Preliminary method for direct quantification of colistin methanesulfonate by attenuated total reflectance Fourier transform infrared spectroscopy.


:Colistin use has increased in response to the advent of infections caused by multidrug-resistant organisms. It is administered parenterally as an inactive prodrug, colistin methanesulfonate (CMS). Various formulations of CMS and labeling conventions can lead to confusion about colistin dosing, and questions remain about the pharmacokinetics of CMS. Since CMS does not have strong UV absorbance, current methods employ a laborious process of chemical conversion to colistin followed by precolumn derivatization to detect formed colistin by high-performance liquid chromatography. Here, we report a method for direct quantification of colistin methanesulfonate by attenuated total reflectance Fourier transform infrared spectroscopy (ATR FTIR).


Niece KL,Akers KS




Has Abstract


2015-09-01 00:00:00














  • Nonradioactive DNA probe for detection of gene for methicillin resistance in Staphylococcus aureus.

    abstract::A DNA probe was developed by inserting, in the SmaI site of pBluescript sK, a 528-bp fragment of the gene responsible for intrinsic resistance to beta-lactam antibiotics in Staphylococcus aureus (mec determinant). The mec probe provided a useful tool for the rapid identification of the intrinsic resistance trait and f...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Ligozzi M,Rossolini GM,Tonin EA,Fontana R

    更新日期:1991-03-01 00:00:00

  • Inhibition by ganciclovir of cell growth and DNA synthesis of cells biochemically transformed with herpesvirus genetic information.

    abstract::The ability of LM cells, thymidine kinase-deficient LM cells (LMTK-), and LMTK- cells transformed to the LMTK+ phenotype by herpes simplex virus type 1 genetic information (LH7 cells) to anabolize the acyclovir congener ganciclovir was examined. About 50-fold more ganciclovir triphosphate was produced by LH7 cells tha...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: St Clair MH,Lambe CU,Furman PA

    更新日期:1987-06-01 00:00:00

  • Burkholderia pseudomallei class a beta-lactamase mutations that confer selective resistance against ceftazidime or clavulanic acid inhibition.

    abstract::Burkholderia pseudomallei, the causative agent of melioidosis, is inherently resistant to a variety of antibiotics including aminoglycosides, macrolides, polymyxins, and beta-lactam antibiotics. Despite resistance to many beta-lactams, ceftazidime and beta-lactamase inhibitor-beta-lactam combinations are commonly used...

    journal_title:Antimicrobial agents and chemotherapy

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    authors: Tribuddharat C,Moore RA,Baker P,Woods DE

    更新日期:2003-07-01 00:00:00

  • In vitro activity of polymyxin B plus imipenem, meropenem, or tigecycline against KPC-2-producing Enterobacteriaceae with high MICs for these antimicrobials.

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    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Barth N,Ribeiro VB,Zavascki AP

    更新日期:2015-01-01 00:00:00

  • Substrate inhibition of beta-lactamases, a method for predicting enzymatic stability of cephalosporins.

    abstract::Selected cephalosporins, including cefamandole, cephaloridine, cephaloglycin, and cefoxitin, were examined for their ability to inhibit the enzymatic activity of and act as substrates for beta-lactamases produced by Enterobacter cloacae and Staphylococcus aureus. Enzyme inhibition was determined by Michaelis-Menten ki...

    journal_title:Antimicrobial agents and chemotherapy

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    authors: Mahoney DF,Koppel GA,Turner JR

    更新日期:1976-09-01 00:00:00

  • Oral rimantadine hydrochloride therapy of influenza A virus H3N2 subtype infection in adults.

    abstract::In a randomized, double-blind trial involving patients with uncomplicated influenza A H3N2 subtype virus infection, rimantadine treatment (200 mg/day for 5 days) was associated with significant reductions in nasal secretion viral titers (days 2 through 4), maximal temperature (days 2 and 3), time until defervescence (...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Hayden FG,Monto AS

    更新日期:1986-02-01 00:00:00

  • Five-Year Survey (2014 to 2018) of Azole Resistance in Environmental Aspergillus fumigatus Isolates from China.

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    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Cao D,Wu R,Dong S,Wang F,Ju C,Yu S,Xu S,Fang H,Yu Y

    更新日期:2020-09-21 00:00:00

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    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Krizsan A,Knappe D,Hoffmann R

    更新日期:2015-10-01 00:00:00

  • In vitro interaction between fluconazole and triclosan against clinical isolates of fluconazole-resistant Candida albicans determined by different methods.

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    journal_title:Antimicrobial agents and chemotherapy

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    authors: Yu L,Ling G,Deng X,Jin J,Jin Q,Guo N

    更新日期:2011-07-01 00:00:00

  • Minocycline in the chemoprophylaxis of meningococcal disease.

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    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Guttler RB,Beaty HN

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  • Differential Antimicrobial Susceptibilities of Granulicatella adiacens and Abiotrophia defectiva.

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    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Mushtaq A,Greenwood-Quaintance KE,Cole NC,Kohner PC,Ihde SM,Strand GJ,Harper LW,Virk A,Patel R

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  • Role of Lock Therapy for Long-Term Catheter-Related Infections by Multidrug-Resistant Bacteria.

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    journal_title:Antimicrobial agents and chemotherapy

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    authors: Freire MP,Pierrotti LC,Zerati AE,Benites L,da Motta-Leal Filho JM,Ibrahim KY,Araujo PH,Abdala E

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  • Inhibitors of methionyl-tRNA synthetase have potent activity against Giardia intestinalis trophozoites.

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    journal_title:Antimicrobial agents and chemotherapy

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    authors: Ranade RM,Zhang Z,Gillespie JR,Shibata S,Verlinde CL,Hol WG,Fan E,Buckner FS

    更新日期:2015-11-01 00:00:00

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    journal_title:Antimicrobial agents and chemotherapy

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    authors: Schryvers AB,Ogunariwo J,Chamberland S,Godfrey AJ,Rabin HR,Bryan LE

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  • Characteristics of Carbapenemase-Producing Enterobacteriaceae in Wastewater Revealed by Genomic Analysis.

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    journal_title:Antimicrobial agents and chemotherapy

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    更新日期:2018-04-26 00:00:00

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    authors: Takano T,Hung WC,Shibuya M,Higuchi W,Iwao Y,Nishiyama A,Reva I,Khokhlova OE,Yabe S,Ozaki K,Takano M,Yamamoto T

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    authors: Gaurivaud P,Laigret F,Bove JM

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    authors: DiPiro JT,Bayoumi SM,Vallner JJ,Nesbit RR,Gokhale R,Rissing JP

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    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Schentag JJ,Plaut ME,Cerra FB

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    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Singh SK,Gurusiddaiah S

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    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Kadlec K,Schwarz S

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  • Bactericidal activities of synthetic human leukocyte cathepsin G-derived antibiotic peptides and congeners against Actinobacillus actinomycetemcomitans and Capnocytophaga sputigena.

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    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Miyasaki KT,Bodeau AL,Pohl J,Shafer WM

    更新日期:1993-12-01 00:00:00

  • Fluoroquinolone resistance protein NorA of Staphylococcus aureus is a multidrug efflux transporter.

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    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Neyfakh AA,Borsch CM,Kaatz GW

    更新日期:1993-01-01 00:00:00

  • Mycobacterium tuberculosis DNA gyrase: interaction with quinolones and correlation with antimycobacterial drug activity.

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    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Aubry A,Pan XS,Fisher LM,Jarlier V,Cambau E

    更新日期:2004-04-01 00:00:00

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    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Adams JM,Shelton MJ,Hewitt RG,Grasela TH,DeRemer M,Morse GD

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    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Slee AM,O'Connor JR

    更新日期:1983-03-01 00:00:00

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    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Moreira RA,Mendanha SA,Fernandes KS,Matos GG,Alonso L,Dorta ML,Alonso A

    更新日期:2014-06-01 00:00:00

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    abstract::Exposure of any of six clinical isolates of Staphylococcus aureus to daptomycin alone or in combination with vancomycin or oxacillin (compared with vancomycin or oxacillin alone) led to a dampened macrophage inflammatory response with diminished tumor necrosis factor secretion and reduced accumulation of inducible nit...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: English BK,Maryniw EM,Talati AJ,Meals EA

    更新日期:2006-06-01 00:00:00