycin for their skin and skin structure infection (SSSI), patients who experienced acute kidney injury (AKI) had considerably higher 30-day readmission rates. Nearly half of the observed 30-day readmissions were due to non-SSSI-related reasons, which is consistent with the p...

journal_title：Antimicrobial agents and chemotherapy

authors： Patel N,Stornelli N,Sangiovanni RJ,Huang DB,Lodise TP

更新日期：2020-09-21 00:00:00

abstract：:Moxifloxacin (MXF) is a fluoroquinolone antibiotic that is effective against respiratory infections. However, the mechanisms of MXF lung diffusion are unknown. Active transport in other tissues has been suggested for several members of the fluoroquinolone family. In this study, transport of MXF was systematically inve...

journal_title：Antimicrobial agents and chemotherapy

authors： Brillault J,De Castro WV,Harnois T,Kitzis A,Olivier JC,Couet W

更新日期：2009-04-01 00:00:00

abstract：:Mycobacterium tuberculosis infection is responsible for a global pandemic. New drugs are needed that do not show cross-resistance with the existing front-line therapeutics. A triazine antitubercular hit led to the design of a related pyrimidine family. The synthesis of a focused series of these analogs facilitated exp...

journal_title：Antimicrobial agents and chemotherapy

authors： Inoyama D,Paget SD,Russo R,Kandasamy S,Kumar P,Singleton E,Occi J,Tuckman M,Zimmerman MD,Ho HP,Perryman AL,Dartois V,Connell N,Freundlich JS

更新日期：2018-02-23 00:00:00

abstract：:A case of Mycobacterium leprae rifampin resistance after irregular antileprosy treatments since 1971 is reported. Whole-genome sequencing from four longitudinal samples indicated relapse due to acquired rifampin resistance and not to reinfection with another strain. A putative compensatory mutation in rpoC was also de...

journal_title：Antimicrobial agents and chemotherapy

authors： Avanzi C,Maia RC,Benjak A,Nery JA,Sales AM,Miranda A,Duppre NC,Nogueira Brum Fontes A,Pereira da Silva T,Olmo Pinheiro R,Neves-Manta F,Moreira SJM,Busso P,Sarno EN,Suffys PN,Cole ST,Moraes MO

更新日期：2020-06-23 00:00:00

abstract：:Ceftolozane-tazobactam, a combination of the novel antipseudomonal cephalosporin ceftolozane and the well-established extended-spectrum β-lactamase inhibitor tazobactam, is approved for treating complicated urinary tract infections (cUTI) and complicated intra-abdominal infections (cIAI) in adults. To determine doses ...

journal_title：Antimicrobial agents and chemotherapy

authors： Larson KB,Patel YT,Willavize S,Bradley JS,Rhee EG,Caro L,Rizk ML

更新日期：2019-05-24 00:00:00

abstract：:The Autobac I system was used to evaluate the antibiotic susceptibility pattern of methicillin-resistant Staphylococcus aureus isolates. The results of the Autobac I were compared with the results of the disk diffusion method. The disk diffusion susceptibility pattern showed resistance to methicillin/oxacillin, penici...

journal_title：Antimicrobial agents and chemotherapy

authors： Cleary TJ,Maurer D

更新日期：1978-05-01 00:00:00

abstract：:Letermovir, GW275175X (a benzimidazole), and tomeglovir (Bay38-4766) are chemically unrelated human cytomegalovirus (CMV) terminase complex inhibitors that have been tested in human subjects. UL56 gene mutations are the dominant pathway of letermovir resistance, while UL89 and UL56 mutations are known to confer benzim...

journal_title：Antimicrobial agents and chemotherapy

authors： Chou S

更新日期：2017-10-24 00:00:00

abstract：:We conducted time-kill studies to evaluate the inhibitory activities of either cefotaxime or minocycline alone and the two drugs in combination against a clinical strain of Vibrio vulnificus. The MICs of cefotaxime and minocycline were 0.03 and 0.06 microg/ml, respectively. When approximately 5 x 10(5) CFU of V. vulni...

journal_title：Antimicrobial agents and chemotherapy

authors： Chuang YC,Liu JW,Ko WC,Lin KY,Wu JJ,Huang KY

更新日期：1997-10-01 00:00:00

abstract：:A novel beta-lactamase gene, blaOXA-61, from Campylobacter jejuni GC015 was cloned and its nucleotide sequence determined. blaOXA-61 encodes a protein of 257 amino acids in which the active-site STFK tetrad and conserved class D beta-lactamase motifs YGN and KTG were identified. A conserved sequence upstream of blaOXA...

journal_title：Antimicrobial agents and chemotherapy

authors： Alfredson DA,Korolik V

更新日期：2005-06-01 00:00:00

abstract：:Structural analysis of two new beta-lactam antibiotics, A16884A and A16886B, indicated that they, like cephalosporin C, were composed of modified valine and cysteine residues, and alpha-aminoadipic acid. However, acid hydrolysis of A16886B and A16884A produced three times as much glycine as did hydrolysis of cephalosp...

journal_title：Antimicrobial agents and chemotherapy

authors： Brannon DR,Mabe JA,Ellis R,Whitney JG,Nagarajan R

更新日期：1972-03-01 00:00:00

abstract：:Although obesity is prevalent among children in the United States, pharmacokinetic (PK) data for obese children are limited. Clindamycin is a commonly used antibiotic that may require dose adjustment in obese children due to its lipophilic properties. We performed a clindamycin population PK analysis using data from t...

journal_title：Antimicrobial agents and chemotherapy

authors： Smith MJ,Gonzalez D,Goldman JL,Yogev R,Sullivan JE,Reed MD,Anand R,Martz K,Berezny K,Benjamin DK Jr,Smith PB,Cohen-Wolkowiez M,Watt K,Best Pharmaceuticals for Children Act—Pediatric Trials Network Steering Committee.

更新日期：2017-03-24 00:00:00

abstract：:Carbovir is a novel carbocyclic nucleoside which has been shown to have potent in vitro activity against human immunodeficiency virus, the causative agent of acquired immunodeficiency syndrome. Sprague-Dawley male rats were used to investigate the pharmacokinetics and bioavailability of carbovir. Six rats received car...

journal_title：Antimicrobial agents and chemotherapy

authors： Yeom YH,Remmel RP,Huang SH,Hua M,Vince R,Zimmerman CL

更新日期：1989-02-01 00:00:00

abstract：:Loss of viability of toxin-treated cells of Saccharomyces cerevisiae SCF 1717 could be prevented in the period before they altered physiologically if cells were incubated in media with a suitable concentration of potassium (0.08 to 0.13 M) and hydrogen ions (pH 6.2 to 6.7). Incorporation of higher amounts of potassium...

journal_title：Antimicrobial agents and chemotherapy

authors： Middelbeek EJ,Crützen QH,Vogels GD

更新日期：1980-10-01 00:00:00

abstract：:A total of 636 vancomycin-resistant Enterococcus faecium (VRE) isolates that had been obtained between 1994 and 1999 from the Medical School Hospital of the University of Michigan, Ann Arbor, were tested for bacteriocin production. Two hundred seventy-seven (44%) of the strains were bacteriocinogenic; and 193 of these...

journal_title：Antimicrobial agents and chemotherapy

authors： Inoue T,Tomita H,Ike Y

更新日期：2006-04-01 00:00:00

abstract：:Four species of members of the family Enterobacteriaceae harboring extended-spectrum beta-lactamase (ESBL) were recovered in a single patient hospitalized in an intensive care unit. Among these isolates, we describe for the first time an ESBL-producing Providencia rettgeri strain. Bacteria from the same species were s...

journal_title：Antimicrobial agents and chemotherapy

authors： Marchandin H,Carriere C,Sirot D,Pierre HJ,Darbas H

更新日期：1999-08-01 00:00:00

abstract：:Determination of the neutrophil gelatinase-associated lipocalin (NGAL) level can be used to detect acute kidney injury (AKI) earlier than determination of the serum creatinine (SCr) level in settings such as cardiac surgery, contrast nephropathy, and intensive care units. We hypothesized that urine NGAL (UrNGAL) would...

journal_title：Antimicrobial agents and chemotherapy

authors： Rocha PN,Macedo MN,Kobayashi CD,Moreno L,Guimarães LH,Machado PR,Badaró R,Carvalho EM,Glesby MJ

更新日期：2015-11-01 00:00:00

abstract：:The binding of penicillin G to a stable L-form from Staphylococcus aureus followed saturation-type kinetics with saturation achieved at 0.75 nmol/ml, the same as with its parent strain. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Suginaka H

更新日期：1976-03-01 00:00:00

abstract：:A comparison of the daclatasvir (DCV [BMS-790052]) resistance barrier on authentic or hybrid replicons containing NS5A from hepatitis C virus (HCV) genotypes 1 to 6 (GT-1 to -6) was completed using a replicon elimination assay. The data indicated that genotype 1b (GT-1b) has the highest relative resistance barrier and...

journal_title：Antimicrobial agents and chemotherapy

authors： Wang C,Jia L,O'Boyle DR 2nd,Sun JH,Rigat K,Valera L,Nower P,Huang X,Kienzle B,Roberts S,Gao M,Fridell RA

更新日期：2014-09-01 00:00:00

abstract：:The in vitro activity of CEM-101, a new fluoroketolide, was determined against Gram-positive organisms with various macrolide susceptibility profiles. Experiments for determination of the MICs and minimum bactericidal concentrations (MBCs), timed killing, single-step and multistep mutation rates, the erythromycin indu...

journal_title：Antimicrobial agents and chemotherapy

authors： Woosley LN,Castanheira M,Jones RN

更新日期：2010-05-01 00:00:00

abstract：:Increasing mobile colistin resistance, mediated by the mcr gene family, in Enterobacteriaceae has become a global concern. Among the 10 reported mcr genes, mcr-8 was first identified in Klebsiella pneumoniae, which could cause severe infections with high mortality. Information about the prevalence and genetic context ...

journal_title：Antimicrobial agents and chemotherapy

authors： Wu B,Wang Y,Ling Z,Yu Z,Shen Z,Zhang S,Wang X

更新日期：2020-12-16 00:00:00

abstract：:Isoxyl (ISO), a thiourea derivative that was successfully used for the clinical treatment of tuberculosis during the 1960s, is an inhibitor of the synthesis of oleic and mycolic acids in Mycobacterium tuberculosis. Its effect on oleic acid synthesis has been shown to be attributable to its inhibitory activity on the s...

journal_title：Antimicrobial agents and chemotherapy

authors： Korduláková J,Janin YL,Liav A,Barilone N,Dos Vultos T,Rauzier J,Brennan PJ,Gicquel B,Jackson M

更新日期：2007-11-01 00:00:00

abstract：:Candida krusei ATCC 6258 was tested by eight laboratories using 96-well plates containing checkerboard pairwise combinations of amphotericin B (AMB), posaconazole (PSC), caspofungin (CSP), and voriconazole (VRC). The methodology led to reproducible results across the laboratories. All drug combinations yielded MICs lo...

journal_title：Antimicrobial agents and chemotherapy

authors： Chaturvedi V,Ramani R,Ghannoum MA,Killian SB,Holliday N,Knapp C,Ostrosky-Zeichner L,Messer SA,Pfaller MA,Iqbal NJ,Arthington-Skaggs BA,Vazquez JA,Sein T,Rex JH,Walsh TJ

更新日期：2008-04-01 00:00:00

abstract：:Chikungunya virus (CHIKV; genus Alphavirus) is the causative agent of chikungunya fever. CHIKV replication can be inhibited by some broad-spectrum antiviral compounds; in contrast, there is very little information about compounds specifically inhibiting the enzymatic activities of CHIKV replication proteins. These pro...

journal_title：Antimicrobial agents and chemotherapy

authors： Das PK,Puusepp L,Varghese FS,Utt A,Ahola T,Kananovich DG,Lopp M,Merits A,Karelson M

更新日期：2016-11-21 00:00:00

abstract：:Many gram-negative bacteria are known to be remarkably resistant to hydrophobic noxious agents by virtue of their outer membranes (OM). We investigated, by using four different assay methods, the ability of sodium hexametaphosphate (HMP) to disrupt this OM barrier. (i) In the growth inhibition assay, HMP was found to ...

journal_title：Antimicrobial agents and chemotherapy

authors： Vaara M,Jaakkola J

更新日期：1989-10-01 00:00:00

abstract：:Fusidic acid (FA), which was approved in the 1960s in many European and Asian countries, has gained renewed interest due to its continued effectiveness against methicillin-resistant Staphylococcus aureus As rhabdomyolysis has been reported upon coadministration of FA with statins, we aimed to elucidate the underlying ...

journal_title：Antimicrobial agents and chemotherapy

authors： Gupta A,Harris JJ,Lin J,Bulgarelli JP,Birmingham BK,Grimm SW

更新日期：2016-09-23 00:00:00

abstract：:The treatment of dermatophytoses, including onychomycosis, has come a long way over the past few decades with the introduction of oral antifungals (e.g., terbinafine and itraconazole). However, with these advancements in oral therapies come several undesirable effects, such as kidney and liver toxicity, along with dru...

journal_title：Antimicrobial agents and chemotherapy

authors： Long L,Hager C,Ghannoum M

更新日期：2016-03-25 00:00:00

abstract：:Echinocandins are a preferred therapy for invasive candidiasis due to their potency and broad spectrum. Resistance, especially in Candida glabrata, is an emerging threat to their use. Pharmacodynamic (PD) studies examining reduced susceptibility secondary to fks mutations in C. glabrata are lacking. The current study ...

journal_title：Antimicrobial agents and chemotherapy

authors： Lepak A,Castanheira M,Diekema D,Pfaller M,Andes D

更新日期：2012-11-01 00:00:00

abstract：:We evaluated the efficacy, safety, and tolerance of cefotaxime in 35 adults (25 with pleuropulmonary infections, 7 with genitourinary tract infections, and 3 with soft tissue infections). Of these 35 patients, 18 (51.4%) were seriously or critically ill. In vitro susceptibility testing revealed that 90.4% of the patho...

journal_title：Antimicrobial agents and chemotherapy

authors： Mullaney DT,John JF Jr

更新日期：1982-03-01 00:00:00

abstract：:Human immunodeficiency virus type 1 (HIV-1) produces two polyproteins, Pr55(Gag) and Pr160(Gag-Pol), that are cleaved into mature functional subunits by the virally encoded protease. Drugs that inhibit this protease are an important part of anti-HIV therapy. We studied the ordered accumulation of Gag and Gag-Pol proce...

journal_title：Antimicrobial agents and chemotherapy

authors： Speck RR,Flexner C,Tian CJ,Yu XF

更新日期：2000-05-01 00:00:00