Emergence of Mycobacterium leprae Rifampin Resistance Evaluated by Whole-Genome Sequencing after 48 Years of Irregular Treatment.

abstract：:Mutations in the kelch propeller domain (K13 propeller) of Plasmodium falciparum parasites from Southeast Asia are associated with reduced susceptibility to artemisinin. We exposed in vitro-cultured stage V gametocytes from Cambodian K13 propeller mutant parasites to dihydroartemisinin and evaluated the inhibition of ...

journal_title：Antimicrobial agents and chemotherapy

authors： Lozano S,Gamallo P,González-Cortés C,Presa Matilla JL,Fairhurst RM,Herreros E,Amaratunga C,Rodrigues J

更新日期：2018-11-26 00:00:00

abstract：:Thein vitroantibacterial activities of ceftazidime-avibactam and comparator agents were evaluated using reference broth microdilution methods against 1,743Pseudomonas aeruginosaisolates collected in 2014 from 69 U.S. medical centers, representing each of the nine census regions. Ceftazidime-avibactam demonstrated pote...

journal_title：Antimicrobial agents and chemotherapy

authors： Huband MD,Castanheira M,Flamm RK,Farrell DJ,Jones RN,Sader HS

更新日期：2016-03-25 00:00:00

abstract：:Two neuraminidase (NA) inhibitors, zanamivir (Relenza) and oseltamivir phosphate (Tamiflu), have been licensed for the treatment of and prophylaxis against influenza. In this paper, the new potent NA inhibitor R-125489 is reported for the first time. R-125489 inhibited the NA activities of various type A and B influen...

journal_title：Antimicrobial agents and chemotherapy

authors： Yamashita M,Tomozawa T,Kakuta M,Tokumitsu A,Nasu H,Kubo S

更新日期：2009-01-01 00:00:00

abstract：:A carbapenem-resistant Serratia marcescens strain, 10mdr148, was identified in a Japanese hospital in 2010. The carbapenem resistance of this strain was attributed to the production of a novel metallo-β-lactamase (MBL), named SMB-1 (Serratia metallo-β-lactamase). SMB-1 possessed a zinc binding motif, H(Q)XHXDH (residu...

journal_title：Antimicrobial agents and chemotherapy

authors： Wachino J,Yoshida H,Yamane K,Suzuki S,Matsui M,Yamagishi T,Tsutsui A,Konda T,Shibayama K,Arakawa Y

更新日期：2011-11-01 00:00:00

abstract：:Antimicrobial susceptibility patterns of 112 clinical isolates, 28 type strains, and 9 reference strains of Nocardia were determined using the Sensititre Rapmyco microdilution panel (Thermo Fisher, Inc.). Isolates were identified by highly discriminatory multilocus sequence analysis and were chosen to represent the di...

journal_title：Antimicrobial agents and chemotherapy

authors： McTaggart LR,Doucet J,Witkowska M,Richardson SE

更新日期：2015-01-01 00:00:00

abstract：:We have used the endogenous reverse transcriptase reaction of viral core particles from duck liver to elucidate the mechanism of inhibition of duck hepatitis B virus (DHBV) replication by the nucleoside analog (-)-beta-L-2',3'-dideoxy-3'-thiacytidine (3TC). As is the case in human immunodeficiency virus replication, 3...

journal_title：Antimicrobial agents and chemotherapy

authors： Severini A,Liu XY,Wilson JS,Tyrrell DL

更新日期：1995-07-01 00:00:00

abstract：:Interpretive agreements among the results of fluconazole broth microdilution tests, Etests, and disk diffusion tests were documented by evaluating 495 Candida spp. Microdilution reference test results were in agreement with 96% of the Etest results; most discrepancies were minor differences. Fluconazole resistance of ...

journal_title：Antimicrobial agents and chemotherapy

authors： Barry AL,Pfaller MA,Rennie RP,Fuchs PC,Brown SD

更新日期：2002-06-01 00:00:00

abstract：:While it is well-known that adjunctive corticosteroid use improves the outcome of moderate-to-severe Pneumocystis jirovecii pneumonia (PcP) in patients with human immunodeficiency virus (HIV), there are limited data on its efficacy in non-HIV-infected patients with PcP. Patients undergoing fiber-optic bronchoscopy wit...

journal_title：Antimicrobial agents and chemotherapy

authors： Moon SM,Kim T,Sung H,Kim MN,Kim SH,Choi SH,Jeong JY,Woo JH,Kim YS,Lee SO

更新日期：2011-10-01 00:00:00

abstract：:The tight packing of six fatty acids in the lipid A constituent of lipopolysaccharide (LPS) has been proposed to contribute to the unusually low permeability of the outer membrane of gram-negative enteric bacteria to hydrophobic antibiotics. Here it is shown that the Escherichia coli msbB mutant, which elaborates defe...

journal_title：Antimicrobial agents and chemotherapy

authors： Vaara M,Nurminen M

更新日期：1999-06-01 00:00:00

abstract：:The effect of ganciclovir [9-(1,3-dihydroxy-2-propoxymethyl)guanine] on herpes simplex virus type 1 DNA and protein synthesis was studied. Ganciclovir markedly inhibited the synthesis of viral DNA and gamma proteins in a dose-dependent manner. However, the synthesis of viral beta proteins was significantly increased b...

journal_title：Antimicrobial agents and chemotherapy

authors： Chun YS,Park NH

更新日期：1987-02-01 00:00:00

abstract：:The effects of cefodizime and cefuroxime on neutrophil phagocytosis and reactive oxygen production in 54 patients undergoing elective coronary artery bypass grafting were studied. Both drugs were administered twice at a dosage of 40 mg/kg of body weight (pre- and intraoperative). Phagocytic capacity was assessed by me...

journal_title：Antimicrobial agents and chemotherapy

authors： Wenisch C,Bartunek A,Zedtwitz-Liebenstein K,Hiesmayr M,Parschalk B,Pernerstorfer T,Graninger W

更新日期：1997-07-01 00:00:00

abstract：:The effectiveness of spiramycin for the treatment of rhesus monkey fetuses congenitally infected with Toxoplasma gondii was studied. Eight monkeys were infected at day 90 of pregnancy. This is comparable to the second trimester of organogenetic development in humans. Transmission of infection was found prenatally in f...

journal_title：Antimicrobial agents and chemotherapy

authors： Schoondermark-Van de Ven E,Melchers W,Camps W,Eskes T,Meuwissen J,Galama J

更新日期：1994-09-01 00:00:00

abstract：:Cefodizime, an iminomethoxy aminothiazolyl cephalosporin similar to moxalactam and ceftazidime, was less active (minimal inhibitory concentration, 1.6 to 12 micrograms) than cefazolin or cefotaxime against Staphylococcus aureus and Staphylococcus epidermidis. It inhibited Haemophilus and Neisseria spp. at less than 0....

journal_title：Antimicrobial agents and chemotherapy

authors： Scully BE,Jules K,Neu HC

更新日期：1983-06-01 00:00:00

abstract：:We investigated the antistaphylococcal activity of daptomycin, vancomycin, oxacillin, gentamicin, and rifampin in human monocyte-derived macrophages. Compared with vancomycin and oxacillin, daptomycin had the most rapid and greatest antibacterial activity, but that of oxacillin was most sustained. The combination of d...

journal_title：Antimicrobial agents and chemotherapy

authors： Baltch AL,Ritz WJ,Bopp LH,Michelsen PB,Smith RP

更新日期：2007-04-01 00:00:00

abstract：:Infection with multiple ganciclovir-resistant human cytomegalovirus mutants, containing different substitutions and deletions in the UL97 gene, was found in a patient with severe combined immunodeficiency (SCID) within 3 weeks of ganciclovir therapy. A novel 11-codon deletion at positions 590 to 600 was identified. Th...

journal_title：Antimicrobial agents and chemotherapy

authors： Wolf DG,Yaniv I,Ashkenazi S,Honigman A

更新日期：2001-02-01 00:00:00

abstract：:We previously showed that simian immunodeficiency virus-infected macaque macrophages contacting uninfected CD4+ lymphocytes caused extensive cell fusion and synthesis of phlogistic cytokines. In this study, macaque macrophage cultures inoculated with SIVmac251 and treated simultaneously with 10 microM 3'-azidothymidin...

journal_title：Antimicrobial agents and chemotherapy

authors： McEntee MF,Flexner C,Farzadegan H,Pitha P,Narayan O

更新日期：1993-02-01 00:00:00

abstract：:The objective of this study was to assess the association between previous antibiotic use, particularly long-term prophylaxis, and the occurrence of subsequent resistant infections in children with index infections due to extended-spectrum-cephalosporin-resistant Enterobacteriaceae We also investigated the concordance...

journal_title：Antimicrobial agents and chemotherapy

authors： Das S,Adler AL,Miles-Jay A,Kronman MP,Qin X,Weissman SJ,Burnham CA,Elward A,Newland JG,Selvarangan R,Sullivan KV,Zaoutis T,Zerr DM

更新日期：2017-04-24 00:00:00

abstract：:Tetracycline analogs fell into two classes on the basis of their mode of action. Tetracycline, chlortetracycline, minocycline, doxycycline, and 6-demethyl-6-deoxytetracycline inhibited cell-free translation directed by either Escherichia coli or Bacillus subtilis extracts. A second class of analogs tested, including c...

journal_title：Antimicrobial agents and chemotherapy

authors： Rasmussen B,Noller HF,Daubresse G,Oliva B,Misulovin Z,Rothstein DM,Ellestad GA,Gluzman Y,Tally FP,Chopra I

更新日期：1991-11-01 00:00:00

abstract：:Unlike mammalian cells, malarial parasites are completely dependent on the de novo pyrimidine pathway and lack the enzymes to salvage preformed pyrimidines. In the present study, first, it is shown that 1843U89, even without polyglutamylation, is a potent folate-based inhibitor of purified malarial parasite thymidylat...

journal_title：Antimicrobial agents and chemotherapy

authors： Jiang L,Lee PC,White J,Rathod PK

更新日期：2000-04-01 00:00:00

abstract：:β-Lactam antibiotics that inhibit penicillin-binding proteins (PBPs) have been widely used in the treatment of bacterial infections. However, the molecular basis underlying the different inhibitory potencies of β-lactams against specific PBPs is not fully understood. Here, we present the crystal structures of penicill...

journal_title：Antimicrobial agents and chemotherapy

authors： Jeong JH,Cha HJ,Kim YG

更新日期：2018-08-27 00:00:00

abstract：:Pseudomonas aeruginosa is a multidrug-resistant nosocomial pathogen. We showed previously that thiostrepton (TS), a Gram-positive thiopeptide antibiotic, is imported via pyoverdine receptors and synergizes with iron chelator deferasirox (DSX) to inhibit the growth of P. aeruginosa and Acinetobacter baumannii clinical ...

journal_title：Antimicrobial agents and chemotherapy

authors： Chan DCK,Guo I,Burrows LL

更新日期：2020-02-21 00:00:00

abstract：:Diabetic foot ulcer treatment currently focuses on targeting bacterial biofilms, while dismissing fungi. To investigate this, we used an in vitro biofilm model containing bacteria and fungi, reflective of the wound environment, to test the impact of antimicrobials. Here we showed that while monotreatment approaches in...

journal_title：Antimicrobial agents and chemotherapy

authors： Townsend EM,Sherry L,Kean R,Hansom D,Mackay WG,Williams C,Butcher J,Ramage G

更新日期：2017-08-24 00:00:00

abstract：:Ninety-two strains of Yersinia pestis recovered over a 21-year period were evaluated for susceptibility to traditional and newer antimicrobial agents. In vitro resistance was noted only against rifampin and imipenem (approximately 20% of strains). The most active compounds (MIC at which 90% of the isolates tested are ...

journal_title：Antimicrobial agents and chemotherapy

authors： Wong JD,Barash JR,Sandfort RF,Janda JM

更新日期：2000-07-01 00:00:00

abstract：:Mining existing agents that enhance the therapeutic potential of ergosterol biosynthesis inhibitors (EBI) is a promising approach to improve Chagas disease chemotherapy. In this study, we evaluated the effect of ravuconazole, an EBI, combined with amlodipine, a calcium channel blocker, upon Trypanosoma cruzi experimen...

journal_title：Antimicrobial agents and chemotherapy

authors： Machado YA,Bahia MT,Caldas IS,Mazzeti AL,Novaes RD,Vilas Boas BR,Santos LJS,Martins-Filho OA,Marques MJ,Diniz LF

更新日期：2020-07-22 00:00:00

abstract：:The radical-based theory proposes that three major classes of bactericidal antibiotics, i.e., β-lactams, quinolones, and aminoglycosides, have in common the downstream formation of lethal levels of reactive oxygen species (ROS) as part of the killing mechanism. If bactericidal antibiotics exhibit a common mechanism, t...

journal_title：Antimicrobial agents and chemotherapy

authors： Hoeksema M,Brul S,Ter Kuile BH

更新日期：2018-05-25 00:00:00

abstract：:Two patients (patients A and B) infected with Salmonella typhimurium failed ciprofloxacin therapy, and the posttherapy isolates had reduced susceptibilities to quinolones; 6 of 11 isolates from patient B were also cross-resistant to chemically unrelated agents. No transferable resistance, chloramphenicol-acetylating e...

journal_title：Antimicrobial agents and chemotherapy

authors： Piddock LJ,Griggs DJ,Hall MC,Jin YF

更新日期：1993-04-01 00:00:00

abstract：:The antiviral activity of a new series of thymidine analogs was determined against vaccinia virus (VV), cowpox virus (CV), herpes simplex virus, and varicella-zoster virus. Several compounds were identified that had good activity against each of the viruses, including a set of novel 5-substituted deoxyuridine analogs....

journal_title：Antimicrobial agents and chemotherapy

authors： Prichard MN,Keith KA,Johnson MP,Harden EA,McBrayer A,Luo M,Qiu S,Chattopadhyay D,Fan X,Torrence PF,Kern ER

更新日期：2007-05-01 00:00:00

abstract：:This analysis was conducted to determine whether the hepatitis C virus (HCV) viral kinetics (VK) model can predict viral load (VL) decreases for nonnucleoside polymerase inhibitors (NNPolIs) and protease inhibitors (PIs) after 3-day monotherapy studies of patients infected with genotype 1 chronic HCV. This analysis in...

journal_title：Antimicrobial agents and chemotherapy

authors： Reddy MB,Morcos PN,Le Pogam S,Ou Y,Frank K,Lave T,Smith P

更新日期：2012-06-01 00:00:00

abstract：:Two optically active (100% enantiomeric excess) isomers of ofloxacin [(+/-)-ofloxacin; DL-8280; (+/-)-9-fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-7 H-pyrido[1,2,3-de] [1,4] benzoxazine-6-carboxylic acid] were prepared by use of their optically resolved synthetic intermediates. One of the isomers, (...

journal_title：Antimicrobial agents and chemotherapy

authors： Hayakawa I,Atarashi S,Yokohama S,Imamura M,Sakano K,Furukawa M

更新日期：1986-01-01 00:00:00

abstract：:Eighteen patients developed abnormally low serum glutamic oxaloacetic transaminase values during metronidazole therapy. Metronidazole absorbs at 340 nm, simulating reduced nicotinamide adenine dinucleotide, which is the final colorimetric product of the serum glutamic oxaloacetic transaminase assay. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Rissing JP,Newman C,Moore WL Jr

更新日期：1978-10-01 00:00:00