Tilorone hydrochloride: an oral interferon-inducing agent.

abstract：:Intraoperative biliary cefamandole concentrations were determined in 16 patients with hepatobiliary pathology. These included seven patients with cholelithiasis, five with acute cholecystitis, two with recurrent ascending cholangitis, and two with liver abscesses. Bile collected 0.5 to 2.5 h after the last antibiotic ...

journal_title：Antimicrobial agents and chemotherapy

authors： Uwaydah M,Kantarjian H,Osseiran M,Bal'a F

更新日期：1982-12-01 00:00:00

abstract：:Currently, CTX-M β-lactamases are among the most prevalent and most heterogeneous extended-spectrum β-lactamases (ESBLs). In general, CTX-M enzymes are susceptible to inhibition by β-lactamase inhibitors. However, it is unknown if the pathway to inhibition by β-lactamase inhibitors for CTX-M ESBLs is similar to TEM an...

journal_title：Antimicrobial agents and chemotherapy

authors： Bethel CR,Taracila M,Shyr T,Thomson JM,Distler AM,Hujer KM,Hujer AM,Endimiani A,Papp-Wallace K,Bonnet R,Bonomo RA

更新日期：2011-07-01 00:00:00

abstract：:The 747-bp cfiA gene, which encodes a metallo-beta-lactamase, and the regions flanking cfiA in six imipenem-resistant and four imipenem-susceptible Bacteroides fragilis strains isolated in Japan were analyzed by PCR and DNA sequencing. The nucleotide sequences of the cfiA genes (designated cfiA(1) to cfiA(10)) of all ...

journal_title：Antimicrobial agents and chemotherapy

authors： Kato N,Yamazoe K,Han CG,Ohtsubo E

更新日期：2003-03-01 00:00:00

abstract：:Doxycycline is the treatment of choice for canine monocytic ehrlichiosis (CME), a well-characterized disease and valuable model for tick-borne zoonoses. Conflicting reports of clearance of Ehrlichia canis after treatment with doxycycline suggested that the disease phase during which treatment is initiated influences o...

journal_title：Antimicrobial agents and chemotherapy

authors： McClure JC,Crothers ML,Schaefer JJ,Stanley PD,Needham GR,Ewing SA,Stich RW

更新日期：2010-12-01 00:00:00

abstract：:Minibacterium massiliensis strain CIP107820 is a recently discovered waterborne Gram-negative rod isolated from hospital water samples. It harbors a chromosomally located gene encoding an Ambler class A extended-spectrum β-lactamase termed MIN-1, sharing 56%, 54%, and 51% amino acid identities with β-lactamases LUT-1,...

journal_title：Antimicrobial agents and chemotherapy

authors： Bercot B,Nordmann P,Drancourt M,Poirel L

更新日期：2012-07-01 00:00:00

abstract：:No studies have investigated whether discontinuation of ethambutol (EMB) based on the susceptibility to isoniazid and rifampin as determined by the GenoType MTBDRplus assay would be appropriate. We aimed to determine the feasibility of discontinuing EMB before the end of intensive phase treatment based on the result o...

journal_title：Antimicrobial agents and chemotherapy

authors： Jo KW,Kim M,Kim YJ,Lee HK,Kim HK,Jeon D,Lyu J,Park HK,Mok J,Kim JS,Heo EY,Choi SB,Yim JJ,Shim TS

更新日期：2019-09-16 00:00:00

abstract：:We examined an E-test-based strategy for testing the combination of itraconazole and amphotericin B, the latter given either sequentially or concomitantly, in isolates of Aspergillus fumigatus. An antagonistic interaction between the two drugs was noted, especially with the sequential administration of amphotericin B....

journal_title：Antimicrobial agents and chemotherapy

authors： Kontoyiannis DP,Lewis RE,Sagar N,May G,Prince RA,Rolston KV

更新日期：2000-10-01 00:00:00

abstract：:Recent Food and Drug Administration (FDA) guidance endorses the use of an early clinical response endpoint as the primary outcome for community-acquired bacterial pneumonia (CABP) trials. While antibiotics will now be approved for CABP, in practice they will primarily be used to treat patients with community-acquired ...

journal_title：Antimicrobial agents and chemotherapy

authors： Zasowski E,Butterfield JM,McNutt LA,Cohen J,Cosler L,Pai MP,Gottwald J,Chen WZ,Lodise TP

更新日期：2014-07-01 00:00:00

abstract：:The in vivo efficacy of ciprofloxacin or pefloxacin alone or in combination with fosfomycin was evaluated in experimental aortic valve endocarditis induced in 133 rabbits by a multidrug-susceptible or multidrug-resistant strain of Pseudomonas aeruginosa. Therapy was initiated early (12 h after infection), when bacteri...

journal_title：Antimicrobial agents and chemotherapy

authors： Xiong YQ,Potel G,Caillon J,Stephant G,Jehl F,Bugnon D,Le Conte P,Baron D,Drugeon H

更新日期：1995-02-01 00:00:00

abstract：:We asked whether beta-lactamase inhibitors (BLIs) increased the activity of daptomycin (DAP) against methicillin-resistant Staphylococcus aureus (MRSA), the peptide antibiotic colistin (COL) against the emerging Gram-negative nosocomial pathogen Acinetobacter baumannii, and the human host defense peptide cathelicidin ...

journal_title：Antimicrobial agents and chemotherapy

authors： Sakoulas G,Rose W,Berti A,Olson J,Munguia J,Nonejuie P,Sakoulas E,Rybak MJ,Pogliano J,Nizet V

更新日期：2017-01-24 00:00:00

abstract：:We have determined the antifungal susceptibilities of 34 clinical isolates of the dimorphic fungus Sporothrix schenckii to 11 drugs using a microdilution method. In general, the type of growth phase (mycelial or yeast) and the temperature of incubation (30 or 35 degrees C) exerted a significant influence on the MICs. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Trilles L,Fernández-Torres B,Dos Santos Lazéra M,Wanke B,de Oliveira Schubach A,de Almeida Paes R,Inza I,Guarro J

更新日期：2005-09-01 00:00:00

abstract：:Amphotericin B and N-D-ornithyl amphotericin B methyl ester were compared for therapeutic efficacies against experimentally induced cryptococcal meningitis and Candida albicans endocarditis with pyelonephritis in rabbits. Antifungal activity of the two polyenes in vitro was similar for the yeasts used in these experim...

journal_title：Antimicrobial agents and chemotherapy

authors： Perfect JR,Durack DT

更新日期：1985-12-01 00:00:00

abstract：:The effect of moxalactam and cefuroxime on mitogen-stimulated human peripheral blood mononuclear leukocytes was studied. Mononuclear leukocytes, mitogen, and antibiotic were added to microtiter wells. Cells were cultured for 3 days, pulsed with tritiated thymidine, and then counted. Compared with control cell cultures...

journal_title：Antimicrobial agents and chemotherapy

authors： Manzella JP,Clark JK

更新日期：1983-03-01 00:00:00

abstract：:A new SHV-derived extended-spectrum beta-lactamase (SHV-24) conferring high-level resistance to ceftazidime but not cefotaxime and cefazolin was identified in Japan. This enzyme was encoded by a transferable 150-kb plasmid from an Escherichia coli clinical isolate. The pI and K(m) for CAZ of this enzyme were 7.5 and 3...

journal_title：Antimicrobial agents and chemotherapy

authors： Kurokawa H,Yagi T,Shibata N,Shibayama K,Kamachi K,Arakawa Y

更新日期：2000-06-01 00:00:00

abstract：:Candida albicans biofilms are generally considered to be resistant to azole antifungal agents but susceptible to echinocandins. We demonstrate that in a sequential therapy regimen, treatment with fluconazole first followed by caspofungin leads to a significant decrease of the efficacy of this echinocandin. Cellular st...

journal_title：Antimicrobial agents and chemotherapy

authors： Sarkar S,Uppuluri P,Pierce CG,Lopez-Ribot JL

更新日期：2014-01-01 00:00:00

abstract：:The evolution of the highly pathogenic H5N1 influenza virus produces genetic variations that can lead to changes in antiviral susceptibility and in receptor-binding specificity. In countries where the highly pathogenic H5N1 virus is endemic or causes regular epidemics, the surveillance of these changes is important fo...

journal_title：Antimicrobial agents and chemotherapy

authors： Naughtin M,Dyason JC,Mardy S,Sorn S,von Itzstein M,Buchy P

更新日期：2011-05-01 00:00:00

abstract：:The pharmacokinetics, oral bioavailability, and ex vivo antimalarial activity of mirincamycin isomers in a healthy rhesus monkey model were assessed to support lead optimization of novel nonhemolytic drugs for radical cure and causal prophylaxis of malaria. Fourteen male rhesus monkeys were randomized to four groups, ...

journal_title：Antimicrobial agents and chemotherapy

authors： Khemawoot P,Saunders D,Rasameesoraj M,Melendez V,Imerbsin R,Ohrt C,Fracisco S,Teja-Isavadharm P

更新日期：2011-12-01 00:00:00

abstract：:This work in conjunction with the results presented in an earlier report (M. A. Purdy and K. L. Yielding, Antimicrob. Agents Chemother. 10:182--184, 1976) showed the following. (i) Nalidixic acid and novobiocin could inhibit post-ultraviolet and post-X-ray survival, implicating gyrase function in deoxyribonucleic acid...

journal_title：Antimicrobial agents and chemotherapy

authors： Purdy MA,Yielding KL

更新日期：1979-09-01 00:00:00

abstract：:There is significant interest in the development of mass spectrometry (MS) methods for antimicrobial resistance protein detection, given the ability of these methods to confirm protein expression. In this work, we studied the performance of a liquid chromatography, tandem MS multiple-reaction monitoring (LC-MS/MS MRM)...

journal_title：Antimicrobial agents and chemotherapy

authors： Wang H,Strich JR,Drake SK,Chen Y,Youn JH,Rosenberg AZ,Gucek M,Dekker JP,Suffredini AF

更新日期：2019-08-23 00:00:00

abstract：:Streptococcus pneumoniae is a leading cause of pneumonia, meningitis, septicemia, and middle ear infections. The incidence of S. pneumoniae isolates that are not susceptible to penicillin has risen worldwide and may be above 20% in some countries. Beta-lactam antibiotic resistance in pneumococci is associated with sig...

journal_title：Antimicrobial agents and chemotherapy

authors： Jensen A,Valdórsson O,Frimodt-Møller N,Hollingshead S,Kilian M

更新日期：2015-01-01 00:00:00

abstract：:Antimicrobial susceptibility patterns of 112 clinical isolates, 28 type strains, and 9 reference strains of Nocardia were determined using the Sensititre Rapmyco microdilution panel (Thermo Fisher, Inc.). Isolates were identified by highly discriminatory multilocus sequence analysis and were chosen to represent the di...

journal_title：Antimicrobial agents and chemotherapy

authors： McTaggart LR,Doucet J,Witkowska M,Richardson SE

更新日期：2015-01-01 00:00:00

abstract：:Human norovirus (HuNoV) is a major cause of nonbacterial gastroenteritis worldwide, yet despite its impact on society, vaccines and antivirals are currently lacking. A HuNoV replicon system has been widely applied to the evaluation of antiviral compounds and has thus accelerated the process of drug discovery against H...

journal_title：Antimicrobial agents and chemotherapy

authors： Kitano M,Hosmillo M,Emmott E,Lu J,Goodfellow I

更新日期：2018-04-26 00:00:00

abstract：:When developing novel microbicide products for the prevention of HIV infection, the preclinical safety program must evaluate not only the active pharmaceutical ingredient but also the product itself. To that end, we applied several relatively standard toxicology study methodologies to female sheep, incorporating an as...

journal_title：Antimicrobial agents and chemotherapy

authors： Holt JD,Cameron D,Dias N,Holding J,Muntendam A,Oostebring F,Dreier P,Rohan L,Nuttall J

更新日期：2015-07-01 00:00:00

abstract：:Omadacycline is an aminomethylcycline antibiotic with in vitro activity against pathogens causing community-acquired bacterial pneumonia (CABP). This study investigated the activity of omadacycline against Legionella pneumophila strains isolated between 1995 and 2014 from nosocomial or community-acquired respiratory i...

journal_title：Antimicrobial agents and chemotherapy

authors： Dubois J,Dubois M,Martel JF

更新日期：2020-04-21 00:00:00

abstract：:An inhibitor-based characterization system which allowed the identification of beta-lactamases after isoelectric focusing on polyacrylamide gels was developed. This system, using potassium clavulanate and oxacillin, distinguished type I chromosomally mediated enzymes from other beta-lactamases of gram-negative bacteri...

journal_title：Antimicrobial agents and chemotherapy

authors： Sanders CC,Sanders WE Jr,Moland ES

更新日期：1986-12-01 00:00:00

abstract：:Among 158 Candida glabrata bloodstream isolates collected from numerous centers in China, a resistance to fluconazole was seen in 8.9%. Three isolates (1.9%) were resistant to all echinocandins. Multilocus sequence typing (MLST) revealed that sequence type 7 ([ST7] 65.8%) was the most common type, followed by ST3 (7.6...

journal_title：Antimicrobial agents and chemotherapy

authors： Hou X,Xiao M,Wang H,Yu SY,Zhang G,Zhao Y,Xu YC

更新日期：2018-05-25 00:00:00

abstract：:TAN 1057-resistant Staphylococcus aureus and Escherichia coli strains were selected to elucidate the mechanism of resistance and the mode of action of this dipeptide antibiotic. Cell-free translation with isolated ribosomes and S150 fractions from sensitive and resistant S. aureus strains demonstrated that alterations...

journal_title：Antimicrobial agents and chemotherapy

authors： Limburg E,Gahlmann R,Kroll HP,Beyer D

更新日期：2004-02-01 00:00:00

abstract：:In the present study we determined the resistance patterns of anaerobic bacteria from human saliva and stool specimens and investigated whether there were significant differences in resistance between outpatients and hospitalized patients, regardless of whether they had received antimicrobial agents. No bacterial stra...

journal_title：Antimicrobial agents and chemotherapy

authors： Stark CA,Edlund C,Sjöstedt S,Kristensen G,Nord CE

更新日期：1993-08-01 00:00:00

abstract：:Nucleobase and nucleoside transporters play central roles in the biochemistry of parasitic protozoa, as they lack the ability to synthesize purines de novo and are absolutely reliant upon purine salvage from their hosts. Furthermore, such transporters are potentially critical to the pharmacology of these important hum...

journal_title：Antimicrobial agents and chemotherapy

authors： Al-Salabi MI,de Koning HP

更新日期：2005-09-01 00:00:00

abstract：:In this study, we characterized two tigecycline-resistant Klebsiella pneumoniae isolates from dog urine samples. The isolates were genetically unrelated, belonging to sequence type 11 (ST11) and ST147, both classically related to human isolates. To the best of our knowledge, this is the first identification of tigecyc...

journal_title：Antimicrobial agents and chemotherapy

authors： Ovejero CM,Escudero JA,Thomas-Lopez D,Hoefer A,Moyano G,Montero N,Martin-Espada C,Gonzalez-Zorn B

更新日期：2017-05-24 00:00:00