Methicillin-resistant Staphylococcus aureus susceptibility testing by an automated system, Autobac I.

abstract：:Malaria is the third most significant cause of infectious disease in the world. The search for new antimalarial chemotherapy has become increasingly urgent due to parasite resistance to classical drugs. Trioxaquines are synthetic hybrid molecules containing a trioxane motif (which is responsible for the antimalarial a...

journal_title：Antimicrobial agents and chemotherapy

authors： Benoit-Vical F,Lelièvre J,Berry A,Deymier C,Dechy-Cabaret O,Cazelles J,Loup C,Robert A,Magnaval JF,Meunier B

更新日期：2007-04-01 00:00:00

abstract：:Nonreplicating bacteria are known to be (or at least commonly thought to be) refractory to antibiotics to which they are genetically susceptible. Here, we explore the sensitivity to killing by bactericidal antibiotics of three classes of nonreplicating populations of planktonic bacteria: (i) stationary phase, when the...

journal_title：Antimicrobial agents and chemotherapy

authors： McCall IC,Shah N,Govindan A,Baquero F,Levin BR

更新日期：2019-06-24 00:00:00

abstract：:Ledipasvir (LDV; GS-5885), a component of Harvoni (a fixed-dose combination of LDV with sofosbuvir [SOF]), is approved to treat chronic hepatitis C virus (HCV) infection. Here, we report key preclinical antiviral properties of LDV, including in vitro potency, in vitro resistance profile, and activity in combination wi...

journal_title：Antimicrobial agents and chemotherapy

authors： Cheng G,Tian Y,Doehle B,Peng B,Corsa A,Lee YJ,Gong R,Yu M,Han B,Xu S,Dvory-Sobol H,Perron M,Xu Y,Mo H,Pagratis N,Link JO,Delaney W

更新日期：2016-01-11 00:00:00

abstract：:We describe the pharmacokinetics of raltegravir of a preterm newborn after short-course treatment of the mother tested HIV + the day of delivery. At age 1 month, the circulating concentration of raltegravir in the newborn was 29 ng/ml (the IC95 of RAL against HIV-1 is 15 ng/ml). Raltegravir should therefore be conside...

journal_title：Antimicrobial agents and chemotherapy

authors： Clavel-Osorio C,Cazassus F,Stegmann S,Huc-Anaïs P,Lecam D,Peytavin G

更新日期：2013-12-01 00:00:00

abstract：:In this report, we describe a new method to measure intracellular zidovudine triphosphate (ZDV-TP) levels in peripheral blood mononuclear cells (PBMCs) from patients treated with ZDV by utilizing inhibition of human immunodeficiency virus type 1 reverse transcriptase activity by ZDV-TP. Intracellular levels of ZDV-TP ...

journal_title：Antimicrobial agents and chemotherapy

authors： Robbins BL,Rodman J,McDonald C,Srinivas RV,Flynn PM,Fridland A

更新日期：1994-01-01 00:00:00

abstract：:Colistin use has increased in response to the advent of infections caused by multidrug-resistant organisms. It is administered parenterally as an inactive prodrug, colistin methanesulfonate (CMS). Various formulations of CMS and labeling conventions can lead to confusion about colistin dosing, and questions remain abo...

journal_title：Antimicrobial agents and chemotherapy

authors： Niece KL,Akers KS

更新日期：2015-09-01 00:00:00

abstract：:Febrifugine is the active principal isolated 50 years ago from the Chinese herb chang shan (Dichroa febrifuga Lour), which has been used as an antimalarial in Chinese traditional medicine for more than 2,000 years. However, intensive study of the properties of febrifugine has been hindered for decades due to its side ...

journal_title：Antimicrobial agents and chemotherapy

authors： Jiang S,Zeng Q,Gettayacamin M,Tungtaeng A,Wannaying S,Lim A,Hansukjariya P,Okunji CO,Zhu S,Fang D

更新日期：2005-03-01 00:00:00

abstract：:This study determined the phylogenetic groups and virulence factors of 37 Escherichia coli isolates producing types of CTX-M compared with those of 19 isolates producing different types of extended-spectrum beta-lactamases (ESBLs) in a well-defined North American population. Most CTX-M-14 producers (97%) were from phy...

journal_title：Antimicrobial agents and chemotherapy

authors： Pitout JD,Laupland KB,Church DL,Menard ML,Johnson JR

更新日期：2005-11-01 00:00:00

abstract：:To investigate the effects of posaconazole (POS) and amphotericin B (AMB) combination therapy in cryptococcal infection, we established an experimental model of systemic cryptococcosis in CD1 mice by intravenous injection of three distinct clinical isolates of Cryptococcus neoformans. Therapy was started 24 h after th...

journal_title：Antimicrobial agents and chemotherapy

authors： Barchiesi F,Spreghini E,Schimizzi AM,Maracci M,Giannini D,Carle F,Scalise G

更新日期：2004-09-01 00:00:00

abstract：:Staphylococcal biofilms on surgical implants are the underlying cause of a lack of response to antimicrobial treatment. We investigated the effects of vancomycin (VAN), daptomycin (DAP), fosfomycin (FOS), tigecycline (TGC), and ceftriaxone (CRX), alone and in combination with azithromycin (AZI), on established biofilm...

journal_title：Antimicrobial agents and chemotherapy

authors： Presterl E,Hajdu S,Lassnigg AM,Hirschl AM,Holinka J,Graninger W

更新日期：2009-08-01 00:00:00

abstract：:The efficacy and safety of amoxicillin-clavulanic acid were compared with those of co-trimoxazole in the treatment of acute urinary tract infections. A total of 104 patients (mean age, 52 years) with clinical and laboratory evidence of acute urinary tract infection were enrolled in the study. Characteristics and infec...

journal_title：Antimicrobial agents and chemotherapy

authors： Karachalios GN

更新日期：1985-11-01 00:00:00

abstract：:Morganocin 174-induced lethality was characterized by one-hit kinetics. Although it induced simultaneous inhibition of deoxyribonucleic acid, ribonucleic acid, and protein syntheses, the most striking effect of morganocin was a rapid reduction of intracellular adenosine 5'-triphosphate to less than 10% of the initial ...

journal_title：Antimicrobial agents and chemotherapy

authors： Williams JA,Krizsanovich-Williams K

更新日期：1977-09-01 00:00:00

abstract：:(-)-Beta-D-1',3'-Dioxolane guanosine (DXG) and 2,6-diaminopurine (DAPD) dioxolanyl nucleoside analogues have been reported to be potent inhibitors of human immunodeficiency virus type 1 (HIV-1). We have recently conducted experiments to more fully characterize their in vitro anti-HIV-1 profiles. Antiviral assays perfo...

journal_title：Antimicrobial agents and chemotherapy

authors： Gu Z,Wainberg MA,Nguyen-Ba N,L'Heureux L,de Muys JM,Bowlin TL,Rando RF

更新日期：1999-10-01 00:00:00

abstract：:We examined the cerebrospinal fluid penetration of daptomycin after the addition of dexamethasone and its bactericidal efficacy with and without ceftriaxone in an experimental rabbit model of pneumococcal meningitis. The combination of daptomycin with ceftriaxone was the most efficacious regimen for pneumococcal menin...

journal_title：Antimicrobial agents and chemotherapy

authors： Egermann U,Stanga Z,Ramin A,Acosta F,Stucki A,Gerber P,Cottagnoud M,Cottagnoud P

更新日期：2009-07-01 00:00:00

abstract：:The usefulness of β-lactam antimicrobial agents is threatened as never before by β-lactamase-producing bacteria. For this reason, there has been renewed interest in the development of broad-spectrum β-lactamase inhibitors. Herein we describe the results of dose fractionation and dose-ranging studies carried out using ...

journal_title：Antimicrobial agents and chemotherapy

authors： VanScoy BD,Trang M,McCauley J,Conde H,Bhavnani SM,Friedrich LV,Alexander DC,Ambrose PG

更新日期：2016-06-20 00:00:00

abstract：:Caspofungin (CAS) is approved for second-line management of proven or probable invasive aspergillosis at a dose of 50 mg once daily (QD). Preclinical and limited clinical data support the concept of the dose-dependent antifungal efficacy of CAS with preservation of its favorable safety profile. Little is known, howeve...

journal_title：Antimicrobial agents and chemotherapy

authors： Würthwein G,Cornely OA,Trame MN,Vehreschild JJ,Vehreschild MJ,Farowski F,Müller C,Boos J,Hempel G,Hallek M,Groll AH

更新日期：2013-04-01 00:00:00

abstract：:The most appropriate vancomycin dosing strategy in pediatric patients weighing ≥70 kg (weight based versus non-weight based) to achieve an area under the concentration-time curve (AUC) of ≥400 mg·liter/h and a trough concentration of <20 mg/liter is not known. Population pharmacokinetic analysis determined that dosing...

journal_title：Antimicrobial agents and chemotherapy

authors： Moffett BS,Ivaturi V,Morris J,Akcan Arikan A,Dutta A

更新日期：2019-03-27 00:00:00

abstract：:Heteroresistance is the coexistence of populations with differing nucleotides at a drug resistance locus within a sample of organisms. Although Sanger sequencing is the gold standard for sequencing, it may be less sensitive than deep sequencing for detecting fluoroquinolone heteroresistance in Mycobacterium tuberculos...

journal_title：Antimicrobial agents and chemotherapy

authors： Eilertson B,Maruri F,Blackman A,Herrera M,Samuels DC,Sterling TR

更新日期：2014-06-01 00:00:00

abstract：:Accurate antibiotic susceptibility testing is essential for successful tuberculosis treatment. Recent studies have highlighted the limitations of minimum inhibitory concentrations (MIC) based phenotypic susceptibility methods in detecting other aspects of antibiotic susceptibilities in bacteria. Duration and peak of a...

journal_title：Antimicrobial agents and chemotherapy

authors： Vijay S,Nhung HN,Bao NLH,Thu DDA,Trieu LPT,Phu NH,Thwaites GE,Javid B,Thuong NTT

更新日期：2020-11-30 00:00:00

abstract：:Two aminocyclitol-negative Micromonospora mutants representing two different species, M. purpurea and M. inyoensis, and blocked at different steps in the biosynthetic pathway were paired and cofermented for the synthesis of antibiotics. The two blocked mutants were incapable of producing antibiotics alone except when ...

journal_title：Antimicrobial agents and chemotherapy

authors： Lee BK,Nagabhushan TL,Condon RG,Cooper AB,Waitz JA

更新日期：1978-07-01 00:00:00

abstract：:We developed a high-performance liquid chromatography (HPLC) assay to validate time-kill and postantifungal-effect (PAFE) experiments for voriconazole against Candida albicans, Candida glabrata, and Candida parapsilosis isolates. Voriconazole exerted prolonged fungistatic activity but no PAFE at concentrations achieva...

journal_title：Antimicrobial agents and chemotherapy

authors： Li Y,Nguyen MH,Derendorf H,Cheng S,Clancy CJ

更新日期：2007-08-01 00:00:00

abstract：:A penicillin beta-lactamase (PCase) was extracted from Pseudomonas aeruginosa Rms139(+) and purified by means of column chromatography. The isoelectric point of Rms139 PCase was 5.7 and its molecular weight was 22,500 +/- 1,000. The optimal pH for the hydrolysis of benzylpenicillin was 7.0 to 7.5 and the optimal tempe...

journal_title：Antimicrobial agents and chemotherapy

authors： Sawada Y,Yaginuma S,Tai M,Iyobe S,Mitsuhashi S

更新日期：1976-01-01 00:00:00

abstract：:Whole-genome sequences for Stenotrophomonas maltophilia serial isolates from a bacteremic patient before and after development of levofloxacin resistance were assembled de novo and differed by one single-nucleotide variant in smeT, a repressor for multidrug efflux operon smeDEF. Along with sequenced isolates from five...

journal_title：Antimicrobial agents and chemotherapy

authors： Pak TR,Altman DR,Attie O,Sebra R,Hamula CL,Lewis M,Deikus G,Newman LC,Fang G,Hand J,Patel G,Wallach F,Schadt EE,Huprikar S,van Bakel H,Kasarskis A,Bashir A

更新日期：2015-11-01 00:00:00

abstract：:The penicillin-binding proteins (PBPs) of helical (log-phase) Helicobacter pylori ATCC 43579 were identified by using biotinylated ampicillin. The major PBPs had apparent molecular masses of 47, 60, 63, and 66 kDa; an additional minor PBP of 95 to 100 kDa was also detected. The relative affinities of various beta-lact...

journal_title：Antimicrobial agents and chemotherapy

authors： DeLoney CR,Schiller NL

更新日期：1999-11-01 00:00:00

abstract：:Due to the widespread resistance of bacteria to the available drugs, the discovery of new classes of antibiotics is urgently needed, and naturally occurring antimicrobial peptides (AMPs) are considered promising candidates for future therapeutic use. Amphibian skin is one of the richest sources of such AMPs. In the pr...

journal_title：Antimicrobial agents and chemotherapy

authors： Mangoni ML,Maisetta G,Di Luca M,Gaddi LM,Esin S,Florio W,Brancatisano FL,Barra D,Campa M,Batoni G

更新日期：2008-01-01 00:00:00

abstract：:Children and adolescents with acute myeloid leukemia (AML) are at risk of life-threatening bacterial infections, especially with viridans group streptococci. Primary antibacterial prophylaxis with vancomycin-based regimens reduces this risk but might increase the risks of renal or liver toxicity or Clostridium diffici...

journal_title：Antimicrobial agents and chemotherapy

authors： Sun Y,Huskey RL,Tang L,Inaba H,Gaur AH,Ribeiro R,Rubnitz JE,Wolf J

更新日期：2018-02-23 00:00:00

abstract：:Kill curves were determined for five isolates of Bacteroides fragilis with clindamycin at concentrations equal to the MIC or to 4, 16, and 64 times the MIC. Examination of plots of log CFU per milliliter versus time revealed no association between the clindamycin concentration and the rate and extent of the bactericid...

journal_title：Antimicrobial agents and chemotherapy

authors： Klepser ME,Banevicius MA,Quintiliani R,Nightingale CH

更新日期：1996-08-01 00:00:00

abstract：:Streptomycin binds to the bacterial ribosome and disrupts protein synthesis by promoting misreading of mRNA. Restrictive mutations on the ribosomal subunit protein S12 confer a streptomycin resistance (Strr) phenotype and concomitantly increase the accuracy of the decoding process and decrease the rate of translation....

journal_title：Antimicrobial agents and chemotherapy

authors： Chen C,Blumentritt CA,Curtis MM,Sperandio V,Torres AG,Dudley EG

更新日期：2013-09-01 00:00:00

abstract：:Multivariate techniques such as principal component analysis or similar factor analysis help in analyses of the simultaneous interrelationships among several variables. A comparative multivariate analysis on the in vitro activities of eight antimicrobial agents, including the novel molecule daptomycin, is presented. M...

journal_title：Antimicrobial agents and chemotherapy

authors： Hernández JM,Conforti P

更新日期：1994-02-01 00:00:00

abstract：:Macrolides are the antimicrobials of choice for treating human campylobacteriosis. The recent emergence of erm(B) in Campylobacter bacteria threatens the utility of this class of antibiotics. Here we report the constitutive and inducible expression of erm(B) in Campylobacter isolates derived from diarrheal patients an...

journal_title：Antimicrobial agents and chemotherapy

authors： Deng F,Shen J,Zhang M,Wu C,Zhang Q,Wang Y

更新日期：2015-10-01 00:00:00